https://doi.org/10.4081/ejh.2023.3570

Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis

Vol. 67 No. 1 (2023)
Submitted: 28 September 2022
Accepted: 28 December 2022
Published: 11 January 2023
Neurokinin-1 receptor, ERK, cervical cancer, apoptosis
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Authors

Liyun Guan
Department of Oncology, The Third Hospital of Shijiazhuang, China.
Shifa Yuan
Department of General Surgery, Hospital of Hebei Province Crop of Chinese Armed Police Force, Shijiazhuang, China.
Jing Ma
shj911la@gmail.com
Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Hong Liu
Department of Gynecology and Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Lizhen Huang
Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang , China.
Fengzhen Zhang
Department of Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Neurokinin-1 receptor (NK1R) belongs to tachykinin receptor family. Recent studies have suggested that NK1R was upregulated in cancer tissues including breast cancer, glioma and melanoma. Furthermore, NK1R antagonists have been employed to exert anti-tumor effect and promote cancer cell apoptosis. However, the role of NK1R in cervical cancer remains largely unknown. In this study, we aimed to detect the expression of NK1R in cervical cancer and evaluate the anti-tumor effects of NK1R antagonist on cervical cancer cells. We found that NK1R was highly expressed in cervical cancer tissues than in adjacent normal cervical tissues. Furthermore, by using NK1R antagonist we demonstrated that NK1R antagonist inhibited the viability and induced the apoptosis of cervical cancer cells in a dose-dependent manner, and the mechanism may be related to the inhibition of ERK activation and the regulation of apoptosis proteins Bcl-2 and BAX. In conclusion, these findings suggest that NK1R plays an oncogenic role in cervical cancer and is a promising target for cervical cancer therapy.

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Ethics Approval

This study was approved by Ethics Committee of Hebei Medical University (approval No. 2018019)

Supporting Agencies

Hebei Province Medical Science Research Key Project Program

How to Cite

Guan, L., Yuan, S., Ma, J., Liu, H., Huang, L., & Zhang, F. (2023). Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis. European Journal of Histochemistry, 67(1). https://doi.org/10.4081/ejh.2023.3570
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