Appearance of β-dystroglycan precedes the formation of glio-vascular end-feet in developing rat brain

  • Mihály Kálmán | kalmanprof@gmail.com Semmelweis University, Department of Anatomy, Histology and Embryology, Hungary.
  • Erzsébet Oszwald Semmelweis University, Department of Anatomy, Histology and Embryology, Hungary.
  • István Adorján Semmelweis University, Department of Anatomy, Histology and Embryology, Hungary.

Abstract

Dystroglycan has an important role in binding of perivascular glial end-feet tothe basal lamina. Its β-subunit is localized in the glial end-feet. The investigation period lasted from E(embryonic day)12 to E20. Laminin and β-dystroglycan were detected by immunohistochemistry, the glial localization of the latter one was supported  by electron microscopy. The immatureglial structures were visualized by the immunostaining of nestin. The β-dystroglycan immunoreactivity appeared at E16 following the laminin of basal lamina but preceding the perivascular processes of radial glia (E18) and astrocyte-like cells (E20). It occurred in cell bodies which attached to the vessels directly but not with vascular processes and end-feet. The presence of β-dystroglycan in such immature cells may promote their differentiation to perivascular astrocytes and influence the formation of the glio-vascular processes.

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Published
2018-05-18
Section
Brief Reports
Supporting Agencies
Semmelweis University
Keywords:
Brain development, dystroglycan, glial end-feet, glio-vascular, nestin.
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How to Cite
Kálmán, M., Oszwald, E., & Adorján, I. (2018). Appearance of β-dystroglycan precedes the formation of glio-vascular end-feet in developing rat brain. European Journal of Histochemistry, 62(2). https://doi.org/10.4081/ejh.2018.2908