Rhodiola Rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour


Rhodiola rosea L. (Crassulaceae) is a plant that lives at high altitude in Europe and Asia, usually used for its high capacity to increase the organism resistance to different stress conditions. Although a few international literature supports these effects, today R. rosea has become a common component of many dietary supplements also in the Western world. The aim of the present study was to investigate the effect of the R. rosea roots aqueous extract on in vitro human erythrocytes exposed to hypochlorous acid (HOCl)- oxidative stress. Several damages occur in human erythrocytes exposed in vitro to HOCl, among these membrane protein and lipid modifications, shifting from the discocyte shape to the echinocyte one, and determining lysis ultimately. Therefore, in the present work, the evaluation of the antioxidant capacity of the Rhodiola extract has been carried out by means of scanning electron microscopy and of hemolytic behaviour on human erythrocytes exposed to HOCl in the presence of increasing doses of the aqueous extract in different experimental environments (co-incubation and subsequent incubations). The results obtained are consistent with a significative protection of the extract in presence of the oxidative agent, but a cautionary note emerges from the analysis of the data related to the cell exposition to the plant extract in the absence of any induced oxidative stress. In fact, the addition to erythrocyte of high doses of R. rosea extract always determines severe alterations of the cell shape.


Download data is not yet available.
Original Papers
Abstract views: 246

PDF: 1127
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Battistelli, M., De Sanctis, R., De Bellis, R., Cucchiarini, L., Dachà, M., & Gobbi, P. (2009). Rhodiola Rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour. European Journal of Histochemistry, 49(3), 243-254. https://doi.org/10.4081/951

Most read articles by the same author(s)