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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Marco Biggiogera, Italy

1.9
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3.7
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1.9
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3.7
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  • Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling

    Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng
    17-06-2025
    https://doi.org/10.4081/ejh.2025.4218
    1725
    PDF: 672
    HTML: 34
  • Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

    Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan
    13-05-2024
    https://doi.org/10.4081/ejh.2024.3917
    2149
    PDF: 911
    HTML: 54
  • Wheat germ agglutinin staining as a suitable method for detection and quantification of fibrosis in cardiac tissue after myocardial infarction

    B. Emde, A. Heinen, A. Gödecke, K. Bottermann
    17-12-2014
    https://doi.org/10.4081/ejh.2014.2448
    9950
    PDF: 5054
    HTML: 2218
  • Immunofluorescence signal intensity measurements as a semi-quantitative tool to assess sarcoglycan complex expression in muscle biopsy

    Simona Zanotti, Francesca Magri, Francesca Poggetti, Michela Ripolone, Daniele Velardo, Francesco Fortunato, Patrizia Ciscato, Maurizio Moggio, Stefania Corti, Giacomo Pietro Comi, Monica Sciacco
    01-09-2022
    https://doi.org/10.4081/ejh.2022.3418
    1542
    PDF: 937
    HTML: 32
  • Bile duct ligature in young rats: A revisited animal model for biliary atresia

    Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastián San Martin, Sandra Montedonico
    13-09-2017
    https://doi.org/10.4081/ejh.2017.2803
    2239
    PDF: 1013
    HTML: 159
  • Genetic deletion of P-selectin prevents fibrosis development by inhibiting the neutrophil megakaryocyte emperipolesis in the Gata1low mouse model for myelofibrosis

    Francesca Arciprete, Viola Velardi, Antonio Di Virgilio, Paola Verachi, Claudio Carta, Giulia Pozzi, Vincenzo Roberti, Giorgio Vivacqua, Rosalba Rana, Maria Zingariello
    16-12-2025
    https://doi.org/10.4081/ejh.2025.4427
    839
    PDF: 417
    HTML: 11
  • The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways

    Zhi Wang, Guihua Jian, Teng Chen, Yiping Chen, Junhui Li, Niansong Wang
    01-03-2023
    https://doi.org/10.4081/ejh.2023.3648
    5063
    PDF: 1182
    HTML: 47
  • Growth patterns of hepatocellular carcinoma with HBV infection

    Study of liver in HBV-related hepatocellular carcinoma: Stereology shows quantitative differences in liver structure

    Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb
    18-09-2018
    https://doi.org/10.4081/ejh.2018.2950
    1726
    PDF: 694
    HTML: 25
  • Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

    Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferra
    21-06-2022
    https://doi.org/10.4081/ejh.2022.3391
    4202
    PDF: 1990
    HTML: 65
  • Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling

    Kaizheng Liu, Jinyu Pan, Quan Liu, Yang Huang, Liqun Shang, Yi Zhang, Jinming Wen, Huayang Li, Zhongkai Wu
    15-06-2026
    https://doi.org/10.4081/ejh.2026.4569
    200
    PDF: 176
    HTML: 7
  • Contribution of intestinal smooth muscle to Crohn's disease fibrogenesis

    C. Severi, R. Sferra, A. Scirocco, A. Vetuschi, N. Pallotta, A. Pronio, R. Caronna, G. Di Rocco, E. Gaudio, E. Corazziari, P. Onori
    17-12-2014
    https://doi.org/10.4081/ejh.2014.2457
    3070
    PDF: 1222
    HTML: 438
  • Defense and protection mechanisms in lung exposed to asbestiform fiber: the role of macrophage migration inhibitory factor and heme oxygenase-1

    Carla Loreto, Rosario Caltabiano, Adriana Carol Eleonora Graziano, Sergio Castorina, Claudia Lombardo, Vera Filetti, Ermanno Vitale, Giuseppe Rapisarda, Venera Cardile, Caterina Ledda, Venerando Rapisarda
    16-04-2020
    https://doi.org/10.4081/ejh.2020.3073
    1455
    PDF: 868
    HTML: 26
  • Forever particles: histochemistry in the plasticene age

    Beatrice Camia, Andrea Casasco, Manuela Monti
    01-08-2025
    https://doi.org/10.4081/ejh.2025.4226
    1524
    PDF: 653
    HTML: 62
  • Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells

    Huina Su, Ruiqiong Ma, Dehui Su, Cheng Tan, Ye Zhu, Xin Yang
    21-04-2026
    https://doi.org/10.4081/ejh.2026.4537
    997
    PDF: 617
    HTML: 22
  • Comparison of different histological protocols for the preservation and quantification of the intestinal mucus layer in pigs

    Ilen Röhe, Friedrich Joseph Hüttner, Johanna Plendl, Barbara Drewes, Jürgen Zentek
    05-02-2018
    https://doi.org/10.4081/ejh.2018.2874
    4288
    PDF: 1842
    HTML: 305
  • Colchicine alleviates severe acute pancreatitis in rats by inhibiting acinar cell ferroptosis via LCN2/MAPK/ERK signaling axis

    Liu Yang, Xiaoyi Zheng, Yang Zhang, Yue Li, Lei Li, Feng Liu
    11-05-2026
    https://doi.org/10.4081/ejh.2026.4557
    457
    PDF: 660
    Supplementary: 50
    HTML: 8
  • Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

    Hai-rong Fu, Xiao-shan Li, Yong-hui Zhang, Bin-bin Feng, Lian-hong Pan
    07-09-2020
    https://doi.org/10.4081/ejh.2020.3131
    1369
    PDF: 982
    HTML: 19
  • circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes

    Ziyang Yu, Wenbo Xu, Yirong Teng, Tingting Li, Ren Guo, Ju Li, Xichen Li, Yanping Li, Yinglu Hao
    22-08-2025
    https://doi.org/10.4081/ejh.2025.4230
    440
    PDF: 368
    HTML: 12
  • Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

    Liying Shen, Kongjie Lu, Zhenfeng Chen, Yingwei Zhu, Cong Zhang, Li Zhang
    07-12-2023
    https://doi.org/10.4081/ejh.2023.3816
    1259
    PDF: 759
    HTML: 40
  • Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis

    A.C. Croce, G. Bottiroli
    12-12-2014
    https://doi.org/10.4081/ejh.2014.2461
    15018
    PDF: 6227
    HTML: 8011
  • Twenty years of histochemistry in the third millennium, browsing the scientific literature

    Carlo Pellicciari
    29-12-2020
    https://doi.org/10.4081/ejh.2020.3213
    1455
    PDF: 566
    HTML: 17
  • The role of miRNA-29b1 on the hypoxia-induced apoptosis in mammalian cardiomyocytes

    Bo Dai, Hailin Liu, Dingmin Juan, Kaize Wu, Ruhao Cao
    27-06-2024
    https://doi.org/10.4081/ejh.2024.4021
    1109
    PDF: 621
    HTML: 35
  • The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis

    Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti
    10-11-2020
    https://doi.org/10.4081/ejh.2020.3175
    1956
    PDF: 1012
    Supplementary: 205
    HTML: 34
  • Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

    Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan
    17-06-2025
    https://doi.org/10.4081/ejh.2025.4168
    708
    PDF: 424
    HTML: 21
  • Histochemistry as a versatile research toolkit in biological research, not only an applied discipline in pathology

    Carlo Pellicciari
    21-12-2018
    https://doi.org/10.4081/ejh.2018.3006
    2221
    PDF: 835
    HTML: 32
  • Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication in vitro by reinforcing miR-192-5p/ATG7-induced autophagy

    Minkai Cao, Deping Yuan, Hongxiu Jiang, Guanlun Zhou, Chao Chen, Guorong Han
    02-09-2022
    https://doi.org/10.4081/ejh.2022.3438
    1606
    PDF: 990
    HTML: 52
  • Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

    C. Pellicciari
    30-12-2014
    https://doi.org/10.4081/ejh.2014.2474
    2467
    PDF: 717
    HTML: 826
  • Fibroblast activating protein-α expression in squamous cell carcinoma of the esophagus in primary and irradiated tumors: the use of archival FFPE material for molecular techniques

    Renata Tabola, Magdalena Zaremba-Czogalla, Dagmara Baczynska, Roberto Cirocchi, Kamila Stach, Krzysztof Grabowski, Katarzyna Augoff
    20-06-2017
    https://doi.org/10.4081/ejh.2017.2793
    1904
    PDF: 801
    HTML: 102
  • Is there still room for novelty, in histochemical papers?

    Carlo Pellicciari
    16-12-2016
    https://doi.org/10.4081/ejh.2016.2758
    2999
    PDF: 745
    HTML: 284
  • A modified Verhoeff-van Gieson elastin histochemical stain to enable pulmonary arterial hypertension model characterization

    K.R. Percival, Z. A. Radi
    11-02-2016
    https://doi.org/10.4081/ejh.2016.2588
    3507
    PDF: 1727
    HTML: 1770
  • Histochemistry in biology and medicine: a message from the citing journals

    Carlo Pellicciari
    23-12-2015
    https://doi.org/10.4081/ejh.2015.2610
    3276
    PDF: 916
    HTML: 901
  • Expression pattern of thymosin beta 4 in the adult human liver

    S. Nemolato, P. Van Eyken, T. Cabras, F. Cau, M.U. Fanari, A. Locci, D. Fanni, C.L.P. Gerosa, I. Messana, M. Castagnola, G. Faa
    e25
    07-09-2011
    https://doi.org/10.4081/ejh.2011.e25
    1655
    PDF: 741
    HTML: 1416
  • Elastofibroma dorsi: a histochemical and immunohistochemical study

    A. Di Vito, E. Scali, G. Ferraro, C. Mignogna, I. Presta, C. Camastra, C. Palmieri, G. Donato, T. Barni
    19-02-2015
    https://doi.org/10.4081/ejh.2015.2459
    2825
    PDF: 964
    HTML: 1104
  • Different iron-handling in inflamed small and large cholangiocytes and in small and large-duct type intrahepatic cholangiocarcinoma

    Romina Mancinelli, Antimo Cutone, Luigi Rosa, Maria Stefania Lepanto, Paolo Onori, Luigi Pannarale, Antonio Franchitto, Eugenio Gaudio, Piera Valenti
    19-10-2020
    https://doi.org/10.4081/ejh.2020.3156
    1808
    PDF: 810
    HTML: 26
  • Low ozone concentrations do not exert cytoprotective effects on tamoxifen-treated breast cancer cells in vitro

    Chiara Rita Inguscio, Flavia Carton, Barbara Cisterna, Manuela Rizzi, Francesca Boccafoschi, Gabriele Tabaracci, Manuela Malatesta
    09-09-2024
    https://doi.org/10.4081/ejh.2024.4106
    1982
    PDF: 341
    HTML: 17
  • Regenerative potential of the Bichat fat pad determined by the quantification of multilineage differentiating stress enduring cells

    Giamaica Conti, Dario Bertossi, Elena Dai Prè, Chiara Cavallini, Maria Teresa Scupoli, Giulia Ricciardi, Pierpaolo Parnigotto, Yves Saban, Andrea Sbarbati, Pierfrancesco Nocini
    23-10-2018
    https://doi.org/10.4081/ejh.2018.2900
    2600
    PDF: 1002
    HTML: 54
  • Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

    Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai
    14-10-2022
    https://doi.org/10.4081/ejh.2022.3510
    1421
    PDF: 727
    HTML: 42
  • Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation

    Yuejuan Cao, Li Cui, Shaoyong Tuo, Hongze Liu, Shaonan Cui
    24-04-2024
    https://doi.org/10.4081/ejh.2024.4004
    2129
    PDF: 654
    HTML: 28
  • Is mastocytic colitis a specific clinical-pathological entity?

    Filippo Vernia, Tiziana Tatti, Stefano Necozione, Annalisa Capannolo, Nicola Cesaro, Marco Magistroni, Marco Valvano, Simona Pompili, Roberta Sferra, Antonella Vetuschi, Giovanni Latella
    28-11-2022
    https://doi.org/10.4081/ejh.2022.3499
    1859
    PDF: 699
    HTML: 27
  • Diagnosis of sudden cardiac death due to early myocardial ischemia: An ultrastructural and immunohistochemical study

    Silvia Damiana Visonà, Donatella Benati, Maria Cristina Monti, Mirco Galiè, Luisa Andrello, Andrea Frontini, Antonio Osculati
    03-04-2018
    https://doi.org/10.4081/ejh.2018.2866
    2873
    PDF: 1364
    Supplementary: 267
    HTML: 83
  • Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway

    Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu Xu
    12-12-2023
    https://doi.org/10.4081/ejh.2023.3908
    1722
    PDF: 568
    HTML: 28
  • Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium

    Arianna Casini, Giorgio Vivacqua, Rosa Vaccaro, Anastasia Renzi, Stefano Leone, Luigi Pannarale, Antonio Franchitto, Paolo Onori, Romina Mancinelli, Eugenio Gaudio
    19-10-2023
    https://doi.org/10.4081/ejh.2023.3846
    1861
    PDF: 695
    HTML: 35
  • Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells

    Weidong Wang, Sheng Chen, Yuan Wang, Cui Jie, Weimin Shen
    01-09-2025
    https://doi.org/10.4081/ejh.2025.4241
    594
    PDF: 520
    HTML: 13
  • Effect of interleukin-1beta and dehydroepiandrosterone on the expression of lumican and fibromodulin in fibroblast-like synovial cells of the human temporomandibular joint

    K. Okamoto, N. Kiga, Y. Shinohara, I. Tojyo, S. Fujita
    23-02-2015
    https://doi.org/10.4081/ejh.2015.2440
    2535
    PDF: 1179
    HTML: 592
  • Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma

    Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta
    10-10-2023
    https://doi.org/10.4081/ejh.2023.3879
    4804
    PDF: 835
    HTML: 32
  • Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity

    Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Seyed-Moayed Alavian, Kamran B. Lankarani, Parisa Farrokh, Jens Randel Nyengaard
    29-01-2018
    https://doi.org/10.4081/ejh.2018.2859
    2402
    PDF: 1111
    HTML: 84
  • Transmission electron microscopy for nanomedicine: novel applications for long-established techniques

    Manuela Malatesta
    09-12-2016
    https://doi.org/10.4081/ejh.2016.2751
    2488
    PDF: 1568
    HTML: 270
  • Expression of hyaluronan synthase 3 in deformed human temporomandibular joint discs: in vivo and in vitro studies

    T. Matsumoto, M. Inayama, I. Tojyo, N. Kiga, S. Fujita
    e50
    15-12-2010
    https://doi.org/10.4081/ejh.2010.e50
    1739
    PDF: 746
    HTML: 1413
  • High expression of both desmoplastic stroma and epithelial to mesenchymal transition markers associate with shorter survival in pancreatic ductal adenocarcinoma

    Damián Sánchez-Ramírez, Rafael Medrano-Guzmán, Fernando Candanedo-González, Jazmín De Anda-González, Luis Enrique García-Rios, Vadim Pérez-Koldenkova, Marcos Gutiérrez-de la Barrera, Sara Rodríguez-Enríquez, Marco Velasco-Velázquez, Silvia Cecilia Pacheco-Velázquez, Patricia Piña-Sánchez, Héctor Mayani, Alejandro Gómez-Delgado, Alberto Monroy-García, Ana Karen Martínez-Lara, Juan José Montesinos
    17-02-2022
    https://doi.org/10.4081/ejh.2022.3360
    2711
    PDF: 1075
    HTML: 47
  • NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway

    Li Fan, Feng Xu, Shouyong Liu, Ding Wu, Suchun Wang, Xin Pan, Yulin Zhou, Le Qu, Wenquan Zhou
    30-06-2025
    https://doi.org/10.4081/ejh.2025.4221
    1184
    PDF: 532
    HTML: 25
  • Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

    Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen
    13-10-2025
    https://doi.org/10.4081/ejh.2025.4254
    900
    PDF: 465
    HTML: 44
  • Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

    Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang
    29-04-2024
    https://doi.org/10.4081/ejh.2024.4019
    2043
    PDF: 780
    HTML: 30
  • Altered alkaline phosphatase activity in obese Zucker rats liver respect to lean Zucker and Wistar rats discussed in terms of all putative roles ascribed to the enzyme

    V. Bertone, E. Tarantola, A. Ferrigno, E. Gringeri, S. Barni, M. Vairetti, I. Freitas
    e5
    08-02-2011
    https://doi.org/10.4081/ejh.2011.e5
    1533
    PDF: 834
    HTML: 3577
  • P07 | DISRUPTED GUT-VASCULAR BARRIER AND INFLAMMATORY REMODELING IN MNGIE: A SPATIAL TRANSCRIPTOMIC AND HISTOLOGICAL STUDY S. Blando1, E. Boschetti1, I. Neri1, L. Caporali2, C. Fiorini2, D. Ormanbekova2, C. Malagelada3, I. Rusciano1, V. Carelli2, R. De Giorgio4, L. Manzoli1, S. Ratti1 | 1Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Italy; 2IRCCS Institute of Neurological Sciences of Bologna, Neurogenetics Program, Bologna, Italy; 3Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; 4Department of Translational Medicine, University of Ferrara, Ferrara, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4327
    189
  • Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling

    You-Jie Liu, Hua-Jun Wang, Zhao-Wen Xue, Lek-Hang Cheang, Man-Seng Tam, Ri-Wang Li, Jie-Ruo Li, Hui-Ge Hou, Xiao-Fei Zheng
    07-09-2021
    https://doi.org/10.4081/ejh.2021.3297
    1913
    PDF: 1002
    Supplementary: 184
    HTML: 29
  • Histochemistry as an irreplaceable approach for investigating functional cytology and histology

    C. Pellicciari
    e41
    19-12-2013
    https://doi.org/10.4081/ejh.2013.e41
    3448
    PDF: 962
    HTML: 413
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Vol. 70 No. 2 (2026)
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice
Nana Bao et al.
20 April 2026
Vol. 70 No. 2 (2026)
Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells
Huina Su et al.
21 April 2026
Vol. 70 No. 2 (2026)
Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model
Juan Fan et al.
20 April 2026

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European Journal of Histochemistry

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