Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway

  • S. Marzo University of Pavia, Italy.
  • V. Galimberti University of Pavia, Italy.
  • M. Biggiogera | marcobig@unipv.it University of Pavia, Italy.

Abstract

KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.

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Author Biographies

S. Marzo, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
V. Galimberti, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
M. Biggiogera, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
Published
2014-03-11
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Section
Brief Reports
Keywords:
cell nucleus, cerebral cavernous malformations, KRIT1, transcription, electron microscopy, immunocytochemistry.
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How to Cite
Marzo, S., Galimberti, V., & Biggiogera, M. (2014). Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway. European Journal of Histochemistry, 58(1). https://doi.org/10.4081/ejh.2014.2358

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