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• LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou^1-6, M. Najajreh^1-4, D.P. Cook⁷, C.H. Maurer^1,2, S. Bärthel⁸, P. Putze⁸, H.A. Messal⁹, S.K. Ravichandran^1-3, T. Richter¹⁰, M. Knolle¹¹, T. Metzler¹², A.R. Shastri^1,2,3, R. Öllinger¹³, J. Jasper^1,2,3, L. Schmidleitner^1,2,3, C.Schneeweis⁸, H. Ishikawa-Ankerhold¹⁴, T. Engleitner¹³, S. Dobiasch¹⁵, I. Heid, M.D. Luecken¹⁶, K. Steiger¹², G. Kaissis¹¹, J. Van Rheenen⁹, F.J. Theis¹⁰, D. Saur⁸, R. Rad¹³, M. Reichert^{1,2,3,4,5,17,18} | ¹Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ²Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ³Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; ⁴Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; ⁵Bavarian Cancer Research Center (BZKF), Munich, Germany; ⁶Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; ⁷University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; ⁸Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; ⁹Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. ¹⁰Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; ¹¹Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; ¹²Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; ¹³Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; ¹⁴Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; ¹⁵Department of Radiation Oncology, Technical University of Munich, Germany; ¹⁶Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); ¹⁷German Cancer Consortium (DKTK), Munich, Germany; ¹⁸Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4289

  318
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  Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine

  Flavia Carton, Manuela Malatesta

  24-11-2022

  https://doi.org/10.4081/ejh.2022.3603

  1215

  PDF: 510

  HTML: 24

• P15 | EXPLORING NEUROTROPHIN-MEDIATED MECHANISMS IN ISCHEMIC CEREBRAL ORGANOIDS THROUGH INTEGRATED MULTI-OMICS ANALYSIS Chiara Giorgi¹, Fabrizio Ammannito¹, Vanessa Castelli¹, Annamaria Cimini^1|2, Michele d’Angelo^1|2 | ¹Dept. of Life, Health and Environmental Science, University of L'Aquila, Italy; ²Sbarro Institute for Cancer Research and Molecular Medicine, Dept. of Biology, Temple University, Philadelphia, PA, USA.

  GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

  22-06-2026

  https://doi.org/10.4081/ejh.2026.4711

  115

  PDF: 34
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  Novel understanding on genetic mechanisms of enteric neuropathies leading to severe gut dysmotility

  Francesca Bianco, Giulia Lattanzio, Luca Lorenzini, Chiara Diquigiovanni, Maurizio Mazzoni, Paolo Clavenzani, Laura Calzà, Luciana Giardino, Catia Sternini, Elena Bonora, Roberto De Giorgio

  25-11-2021

  https://doi.org/10.4081/ejh.2021.3289

  2630

  PDF: 1415

  HTML: 60

• P09 | THERAPEUTIC POTENTIAL OF NEUROTROPHINS IN AUTISM SPECTRUM DISORDER F. D’Egidio¹, M.S. Scenna¹, M. d’Angelo^1|2, V. Castelli¹, A. Cimini^1|2 | ¹University of L’Aquila, Dpt. of Life, Health and Environmental Sciences, L’Aquila, Italy; ²Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA, USA

  GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

  22-06-2026

  https://doi.org/10.4081/ejh.2026.4705

  89

  PDF: 33

• P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante¹, L. Leanza², E. Guerra³, F. Vianello⁴, C. Iacovino¹, S. Lattanzio¹, L. Morello¹, G. Stati¹, P. Simeone³, P. Lanuti³, S. Alberti⁵, M. Reichert⁶, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Biology, University of Padua, Padua, Italy; ³Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; ⁴Department of Biology, University of Padua, Padua, Italy; ⁵Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; ⁶Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4348

  213
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  Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

  Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

  07-04-2025

  https://doi.org/10.4081/ejh.2025.4182

  1259

  PDF: 746

  HTML: 50