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A PRECLINICAL STUDY ON THE MODULATION OF THE MICROBIOTA–GUT–BRAIN AXIS BY A FUNCTIONAL SNACK PROMOTING HEALTHY AGING Bellitto V1, Grasselli F1, Martinelli I2, Nittari G2, Vittadini E1, Eleuteri AM1, Tayebati SK2, Bonfili L1 and Tomassoni D1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Italy
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GAIT CHARACTERIZATION IN A MOUSE MODEL OF CHRONIC MILD STRESS- AND 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROINFLAMMATION Serinelli FC1, Kashyrina M2, De Nuccio F2, Panaro MA3, Cianciulli A3, Ruggiero M3, Porro C4, Ichas F5, Nicolardi N1 and Lofrumento DD1 | 1Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy; 2Department of Experimental Medicine, University of Salento, Lecce, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 4Department of Clinical and Experimental Medicine, University of Foggia, Italy; 5Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, France
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GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy
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P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | 1Marmara Uni School of Medicine, Istanbul, Türkiye; 2Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; 3Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; 4Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye
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Forever particles: histochemistry in the plasticene age
1451PDF: 605HTML: 59 -
73 | PROTECTIVE ROLE FOR OLEOYLETHANOLAMIDE IN THE HUMAN BRAIN: EFFECTS ON THE MODULATION OF NEUROINFLAMMATION AND INSULIN RESISTANCE IN HUMAN ASTROCYTES Lucia Sileo1, Giulia Scanavino1, Silvana Gaetani2, Ada MariaTata1 | 1Dept. of Biology and Biotechnologies "Charles Darwin", University of Rome "Sapienza", Rome, Italy; 2Dept. of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome "Sapienza", Rome, Italy
85PDF: 35 -
LOCUS COERULEUS STRUCTURAL INTEGRITY IS ASSOCIATED WITH CIRCULATING SOLUBLE AXL IN ALZHEIMER’S DISEASE Galgani A1, Scotto M2, Mary A3, Lombardo F4, Martini N4, Siciliano G5, Ceravolo R5, Heneka MT3,6 and Giorgi FS1,7 | 1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy; 2Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; 3Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; 4Department of Radiology, Fondazione Toscana “G. Monasterio”, Pisa, Italy; 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; 7I.R.C.C.S. Stella Maris, Calambrone, Pisa, Italy
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P03 | ALTERED NEUROTRANSMISSION AND METABOLISM IN A GFAP R239C ZEBRAFISH MODEL OF ALEXANDER DISEASE S. Candiani1|2, M. Bozzo1, V. Bazzurro1, D. Bellitto3, A. Tripi1, S. Ferrando1, G. Rosa1, T. Bacchetti3 | 1Dept. of Biology, University of Genova, Italy; 2RCCS Azienda Ospedaliera Metropolitana, Genova, Italy; 3UO Proteomica e Spettrometria di Massa, IRCCS Ospedale Policlinico San Martino, Genova, Italy
117PDF: 32 -
A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL 5xFAD Chicote J1, Rosano V1, Mezzanotte M1, Bertinaria M2, Marini E2, Vercelli A1 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Drug Science and Technology, University of Turin, Italy
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A PILOT STUDY TO INVESTIGATE THE ANTIAGING EFFECTS OF THE OLIVE POMACE BY-PRODUCT ON THE BRAIN OF DROSOPHILA MELANOGASTER Makladissi S1†, Tomassoni D2†*, Nardin T3, Bellitto V2, Cappelli A2, Di Cara F1‡ and Beghelli D2‡ | 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; 2School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, MC, Italy ; 3Chemical Unit Oenological Vines Agri-food - Technology Transfer Centre Foundation Edmund Mach, TN, Italy †These authors equally contributed. ‡These authors share the authorship
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04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE G. Abruscato1, L. Sileo2, G. Scanavino2, C. Guerriero2, M. Mauro1, M. Vazzana1|3, V. Arizza1|3, C. Luparello1|3, A.M.Tata2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Dept. of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center (NBFC), Italy
277PDF: 48 -
P01 | BET PROTEIN INHIBITION ATTENUATES MICROGLIAL ACTIVATION AND OXIDATIVE STRESS IN A CELLULAR MODEL OF PARKINSON’S DISEASE E. Bisesto1, D. Pensabene1, M. Colardo1, M. Varone1, M. Segatto1 | 1Dept. of Biosciences and territory, University of Molise, Pesche (IS), Italy
82PDF: 20 -
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy
3155PDF: 1735Video 1: 262Video 2: 307HTML: 29 -
SHORT-TERM EXPOSURE TO PARTICULATE MATTER TRIGGERS SELECTIVE MOLECULAR AND BEHAVIORAL ALTERATIONS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS Bonato M1,2, Montarolo F1,2, Cerrato V1,2, Parolisi R1,2, Abbadessa G3, Caudana M3, Di Cintio N1,2, De Francia S3, Bertolotto A2,4, Buffo A1,2, and Boda E1,2 | 1Dept. of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (Turin), Italy; 3Department of Clinical and Biological Sciences, University of Turin, Orbassano (Turin), Italy; 4Koelliker Hospital, Turin, Italy
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3-hydroxi-anthranilic acid is early expressed in stroke
2378PDF: 742HTML: 312 -
KAEMPFEROL TARGETS LIPID BALANCE, ENDOCANNABINOID PATHWAYS, AND PPAR-α IN THE RAT CEREBRAL CORTEX AFTER TRANSIENT BILATERAL COMMON CAROTID ARTERY OCCLUSION AND REPERFUSION Serra MP#, Carta G#, Murru E, Boi M, Manca C, Lai Y, Cabboi M, Carta A, Banni S* and Quartu M* | Department of Biomedical Sciences, University of Cagliari, Italy #equal contribution; *co-seniorship
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P12 | NEUROBIOLOGICAL IMPACT OF CITRUS BERGAMIA IN THE IDIOPHATIC AUTISM MODEL BTBR D. Minervini1, I. Olivito1, A. Vivacqua2|3, L. Bartella4|5, L. Di Donna4|5, R. Alò1, R.M. Facciolo1 | 1Comparative Neuroanatomy Lab; Biology, Ecology and Earth Sciences Dept., University of Calabria, Rende (CS), Italy; 2Dept. of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy; 3Centro Sanitario, University of Calabria, Rende (CS), Italy; 4QUASIORA Lab., AGRINFRA Research Net, University of Calabria, Rende (CS), Italy; 5Chimica and Tecnologie Chimiche Dept., University of Calabria, Rende (CS), Italy
83PDF: 25 -
NEUROBIOLOGY OF SUICIDE: MORPHOLOGICAL ASSESSMENT OF MICROGLIAL NETWORK IN HUMAN POST-MORTEM PREFRONTAL CORTEX Tambuzzi S1, Bertolotto N2, Massari S2, Madaschi L3, Alini M2, Brandolese D2, Ubezio MC1, Cattaneo C1 and Amadeo A2 | 1Institute of Forensic Medicine, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; 2Department of Biosciences, Università degli Studi di Milano, Milan, Italy; 3UNITECH NOLIMITS, Università degli Studi di Milano, Milan, Italy
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P30 | P75NTR MODULATION IMPROVES RESILIENCE TO OXIDATIVE DAMAGE IN A MICROGLIAL CELL MODEL OF PARKINSON’S DISEASE A. Valenza1, D. Pensabene2, F. Rendina1, M. Muzzi2, A. Fracassi3, M. Segatto2, S. Moreno1|3 | 1Dept. of Science, University Roma Tre, Rome, Italy; 2Dept. of Biosciences and Territory, University of Molise, Pesche, Italy; 3Dept. of Neurology, UTMB, Galveston, TX, USA
95PDF: 17
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