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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Marco Biggiogera, Italy

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1.9
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  • DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells

    Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu
    03-05-2017
    https://doi.org/10.4081/ejh.2017.2775
    2833
    PDF: 1132
    HTML: 206
  • High expression of both desmoplastic stroma and epithelial to mesenchymal transition markers associate with shorter survival in pancreatic ductal adenocarcinoma

    Damián Sánchez-Ramírez, Rafael Medrano-Guzmán, Fernando Candanedo-González, Jazmín De Anda-González, Luis Enrique García-Rios, Vadim Pérez-Koldenkova, Marcos Gutiérrez-de la Barrera, Sara Rodríguez-Enríquez, Marco Velasco-Velázquez, Silvia Cecilia Pacheco-Velázquez, Patricia Piña-Sánchez, Héctor Mayani, Alejandro Gómez-Delgado, Alberto Monroy-García, Ana Karen Martínez-Lara, Juan José Montesinos
    17-02-2022
    https://doi.org/10.4081/ejh.2022.3360
    2858
    PDF: 1118
    HTML: 65
  • miR-126 targeting GOLPH3 inhibits the epithelial-mesenchymal transition of gastric cancer BGC-823 cells and reduces cell invasion

    Jiancai Ouyang, Fuhu Song, He Li, Rui Yang, Haicheng Huang
    28-10-2020
    https://doi.org/10.4081/ejh.2020.3168
    1623
    PDF: 712
    HTML: 46
  • MiR-122-5p inhibits the epithelial mesenchymal transition of liver cancer cells by inducing hiPSCs to differentiate into hepatocyte-like cells

    Qianzhe Xing, Yanjie Xu, Ying Luo, Chenglong Li, Peng Wang, Bin Kang, Chengjun Lu
    06-05-2025
    https://doi.org/10.4081/ejh.2025.4190
    925
    PDF: 500
    HTML: 54
  • SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells via activating TGF-β/Smad2/3 signaling

    Yiyu Qin, Jian Li, Hongchao Han, Yongliang Zheng, Haiming Lei, Yang Zhou, Hongyan Wu, Guozhe Zhang, Xiang Chen, Zhengping Chen
    28-12-2023
    https://doi.org/10.4081/ejh.2023.3899
    1348
    PDF: 430
    HTML: 19
  • Lobetyolin suppressed lung cancer in a mouse model by inhibiting epithelial-mesenchymal transition

    Lu Liu, Zhankui Liu, Liu Yang, Xue Wu, Jiaying Zhu, Lili Liu, Yang Liu
    04-07-2022
    https://doi.org/10.4081/ejh.2022.3423
    2348
    PDF: 1008
    HTML: 93
  • Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps?

    Antonella Vetuschi, Simon Pompili, Gian Piero Di Marco, Federico Calvaruso, Enz Iacomino, Lidia Angelosante, Claudio Festuccia, Alessandro Colapietro, Roberta Sferra
    23-01-2020
    https://doi.org/10.4081/ejh.2020.3079
    2290
    PDF: 1372
    HTML: 33
  • LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

    Yiming Zhang, Wanqiong Zheng, Liang Zhang, Yechun Gu, Lihe Zhu, Yingpeng Huang
    20-06-2023
    https://doi.org/10.4081/ejh.2023.3667
    1435
    PDF: 835
    Supplementary: 140
    HTML: 46
  • E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway

    Zhijing Wang, Xiaohua Qin, Shanshan Liu, Yilei Wen, Bikan Lan, Hantao Liao, Haixian Wei
    26-05-2025
    https://doi.org/10.4081/ejh.2025.4196
    1673
    PDF: 696
    HTML: 46
  • miR-627-5p inhibits malignant progression of cervical cancer by targeting ANGPTL4

    Xinghua Wu, Kai Lin, Chen Gao, Yinfang Ni, Li Zhang, Tailai Yang, Jinguo Chen
    07-04-2025
    https://doi.org/10.4081/ejh.2025.4161
    1775
    PDF: 578
    HTML: 56
  • Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

    Kui Long, Xiang Kui, Qingbin Zeng, Wenzhi Dong
    17-04-2025
    https://doi.org/10.4081/ejh.2025.4176
    1639
    PDF: 737
    Supplementary: 159
    HTML: 61
  • DPY30 promotes the growth and survival of osteosarcoma cell by regulating the PI3K/AKT signal pathway

    Gong Cheng, Fengmin An, Zhilin Cao, Mingdi Zheng, Zhongyuan Zhao, Hao Wu
    22-12-2022
    https://doi.org/10.4081/ejh.2023.3413
    1474
    PDF: 743
    Supplementary: 141
    HTML: 52
  • P22 | COORDINATION OF MITOPHAGY AND EMT PROGRAMS IN BRAIN TUMOR CELL PLASTICITY Ilaria Montano1, Valeria Nanni1, Manuela Giansanti2, Veronica Marabitti1|3, Francesca Nazio1 | 1Department of Biology, University of Rome Tor Vergata, Rome, Italy; 2Innate Lymphoid Cells Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy; 3Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy

    GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
    22-06-2026
    https://doi.org/10.4081/ejh.2026.4718
    119
    PDF: 80
  • miRNA-877-5p inhibits malignant progression of prostate cancer by directly targeting SSFA2

    Wanchun Wang, Jun Yi, Degang Dong, Wenli Mao, Xuanyu Wang, Zhangren Yan
    20-09-2021
    https://doi.org/10.4081/ejh.2021.3243
    1531
    PDF: 802
    HTML: 52
  • Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma

    Sikuan Zheng, Yue Liu, Haohe Sun, Jingyu Jia, Tianlong Wu, Rui Ding, Xigao Cheng
    03-09-2021
    https://doi.org/10.4081/ejh.2021.3264
    2242
    PDF: 821
    Supplementary: 186
    HTML: 48
  • Aberrant expression of CCDC69 in breast cancer and its clinicopathologic significance

    Jinjiao Li, Panshi Zhang, Yun Xia
    22-02-2021
    https://doi.org/10.4081/ejh.2021.3207
    1744
    PDF: 948
    HTML: 51
  • Tumor cells-derived exosomal PD-L1 promotes the growth and invasion of lung cancer cells in vitro via mediating macrophages M2 polarization

    Xiangjun Lu, Jian Shen, Siyuan Huang, Dongdong Liu, Haitao Wang
    01-08-2023
    https://doi.org/10.4081/ejh.2023.3784
    2356
    PDF: 1012
    HTML: 42
  • Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

    Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou
    06-08-2025
    https://doi.org/10.4081/ejh.2025.4228
    1589
    PDF: 819
    HTML: 53
  • The role of miR-143-3p/FNDC1 axis on the progression of non-small cell lung cancer

    Zhanshu Ma, Qi Gao, Wenjing Xin, Lei Wang, Yan Chen, Chang Su, Songyan Gao, Ruiling Sun
    03-05-2023
    https://doi.org/10.4081/ejh.2023.3577
    2288
    PDF: 688
    HTML: 49
  • Polydatin reverses oxidation low lipoprotein (oxLDL)-induced apoptosis of human umbilical vein endothelial cells via regulating the miR-26a-5p/BID axis

    Dajie Wang, Zhaofeng Zhou, Liang Yuan
    20-09-2022
    https://doi.org/10.4081/ejh.2022.3505
    1513
    PDF: 703
    HTML: 66
  • Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

    Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai
    14-10-2022
    https://doi.org/10.4081/ejh.2022.3510
    1517
    PDF: 766
    HTML: 57
  • Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study

    A. Santoro, G. Pannone, M.E. Errico, D. Bifano, G. Lastilla, P. Bufo, C. Loreto, V. Donofrio
    e25
    02-07-2012
    https://doi.org/10.4081/ejh.2012.e25
    1673
    PDF: 746
    HTML: 5509
  • Expression of E-cadherin, Ki-67, and p53 in urinary bladder cancer in relation to progression, survival, and recurrence

    Stanislav Ziaran, Stefan Harsanyi, Katarina Bevizova, Zuzana Varchulova Novakova, Branislav Trebaticky, Peter Bujdak, Stefan Galbavy, Lubos Danisovic
    26-03-2020
    https://doi.org/10.4081/ejh.2020.3098
    1745
    PDF: 931
    HTML: 40
  • Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study

    Roberta Sferra, Simona Pompili, Luca Ventura, Caroline Dubuquoy, Silvia Speca, Eugenio Gaudio, Giovanni Latella, Antonella Vetuschi
    31-07-2018
    https://doi.org/10.4081/ejh.2018.2956
    2126
    PDF: 1081
    Supplementary: 265
    HTML: 63
  • Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

    Yan Wang, Jie Sun, Ninghua Yao
    16-11-2021
    https://doi.org/10.4081/ejh.2021.3304
    1912
    PDF: 721
    HTML: 68
  • The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

    Huyi Liu, Xiangdao Cai , Jia Liu, Fengxiang Zhang , Andong He, Ruiman Li
    25-11-2021
    https://doi.org/10.4081/ejh.2021.3323
    2094
    PDF: 816
    HTML: 54
  • Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway

    Xiaoyan Chu, Jun Lou, Yun Yi, Linlin Zhong, Ouping Huang
    11-05-2023
    https://doi.org/10.4081/ejh.2023.3653
    1637
    PDF: 796
    HTML: 57
  • Quantification of morphology of canine circumanal gland tumors: a fractal based study

    I.C. Šoštarić-Zuckermann, K. Severin, M. Huzak, M. Hohšteter, A. Gudan Kurilj, B. Artuković, A. Džaja, Ž. Grabarević
    11-04-2016
    https://doi.org/10.4081/ejh.2016.2609
    2021
    PDF: 818
    HTML: 398
  • miR-19a targeting CLCA4 to regulate the proliferation, migration, and invasion of colorectal cancer cells

    Huiwen Li, Bo Huang
    10-03-2022
    https://doi.org/10.4081/ejh.2022.3381
    2368
    PDF: 831
    HTML: 48
  • Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?

    Y.F. Costa, K.C. Tjioe, S. Nonogaki, F.A. Soares, J.R. Pereira Lauris, D. Tostes Oliveira
    24-02-2015
    https://doi.org/10.4081/ejh.2015.2451
    2129
    PDF: 781
    HTML: 745
  • Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma

    W. Theunissen, D. Fanni, S. Nemolato, E. Di Felice, T. Cabras, C. Gerosa, P. Van Eyken, I. Messana, M. Castagnola, G. Faa
    11-03-2014
    https://doi.org/10.4081/ejh.2014.2242
    3384
    PDF: 1161
    HTML: 513
  • Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells

    Yinping Zeng, Jiajun Huang, Tingting Duan, Xiaofeng Wang
    28-05-2026
    https://doi.org/10.4081/ejh.2026.4540
    475
    PDF: 346
    HTML: 31
  • The matrix stiffness is increased in the eutopic endometrium of adenomyosis patients: a study based on atomic force microscopy and histochemistry

    Xiaowen Wang, Wenbin Cai, Ting Liang, Hui Li, Yingjie Gu, Xiaojiao Wei, Hong Zhang, Xiaojun Yang
    04-12-2024
    https://doi.org/10.4081/ejh.2024.4131
    2433
    PDF: 658
    HTML: 110
  • SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway

    Shengwen Wang, Gang Yang, Qian Zhang, Yanbei Zhang
    18-05-2026
    https://doi.org/10.4081/ejh.2026.4544
    341
    PDF: 362
    Supplementary: 65
    HTML: 26
  • P37 | THE ROLE OF ACTIN-BINDING PROTEINS IN ENDOMETRIOSIS W. Arendt1, M. Hałas-Wiśniewska1, M. Gagat2, M. Izdebska1 | 1Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; 2Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4359
    273
  • Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex

    L. Vinci, A. Ravarino, V. Fanos, A.G. Naccarato, G. Senes, C. Gerosa, G. Bevilacqua, G. Faa, R. Ambu
    01-02-2016
    https://doi.org/10.4081/ejh.2016.2563
    4917
    PDF: 2583
    HTML: 1652
  • P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu1, C.G. Lison2, F. Etzi3, A. Pisano3, C. Farace3, A. Sabalic3, D. Tutedde3, J.A. Marchal4, R. Madeddu5 | 1Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; 2Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; 3Department of Biomedical Science, University of Sassari, Sassari, Italy; 4Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; 5Department of Biomedical Science, University of Sassari, Sassari, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4364
    246
  • Substance P is overexpressed in cervical squamous cell carcinoma and promoted proliferation and invasion of cervical cancer cells in vitro

    Ying Wang, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang
    31-07-2023
    https://doi.org/10.4081/ejh.2023.3746
    1157
    PDF: 548
    HTML: 41
  • Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

    Jun Pan, Yi Zhao, Yu Zhang, Yuhe Zhou, Fengxuan Zhang, Yitian Chen, Xiaoyuan Chu
    24-04-2025
    https://doi.org/10.4081/ejh.2025.4203
    1002
    PDF: 458
    HTML: 81
  • Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

    ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu
    11-11-2024
    https://doi.org/10.4081/ejh.2024.4063
    1830
    PDF: 689
    HTML: 43
  • Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

    Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou
    02-12-2021
    https://doi.org/10.4081/ejh.2021.3331
    2850
    PDF: 1638
    HTML: 55
  • microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

    Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu
    10-05-2022
    https://doi.org/10.4081/ejh.2022.3333
    2524
    PDF: 1016
    HTML: 50
  • IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH

    Yan Zhou, Shanshan Liu, Yan Luo, Meiying Zhang, Xueling Jiang, Yan Xiong
    03-12-2020
    https://doi.org/10.4081/ejh.2020.3177
    2421
    PDF: 961
    HTML: 31
  • Expression of lumican related to CD34 and VEGF in the articular disc of the human temporomandibular joint.

    N. Kiga, I. Tojyo, T. Matsumoto, Y. Hiraishi, Y. Shinohara, S. Fujita
    e34
    08-07-2010
    https://doi.org/10.4081/ejh.2010.e34
    1983
    PDF: 700
    HTML: 3543
  • CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis

    Yangying Peng, Shaojie Ding, Ping Xu, Xueyan Zhang, Jianzhang Wang, Tiantian Li, Liyun Liao, Xinmei Zhang
    06-08-2024
    https://doi.org/10.4081/ejh.2024.4052
    1275
    PDF: 849
    HTML: 60
  • Characterizing the activation of the Wnt signaling pathway in hilar cholangiocarcinoma using a tissue microarray approach

    W. Chen, J. Liang, L. Huang, J. Cai, Y. Lei, J. Lai, L. Liang, K. Zhang
    09-02-2016
    https://doi.org/10.4081/ejh.2016.2536
    2029
    PDF: 942
    HTML: 359
  • Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis

    Jindong Li, Jie Kang, Weiyan Liu, Jiazhe Liu, Gaofeng Pan, Anwei Mao, Qing Zhang, Jingfeng Lu, Junbin Ding, Hongchang Li
    25-10-2022
    https://doi.org/10.4081/ejh.2022.3529
    1955
    PDF: 957
    HTML: 56
  • MicroRNA-29b-3p promotes 5-fluorouracil resistance via suppressing TRAF5-mediated necroptosis in human colorectal cancer

    Shuimei Wu, Yun Zhou, Ping Liu, Hui Zhang, Wanliang Wang, Yuan Fang, Xiang Shen
    22-06-2021
    https://doi.org/10.4081/ejh.2021.3247
    2293
    PDF: 1130
    Supplementary: 239
    HTML: 33
  • Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

    Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Diao
    17-11-2021
    https://doi.org/10.4081/ejh.2021.3255
    1387
    PDF: 737
    HTML: 62
  • NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway

    Li Fan, Feng Xu, Shouyong Liu, Ding Wu, Suchun Wang, Xin Pan, Yulin Zhou, Le Qu, Wenquan Zhou
    30-06-2025
    https://doi.org/10.4081/ejh.2025.4221
    1317
    PDF: 580
    HTML: 46
  • Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study

    V.N. Karavana, H. Gakiopoulou, E.A. Lianos
    15-04-2014
    https://doi.org/10.4081/ejh.2014.2308
    2329
    PDF: 1020
    HTML: 665
  • GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

    Mário S. de Souza Albuquerque, Antônio F. da Silva-filho, Marina Ferraz Cordeiro, Maria de Fátima Deodato de Souza, Michael W.L. Quirino, Luiza R. Amorim Lima, Maira G. da Rocha Pitta, Mario R. Martins, Moacyr J.B. de Melo Rêgo
    14-06-2018
    https://doi.org/10.4081/ejh.2018.2931
    3780
    PDF: 679
    Supplementary: 284
    HTML: 52
  • Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study

    Sonia Fantone, Giovanni Tossetta, Rodolfo Montironi, Martina Senzacqua , Daniela Marzioni, Roberta Mazzucchelli
    19-10-2020
    https://doi.org/10.4081/ejh.2020.3147
    2298
    PDF: 884
    HTML: 41
  • 17 | EXPLORING THE FUNCTIONAL ROLE OF THE PROTEOGLYCAN ESM1 IN THE BREAST CANCER TUMOR MICROENVIRONMENT E. Peri1, S. Feo1|2, E. Roz3, A. D’Ascola4, P. Cancemi1|2 | 1Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy; 2Experimental Center of Onco Biology (COBS), Palermo, Italy; 3La Maddalena Hospital III Level Oncological Department, Palermo, Italy; 4Department of Clinical and Experimental Medicine, University of Messina, Italy

    GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
    22-06-2026
    https://doi.org/10.4081/ejh.2026.4635
    175
    PDF: 110
  • Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

    Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin
    23-10-2024
    https://doi.org/10.4081/ejh.2024.4098
    2760
    PDF: 621
    HTML: 54
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Vol. 70 No. 2 (2026)
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice
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Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model
Juan Fan et al.
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European Journal of Histochemistry

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