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18 | EARLY-DIFFERENTIATED C2C12 MYOTUBES RELEASE A PRO-TROPHIC SECRETOME THAT MODULATES NSC-34 MATURATION: IMPLICATIONS FOR NEUROMUSCULAR CROSSTALK IN AMYOTROPHIC LATERAL SCLEROSIS E. Carata, M. Muci, E. Panzarini | Dept. of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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Effects of cadmium on the glial architecture in lizard brain
3114PDF: 819HTML: 370 -
31 | LOSS OF IMPG2 PARALOGS LEADS TO RETINAL DEGENERATION IN ZEBRAFISH DOUBLE KNOCK-OUT MODEL C. Fogliano1, A. Cumplido Mayoral2, L. Balasco2, S. Casarosa2|3, B. Avallone1 | 1Dept. of Biology, University of Naples Federico II, Italy 2Dept. of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy; 3Center for Medical Sciences, University of Trento, Italy
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ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy
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P76 | PERICAPILLARY SPACES IN THE SHEEP PINEAL GLAND – 2D AND 3D ANALYSIS N. Szyrynska, B. Lewczuk | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
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3-hydroxi-anthranilic acid is early expressed in stroke
2358PDF: 720HTML: 311 -
INVESTIGATION OF STRUCTURAL PRESERVATION OF PERIPHERAL NERVE EXTRACELLULAR MATRIX FOLLOWING EX VIVO LIMB PERFUSION Metafune M1,2, Haastert-Talini K3, Muratori L1,2 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy; 2Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Lower-Saxony, Germany
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P31 | MORPHOLOGICAL AND ULTRASTRUCTURAL MARKERS OF RADIATION-INDUCED ADIPOSE TISSUE DAMAGE E. Guerra1, S. Lattanzio1, G. Furini2, G. Scabia2, E. Mota-Silva2, M. Maffei2, S. Cinti3, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2CNR Institute of Clinical Physiology, Pisa, Italy; 3Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche (Polytechnic University of Marche), Ancona, Italy
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THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft1, L. Tratnjek1, A. Janev1, N. Resnik1, U. Cerkvenik1, U. D. Jerman1, G. Markovič1, T.Ž. Ramuta1, T. Višnjar1, Ž. Sardoč1, A.Punčuh1, S. Kralj2, M. Čemažar3, P. Veranič1 |1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 2Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; 3Institute of Oncology Ljubljana, Ljubljana, Slovenia
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P40 | VOLUME ELECTRON MICROSCOPY REVEALS SPECIFIC FEATURES OF MITOTIC CELLS IN THE PINEAL ORGAN OF THE DOMESTIC TURKEY B. Lewczuk, N. Szyryńska, M. Prusik | Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Poland
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TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy
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Forever particles: histochemistry in the plasticene age
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P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri1, M.V. Marvi1, V. Righi2, V. Papa3, E. Boschetti1, S. Blando1, E. Franceschi4, M. Zoli4, D. Mazzatenta4, N. Neri4, A. Vignaroli4, L. Cocco1, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Sciences, University of Bologna, Bologna, Italy; 3IRCCS St. Orsola, Bologna, Italy; 4IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
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An improved method for preparation of mouse retinal cryosections
2344PDF: 1413Supplementary: 191HTML: 597 -
P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy
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MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F1, Russo L2, Jorkesh A2, Khodaparast S1, Gambarotta G1, Ronchi G1 and Cescon M2 | 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy
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ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano1, F. E. Bellomi1, F. Arciprete1, V. Velardi1, L. La Barbera2, M. Falchi3, M. Bacioglu4, R. Mancinelli5, M. D’Amelio2, M. Spillantini4, M. Zingariello1, G. Vivacqua1,6 | 1Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; 2Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; 3National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; 4Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; 5Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; 6Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
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MICROBIAL INFLUENCE ON PERIPHERAL NERVOUS SYSTEM: INSIGHTS FROM GERM-FREE AND RECOLONIZED MICE Farzin S1, Pellegrino D1, Cicconetti C2, Bertone F1, Oliviero S2, Basic M3, Bolsega S3, Haastert-Talini K4, Cescon M5, Gambarotta G1 and Ronchi G1 | 1Department of Clinical and Biological Sciences (DSCB), University of Torino, Orbassano, (Torino), Italy; 2Department of Life Sciences and System Biology, University of Torino, Torino, Italy; 3Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Lower- Saxony, Germany; 4Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Lower-Saxony, Germany; 5Department of Molecular Medicine, University of Padova, Padova, Italy
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49 | TWEEN 60-COATED COPPER NANOPARTICLES FOR BIOMEDICAL APPLICATION: CHARACTERIZATION AND IN VITRO EVALUATION S. Mariano1|2, S.C. Resta3, G.C. Carbone1|2, A. Talà3, D. Manno1|2, A. Serra1|2, G. Quarta1|2, E. Panzarini3, L. Calcagnile1|2 | 1Department of Mathematics and Physics, University of Salento, Lecce, Italy; 2CEDAD (Center of Applied Physics, Datation and Diagnostics), Department of Mathematics and Physics, University of Salento, Lecce, Italy; 3Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy
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PATHOMICS – A NOVEL OMICS APPROACH FOR HISTOPATHOLOGY P. Boor1,2 | 1Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; 2Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
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P72 | A SWAB NEGATIVE PATIENT AFTER SARS-COV-2 INFECTION DISPLAYS INCREASE OF VEGF AND FIBRONECTIN ASSOCIATED WITH ALTERATIONS OF INTERCELLULAR JUNCTIONS C. Simioni1, J.M. Sanz2, R. Gafà3, G. Cenacchi4, S. Occhionorelli3, R. Rizzo5, D. Bortolotti5, A. Passaro3, L.M. Neri3 | 1Department of Life Sciences and Biotechnology, University of Ferrara, Italy; 2Department of Chemical, Pharmaceutical and Agricultural, Sciences, University of Ferrara, Italy; 3Department of Translational Medicine, University of Ferrara, Italy; 4Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Italy; 5Department of Environmental and Prevention Sciences, University of Ferrara, Italy
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EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy
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