Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformation

Published: 30 June 2009
Abstract Views: 564
PDF: 459
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Kaposi’s Sarcoma (KS) is an angioproliferative disease associated with human herpesvirus 8 (HHV-8) infection.We have characterized the morphologic and phenotypic modifications of HUVEC in a model of productive HHV-8 infection. HHV-8 replication was associated with ultra-structural changes, flattened soma and a loss of marginal folds and intercellular contacts, and morphologic features, spindle cell conversion and cordon-like structures formation. Phenotypic changes observed on cordon-like structures included partial loss and redistribution of CD31/PECAM-1 and VE-cadherin, uPAR upregulation and de novo expression of CD13/APN. Such changes demonstrate the induction, in HUVEC, of an angiogenic profile. Most of these findings are directly linked to HHV-8-encoded proteins expression, suggesting that HHV-8 itself may participate to the initial steps of the angiogenic transformation in KS.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Foglieni, C., Scabini, S., Belloni, D., Broccolo, F., Lusso, P., Malnati, M., & Ferrero, E. (2009). Productive infection of HUVEC by HHV-8 is associated with changes compatible with angiogenic transformation. European Journal of Histochemistry, 49(3), 273–284. https://doi.org/10.4081/954