High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling

Submitted: 13 September 2016
Accepted: 9 November 2016
Published: 21 November 2016
Abstract Views: 1070
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High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.

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Supporting Agencies

Italian Ministry and Research and Instruction, grant PRIN 2010-2011,

How to Cite

Tossetta, G., Avellini, C., Licini, C., Giannubilo, S., Castellucci, M., & Marzioni, D. (2016). High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling. European Journal of Histochemistry, 60(4). https://doi.org/10.4081/ejh.2016.2724