Letters to the Editor
Vol. 46 No. 4 (2002)
https://doi.org/10.4081/1750

Nuclear localization of phosphorylated c-Myc protein in human tumor cells.

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Received: 14 May 2010
Accepted: 14 May 2010
Published: 14 May 2010
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c-Myc, fibrillarin, fluorescence microscopy, immunocytochemistry, nuclear bodies, nucleolus

Authors

C. Soldani
pelli@unipv.it
M.G. Bottone
M. Biggiogera
C. Alpini
A.I. Scovassi
T. Martin
C. Pellicciari
Using immunocytochemical techniques at light and electron microscopy, we analysed the distribution of phosphorylated c-Myc in actively proliferating human HeLa cells. The distribution pattern of c-Myc was also compared with those of other ribonucleoprotein (RNP)-containing components (PANA, hnRNP-core proteins, fibrillarin) or RNP-associated nuclear proteins (SC-35 splicing factor). Our results provide the first evidence that phosphorylated c-Myc accumulates in the nucleus of tumor cells, where it colocalizes with fibrillarin, both in the nucleolus and in extranucleolar structures.

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1.
Soldani C, Bottone M, Biggiogera M, Alpini C, Scovassi A, Martin T, et al. Nuclear localization of phosphorylated c-Myc protein in human tumor cells. Eur J Histochem [Internet]. 2010 May 14 [cited 2026 Jan. 23];46(4):377-80. Available from: https://www.ejh.it/ejh/article/view/1750