https://doi.org/10.4081/ejh.2023.3655

Expression and clinical significance of HER2/neu, aromatase P450 and adhesion molecule CD24 in endometrial cancer

Vol. 67 No. 3 (2023)
Submitted: 27 January 2023
Accepted: 31 July 2023
Published: 10 August 2023
Aromatase P450, adhesion molecule CD24, HER2/neu, endometrial cancer
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Authors

Liyun Guan
Department of Oncology, The Third Hospital of Shijiazhuang, China.
Ying Wang
15833925141@139.com
https://orcid.org/0000-0003-0478-0502
Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jianxin Cheng
Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jun Zhang
Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Shan Kang
Department of Obstetrics and Gynecology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

This study aimed at exploring the expression and clinical significance of aromatase P450, adhesion molecule CD24 and HER2/neu in endometrial cancer. The expression of aromatase P450, adhesion molecule CD24 and HER2/neu was detected by immunohistochemistry in 15 cases of endometrial hyperplasia group, 50 cases of endometrial adenocarcinoma and 3 cases of uterine papillary adenocarcinoma, with 15 cases of normal endometrium as control group. We detected no expression of aromatase P450, adhesion molecule CD24 or HER2/neu in control group. Aromatase P450 positive expression rate was 66.7% in endometrial hyperplasia group and 70.3% in endometrial carcinoma group, without significant difference (p>0.05). There was no significant difference (p>0.05) in the positive expression rate of aromatase P450 between different myometrial invasion groups of endometrial adenocarcinomas. CD24 positive expression rate was 40.0% in endometrial hyperplasia group and 79.6% in endometrial carcinoma group, with significant difference (p<0.05). HER2/neu positive expression rate was 26.7% in the endometrial hyperplasia group and 57% in endometrial carcinoma group, with significant difference (p<0.05). In conclusion, aromatase P450 may be one factor associated with endometrial cancer cell proliferation, while CD24 and HER2/neu may be important factors associated with the invasion and metastasis of endometrial cancer.

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Europe PMC
Zheng R, Zhang S, Zeng H, Wang S, Sun K, Chen R, et al. Cancer incidence and mortality in China, 2016. J Nat Cancer Center 2022;2:1-9. DOI: https://doi.org/10.1016/j.jncc.2022.02.002
Yang X, Ma K, Chen R, Zhang N, Meng Y, Wen J, et al. Immunocytochemical examination of PTEN and Ki-67 for endometrial carcinoma using thin-layer endometrial preparations. Biocell 2021;45:923-32. DOI: https://doi.org/10.32604/biocell.2021.013625
Richards JA, Petrel TA, Brueggemeier RW. Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells. J Steroid Biochem 2002;80:203-12. DOI: https://doi.org/10.1016/S0960-0760(01)00187-X
Brodie AMH, Lu Q, Long BJ, Fulton A, Chen T, Macpherson N, et al. Aromatase and COX-2 expression in human breast cancers. J. Steroid Biochem 2001;79:41-7. DOI: https://doi.org/10.1016/S0960-0760(01)00131-5
Kaipparettu BA, Malik S, Konduri SD, Liu W, Rokavec M, Van Der Kuip H, et al. Estrogen-mediated downregulation of CD24 in breast cancer cells. Int J Cancer 2008;123:66-72. DOI: https://doi.org/10.1002/ijc.23480
Altevogt P, Sammar M, Hüser L, Kristiansen G. Novel insights into the function of CD24: A driving force in cancer. Int J Cancer 2021;148:546-59. DOI: https://doi.org/10.1002/ijc.33249
Ferretti G, Felici A, Papaldo P, Fabi A, Cognetti F. HER2/neu role in breast cancer: from a prognostic foe to a predictive friend. Curr Opin Obstet Gynecol 2007;19:56-62. DOI: https://doi.org/10.1097/GCO.0b013e328012980a
Buza N, Roque DM, Santin AD. HER2/neu in endometrial cancer: a promising therapeutic target with diagnostic challenges. Arch Pathol Lab Med 2014;138:343-50. DOI: https://doi.org/10.5858/arpa.2012-0416-RA
Gardella B, Dominoni M, Bogliolo S, Cassani C, Carletti GV, De Silvestri A, et al. Palliative treatment of endometrial cancer: what is the role of anastrozole in elderly women? BMC Palliat Care 2021;20:28. DOI: https://doi.org/10.1186/s12904-021-00719-0
Berstein LM, Tchernobrovkina AE, Gamajunova VB, Kovalevskij AJ, Vasilyev DA, Chepik OF, et al. Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer. J Cancer Res Clin Oncol 2003;129:245-9. DOI: https://doi.org/10.1007/s00432-003-0427-9
Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J. Reproductive system: aromatase and estrogens. Mol Cell Endocrinol 2002;193:137-43. DOI: https://doi.org/10.1016/S0303-7207(02)00107-7
Qian B, Huang Y, Qiu Z, Ying X, Yang G, Li H, et al. Tet methylcytosine dioxygenase 2 suppresses renal cell cancer proliferation and metastasis by regulating the miR-200c-SCD axis. Biocell 2021;45:599-615. DOI: https://doi.org/10.32604/biocell.2021.014633
Lin CY, Tsai CL, Chao A, Lee LY, Chen WC, Tang YH, et al. Nucleophosmin/B23 promotes endometrial cancer cell escape from macrophage phagocytosis by increasing CD24 expression. J Mol Med (Berl) 2021;99:1125-37. DOI: https://doi.org/10.1007/s00109-021-02079-x
Wu Y, Soslow RA, Marshall DS, Leitao M, Chen B. Her-2/neu expression and amplification in early stage ovarian surface epithelial neoplasms. Gynecol Oncol 2004;95:570-5. DOI: https://doi.org/10.1016/j.ygyno.2004.08.043
Wang X, Yue J, Kang Y, Dai Z, Ju J, Wang J, et al. Combined chemo-endocrine therapy as a potential new option for HR+/HER2- advanced breast cancer: a prospective study of fulvestrant plus oral vinorelbine. Cancer Biol Med 2023;20:287-96. DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0702
Han S, Park S, An J, Yang J-Y, Chung J-W, Kim YJ, et al. HER2 as a potential biomarker of lymph node metastasis in undifferentiated early gastric cancer. Sci Rep 2020;10:5270. DOI: https://doi.org/10.1038/s41598-020-61567-1
Cao L, Basudan A, Sikora MJ, Bahreini A, Tasdemir N, Levine KM, et al. Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma. Cancer Lett 2019;461:21-30. DOI: https://doi.org/10.1016/j.canlet.2019.06.011
Buchynska LG, Brieieva OV, Iurchenko NP. Assessment of HER-2 neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas. Exp Oncol 2019;41:138-43. DOI: https://doi.org/10.32471/exp-oncology.2312-8852.vol-41-no-2.12973
Afify AM, Werness BA, Mark HFL. HER-2/neu oncogene amplification in stage I and stage III ovarian papillary serous carcinoma. Exp Mol Pathol 1999;66:163-9. DOI: https://doi.org/10.1006/exmp.1999.2255
Malamou-Mitsi V, Crikoni O, Timotheadou E, Aravantinos G, Vrettou E, Agnantis N, et al. Prognostic significance of HER-2, p53 and Bcl-2 in patients with epithelial ovarian cancer. Anticancer Res 2007;27:1157-65.
Rubin SC, Finstad CL, Wong GY, Almadrones L, Plante M, Lloyd KO. Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: A multivariate analysis. Am J Obstet Gynecol 1993;168:162-9. DOI: https://doi.org/10.1016/S0002-9378(12)90907-2
Yang Y, Zhang M, Wang Y. The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy. J Nat Cancer Center 2022; 2:277-90. DOI: https://doi.org/10.1016/j.jncc.2022.09.002

Ethics Approval

this study was approved by ethics board of Hebei Medical University, Shijiazhuang, China (approval No. 202871)

Supporting Agencies

Key Medical Science Research Program of Hebei Province

How to Cite

Guan, L., Wang, Y., Cheng, J., Zhang, J., & Kang, S. (2023). Expression and clinical significance of HER2/neu, aromatase P450 and adhesion molecule CD24 in endometrial cancer. European Journal of Histochemistry, 67(3). https://doi.org/10.4081/ejh.2023.3655
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