Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformation
AbstractKaposi’s Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection.We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR upregulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.
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Copyright (c) 2009 C Foglieni, S Scabini, D Belloni, F Broccolo, P Lusso, MS Malnati, E Ferrero
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