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Endoplasmic reticulum stress contributed to inflammatory bowel disease by activating p38 MAPK pathway

Yan Long, Yan Zhao, Xiaoqing Ma, Ya Zeng, Tian Hu, Weijie Wu, Chongtian Deng, Jinyue Hu, Yueming Shen

23-05-2022

https://doi.org/10.4081/ejh.2022.3415

2545

PDF: 1256

HTML: 64
Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells in vitro

Xilin Ge, Caoxin Huang, Wenting Chen, Chen Yang, Wenfang Huang, Jia Li, Shuyu Yang

25-11-2024

https://doi.org/10.4081/ejh.2024.4140

2169

PDF: 730

HTML: 34
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice

Nana Bao, Min Zhang, Ming Tang, Ziyi Shen, Shenglin Wang, Guohui Jiang

20-04-2026

https://doi.org/10.4081/ejh.2026.4548

685

PDF: 405

Raw data: 54

HTML: 23
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu

03-03-2026

https://doi.org/10.4081/ejh.2026.4530

585

PDF: 481

HTML: 13
Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction

Jinshuang Li, Dawei Xu, Ce Shi, Chunqi Cheng, Ziheng Xu, Xingjuan Gao, Yong Cheng

28-10-2024

https://doi.org/10.4081/ejh.2024.4122

1627

PDF: 641

HTML: 24
Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands

Tadashi Yasui, Hiroshi Gomi, Taishi Kitahara, Azuma Tsukise

08-08-2017

https://doi.org/10.4081/ejh.2017.2828

1904

PDF: 740

HTML: 157
The possible alleviating effect of garlic supplement on the neural retina in a rat model of hypercholesterolemia: a histological and immunohistochemical study

Eetmad A. Arafat, Eman M.I. Youssef, Hanaa A. Khalaf

16-12-2021

https://doi.org/10.4081/ejh.2021.3322

1372

PDF: 625

HTML: 27
Calcium-induced alteration of mitochondrial morphology and mitochondrial-endoplasmic reticulum contacts in rat brown adipocytes

I. Golic, K. Velickovic, M. Markelic, A. Stancic, A. Jankovic, M. Vucetic, V. Otasevic, B. Buzadzic, B. Korac, A. Korac

09-09-2014

https://doi.org/10.4081/ejh.2014.2377

3503

PDF: 1238

HTML: 1551
Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

Liying Shen, Kongjie Lu, Zhenfeng Chen, Yingwei Zhu, Cong Zhang, Li Zhang

07-12-2023

https://doi.org/10.4081/ejh.2023.3816

1259

PDF: 757

HTML: 40
Forever particles: histochemistry in the plasticene age

Beatrice Camia, Andrea Casasco, Manuela Monti

01-08-2025

https://doi.org/10.4081/ejh.2025.4226

1520

PDF: 649

HTML: 62
Ion channels alterations in the forebrain of high-fat diet fed rats

Proshanta Roy, Ilenia Martinelli, Michele Moruzzi, Federica Maggi, Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni

23-11-2021

https://doi.org/10.4081/ejh.2021.3305

2303

PDF: 1190

HTML: 47
Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

Jacopo J.V. Branca, Donatello Carrino, Ferdinando Paternostro, Massimo Gulisano, Matteo Becatti, Lorenzo Di Cesare Mannelli, Alessandra Pacini

10-11-2021

https://doi.org/10.4081/ejh.2021.3285

1517

PDF: 835

HTML: 18
Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu

11-11-2024

https://doi.org/10.4081/ejh.2024.4063

1703

PDF: 634

HTML: 24
Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma

Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta

10-10-2023

https://doi.org/10.4081/ejh.2023.3879

4792

PDF: 834

HTML: 32
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy

Valentina Alda Carozzi, Chiara Salio, Virginia Rodriguez-Menendez, Elisa Ciglieri, Francesco Ferrini

19-10-2021

https://doi.org/10.4081/ejh.2021.3276

3198

PDF: 1765

Video 1: 271

Video 2: 319

HTML: 31
Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study

Giada Remoli, Chiara Rita Inguscio, Federico Boschi, Gabriele Tabaracci, Manuela Malatesta, Barbara Cisterna

26-01-2026

https://doi.org/10.4081/ejh.2026.4440

1333

PDF: 289

HTML: 16
Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells

Manuela Costanzo, Federico Boschi, Flavia Carton, Giamaica Conti, Viviana Covi, Gabriele Tabaracci, Andrea Sbarbati, Manuela Malatesta

03-09-2018

https://doi.org/10.4081/ejh.2018.2969

2725

PDF: 864

Supplementary: 381

HTML: 47
The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis

Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti

10-11-2020

https://doi.org/10.4081/ejh.2020.3175

1956

PDF: 1012

Supplementary: 205

HTML: 34
Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro

Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen

09-09-2024

https://doi.org/10.4081/ejh.2024.4101

1407

PDF: 477

HTML: 18
Fine structural detection of calcium ions by photoconversion

V. Poletto, V. Galimberti, G. Guerra, V. Rosti, F. Moccia, M. Biggiogera

10-08-2016

https://doi.org/10.4081/ejh.2016.2695

1856

PDF: 795

Supplementary: 319

HTML: 140
Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma

Zhiyang Wang, Jing Li, Ziwei Liu, Ling Yue

20-03-2023

https://doi.org/10.4081/ejh.2023.3622

1659

PDF: 880

HTML: 41
Subcutaneous adipose tissue classification

A. Sbarbati, D. Accorsi, D. Benati, L. Marchetti, G. Orsini, G. Rigotti, P. Panettiere

e48

25-11-2010

https://doi.org/10.4081/ejh.2010.e48

4108

PDF: 1428

HTML: 2700
Ultrastructural analysis of different human mesenchymal stem cells after in vitro expansion: a technical review

M. Miko, L. Danisovic, A. Majidi, I. Varga

26-10-2015

https://doi.org/10.4081/ejh.2015.2528

2707

PDF: 902

HTML: 843
Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

E. Guerriero, M. Accardo, F. Capone, G. Colonna, G. Castello, S. Costantini

01-12-2014

https://doi.org/10.4081/ejh.2014.2433

4269

PDF: 855

HTML: 425
Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi

23-06-2022

https://doi.org/10.4081/ejh.2022.3377

1869

PDF: 1007

HTML: 29
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo

21-06-2022

https://doi.org/10.4081/ejh.2022.3426

1546

PDF: 936

HTML: 34
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

29-02-2024

https://doi.org/10.4081/ejh.2024.3977

2343

PDF: 1292

Supplementary: 123

HTML: 230
IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

21-08-2025

https://doi.org/10.4081/ejh.2025.4316

318
LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury

Guoyue Liu, Cunzhi Yin, Mingjiang Qian, Xuan Xiao, Hang Wu, Fujian Fu

31-05-2023

https://doi.org/10.4081/ejh.2023.3535

1316

PDF: 738

HTML: 39
Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

Hai-rong Fu, Xiao-shan Li, Yong-hui Zhang, Bin-bin Feng, Lian-hong Pan

07-09-2020

https://doi.org/10.4081/ejh.2020.3131

1369

PDF: 982

HTML: 19
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

1338

PDF: 801

HTML: 28
Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen

13-10-2025

https://doi.org/10.4081/ejh.2025.4254

899

PDF: 463

HTML: 44
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin

23-10-2024

https://doi.org/10.4081/ejh.2024.4098

2606

PDF: 549

HTML: 39
microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu

10-05-2022

https://doi.org/10.4081/ejh.2022.3333

2180

PDF: 970

HTML: 34
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1456

PDF: 751

HTML: 25
Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

27-07-2023

https://doi.org/10.4081/ejh.2023.3506

1909

PDF: 1162

HTML: 27
Transmission electron microscopy for nanomedicine: novel applications for long-established techniques

Manuela Malatesta

09-12-2016

https://doi.org/10.4081/ejh.2016.2751

2488

PDF: 1568

HTML: 270
61 | ROTENONE-INDUCED OXIDATIVE STRESS TRIGGERS PEROXISOMAL ALTERATIONS IN BV-2 MICROGLIAL CELLS F. Rendina¹, A. Valenza¹, M. Muzzi², D. Pensabene², A. Fracassi³, M. Segatto², S. Moreno^1|3 | ¹Dept. of Science, University Roma Tre, Rome, Italy. ²Dept. of Biosciences and Territory, University of Molise, Pesche, Italy. ³Dept. of Neurology, UTMB, Galveston, TX, USA

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4679

91

PDF: 57
Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas

D.G.B. AraÃºjo, L. Nakao, P. Gozzo, C.D.A. Souza, V. Balderrama, E.S. Gugelmin, A.P. Kuczynski, M. Olandoski, L. de Noronha

06-03-2014

https://doi.org/10.4081/ejh.2014.2228

3120

PDF: 1310

HTML: 366
Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling

Kaizheng Liu, Jinyu Pan, Quan Liu, Yang Huang, Liqun Shang, Yi Zhang, Jinming Wen, Huayang Li, Zhongkai Wu

15-06-2026

https://doi.org/10.4081/ejh.2026.4569

197

PDF: 173

HTML: 7
High WTAP expression level as a promising biomarker for poor prognosis in colorectal cancer: a pilot study

Michela Relucenti, Claudia Tito, Paolo Mercantini, Emanuela Pilozzi, Claudio Barbaranelli, Loredana Cristiano, Daniela Savarese, Daniela Bastianelli, Francesco Fazi, Vincenzo Petrozza, Xiaobo Li, Rui Chen, Selenia Miglietta, Giuseppe Familiari

16-12-2024

https://doi.org/10.4081/ejh.2024.4145

1497

PDF: 622

HTML: 12
Ultrastructural histochemistry in biomedical research: Alive and kicking

Manuela Malatesta

07-11-2018

https://doi.org/10.4081/ejh.2018.2990

2041

PDF: 758

HTML: 34
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis

F. Aredia, M. Malatesta, P. Veneroni, M.G. Bottone

01-12-2015

https://doi.org/10.4081/ejh.2015.2571

2486

PDF: 829

HTML: 771
Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan

13-05-2024

https://doi.org/10.4081/ejh.2024.3917

2148

PDF: 909

HTML: 54
Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

14-04-2016

https://doi.org/10.4081/ejh.2016.2640

3321

PDF: 1451

HTML: 603
46 | DEFINING FAM46C-DEPENDENT LIPID REMODELLING IN CELLULAR HOMEOSTASIS Isidora Alempijevic¹, Federica De Grossi¹, Annarita Miluzio¹, Ivan Ferrari¹, Elisa Arsuffi¹, Marilena Mancino¹, Stefano Biffo^1|2, Nicola Manfrini^1|2 | ¹INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy; ²Department of Biosciences, University of Milan, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4664

128

PDF: 50
Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu

17-11-2025

https://doi.org/10.4081/ejh.2025.4426

1095

PDF: 545

HTML: 22
Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci

Michela Battistelli, Marta Favero, Debora Burini, Giovanni Trisolino, Dante Dallari, Lucia De Franceschi, Steven R. Goldring, Mary B. Goldring, Elisa Belluzzi, Giuseppe Filardo, Brunella Grigolo, Elisabetta Falcieri, Eleonora Olivotto

11-02-2019

https://doi.org/10.4081/ejh.2019.2998

2813

PDF: 1394

Supplementary: 264

HTML: 58
β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet

Zhe Gao, Guang-Yao Song, Lu-Ping Ren, Hui-Juan Ma, Bo-Qing Ma, Shu-Chun Chen

15-09-2020

https://doi.org/10.4081/ejh.2020.3160

1797

PDF: 907

HTML: 22
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway

Hongmei Yin, Xiumei Han, Qun Zhang, Duojie Li, Fan Wang

26-01-2026

https://doi.org/10.4081/ejh.2026.4422

741

PDF: 436

Supplementary: 66

Original gels: 69

HTML: 26
Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

07-04-2025

https://doi.org/10.4081/ejh.2025.4182

1277

PDF: 766

HTML: 51
Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish

Leen Uyttebroek, Casper Pype, Guy Hubens, Jean-Pierre Timmermans, Luc van Nassauw

28-08-2020

https://doi.org/10.4081/ejh.2020.3161

2239

PDF: 1280

HTML: 31
ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4291

275
Potential effect of fish oil to preserve expression of cell cycle and tight junction regulating genes in colon after di-isononyl phthalate ingestion in albino Wistar rats

Ahmed S. Ahmed, Hoda A. Ibrahim, Ehab M. Hantash

31-05-2021

https://doi.org/10.4081/ejh.2021.3232

1435

PDF: 544

HTML: 22
27 | CELLULAR AND MOLECULAR MECHANISMS OF GADOLINIUM TOXICITY IN SERTOLI CELLS Sara Falvo¹, Giulia Grillo¹, Gabriella Chieffi Baccari¹, Giuseppe Petito¹, Massimo Venditti², Maria Maddalena Di Fiore¹, Tiziana Cappello³, Maria Maisano³, Alessandra Santillo¹ | ¹Dept of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania L. Vanvitelli, Caserta, Italy; ²Dept of Experimental Medicine, University of Campania L. Vanvitelli, Napoli, Italy; ³Dept of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4645

87

PDF: 44
Immunolocalization of aromatase P450 in the epididymis of Podarcis sicula and Rattus rattus

Luigi Rosati, Marina Prisco, Mariana Di Lorenzo, Maria De Falco, Piero Andreuccetti

27-01-2020

https://doi.org/10.4081/ejh.2020.3080

1911

PDF: 835

HTML: 17
Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases

G. Natale, E. Pompili, F. Biagioni, S. Paparelli, P. Lenzi, F. Fornai

e5

07-03-2013

https://doi.org/10.4081/ejh.2013.e5

3404

PDF: 842

HTML: 210
Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan

17-06-2025

https://doi.org/10.4081/ejh.2025.4168

707

PDF: 422

HTML: 21
Histochemical and biometric study of the gastrointestinal system of Hyla orientalis (Bedriaga, 1890) (Anura, Hylidae)

E. Akat, H. ArÄ±kan, B. GÃ¶Ã§men

28-11-2014

https://doi.org/10.4081/ejh.2014.2452

3481

PDF: 974

HTML: 442
ECRG4 expression in normal rat tissues: expression study and literature review

A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro

18-05-2015

https://doi.org/10.4081/ejh.2015.2458

3122

PDF: 1220

Supplementary: 416

HTML: 1022

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