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VGF AS BIOMARKER OF PRE-SYMPTOMATIC PHASE OF PARKINSON’S DISEASE Manai AL1, Modi A2, Noli B1, Choudhary SM2, Ruda-Kucerova J3, Dražanová E3,4, Khairnar A2,5, Cocco C1 | 1Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy; 2International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; 3Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 4Institute of Scientific Instruments of the CAS, v. v. i., Brno, Czech Republic; 5Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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ALPHA SYNUCLEIN REGULATION IN BRAIN AND BONE MARROW IS RELETED TO THE DIFFERENTIAL EXPRESSION OF GATA1 TRANSCRIPTION FACTOR Velardi V1, Arciprete F1, Caturano C1, Rana RA1, Mancinelli R2, Zingariello M1 and Vivacqua G1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy
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ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano1, F. E. Bellomi1, F. Arciprete1, V. Velardi1, L. La Barbera2, M. Falchi3, M. Bacioglu4, R. Mancinelli5, M. D’Amelio2, M. Spillantini4, M. Zingariello1, G. Vivacqua1,6 | 1Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; 2Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; 3National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; 4Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; 5Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; 6Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
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