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  Endoplasmic reticulum stress contributed to inflammatory bowel disease by activating p38 MAPK pathway

  Yan Long, Yan Zhao, Xiaoqing Ma, Ya Zeng, Tian Hu, Weijie Wu, Chongtian Deng, Jinyue Hu, Yueming Shen

  23-05-2022

  https://doi.org/10.4081/ejh.2022.3415

  2366

  PDF: 1172

  HTML: 59
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  Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells in vitro

  Xilin Ge, Caoxin Huang, Wenting Chen, Chen Yang, Wenfang Huang, Jia Li, Shuyu Yang

  25-11-2024

  https://doi.org/10.4081/ejh.2024.4140

  2023

  PDF: 646

  HTML: 32
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  Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice

  Nana Bao, Min Zhang, Ming Tang, Ziyi Shen, Shenglin Wang, Guohui Jiang

  20-04-2026

  https://doi.org/10.4081/ejh.2026.4548

  406

  PDF: 269

  Raw data: 41

  HTML: 17
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  SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

  Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu

  03-03-2026

  https://doi.org/10.4081/ejh.2026.4530

  493

  PDF: 386

  HTML: 10
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  Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction

  Jinshuang Li, Dawei Xu, Ce Shi, Chunqi Cheng, Ziheng Xu, Xingjuan Gao, Yong Cheng

  28-10-2024

  https://doi.org/10.4081/ejh.2024.4122

  1510

  PDF: 579

  HTML: 20
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  Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands

  Tadashi Yasui, Hiroshi Gomi, Taishi Kitahara, Azuma Tsukise

  08-08-2017

  https://doi.org/10.4081/ejh.2017.2828

  1829

  PDF: 698

  HTML: 154
• 

  The possible alleviating effect of garlic supplement on the neural retina in a rat model of hypercholesterolemia: a histological and immunohistochemical study

  Eetmad A. Arafat, Eman M.I. Youssef, Hanaa A. Khalaf

  16-12-2021

  https://doi.org/10.4081/ejh.2021.3322

  1311

  PDF: 561

  HTML: 23
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  Calcium-induced alteration of mitochondrial morphology and mitochondrial-endoplasmic reticulum contacts in rat brown adipocytes

  I. Golic, K. Velickovic, M. Markelic, A. Stancic, A. Jankovic, M. Vucetic, V. Otasevic, B. Buzadzic, B. Korac, A. Korac

  09-09-2014

  https://doi.org/10.4081/ejh.2014.2377

  3430

  PDF: 1156

  HTML: 1547
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  Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

  Liying Shen, Kongjie Lu, Zhenfeng Chen, Yingwei Zhu, Cong Zhang, Li Zhang

  07-12-2023

  https://doi.org/10.4081/ejh.2023.3816

  1211

  PDF: 698

  HTML: 37
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  Forever particles: histochemistry in the plasticene age

  Beatrice Camia, Andrea Casasco, Manuela Monti

  01-08-2025

  https://doi.org/10.4081/ejh.2025.4226

  1052

  PDF: 533

  HTML: 57
• 

  Ion channels alterations in the forebrain of high-fat diet fed rats

  Proshanta Roy, Ilenia Martinelli, Michele Moruzzi, Federica Maggi, Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni

  23-11-2021

  https://doi.org/10.4081/ejh.2021.3305

  2218

  PDF: 1109

  HTML: 43
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  Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

  Jacopo J.V. Branca, Donatello Carrino, Ferdinando Paternostro, Massimo Gulisano, Matteo Becatti, Lorenzo Di Cesare Mannelli, Alessandra Pacini

  10-11-2021

  https://doi.org/10.4081/ejh.2021.3285

  1468

  PDF: 794

  HTML: 15
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  Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

  ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu

  11-11-2024

  https://doi.org/10.4081/ejh.2024.4063

  1599

  PDF: 563

  HTML: 20
• 

  Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma

  Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta

  10-10-2023

  https://doi.org/10.4081/ejh.2023.3879

  4544

  PDF: 780

  HTML: 27
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  2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy

  Valentina Alda Carozzi, Chiara Salio, Virginia Rodriguez-Menendez, Elisa Ciglieri, Francesco Ferrini

  19-10-2021

  https://doi.org/10.4081/ejh.2021.3276

  3075

  PDF: 1704

  Video 1: 247

  Video 2: 292

  HTML: 27
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  Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study

  Giada Remoli, Chiara Rita Inguscio, Federico Boschi, Gabriele Tabaracci, Manuela Malatesta, Barbara Cisterna

  26-01-2026

  https://doi.org/10.4081/ejh.2026.4440

  1233

  PDF: 233

  HTML: 13
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  Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells

  Manuela Costanzo, Federico Boschi, Flavia Carton, Giamaica Conti, Viviana Covi, Gabriele Tabaracci, Andrea Sbarbati, Manuela Malatesta

  03-09-2018

  https://doi.org/10.4081/ejh.2018.2969

  2620

  PDF: 819

  Supplementary: 348

  HTML: 45
• 

  The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis

  Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti

  10-11-2020

  https://doi.org/10.4081/ejh.2020.3175

  1912

  PDF: 972

  Supplementary: 195

  HTML: 31

• Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro

  Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen

  09-09-2024

  https://doi.org/10.4081/ejh.2024.4101

  1308

  PDF: 441

  HTML: 17
• 

  Fine structural detection of calcium ions by photoconversion

  V. Poletto, V. Galimberti, G. Guerra, V. Rosti, F. Moccia, M. Biggiogera

  10-08-2016

  https://doi.org/10.4081/ejh.2016.2695

  1785

  PDF: 763

  Supplementary: 307

  HTML: 139
• 

  Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma

  Zhiyang Wang, Jing Li, Ziwei Liu, Ling Yue

  20-03-2023

  https://doi.org/10.4081/ejh.2023.3622

  1288

  PDF: 759

  HTML: 38
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  Subcutaneous adipose tissue classification

  A. Sbarbati, D. Accorsi, D. Benati, L. Marchetti, G. Orsini, G. Rigotti, P. Panettiere

  e48

  25-11-2010

  https://doi.org/10.4081/ejh.2010.e48

  3843

  PDF: 1362

  HTML: 2649
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  Ultrastructural analysis of different human mesenchymal stem cells after in vitro expansion: a technical review

  M. Miko, L. Danisovic, A. Majidi, I. Varga

  26-10-2015

  https://doi.org/10.4081/ejh.2015.2528

  2596

  PDF: 870

  HTML: 840
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  Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

  E. Guerriero, M. Accardo, F. Capone, G. Colonna, G. Castello, S. Costantini

  01-12-2014

  https://doi.org/10.4081/ejh.2014.2433

  4069

  PDF: 824

  HTML: 423
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  Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma

  Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi

  23-06-2022

  https://doi.org/10.4081/ejh.2022.3377

  1755

  PDF: 902

  HTML: 26
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  MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

  Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo

  21-06-2022

  https://doi.org/10.4081/ejh.2022.3426

  1484

  PDF: 833

  HTML: 27

• Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

  Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

  29-02-2024

  https://doi.org/10.4081/ejh.2024.3977

  2252

  PDF: 1173

  Supplementary: 110

  HTML: 156

• IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4316

  271
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  LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury

  Guoyue Liu, Cunzhi Yin, Mingjiang Qian, Xuan Xiao, Hang Wu, Fujian Fu

  31-05-2023

  https://doi.org/10.4081/ejh.2023.3535

  1163

  PDF: 651

  HTML: 35
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  Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

  Hai-rong Fu, Xiao-shan Li, Yong-hui Zhang, Bin-bin Feng, Lian-hong Pan

  07-09-2020

  https://doi.org/10.4081/ejh.2020.3131

  1289

  PDF: 939

  HTML: 14
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  Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

  Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

  20-03-2023

  https://doi.org/10.4081/ejh.2023.3639

  1254

  PDF: 731

  HTML: 26
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  Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

  Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen

  13-10-2025

  https://doi.org/10.4081/ejh.2025.4254

  684

  PDF: 394

  HTML: 41
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  microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

  Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu

  10-05-2022

  https://doi.org/10.4081/ejh.2022.3333

  1798

  PDF: 914

  HTML: 31
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  Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

  Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

  06-08-2025

  https://doi.org/10.4081/ejh.2025.4228

  1249

  PDF: 593

  HTML: 22
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  Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

  Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

  27-07-2023

  https://doi.org/10.4081/ejh.2023.3506

  1745

  PDF: 1073

  HTML: 25
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  Transmission electron microscopy for nanomedicine: novel applications for long-established techniques

  Manuela Malatesta

  09-12-2016

  https://doi.org/10.4081/ejh.2016.2751

  2398

  PDF: 1525

  HTML: 266
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  Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

  Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin

  23-10-2024

  https://doi.org/10.4081/ejh.2024.4098

  2341

  PDF: 497

  HTML: 33
• 

  Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas

  D.G.B. Araújo, L. Nakao, P. Gozzo, C.D.A. Souza, V. Balderrama, E.S. Gugelmin, A.P. Kuczynski, M. Olandoski, L. de Noronha

  06-03-2014

  https://doi.org/10.4081/ejh.2014.2228

  3029

  PDF: 1261

  HTML: 365

• 61 | ROTENONE-INDUCED OXIDATIVE STRESS TRIGGERS PEROXISOMAL ALTERATIONS IN BV-2 MICROGLIAL CELLS F. Rendina¹, A. Valenza¹, M. Muzzi², D. Pensabene², A. Fracassi³, M. Segatto², S. Moreno^1|3 | ¹Dept. of Science, University Roma Tre, Rome, Italy. ²Dept. of Biosciences and Territory, University of Molise, Pesche, Italy. ³Dept. of Neurology, UTMB, Galveston, TX, USA

  GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

  22-06-2026

  https://doi.org/10.4081/ejh.2026.4679

  15

  PDF: 11
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  High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study

  Michela Relucenti, Claudia Tito, Paolo Mercantini, Emanuela Pilozzi, Claudio Barbaranelli, Loredana Cristiano, Daniela Savarese, Daniela Bastianelli, Francesco Fazi, Vincenzo Petrozza, Xiaobo Li, Rui Chen, Selenia Miglietta, Giuseppe Familiari

  16-12-2024

  https://doi.org/10.4081/ejh.2024.4145

  1366

  PDF: 575

  HTML: 9
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  Ultrastructural histochemistry in biomedical research: Alive and kicking

  Manuela Malatesta

  07-11-2018

  https://doi.org/10.4081/ejh.2018.2990

  1946

  PDF: 713

  HTML: 30
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  Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis

  F. Aredia, M. Malatesta, P. Veneroni, M.G. Bottone

  01-12-2015

  https://doi.org/10.4081/ejh.2015.2571

  2409

  PDF: 785

  HTML: 767
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  Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

  Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu

  17-11-2025

  https://doi.org/10.4081/ejh.2025.4426

  926

  PDF: 498

  HTML: 19
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  Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci

  Michela Battistelli, Marta Favero, Debora Burini, Giovanni Trisolino, Dante Dallari, Lucia De Franceschi, Steven R. Goldring, Mary B. Goldring, Elisa Belluzzi, Giuseppe Filardo, Brunella Grigolo, Elisabetta Falcieri, Eleonora Olivotto

  11-02-2019

  https://doi.org/10.4081/ejh.2019.2998

  2695

  PDF: 1351

  Supplementary: 243

  HTML: 56
• 

  β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet

  Zhe Gao, Guang-Yao Song, Lu-Ping Ren, Hui-Juan Ma, Bo-Qing Ma, Shu-Chun Chen

  15-09-2020

  https://doi.org/10.4081/ejh.2020.3160

  1713

  PDF: 867

  HTML: 19

• Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

  Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan

  13-05-2024

  https://doi.org/10.4081/ejh.2024.3917

  1973

  PDF: 743

  HTML: 49
• 

  Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

  M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

  14-04-2016

  https://doi.org/10.4081/ejh.2016.2640

  3247

  PDF: 1369

  HTML: 599

• 46 | DEFINING FAM46C-DEPENDENT LIPID REMODELLING IN CELLULAR HOMEOSTASIS Isidora Alempijevic¹, Federica De Grossi¹, Annarita Miluzio¹, Ivan Ferrari¹, Elisa Arsuffi¹, Marilena Mancino¹, Stefano Biffo^1|2, Nicola Manfrini^1|2 | ¹INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy; ²Department of Biosciences, University of Milan, Italy

  GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

  22-06-2026

  https://doi.org/10.4081/ejh.2026.4664

  24

  PDF: 8
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  Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway

  Hongmei Yin, Xiumei Han, Qun Zhang, Duojie Li, Fan Wang

  26-01-2026

  https://doi.org/10.4081/ejh.2026.4422

  662

  PDF: 386

  Supplementary: 49

  Original gels: 49

  HTML: 14
• 

  Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

  Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

  07-04-2025

  https://doi.org/10.4081/ejh.2025.4182

  1193

  PDF: 711

  HTML: 48
• 

  Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish

  Leen Uyttebroek, Casper Pype, Guy Hubens, Jean-Pierre Timmermans, Luc van Nassauw

  28-08-2020

  https://doi.org/10.4081/ejh.2020.3161

  2104

  PDF: 1225

  HTML: 22

• ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4291

  245
• 

  Potential effect of fish oil to preserve expression of cell cycle and tight junction regulating genes in colon after di-isononyl phthalate ingestion in albino Wistar rats

  Ahmed S. Ahmed, Hoda A. Ibrahim, Ehab M. Hantash

  31-05-2021

  https://doi.org/10.4081/ejh.2021.3232

  1368

  PDF: 505

  HTML: 18
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  Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus

  Luigi Rosati, Marina Prisco, Mariana Di Lorenzo, Maria De Falco, Piero Andreuccetti

  27-01-2020

  https://doi.org/10.4081/ejh.2020.3080

  1854

  PDF: 801

  HTML: 14
• 

  Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases

  G. Natale, E. Pompili, F. Biagioni, S. Paparelli, P. Lenzi, F. Fornai

  e5

  07-03-2013

  https://doi.org/10.4081/ejh.2013.e5

  3327

  PDF: 791

  HTML: 209

• 27 | CELLULAR AND MOLECULAR MECHANISMS OF GADOLINIUM TOXICITY IN SERTOLI CELLS Sara Falvo¹, Giulia Grillo¹, Gabriella Chieffi Baccari¹, Giuseppe Petito¹, Massimo Venditti², Maria Maddalena Di Fiore¹, Tiziana Cappello³, Maria Maisano³, Alessandra Santillo¹ | ¹Dept of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; ²Dept of Experimental Medicine, University of Campania L. Vanvitelli, Napoli, Italy; ³Dept of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy

  GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

  22-06-2026

  https://doi.org/10.4081/ejh.2026.4645

  15

  PDF: 7
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  Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

  Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan

  17-06-2025

  https://doi.org/10.4081/ejh.2025.4168

  567

  PDF: 352

  HTML: 18
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  Histochemical and biometric study of the gastrointestinal system of Hyla orientalis (Bedriaga, 1890) (Anura, Hylidae)

  E. Akat, H. Arıkan, B. Göçmen

  28-11-2014

  https://doi.org/10.4081/ejh.2014.2452

  3357

  PDF: 937

  HTML: 440
• 

  ECRG4 expression in normal rat tissues: expression study and literature review

  A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro

  18-05-2015

  https://doi.org/10.4081/ejh.2015.2458

  3043

  PDF: 1172

  Supplementary: 386

  HTML: 1015