FOR AUTHORS
Vol. 70 No. s1 (2026)
Published:
22 June 2026
71st Congress of the Italian Embryological Group-Italian Society of Development and Cell Biology (GEI-SIBSC)
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01 | OVERCOMING HORMONAL BARRIERS TO CARDIAC REGENERATION G. D’Uva1|2 | 1Department of Medical and Surgical Sciences; 2IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy
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02 | MODELING NON-CELL AUTONOMOUS MECHANISMS IN THE ALS PERIPHERAL NERVOUS SYSTEM A. Romano1|2|3 | 1Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 2Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3CNR NANOTEC - Institute of Nanotechnology, Lecce, Italy
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03 | DISTINCTIVE HOMEOSTATIC BALANCE IN CHILDHOOD OBESITY AND ITS RELATIONSHIP WITH BONE HEALTH Maria Felicia Faienza | Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Italy
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04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE G. Abruscato1, L. Sileo2, G. Scanavino2, C. Guerriero2, M. Mauro1, M. Vazzana1|3, V. Arizza1|3, C. Luparello1|3, A.M.Tata2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Dept. of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center (NBFC), Italy
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05 | MITOCHONDRIA DANCE WITH LIGHT: HOW WAVELENGTH CHOREOGRAPHS RESPIRASOMA, NITRIC OXIDE AND OXIDATIVE PHOSPHORYLATION Andrea Amaroli1, Matilde Balbi2, Silvia Ravera2|3 | 1Dept. of Earth, Environmental and Life Sciences, University of Genoa, Italy; 2Dept. of Experimental Medicine, University of Genoa, Italy; 3IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy
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06 | OBESITY-INDUCED TESTICULAR DYSFUNCTION: PROTECTIVE ROLES OF THYROID HORMONES IN HIGH-FAT DIET-FED RATS M.R. Ambruosi1, A. Biasi1, M. Vigliotti2, N. Scopigno2, F. Cioffi2, M. Venditti1 | 1Dept. Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Dept. of Science and Technology, University of Sannio, Benevento, Italy
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07 | FROM GUT MICROBIOTA TO GONADS: BUTYRATE MITIGATES PFAS–PESTICIDE MIXTURE TOXICITY IN ZEBRAFISH SPERMATOGENESIS M. Lombó, N. Baldoni, C. Giommi, O. Carnevali | Dept. of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy
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08 | HUMAN ADIPOSE STEM CELLS: IMPACT OF DONORS’ AGE ON CELL PROPERTIES AND BEHAVIOUR Ludovica Barone1, Federica Rossi1, Federico Tamborini1, Christina Pagiatakis1|2, Roberto Papait1|2, Rosalba Gornati1 | 1Dept of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; 2Dept of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
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09 | MODULATION OF ETOSIS BY BIOACTIVE EXTRACTS DERIVED FROM MARINE RESOURCES AND AGRI-FOOD BY-PRODUCTS F. Bellistrì1, G. Abruscato1, M. Perlotti1, A. Lo Muzzo1, C. Gargano1, F. Longo1, M. Mauro1, R. Chiarelli1, V. Arizza1|3, C. Luparello1|3, G. Sarà2|3, M. Vazzana1|3 | 1Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Department of Earth and Marine Sciences, Palermo, Italy; 3National Biodiversity Future Center, Palermo, Italy
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10 | ASSESSING RECOVERY FROM HYDROCARBON SPILL EXPOSURE IN MEDITERRANEAN MUSSEL MYTILUS GALLOPROVINCIALIS: A MULTI-BIOMARKER APPROACH F. Bertini1, L. Scirè Calabrisotto1, L. Bisanti1, C. La Corte1, M. Dara1, M. Staropoli1, L. T. Marcianò2, G. Santaluna2, L. Greco1, R. Chiarelli3, V. Catania1, D. Parrinello1, M. Cammarata1, M.G. Parisi1 | 1Dept. of Earth and Marine Sciences, University of Palermo, Italy; 2Dept. of Earth and Marine Sciences, University of Palermo, Italy; 3Dept. of Biological, Chemical and Pharmaceutical Sciences and Technology, University of Palermo, Italy
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11 | FROM SIGNALING TO STRUCTURE: TYPE 1 DIABETES DISRUPTS ACTIN NETWORKS IN TESTIS AND SPERMATOZOA A. Biasi1, M. R. Ambruosi1, S. Falvo2, S. Minucci1, M. Venditti1 | 1Dept of Experimental Medicine, University of Campania “L. Vanvitelli”; 2Dept. of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania “L. Vanvitelli”, Italy
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12 | IMPACT OF COCAINE ON GASTROINTESTINAL BARRIER INTEGRITY S. Boccia1, B. Sgangarella Valvano2, A. Mileo3, A. Nebbioso4, A. De Luca1, A. Capaldo5, M. De Falco5|6 | 1Dept. of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy; 3Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 4Dept. of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 5Dept. of Biology, University of Naples Federico II, Naples, Italy
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13 | MULTI-OMICS DISSECTION OF TRANSCRIPTIONAL AND EPIGENETIC REMODELING DURING CARDIAC AGING Daniele Bonisolo1, Simone Serio2, Christina Pagiatakis1|2, Rosalba Gornati1, Giovanni Bernardini1, Roberto Papait1|2 | 1Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; 2Department of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
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14 | NR2F1 MODULATES ACTIVATION DYNAMICS AND MAINTENANCE OF THE ADULT MURINE HIPPOCAMPAL NEURAL STEM CELL POOL S. Bonzano1|2, A. Lippolis1|2, S. Quaresima3, V. Manzini3, E. Dallorto1|2, E. Cacci3, P. Peretto1|2, M. Studer4, V. Licursi5, G. Lupo3, S. De Marchis1|2 | 1Dept. of Life Sciences and Systems Biology (DBIOS), Univ. of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (Turin), Italy; 3Dept. of Biology and Biotechnologies Charles Darwin, Sapienza Univ. of Rome, Italy; 4Univ. Côte d'Azur, CNRS, Inserm, iBV, Nice, France; 5Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy
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15 | BEYOND SURVIVAL: INNATE IMMUNE READOUTS IN ZEBRAFISH FOR ADVANCED BIOMATERIALS ASSESSMENT. C. Bragato, P. Bonfanti, A. Colombo, M. Gualtieri, P. Mantecca | Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Italy
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16 | EXTRACELLULAR VESICLES RELEASED BY CUMULUS CELLS CONTRIBUTE TO THE ACQUISITION OF MOUSE OOCYTE’S DEVELOPMENTAL COMPETENCE Giulia Brazzale1, Mario Zanoni1, Valeria Merico1, Giulia Fiorentino1, Paola Rebuzzini1, Andrea Fantinato1, Margherita Isernia1, Sergio Comincini1, Danilo Cimadomo1|2, Maurizio Zuccotti1 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2IVIRMA Global Research Alliance, IVIRMA Italia, Rome, Italy
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17 | EXPLORING THE FUNCTIONAL ROLE OF THE PROTEOGLYCAN ESM1 IN THE BREAST CANCER TUMOR MICROENVIRONMENT E. Peri1, S. Feo1|2, E. Roz3, A. D’Ascola4, P. Cancemi1|2 | 1Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy; 2Experimental Center of Onco Biology (COBS), Palermo, Italy; 3La Maddalena Hospital III Level Oncological Department, Palermo, Italy; 4Department of Clinical and Experimental Medicine, University of Messina, Italy
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18 | EARLY-DIFFERENTIATED C2C12 MYOTUBES RELEASE A PRO-TROPHIC SECRETOME THAT MODULATES NSC-34 MATURATION: IMPLICATIONS FOR NEUROMUSCULAR CROSSTALK IN AMYOTROPHIC LATERAL SCLEROSIS E. Carata, M. Muci, E. Panzarini | Dept. of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
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19 | ADRENERGIC MODULATION OF THE HYPOTHALAMIC-PITUITARY-THYROID AXIS IN THE LIZARD PODARCIS SICULUS Francesca Carrella1, Assunta Lallo1, Stefania Boccia2, Maria De Falco3|4, Rosaria Sciarrillo1 | 1Department of Science and Technologies, University of Sannio, Benevento, Italy; 2Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Department of Biology, University of Naples “Federico II”, Naples, Italy; 4National Institute of Biostructures and Biosystems (INBB), Rome, Italy
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20 | REPRODUCTIVE DYNAMICS AND PHYSIOLOGICAL CONDITION IN DIFFERENT SIZE CLASSES OF COMMON SOLE (SOLEA SOLEA) FROM THE NORTH-CENTRAL ADRIATIC SEA G. Chemello1, L. Tortora1, C. Santoni1, E. Giorgini1, S. Colella2, G. Gioacchini1 | 1Dept. of Life and Environmental Science, Polytechnic University of Marche, Italy; 2National Research Council (CNR), Institute for Marine Biological Resources and Biotechnology (IRBIM), Italy
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21 | ARSENIC-INDUCED OXIDATIVE AND CELLULAR STRESS IN THE FRESHWATER SNAIL LYMNAEA STAGNALIS T. Chianese, S. Balsamo, R. Leandri, D. Modano, K. Power, R. Scudiero, A. Capaldo | Dept. of Biology, University of Naples Federico II, Italy
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22 | TRANSCRIPTIONAL AND POST-TRANSLATIONAL NETWORKS COORDINATE SELECTIVE AUTOPHAGY TO MAINTAIN ORGANELLE HOMEOSTASIS K. Hartfelt1, M. Petraroia2, T. Persichini2, M. Colasanti2, C. Di Malta3, F. Cecconi4, V. Cianfanelli2 | 1Unit of Cell Stress and Survival, Danish Cancer Institute, Copenhagen, Denmark; 2Dept. of Science, University Roma TRE, Rome, Italy; 3Telethon Institute of Genetics and Medicine, Naples, Italy; 4Dept. of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Rome, Italy
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23 | BIOFUNCTIONALIZED ELECTROSPUN FIBERS FOR SKIN REGENERATION E. Coccia1, R. Imperatore1, E. Mula1|2, M. Paolucci1 | 1Dept. of Sciences and Technologies, University of Sannio, Benevento, Italy; 2Dept. of Organic and Inorganic Chemistry, University of Alcalà, Alcalà de Henares, Spain
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24 | ADMINISTRATION OF BRANCHED-CHAIN AMINO ACIDS AND DI-ALANINE MITIGATES MUSCLE ATROPHY IN A MOUSE MODEL OF CANCER CACHEXIA M. Colardo1, N. Martella1, M. Varone1, D. Pensabene1, G. Caretti2, G. Bianchini3, A. Aramini3, M. Segatto1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Biosciences, University of Milan, Italy; 3Research & Early Development, Dompé Farmaceutici S.p.A., L’Aquila, Italy
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25 | ENHANCING IN VITRO FOLLICULOGENESIS THROUGH OVARIAN TISSUE-ENDOTHELIAL CELL CO-CULTURE: 3D MAPPING OF NEO-CAPILLARY GROWTH AND MATURATION V. De Gregorio1, A. Candela1, V. Genovese2, M. Cimmino1|2, R. Talevi1, R. Gualtieri1 | 1Department of Biology, University of Naples Federico II, Naples, Italy; 2IVF RED srl, Caserta, Italy
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26 | ASSESSING DEVELOPMENTAL TOXICITY OF PSYCHOACTIVE POLLUTANTS USING XENOPUS LAEVIS AS A MODEL S. Di Marino, C. Fogliano, C.M. Motta, B. Avallone, R. Carotenuto | Dept. of Biology, University of Naples Federico II, Italy
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27 | CELLULAR AND MOLECULAR MECHANISMS OF GADOLINIUM TOXICITY IN SERTOLI CELLS Sara Falvo1, Giulia Grillo1, Gabriella Chieffi Baccari1, Giuseppe Petito1, Massimo Venditti2, Maria Maddalena Di Fiore1, Tiziana Cappello3, Maria Maisano3, Alessandra Santillo1 | 1Dept of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; 2Dept of Experimental Medicine, University of Campania L. Vanvitelli, Napoli, Italy; 3Dept of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
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28 | 3D MORPHO-FUNCTIONAL RECONSTRUCTION OF THE PREPUBERTAL MOUSE OVARY COMBINING NANO-COMPUTED TOMOGRAPHY AND CONFOCAL IMAGING A. Fantinato1|4, G. Fiorentino1|4, A. Parrilli2, G. Brazzale1, V. Merico1, P. Rebuzzini1, D. Cimadomo1|3, S. Garagna1, M. Zuccotti1 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2Empa-Swiss Federal Laboratories for Materials Science and Technology, Switzerland; 3IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Italy; 4Equal contribution
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29 | IL-17 FAMILY IN POMACEA CANALICULATA: FIRST EVIDENCE OF A EXCLUSIVE NEURAL-SPECIFIC MEMBER A. Ferri1, S. Sacchi1, C. Losi2, N. Franchi1, U. Rosani3, D. Malagoli1|4 | 1Dept. of Life Science, University of Modena and Reggio Emilia, Italy; 2Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 3Dept. of Biology, University of Padova, Italy; 4NBFC, National Biodiversity Future Center, Italy
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30 | NANO-COMPUTED TOMOGRAPHY 3D MAPPING OF PRIMARY-TO-PREOVULATORY FOLLICLES IN THE MOUSE OVARY ACROSS LIFESPAN G. Fiorentino1|9, A. Fantinato1|9, A. Parrilli2, T. Marzi3, C. Alippi3|4, R. Bellazzi5, L. Rienzi6|7, F.M. Ubaldi8, A. Vaiarelli8, G. Brazzale1, V. Merico1, P. Rebuzzini1, D. Cimadomo1|7, S. Garagna1, M. Zuccotti1 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2Empa-Swiss Federal Laboratories for Materials Science and Technology, Switzerland; 3Faculty of Informatics, Università della Svizzera italiana, Switzerland; 4Dept. of Electronics, Information, and Bioengineering, Politecnico di Milano, Italy; 5Dept. of Computer, Electrical and Biomedical Engineering, University of Pavia, Italy; 6Dept. of Biomolecular Sciences, University of Urbino, Italy; 7IVIRMA Global Research Alliance, IVIRMA Italia, Italy; 8IVIRMA Global Research Alliance, Clinica Valle Giulia, Italy; 9Equal contribution
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31 | LOSS OF IMPG2 PARALOGS LEADS TO RETINAL DEGENERATION IN ZEBRAFISH DOUBLE KNOCK-OUT MODEL C. Fogliano1, A. Cumplido Mayoral2, L. Balasco2, S. Casarosa2|3, B. Avallone1 | 1Dept. of Biology, University of Naples Federico II, Italy 2Dept. of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy; 3Center for Medical Sciences, University of Trento, Italy
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32 | CONTROLLING COMPLEMENT FROM IMMUNITY TO DEVELOPMENT Filippo Bertolasi1, Sandro Sacchi1, Alessandro Vezzi2, Gabriele Sales2, Anita Ferri1, Davide Malagoli1|3, Nicola Franchi1 | 1Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Department of Biology, University of Padova, Italy; 3National Biodiversity Future Center (NBFC), Palermo, Italy
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33 | GADOLINIUM AND REPRODUCTIVE HEALTH IN NON-TARGET ORGANISMS: EVIDENCE FROM MYTILUS GALLOPROVINCIALIS SPECIES M. Galati1, S. Falvo2, G. Vinci1, G. De Marco1, V. Parrino1, T. Cappello1, A. Santillo2, M. Maisano1 | 1Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Dept. of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy
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34 | CYTOTOXIC EFFECTS OF SICILIAN GRAPE SEED OILS ON CANCER CELLS D. Ganci1, G. Abruscato2, R. Chiarelli1, M. Mauro1|2, V. Arizza1|2, M. Vazzana1|2, C. Luparello1|2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2NFBC, National Biodiversity Future Center, Palermo, Italy
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35 | DISSECTING THE REGIONAL ORGANIZATION OF WIRING AND VOLUME TRANSMISSION IN THE SEROTONERGIC SYSTEM G. Gianni, M. Picchi, S. Nazzi, S. Migliarini, N. Barsotti, M. Pasqualetti | Department of Biology, University of Pisa, Italy
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36 | A 3D HUMAN OSTEOBLAST SPHEROID MODEL REVEALS ENDOCRINE DISRUPTOR OSTEOTOXICITY AND THE EFFECTS OF POSTBIOTICS Christian Giommi1|2, Fiorenza Sella1, Marta Lombó1|2|3, Oliana Carnevali1|2 | 1Dept. of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy; 2INBB-Biostructures and Biosystems National Institute, Rome, Italy; 3Dept. of Molecular Biology, Universidad de León, Spain
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37 | INVESTIGATING THE ROLE OF NR2F1 IN NEURAL STEM CELL QUIESCENCE AND ACTIVATION IN THE ADULT SUBVENTRICULAR ZONE Iacono F.1, Licursi V.2, Quaresima S.1, Manzini V.2, Felli A.1, Lippolis A.3|4, Miranda Banos M.E.1, Cacci E.1, Peretto P.3|4, Studer M.5, De Marchis S.3|4, Lupo G.1, Bonzano S.3|4 | 1Department of Biology e Biotechnologies Charles Darwin, Sapienza University of Rome, Italy; 2Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy; 3Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Italy; 4Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano (TO), Italy; 5Univ. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France
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38 | NATURAL ANTIOXIDANTS IN THE FIGHT AGAINST OVARIAN CANCER: IN VITRO EFFECTS OF POLYPHENOLS Lorenzo Ibello, Filomena Mottola, Maria Teresa Gentile, Ilaria Palmieri, Lucia Rocco | Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy
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39 | ENVIRONMENTAL FACTORS INFLUENCE THE PROTECTIVE EFFICACY OF BRASSICA OLERACEA EXTRACTS ON INTESTINAL AND HEPATIC HOMEOSTASIS IN ZEBRAFISH R. Imperatore1, I. Šola2, E. Coccia1, R. Sciarrillo1, M. Paolucci1 | 1Dept. of Sciences and Technologies, University of Sannio, Benevento, Italy; 2Department of Biology, Faculty of Science, University of Zagreb, Croatia
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40 | PREIMPLANTATION EMBRYO MORPHOLOGICAL FEATURES AS NON-INVASIVE MARKERS OF DEVELOPMENT TO BLASTOCYST M. Isernia1|7, A. Fantinato1|7, L. Corso2|7, E. Kayar2, G. Fiorentino1, G. Nicora2, M. Meseguer3, M. Taggi4, F. Innocenti4, G. Coticchio4, A. Vaiarelli5, L. Rienzi4|6, R. Bellazzi2, M. Zuccotti1, D. Cimadomo1|4 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2Dept. of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy; 3IVIRMA Global Research Alliance, IVI Valencia, Spain; 4IVIRMA Global Research Alliance, IVIRMA Italia, Italy; 5IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Italy; 6Dept. of Biomolecular Sciences, University of Urbino, Italy; 7these authors contributed equally
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41 | IMPACT OF POLYETHYLENE MICROPLASTICS ON INTESTINE, OVARY AND BRAIN OF ZEBRAFISH A. La Pietra, A.R. Bianchi, B. Berman, T. Mobilio, A. Chirico, G. Imbimbo, A. De Maio, I. Ferrandino | Dept. of Biology, University of Naples Federico II, Italy
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42 | IMPACT OF MICROPLASTICS AND BISPHENOL A, ALONE AND ABSORBED ON MPS, ON MYTILUS EDULIS EMBRYOS G. La Pusata1, C. Lefebvre2, M. Galati1, E. Pulvirenti3, V. Parrino1, G.O. Conti3, M. Ferrante3, M. Maisano1, J. Cachot2, T. Cappello1 | 1Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2University of Bordeaux, Laboratory EPOC, UMR 5805, Pessac, France; 3Dept. of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, University of Catania, Italy
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43 | OVERVIEW OF EFFECTS OF ENDOCRINE-DISRUPTING CHEMICALS (EDCS) ON THE MORPHOPHYSIOLOGY OF THE THYROID GLAND IN REPTILES: EVIDENCE FROM LACERTIDE PODARCIS SICULUS Assunta Lallo1, Francesca Carrella1, Roberta Imperatore1, Benedetta Sangarella Valvano4, Maria De Falcob3, Rosaria Sciarrillo1 | 1Department of Science and Technologies, University of Sannio, Benevento, Italy; 2Department of Biology, University of Naples “Federico II”, Naples, Italy; 3National Institute of Biostructures and Biosystems (INBB), Rome, Italy; 4Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy
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44 | CHARACTERIZATION OF IMMUNE CELLS IN THE ADIPOSE TISSUE OF OBESE MICE TREATED WITH ANTI-OBESITY THERAPIES G.P. Lombardo1, A. Nunnari1, A. Miller2, M. Kotańska3, S. Fiorentino1, E.R. Lauriano1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 2Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, Italy; 3Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, Krakow, Poland
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45 | HEMOLYMPH REPOPULATION AFTER WITHDRAWAL INVOLVES CIRCULATING AND KIDNEY-RESIDENT HEMOCYTE POPULATIONS IN THE SNAIL POMACEA CANALICULATA C. Losi1, A. Ferri2, S. Sacchi2, M. Montanari2, G. Sansalone2, D. Malagoli2|3 | 1Models and Methods for Material and Environmental Sciences PhD Course, Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 2Dept. of Life Sciences, University of Modena and Reggio Emilia, Italy; 3NBFC-National Biodiversity Future Center, Palermo, Italy
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46 | DEFINING FAM46C-DEPENDENT LIPID REMODELLING IN CELLULAR HOMEOSTASIS Isidora Alempijevic1, Federica De Grossi1, Annarita Miluzio1, Ivan Ferrari1, Elisa Arsuffi1, Marilena Mancino1, Stefano Biffo1|2, Nicola Manfrini1|2 | 1INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy; 2Department of Biosciences, University of Milan, Italy
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47 | SYNERGISTIC LUNG TOXICITY OF PM2.5 AND ENNIATIN B1 IN A CO-CULTURE MODEL S. Marchetti1, F. Caloni2, P. Mantecca1, M. Gualtieri1 | 1POLARIS Research Centre, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Italy; 2Dept. of Environmental Science and Policy, Università degli Studi di Milano, Italy
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48 | ENHANCING ANGIOGENESIS IN HIRUDO VERBANA USING NANOSTRUCTURED SCAFFOLDS PRIMED WITH HUMAN DENTAL PULP STEM CELL SECRETOME G. Marcolli1, S. Zorzetto1, N. Baranzini1|2, L. Pulze1|2, L. Barone1, F. Rossi1, R. Gornati1, A. Grimaldi1|2 | 1Dept. of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; 2Italian Leech Farm (ILFARM) S.r.l, Varese, Italy
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49 | TWEEN 60-COATED COPPER NANOPARTICLES FOR BIOMEDICAL APPLICATION: CHARACTERIZATION AND IN VITRO EVALUATION S. Mariano1|2, S.C. Resta3, G.C. Carbone1|2, A. Talà3, D. Manno1|2, A. Serra1|2, G. Quarta1|2, E. Panzarini3, L. Calcagnile1|2 | 1Department of Mathematics and Physics, University of Salento, Lecce, Italy; 2CEDAD (Center of Applied Physics, Datation and Diagnostics), Department of Mathematics and Physics, University of Salento, Lecce, Italy; 3Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy
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50 | DECIPHERING THE ROLE OF ULK1 IN THE BIOLOGY OF GLIOBLASTOMA MULTIFORME N. Martella1, D. Gargano1, G. Trotto1, A. Ioni2, M. Calvitto1, G. Sferra1, M. Segatto1, M. Catalano2, C. Limatola2, J. Dengjel3, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Physiology and Pharmacology, Sapienza University of Rome, Italy; 3Dept. of Department of Biology, University of Fribourg, Switzerland
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51 | DEVELOPMENTAL TOXICITY OF DIBUTYLPFTALATE ALONE AND IN MIXTURE WITH SUB-TERATOGENIC CONCENTRATIONS OF ETHANOL: PRELIMINARY RESULTS ON XENOPUS LAEVIS EMBRYOS (R-FETAX) E. Menegola1, F. Metruccio2, R. Bacchetta1, M. Battistoni1, F. Di Renzo1 | 1Dept of Environmental Science and Policy Università degli Studi di Milano, Italy; 2ICPS, ASST Fatebenefratelli Sacco, Milan, Italy
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52 | EFFECTS OF DIETARY FRUCTOSE ON DUODENAL MUCIN GLYCOSYLATION AND MUCUS PRODUCTION IN MICE FED A HIGH-FAT DIET D. Mentino1, A. Provera2, C. Vecchio2, A. Antonioli2, A.N. Sheferaw2, N. Taldone1, R. Vitale3, C. Passamonti4, S. Fensore5, F. Prodam2, S. Sutti2, M. Mastrodonato1|6, M. F. Faienza3 | 1Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Italy; 2Department of Health Sciences, University of Piemonte Orientale, Novara, Italy; 3 Department of Mathematics, University of Luxembourg, Belval Esch-sur-Alzette, Luxembourg; 4Department of Socio-Economic, Managerial and Statistical Studies, University of Chieti-Pescara, 3Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Italy; 6National Research Council of Italy (CNR) - Water Research Institute (IRSA),Taranto, Italy
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53 | CYTOTOXIC EFFECTS OF NANOPLASTICS ON THE MALE GONADS OF MYTILUS GALLOPROVINCIALIS Migliaccio Vincenzo1, Romano Rossana2, Luigi Rosati3, Lionetti Lillà1, Motta Chiara Maria3, Palma Simoniello2 | 1Dept. Chemistry and Biology “Adolfo Zambelli” University of Salerno, Italy; 2Dept. of Science and Technology, University Parthenope, Napoli, Italy; 3Dept. of Biology, University of Naples Federico II, Napoli, Italy
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54 | RODLET-LIKE CELLS IN THE YELLOW-LEGGED GULL (LARUS MICHAHELLIS): FIRST EXPLORATORY STUDY OF THE INTESTINAL IMMUNE SYSTEM A. Nunnari1, A. Miller2, G.P. Lombardo1, F. Grosso3, M. Aragona3, E.R. Lauriano1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; 2Department for the Promotion of Human Sciences and Quality of life, San Raffaele University, Rome, Italy; 3Department of Veterinary Sciences, University of Messina, Italy
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55 | A SELF-FOLDING HUMAN NEURAL TUBE MODEL USING 4D SMART SCAFFOLDS C. Dell’Amico1, I. Chiesa2, A. Toffano1, A. Esposito2, P. Mancini2, C. Magliaro2, A. Louvi3, C. De Maria2, M. Onorati1 | 1Department of Biology, Unit of Cell, Molecular, and Developmental Biology, University of Pisa, Italy; 2Department of Information Engineering and Research Center Enrico Piaggio, University of Pisa, Italy; 3Departments of Neurosurgery and Neuroscience, Yale School of Medicine, New Haven, USA
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56 | THE CARDIAC ENHANCER RNA CHHEAF PRESERVES HEART FUNCTION DURING STRESS ADAPTATION VIA RTN4-DEPENDENT AUTOPHAGY C. Pagiatakis, S. Serio, D. Bonisolo, A. Romanò, G. Bernardini, R. Gornati, R. Papait | Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
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57 | PUNICA GRANATUM-DERIVED EXTRACELLULAR VESICLES EFFECTS ON AN IN VITRO GASTROINTESTINAL BARRIER MODEL OF INTESTINAL INFLAMMATION Mariano Stefania1, Carata Elisabetta2, Moris Destino2, Bernardetta Anna Tenuzzo2, Panzarini Elisa2 | 1Department of Mathematics and Physics “E. De Giorgi”, University of Salento, Lecce, Italy; 2Department of Biological Sciences and Technologies, University of Salento, Lecce, Italy
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58 | AN EX VIVO GRAFTING PLATFORM TO DISSECT TISSUE-DEPENDENT GUIDANCE OF SEROTONERGIC AXONS M. Picchi1, M. Hingorani2, S. Migliarini1, S. Nazzi1, G. Gianni1, N. Barsotti1, S. Janusonis2, M. Pasqualetti1 | 1Department of Biology, University of Pisa, Italy; 2Department of Psychological and Brain Sciences, University of California Santa Barbara, USA
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59 | ZEBRAFISH EMBRYOS AS A MODEL FOR IN VIVO EVALUATION OF NANOPARTICLE AND VESICLE BASED DELIVERY SYSTEMS A. Piersanti1, A. Tesoriere1, F. Sernesi1, S. Pozzo2, Grigoletto3, G. Adamo4, A. Bongiovanni4, G. Pasut3, F. Mancin2, N. Tiso1, F. Argenton1 | 1Department of Biology, University of Padova, Padova, Italy; 2Department of Chemistry, University of Padova, Italy; 3Department of Pharmaceutical Sciences, University of Padova, Italy; 4Institute for Research and Biomedical Innovation (IRIB) - National Research Council of Italy (CNR), Palermo, Italy
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60 | CELLULAR DYSHOMEOSTASIS AND REDOX IMBALANCE INDUCED BY CANTHARIDIN IN GLIOBLASTOMA MODELS R. Proietti, V. D’Ezio, A. Presaghi, L. Salsedo, A. Sperati, M.A. Bologna, M. Colasanti, T. Persichini | Dept. of Science, Roma Tre University, Rome, Italy
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61 | ROTENONE-INDUCED OXIDATIVE STRESS TRIGGERS PEROXISOMAL ALTERATIONS IN BV-2 MICROGLIAL CELLS F. Rendina1, A. Valenza1, M. Muzzi2, D. Pensabene2, A. Fracassi3, M. Segatto2, S. Moreno1|3 | 1Dept. of Science, University Roma Tre, Rome, Italy. 2Dept. of Biosciences and Territory, University of Molise, Pesche, Italy. 3Dept. of Neurology, UTMB, Galveston, TX, USA
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62 | APPLICATION OF AN AI-BASED WORKFLOW FOR THE ASSESSMENT OF TESTICULAR DAMAGE IN DOGS Lorenzo Riccio1|2, Maria De Falco2, Nicola Ambrosio3, Angelo Spada3, Francesca Del Porto2, Cristina Marchetti2, Orlando Paciello1, Luigi Rosati2 | 1Dept. of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy; 2Dept. of Biology, University of Naples Federico II, Italy; 3ASL Napoli 2 Nord, Italy
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63 | EVOLUTIONARY STRATEGIES OF CARDIAC GROWTH: THE ICEFISH HEART AS A MODEL TO CONTRAST PATHOLOGICAL CELLULAR MALADAPTATION N. Romano1, R. Gaetani2, M. Gerdol3, C. Bidoli3, M. Mercola4 E. Messina2 | 1Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 2Dept. of Molecular Medicine, Sapienza University, Rome, Italy; 3Dept. of Life Sciences, University of Trieste, Italy; 4Dept. of Medicine and Cardiovascular Institute, Stanford University, Palo Alto, CA, USA
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64 | UNDERSTANDING PROPERTIES OF NEURAL STEM CELLS ISOLATED FROM A MONOGENIC MOUSE MODEL OF AUTISM EXPRESSING THE R451C NLGN3 MUTATION F. Salvadori, T. Diamanti, L. Santini, S. D’Angelo, F. Serafini, M. Fidaleo, G. Lupo, A. De Jaco, E. Cacci | Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, Italy
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65 | EFFECTS OF ENVIRONMENTAL TEMPERATURE VARIATION AND BDNF MODULATION ON THE SPATIO-TEMPORAL SHOALING BEHAVIOUR OF ADULT ZEBRAFISH (DANIO RERIO) REVEALED BY TWO- AND THREE-DIMENSIONAL ANALYSIS A.S. Sanchez Garcia1, F. Frabetti2, G. Brighi2, G. Tedeschi3|4, A. Racca5, E. Alleva5, M. Toni1 | 1Dept. of Biology and Biotechnologies “Charles Darwin”, Rome, Italy; 2Dept. of Medical and Surgical Sciences, Bologna, Italy; 3Dept. of Veterinary Medicine and Animal Science, University of Milan, Italy; 4CRC “Innovation for Well-Being and Environment”, University of Milan, Italy; 5Centre for Behavioural Sciences and Mental Health, Rome, Italy
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66 | THE EVOLUTION OF NEURONAL SCALING IN AMNIOTES G. Sansalone1, S. Castiglione2, G. Girardi2, P. Dell’Albani1, P. Raia1 | 1Department of Life Sciences, University of Modena and Reggio Emilia, Italy; 2DiSTAR, Università di Napoli Federico II, Naples, Italy
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67 | DYNAMICS AND INTRACELLULAR TRAFFICKING OF M2R-DUALSTERIC AGONIST COMPLEX INTO GLIOBLASTOMA CELLS G. Scanavino1, C. Metelli1, L. Sileo1, C. Dallanoce2, Matera2, AM. Tata1 | 1Dept. of Biology and Biotechnology, University of Rome “Sapienza”, Italy; 2Dept. of Pharmaceutical Sciences, University of Milan, Italy
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68 | RESILIENCE ASSOCIATED WITH DEFECTS IN VITAMIN B12 METABOLISM: BALANCING BETWEEN HOMEOSTASIS AND DISEASE E. Selita1, E. Tomaselli2, G. Di Matteo3, L. Mannina3, M. Rossi2|4, D. Passeri2|4, L. Angeloni2|4, M. Fidaleo1|4 | 1Dept of Biology and Biotechnology, Charles Darwin, University of Rome Sapienza, Italy; 2Dept of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Italy; 3Dept of Chemistry and Technology of Drugs, Sapienza University of Rome, Italy; 4Research Centre for Nanotechnology for Engineering of Sapienza (CNIS), Sapienza University of Rome, Italy
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69 | ALCL3 TREATMENTS INDUCED MORPHOLOGICAL AND MICROSCOPICAL ALTERATIONS IN PELOPHYLAX LESSONAE EMBRYOS D. Semeraro1, G. Scillitani1, D. Mentino1, M.V. Guglielmi2, R. Rossi3, M. Mastrodonato1 | 1Dept. Biosciences, Biotechnology and Environment (DBBA), University of Bari Aldo Moro, Italy; 2National Interuniversity Consortium for Marine Sciences (CoNISMa), Rome, Italy; 3Dept. of Pecision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Italy
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70 | IMPACTS OF ANTHROPOGENIC NOISE ON CEPHALOCHORDATES E. Serafini1, M. Bozzo1, E. Bosi1, V. Bazzurro1, G. Blumer2, E. Rodriguéz Quintana3, N. P. Torres Águila3, G. Sabbadin4, E. Panarari5, S. Norland6, M. Pestarino1, S. Ravera7, V. Zaffaroni-Caorsi8, I. Guarneri9, R. M. Alsina-Pagès10, I. Nou-Plana10, G. Zambon8, R. Pennati2, S. Candiani1 | 1DISTAV, University of Genoa, Italy; 2ESP University of Milano, Italy; 3Dep. de Genètica, Microbiologia i Estadística and IRBio, Universitat de Barcelona, Spain; 4DiBio, University of Padua, Italy; 5SZN, Naples, Italy; 6Michael Sars Centre, University of Bergen, Norway; 7DIMES, University of Genoa, Italy; 8DISAT, University of Milano-Bicocca, Italy; 9CNR-ISMAR, Venice, Italy; 10HER, Universitat Ramon Llull - La Salle, Barcelona, Spain
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71 | EFFECT OF DI-N-BUTYL PHTHALATE ON ADIPOGENESIS B. Sgangarella Valvano1, S. Boccia2, A. Mileo3, C. Pivonello4, G. Guerra1, A. De Luca2, M. De Falco5|6 | 1Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy; 2Dept. of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 4Dept. of Public Health, University of Naples Federico II, Naples, Italy; 5Dept. of Biology, University of Naples Federico II, Naples, Italy; 6National Institute of Biostructures and Biosystems (INBB), Rome, Italy
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72 | BACULUM ONTOGENY IN WILD VIETNAMESE PRIMATES REVEALED BY MICRO-CT, 3D MORPHOMETRICS, AND INTERNAL MICROARCHITECTURE F. Spani1, G. Franceschini2, M. Carosi2, T. Nadler3, M. Colasanti2 | 1Dept. of Science and Bio-Technology, Università Campus Bio-Medico di Roma, Italy; 2Dept. of Sciences, Roma Tre University, Italy; 3Three Monkeys Wildlife Conservancy, Vietnam
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73 | PROTECTIVE ROLE FOR OLEOYLETHANOLAMIDE IN THE HUMAN BRAIN: EFFECTS ON THE MODULATION OF NEUROINFLAMMATION AND INSULIN RESISTANCE IN HUMAN ASTROCYTES Lucia Sileo1, Giulia Scanavino1, Silvana Gaetani2, Ada MariaTata1 | 1Dept. of Biology and Biotechnologies "Charles Darwin", University of Rome "Sapienza", Rome, Italy; 2Dept. of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome "Sapienza", Rome, Italy
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74 | IMPACT OF IVERMECTIN ON THE GONADS OF THE MARINE MUSSEL MYTILUS GALLOPROVINCIALIS AND REPERCUSSION ON THE EMBRYO DEVELOPMENT M. Terranova1|2|3, G. La Pusata2, N. Caruso1|2, M. Galati2, A. Fazio2, T. Cappello2, M. Maisano2 | 1Dept. of Earth and Marine Sciences, University of Palermo, Italy; 2Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 3National Biodiversity Future Center (NBFC), Palermo, Italy
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75 | Β-SITOSTEROL-D-GLUCOSIDE TRIGGERS INTESTINAL INFLAMMATION IN ZEBRAFISH LARVAE POSSIBLY LEADING TO NEURODEGENERATION THROUGH THE GUT-BRAIN AXIS Francesca Terrin1, Sofia Faggin2|3, Chiara Consorti4, Stefania Marcotti5, Paolo Bonaldo4, Maria Cecilia Giron2, Nicoletta Plotegher1, Luisa Dalla Valle1 | 1Department of Biology, University of Padova, Italy; 2Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy; 3Institute of Digestive Health Research (IRSD), Toulouse University, France; 4Department of Molecular Medicine, University of Padova, Italy; 5Randall Centre for Cell and Molecular Biophysics, King's College London, London; UK
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76 | DECODING THES PATHOGENESIS: HOW TTC37 SHAPES GUT HOMEOSTASIS AND PERISTALSIS A. Tesoriere1, F. Sernesi1, A. Piersanti1, M. Gasparotto3, L. Dalla Valle1, M. Cananzi2, F. Argenton1 | 1University of Padova, Italy;2University Hospital of Padova, Italy; 3Central Institute of Mental Health, Mannheim, Germany
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77 | TARGETING P75NTR CORRECTS OXIDATIVE AND INFLAMMATORY IMBALANCES IN A CELLULAR MODEL OF RETT SYNDROME M. Varone, M. Colardo, N. Martella, D. Pensabene, E. Bisesto, M. Segatto | Dept of Biosciences and Territory, University of Molise, Pesche, Italy
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P01 | BET PROTEIN INHIBITION ATTENUATES MICROGLIAL ACTIVATION AND OXIDATIVE STRESS IN A CELLULAR MODEL OF PARKINSON’S DISEASE E. Bisesto1, D. Pensabene1, M. Colardo1, M. Varone1, M. Segatto1 | 1Dept. of Biosciences and territory, University of Molise, Pesche (IS), Italy
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P02 | MITOCHONDRIAL DNA COPY NUMBER VARIATION AND ROS PRODUCTION IN ZEBRAFISH AND HUMAN CELL LINES EXPOSED TO HEAVY METALS G.S. Calogero, M. Giuga, A. Mazzurco, G. Manganaro, V. Ferrito, A.M. Pappalardo. | 1Dept. of Biological, Geological and Environmental Sciences, University of Catania, Italy
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P03 | ALTERED NEUROTRANSMISSION AND METABOLISM IN A GFAP R239C ZEBRAFISH MODEL OF ALEXANDER DISEASE S. Candiani1|2, M. Bozzo1, V. Bazzurro1, D. Bellitto3, A. Tripi1, S. Ferrando1, G. Rosa1, T. Bacchetti3 | 1Dept. of Biology, University of Genova, Italy; 2RCCS Azienda Ospedaliera Metropolitana, Genova, Italy; 3UO Proteomica e Spettrometria di Massa, IRCCS Ospedale Policlinico San Martino, Genova, Italy
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P04 | COSTA - COOPERATING FOR A COMMON GOAL: THE HEALTH OF THE MEDITERRANEAN SEA M. Galati1, D. Torre1, S. Savoca1, G. Capillo1, C. Espro2, G. Di Bella2, D. Iannazzo2, A. Germanà3, G. Montalbano3, G. Genovese1, M. Maisano1, T. Cappello1 | 1Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy; 2Dept. of Engineering, University of Messina, Italy; 3Dept. of Veterinary Sciences, University of Messina, Italy
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P05 | COMBINED EMBRYOTOXIC EFFECTS OF MICROPLASTICS AND HEAVY METALS IN XENOPUS LAEVIS S. Di Marino, C. Fogliano, C.M. Motta, B. Avallone, R. Carotenuto | Dept. of Biology, University of Naples Federico II, Italy
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P06 | MODELING THE COMPLEXITY OF THE CENTRAL NERVOUS SYSTEM WITH PATIENT IPSC-DERIVED CEREBRAL ORGANOIDS L. Carpinelli1, D. Sibilia1, P.N. Doronzio2, F. Giacalone1, C. Lisciandrello2, E. Guadagni2, A. Conte3, S. Lattante4, M. Magatti5, A. Silini5, Facility Biobanca6, Facility Citometria a Flusso6, L. Di Pietro1|2, M. Sabatelli3, O. Parolini1|2 | 1Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy; 2Dipartimento di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy; 3Centro Clinico NEMO, Fondazione Policlinico Gemelli IRCCS, Rome, Italy; 4Department of Experimental Medicine, University of Salento, Lecce, Italy; 5Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 6Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy
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P07 | ULVANS AS AN ECO-FRIENDLY TOOL TO MITIGATE CELLULAR IMPAIRMENT INDUCED BY DEXAMETHASONE IN MYTILUS GALLOPROVINCIALIS N. Caruso1|2, G. De Marco2, M. Galati2, La Pusata2, M. Terranova1|2, V. Parrino2, G. Genovese2, T. Cappello2, M. Maisano2 | 1Dept. of Earth and Marine Sciences, University of Palermo, Palermo, Italy; 2Dept. of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
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P08 | ANALYSIS OF THE EFFECTS INDUCED BY VANADIUM-BASED METALLODRUGS IN SEA URCHIN EMBRYOS I. Termine, G. Sangiorgi, A. Terenzi, G. Barone, R. Bonsignore, F. Geraci, R. Chiarelli | Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy
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P09 | THERAPEUTIC POTENTIAL OF NEUROTROPHINS IN AUTISM SPECTRUM DISORDER F. D’Egidio1, M.S. Scenna1, M. d’Angelo1|2, V. Castelli1, A. Cimini1|2 | 1University of L’Aquila, Dpt. of Life, Health and Environmental Sciences, L’Aquila, Italy; 2Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA, USA
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P10 | BIOLOGICAL ACTIVITIES OF CITRUS LIMON-, VITIS VINIFERA- AND ACTINIDIA DELICIOSA-DERIVED EXTRACELLULAR VESICLES ON HUMAN CACO-2 CELLS M. Destino, E. Carata, B.A. Tenuzzo, E. Panzarini | Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy
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P11 | BINARY MIXTURE OF BISPHENOL A (BPA) AND ETHANOL: EFFECTS ON XENOPUS LAEVIS DEVELOPMENT (R-FETAX) F. Di Renzo1, F. Metruccio2, R. Bacchetta1, M. Battistoni1, E. Menegola1 | 1Dept of Environmental Science and Policy Università degli Studi di Milano, Italy; 2ICPS, ASST Fatebenefratelli Sacco, Milan, Italy
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P12 | NEUROBIOLOGICAL IMPACT OF CITRUS BERGAMIA IN THE IDIOPHATIC AUTISM MODEL BTBR D. Minervini1, I. Olivito1, A. Vivacqua2|3, L. Bartella4|5, L. Di Donna4|5, R. Alò1, R.M. Facciolo1 | 1Comparative Neuroanatomy Lab; Biology, Ecology and Earth Sciences Dept., University of Calabria, Rende (CS), Italy; 2Dept. of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy; 3Centro Sanitario, University of Calabria, Rende (CS), Italy; 4QUASIORA Lab., AGRINFRA Research Net, University of Calabria, Rende (CS), Italy; 5Chimica and Tecnologie Chimiche Dept., University of Calabria, Rende (CS), Italy
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P13 | NEURODEGENERATION AND DNA DAMAGE FOLLOWING CO-EXPOSURE TO POLYSTYRENE MICROPLASTICS AND BISPHENOL A IN ZEBRAFISH EMBRYOS A. La Pietra, A.R. Bianchi, B. Berman, A. Petito, A. Chirico, A. Cacace, B. Cozzolino, P. Venditti, A. De Maio, I. Ferrandino | Dept. of Biology, University of Naples Federico II, Italy
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P14 | IMMUNE HANDLING OF PET NANOPLASTICS IN POMACEA CANALICULATA: ACCUMULATION BY CIRCULATING AND TISSUE-RESIDENT HEMOCYTES FOLLOWING ACUTE EXPOSURE A. Ferri1, S. Sacchi1, C. Losi2, M. Amico1, D. Malagoli1 | 1Dept. of Life Science, University of Modena and Reggio Emilia, Italy; 2Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 3NBFC, National Biodiversity Future Center, Italy
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P15 | EXPLORING NEUROTROPHIN-MEDIATED MECHANISMS IN ISCHEMIC CEREBRAL ORGANOIDS THROUGH INTEGRATED MULTI-OMICS ANALYSIS Chiara Giorgi1, Fabrizio Ammannito1, Vanessa Castelli1, Annamaria Cimini1|2, Michele d’Angelo1|2 | 1Dept. of Life, Health and Environmental Science, University of L'Aquila, Italy; 2Sbarro Institute for Cancer Research and Molecular Medicine, Dept. of Biology, Temple University, Philadelphia, PA, USA.
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P16 | DEVELOPMENTAL TOXICITY OF LIGNIN AND NATURAL EXTRACTS-BASED NANO(BIO)PESTICIDES IN ZEBRAFISH EMBRYOS Alessandra Lama, Beatrice Negrini, Pamela Floris, Patrizia Bonfanti, Anita Colombo, Maurizio Gualtieri, Paride Mantecca | Research Centre POLARIS, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Italy
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P17 | FROM HATCHLINGS TO JUVENILES: HISTOLOGICAL ANALYSIS OF HEMOCYTE TISSUE COLONIZATION DURING GROWTH IN THE SNAIL POMACEA CANALICULATA C. Losi1, A. Ferri2, D. Roncuzzi2, G. Lucà2, S. Sacchi2, N. Franchi2, D. Malagoli2|3 | 1Models and Methods for Material and Environmental Sciences PhD Course, Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 2Dept. of Life Sciences, University of Modena and Reggio Emilia, Italy; 3NBFC-National Biodiversity Future Center, Palermo, Italy
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P18 | PRELIMINARY OXPHOS GENES ANALYSIS IN THE STRIPED RED MULLET (MULLAS SURMULETUS LINNAEUS, 1758) G. Manganaro1, G.S. Calogero1, M. Mancuso1, A. Mazzurco1, T. Segvic-Bubic2, V. Ferrito1, A.M. Pappalardo1 | 1Dept. of Biological, Geological and Environmental Sciences, University of Catania, Italy; 2Institute of Oceanography and Fisheries, Split, Croatia
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P19 | IDENTIFICATION OF MIR-129-5P AS A COMMON REGULATOR OF E3 UBIQUITIN LIGASES WITH A POTENTIAL ROLE IN GLIOBLASTOMA PROGRESSION N. Martella1, A.B. Díaz Méndez2, G. Regazzo2, G.F. Bufalieri3, A. Frati4, A. Arcella4, L. Di Marcotullio3, M.G. Rizzo2, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Research, Advanced Diagnostics and Technological Innovation, Translational Oncology Research Unit, IRCCS -Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 4IRCCS Neuromed, Pozzilli (IS), Italy
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P20 | SE4SAFE: A ONE HEALTH APPROACH TO ASSESS THE SAFETY OF BIOGENIC SELENIUM NANOPARTICLES A. Mileo1, S. Boccia2, B Sgangarella Valvano3, T. Pannulo4, F. Esposito4, L. Saviano4, G. Libralato4, M. De Falco4 | 1Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 2Dept. of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy; 4Dept. of Biology, University of Naples Federico II, Naples, Italy
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P21 | INVOLVEMENT OF TELOCYTES IN CARDIAC INFLAMMATION CAUSED BY LPS IN MICE AND THE POTENTIAL ANTI-INFLAMMATORY ROLE OF CANNABIS SATIVA L. A. Miller1, G.P. Lombardo2, A. Nunnari2, G. Pirracchio2, M. Kotańska3, C. Condurso4, E.R. Lauriano2, S. Pergolizzi2 | 1Dept. for the Promotion of Human Sciences and Quality of life, San Raffaele University, Rome, Italy; 2Dept. of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 3Dept. of Pharmacological Screening, Jagiellonian University Medical; College, Kraków, Poland; 4Dept of Veterinary Sciences, University of Messina, Italy
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P22 | COORDINATION OF MITOPHAGY AND EMT PROGRAMS IN BRAIN TUMOR CELL PLASTICITY Ilaria Montano1, Valeria Nanni1, Manuela Giansanti2, Veronica Marabitti1|3, Francesca Nazio1 | 1Department of Biology, University of Rome Tor Vergata, Rome, Italy; 2Innate Lymphoid Cells Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy; 3Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy
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P23 | AN AUTOMATED VERTICAL INCUBATOR FOR RAINBOW TROUT (ONCORHYNCHUS MYKISS) EMBRYOS TO REDUCE FOOD LOSS DURING EARLY DEVELOPMENT M. Zarantoniello1, F. Conti2, A. Mancini3, F. Maradonna1, Anna Laura Eusebi4, F. Fatone4, Ike Olivotto2 | 1Dept. of Agricultural, Food, and Environmental Sciences, Università Politecnica delle Marche, Italy; 2Dept. of Life and Environmental Sciences, Università Politecnica delle Marche, Italy; 3Dept of Information Engineering, Università Politecnica delle Marche, Italy; 4Dept of Science and Engineering of Materials, Environment and Urban Planning, Università Politecnica delle Marche, Italy
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P24 | NUTRACEUTICAL-MEDIATED EFFECTS IN THE MODULATION OF INFLAMMATORY PROCESSES IN AN IN VITRO MODEL OF HUMAN ENDOMETRIAL STROMAL CELLS L. Pietrobelli1, V.C. Divincenzo1, L. Sileo1, G. Scanavino1, E. Vicini2, L. Campagnolo3, V. Corsetti4, A.M. Tata1 | 1Dept. of Biology and Biotechnology “C. Darwin”, Sapienza University of Rome, Italy; 2Dept. of SAIMAL, Section of Histology, Sapienza University of Rome, Italy; 3Dept. of Biomedicine and Prevention, University of Rome Tor Vergata, Italy; 4Institute of Translational Pharmacology (IFT)-CNR, Rome, Italy
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P25 | THE INVASIVE ALGAE CAULERPA RACEMOSA POSES A THREAT TO MUSSEL VIABILITY AND REPRODUCTION S. Balsamo, T. Chianese, A. Allocca, M. Prisco, R. Scudiero, M. De Falco, L. Rosati | Dept. of Biology, University of Naples Federico II, Italy
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P26 | USING HISTOLOGY TO DETECT AND QUANTIFY MICROPLASTICS IN THE COANOCYTES OF THE SPONGE PARALEUCILLA MAGNA KALUTAU ET AL., 2004 (PORIFERA, CALCAREA) D. Semeraro1, A. Schiavo1, M. Fucci1, M. Mastrodonato1, G. Scillitani1, R. Trani1, J. Aguilo-Arce2, C. Longo1 | 1Dept. Biosciences, Biotechnology and Environment (DBBA), University of Bari Aldo Moro Bari, Italy; 2Balearic Oceanographic Centre (IEO-CSIC), Spanish Institute of Oceanography, Muelle de Poniente s/n, Palma de Mallorca, Balearic Islands, Spain
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P27 | THE ECHINOCHROME FROM ARBACIA LIXULA: CHARACTERIZATION AND BIOACTIVE EFFECTS ON ZEBRAFISH EMBRYOS Andrea Claudio Stetco1, Patrizia Pagliara1, Laura Pecoraro1, Aurora Mazzei1, Roberta Schiavone1, Amilcare Barca2, Tiziano Verri1 | 1Dept of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy; 2Dept of Experimental Medicine, University of Salento, Lecce, Italy
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P28 | EFFECTS OF CHRONIC LOW-TEMPERATURE EXPOSURE ON THE BEHAVIOUR OF ADULT ZEBRAFISH (DANIO RERIO) A.S. Sanchez Garcia1, F. Frabetti2, M. Toni1 | 1Dep. of Biology and Biotechnologies “Charles Darwin”, Sapienza University, Rome, Italy; 2Dep. of Medical and Surgical Sciences—DIMEC, University of Bologna, Bologna, Italy
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P29 | AUTOPHAGY IS IMPAIRED IN GSCS-ENRICHED GLIOBLASTOMA MODELS G. Trotto1, M. Calvitto1, N. Martella1, D.Gargano1, M. Cillo2, E. Sgambati1, F. Nazio3, P. Grumati2|4, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy; 3Dept. of Biology, "Tor Vergata" University, Rome, Italy; 4Dept. of Clinical Medicine and Surgery, Federico II University, Naples, Italy
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P30 | P75NTR MODULATION IMPROVES RESILIENCE TO OXIDATIVE DAMAGE IN A MICROGLIAL CELL MODEL OF PARKINSON’S DISEASE A. Valenza1, D. Pensabene2, F. Rendina1, M. Muzzi2, A. Fracassi3, M. Segatto2, S. Moreno1|3 | 1Dept. of Science, University Roma Tre, Rome, Italy; 2Dept. of Biosciences and Territory, University of Molise, Pesche, Italy; 3Dept. of Neurology, UTMB, Galveston, TX, USA
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