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Toll-like receptor 4 expression in the epithelium of inflammatory periapical lesions. An immunohistochemical study

R. Leonardi, R.E. Perrotta, C. Loreto, G. Musumeci, S. Crimi, J.N. dos Santos, M.C. Rusu, P. Bufo, E. Barbato, G. Pannone

26-10-2015

https://doi.org/10.4081/ejh.2015.2547

1894

PDF: 1073

HTML: 360
Expressions of TLR4, MyD88, IRAK4 and NF-κΒ in the oviduct of Chinese brown frog (Rana dybowskii)

Yue Zhang, Ao Zhang, Yue Zhao, Xiaohang Feng, Yuyao Sheng, Haolin Zhang, Qiang Weng, Meiyu Xu

25-09-2019

https://doi.org/10.4081/ejh.2019.3050

1124

PDF: 566

HTML: 19
Evaluation of expression of Toll-Like Receptors 7 and 9, proliferation, and cytoskeletal biomarkers in plaque and guttate psoriasis: A pilot morphological study

Francesca Prignano, Giulia Lombardo, Serena Indino, Federica Ricceri, Laura Cornaghi, Elena B. Donetti

05-03-2021

https://doi.org/10.4081/ejh.2021.3218

1715

PDF: 687

HTML: 18
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

Guangbao He, Yibo He, Hongwei Ni, Kai Wang, Yijun Zhu, Yang Bao

26-07-2023

https://doi.org/10.4081/ejh.2023.3766

2141

PDF: 1347

HTML: 21
Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou

02-12-2021

https://doi.org/10.4081/ejh.2021.3331

2652

PDF: 1502

HTML: 40
Pretreatment with geniposide mitigates myocardial ischemia/reperfusion injury by modulating inflammatory response through TLR4/NF-κB pathway

Yanmei Yao, Leqing Lin, Wenxue Tang, Yueliang Shen, Fayu Chen, Ning Li, Baiyong Wang

08-09-2023

https://doi.org/10.4081/ejh.2023.3742

1233

PDF: 489

HTML: 24
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

1299

PDF: 747

HTML: 26
MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

Francesca Diomede, Maria Zingariello, Marcos F.X.B. Cavalcanti, Ilaria Merciaro, Jacopo Pizzicannella, Natalia de Isla, Sergio Caputi, Patrizia Ballerini, Oriana Trubiani

24-05-2017

https://doi.org/10.4081/ejh.2017.2791

3339

PDF: 1394

HTML: 154
Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway

Yan Yan Li, Ya Ping Feng, Li Liu, Jin Ke, Xing Long

21-06-2022

https://doi.org/10.4081/ejh.2022.3357

2138

PDF: 1126

HTML: 38
The psoriatic shift induced by interleukin 17 is promptly reverted by a specific anti-IL-17A agent in a three-dimensional organotypic model of normal human skin culture

Elena Donetti, Giulia Lombardo, Serena Indino, Laura Cornaghi, Francesca Arnaboldi, Leonardo Pescitelli, Franz Baruffaldi Preis, Francesca Prignano

16-04-2020

https://doi.org/10.4081/ejh.2020.3115

1275

PDF: 793

HTML: 19
Effects of miR-939 and miR-376A on ulcerative colitis using a decoy strategy to inhibit NF-κB and NFAT expression

Yongwei Lin, Zhipeng Zhou, Lang Xie, Yongsheng Huang, Zhenghua Qiu, Lili Ye, Chunhui Cui

15-02-2022

https://doi.org/10.4081/ejh.2022.3316

1893

PDF: 751

HTML: 29
Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea

Wenjing Liu, Shanshan Ming, Xiaobing Zhao, Xin Zhu, Yuxiang Gong

01-09-2023

https://doi.org/10.4081/ejh.2023.3704

1240

PDF: 991

HTML: 25
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

17-09-2024

https://doi.org/10.4081/ejh.2024.4034

1241

PDF: 646

HTML: 13
Study on the mechanism of Shenling Baizhu powder on the pathogenesis of pregnancy complicated with non-alcoholic fatty liver, based on PI3K/AKT/mTOR signal pathway

Yao Le, Zhijun Wang, Qian Zhang, Ling Miao, Xiaohong Wang, Guorong Han

17-09-2024

https://doi.org/10.4081/ejh.2024.4093

2345

PDF: 619

HTML: 58
P74 | EXPRESSION OF PISCIDIN, TLR-4, ERK2 AND P-P38 MAPK IN THE ZEBRAFISH GUT EXPOSED TO PCB-126 AND POSSIBLE PROTECTIVE EFFECTS OF GINESTEIN L. Spiccia¹, A. Miller², G.P. Lombardo¹, V. Natale¹, F. Pellicanò¹, S. Marino¹, A. Nunnari¹, A. Migliorato³, E.R. Laurian¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ²Department of Veterinary Sciences, University of Messina, Messina, Italy; ³Department of Biomedical and Dental Sciences and Morphofunctional Images, University of Messina, Messina, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4399

264
54 | RODLET-LIKE CELLS IN THE YELLOW-LEGGED GULL (LARUS MICHAHELLIS): FIRST EXPLORATORY STUDY OF THE INTESTINAL IMMUNE SYSTEM A. Nunnari¹, A. Miller², G.P. Lombardo¹, F. Grosso³, M. Aragona³, E.R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ²Department for the Promotion of Human Sciences and Quality of life, San Raffaele University, Rome, Italy; ³Department of Veterinary Sciences, University of Messina, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4672

90

PDF: 40
circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes

Ziyang Yu, Wenbo Xu, Yirong Teng, Tingting Li, Ren Guo, Ju Li, Xichen Li, Yanping Li, Yinglu Hao

22-08-2025

https://doi.org/10.4081/ejh.2025.4230

395

PDF: 316

HTML: 9
Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

J. Hansson, A.E. Ericsson, H. Axelson, M.E. Johansson

05-02-2016

https://doi.org/10.4081/ejh.2016.2567

2041

PDF: 781

Supplementary: 310

HTML: 372
Polydatin reverses oxidation low lipoprotein (oxLDL)-induced apoptosis of human umbilical vein endothelial cells via regulating the miR-26a-5p/BID axis

Dajie Wang, Zhaofeng Zhou, Liang Yuan

20-09-2022

https://doi.org/10.4081/ejh.2022.3505

1382

PDF: 617

HTML: 46
Quantitative, structural and molecular changes in neuroglia of aging mammals: A review

Ennio Pannese

23-06-2021

https://doi.org/10.4081/ejh.2021.3249

1779

PDF: 869

HTML: 18
ECRG4 expression in normal rat tissues: expression study and literature review

A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro

18-05-2015

https://doi.org/10.4081/ejh.2015.2458

3093

PDF: 1187

Supplementary: 393

HTML: 1018
From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease

Carolina Pellegrini, Vanessa D'Antongiovanni, Chiara Ippolito, Cristina Segnani, Luca Antonioli, Matteo Fornai, Nunzia Bernardini

22-11-2021

https://doi.org/10.4081/ejh.2021.3278

1592

PDF: 859

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Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro

Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen

09-09-2024

https://doi.org/10.4081/ejh.2024.4101

1348

PDF: 450

HTML: 17
Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation

Francesca Diomede, Soundara Rajan Thangavelu, Ilaria Merciaro, Monica D'Orazio, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani

25-08-2017

https://doi.org/10.4081/ejh.2017.2826

3149

PDF: 1318

HTML: 144
Astragalus Ⅳ ameliorates the dry eye injury in rabbit model via MUC1-ErbB1 pathway

Li Chu, Suhong Ma, Zhiwei Chen, Wenfu Cao

01-04-2021

https://doi.org/10.4081/ejh.2021.3198

1858

PDF: 974

HTML: 25
The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization

R. M. Ruggeri, E. Vitarelli, G. Barresi, F. Trimarchi, S. Benvenga, M. Trovato

e24

03-06-2010

https://doi.org/10.4081/ejh.2010.e24

1488

PDF: 677

HTML: 2606
DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells

Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu

03-05-2017

https://doi.org/10.4081/ejh.2017.2775

2719

PDF: 1046

HTML: 185
Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats

Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Cheng

12-01-2022

https://doi.org/10.4081/ejh.2022.3328

2303

PDF: 1309

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LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

Yiming Zhang, Wanqiong Zheng, Liang Zhang, Yechun Gu, Lihe Zhu, Yingpeng Huang

20-06-2023

https://doi.org/10.4081/ejh.2023.3667

1257

PDF: 742

Supplementary: 99

HTML: 26
Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu

17-11-2025

https://doi.org/10.4081/ejh.2025.4426

996

PDF: 505

HTML: 21
Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (Rana dybowskii)

Yankun Wang, Yuning Liu, Yawei Wang, Ao Zhang, Wenqian Xie, Haolin Zhang, Qiang Weng, Meiyu Xu

20-12-2023

https://doi.org/10.4081/ejh.2023.3890

1406

PDF: 698

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Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

Rong Tian, Gengsheng Mao

12-01-2022

https://doi.org/10.4081/ejh.2022.3350

1847

PDF: 919

HTML: 41
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin

23-10-2024

https://doi.org/10.4081/ejh.2024.4098

2427

PDF: 504

HTML: 35
P41 | INVOLVEMENT OF THE DOLPHIN’S MELON IN IMMUNE FUNCTION G.P. Lombardo¹, A. Miller², L. Spiccia¹, V. Natale¹, F. Pellicanò¹, G. Squadrito¹, E. R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina; ²Department of Veterinary Sciences, University of Messina, Messina, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4363

214
P52 | MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIOXIDANT PROPERTIES OF HEMP EXTRACTS ON THE LIVER OF RATS INVOLVED IN INFLAMMATION CAUSED BY LPS A. Miller¹, M. Kotanska², M. Bednarski², G.P. Lombardo³, V. Natale³, G. Pirracchio³, L. Spiccia³, S. Pergolizzi³, G. Rizzo⁴, E.R. Lauriano³ | ¹Department of Veterinary Sciences, University of Messina, Messina, Italy; ²Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland: ³Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy; ⁴Department of Clinical and Experimental Medicine, University of Messina, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4374

295
Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps?

Antonella Vetuschi, Simon Pompili, Gian Piero Di Marco, Federico Calvaruso, Enz Iacomino, Lidia Angelosante, Claudio Festuccia, Alessandro Colapietro, Roberta Sferra

23-01-2020

https://doi.org/10.4081/ejh.2020.3079

2182

PDF: 1239

HTML: 18
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function

Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng

21-06-2022

https://doi.org/10.4081/ejh.2022.3412

2569

PDF: 1437

HTML: 33
Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription

M. Costanzo, B. Cisterna, A. Vella, T. Cestari, V. Covi, G. Tabaracci, M. Malatesta

21-04-2015

https://doi.org/10.4081/ejh.2015.2515

3141

PDF: 1022

HTML: 413
Mammaglobin, GATA-binding protein 3 (GATA3), and epithelial growth factor receptor (EGFR) expression in different breast cancer subtypes and their clinical significance

Xin Kong, Qi Wang, Jie Li, Ming Li, Fusheng Deng, Chuanying Li

07-04-2022

https://doi.org/10.4081/ejh.2022.3315

1725

PDF: 818

Supplementary: 162

HTML: 19
Forever particles: histochemistry in the plasticene age

Beatrice Camia, Andrea Casasco, Manuela Monti

01-08-2025

https://doi.org/10.4081/ejh.2025.4226

1399

PDF: 575

HTML: 58
44 | CHARACTERIZATION OF IMMUNE CELLS IN THE ADIPOSE TISSUE OF OBESE MICE TREATED WITH ANTI-OBESITY THERAPIES G.P. Lombardo¹, A. Nunnari¹, A. Miller², M. Kotańska³, S. Fiorentino¹, E.R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; ²Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, Italy; ³Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, Krakow, Poland

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4662

83

PDF: 23
Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang

29-04-2024

https://doi.org/10.4081/ejh.2024.4019

1956

PDF: 720

HTML: 28
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1362

PDF: 673

HTML: 23
Sodium hyaluronate promotes proliferation, autophagy, and migration of corneal epithelial cells by downregulating miR-18a in the course of corneal epithelial injury

Yingzhuo Guo, Hua Wang

15-06-2023

https://doi.org/10.4081/ejh.2023.3663

1472

PDF: 645

Supplementary: 129

HTML: 28
Histopathological and immunofluorescent characterization of post-sepsis immune dysregulation in a clinically relevant mouse model

Haoran Tang, Chen Liao, Ning Tang, Hui Li, Yi Liu, Lingling Wang, Zongfang Ren

12-02-2026

https://doi.org/10.4081/ejh.2026.4435

581

PDF: 366

HTML: 14
PDTC ameliorates neuropathic pain by inhibiting microglial activation via blockage of the TNFα-CX3CR1 pathway

Xilei Li, Zhi Ye, Qulian Guo, E Wang, Yundan Pan

12-03-2021

https://doi.org/10.4081/ejh.2021.3184

2224

PDF: 924

HTML: 21
Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

Liying Shen, Kongjie Lu, Zhenfeng Chen, Yingwei Zhu, Cong Zhang, Li Zhang

07-12-2023

https://doi.org/10.4081/ejh.2023.3816

1222

PDF: 716

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