Localization of b-defensin genes in non human primates

Abstract

Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four b-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized b- defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four b-defensin genes, we have mapped the homologous regions to the b-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.

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Published
2009-06-29
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Letters to the Editor
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How to Cite
Ventura, M., Boniotto, M., Pazienza, M., & Palumbo, V. (2009). Localization of b-defensin genes in non human primates. European Journal of Histochemistry, 48(2), 195-200. https://doi.org/10.4081/888