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PATHOMICS – A NOVEL OMICS APPROACH FOR HISTOPATHOLOGY P. Boor1,2 | 1Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany; Electron Microscopy Facility, RWTH Aachen University Hospital, Aachen, Germany; 2Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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Interindividual variability in the expression of surfactant protein A and B in the human lung during development
2106PDF: 813Supplementary: 273HTML: 389 -
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species
2324PDF: 1276Supplementary: 120HTML: 205 -
GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location
3583PDF: 623Supplementary: 244HTML: 34 -
Expression of the endocannabinoid receptors in human fascial tissue
3562PDF: 1861HTML: 2367 -
LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling
1291PDF: 778Supplementary: 110HTML: 30 -
STRESS GRANULES AND α-SYNUCLEIN: INTERPLAY BETWEEN CELLULAR STRESS AND PROTEIN AGGREGATION IN PARKINSON’S DISEASE Zanchi G1, Novello C1, Calogero AM2, Mazzetti S2, Bonaldo B1, Gomez MCL1, Rolando C1, Calandrella D2,3, Pezzoli G2 and Cappelletti G1 | 1Department of Biosciences, University of Milan, Milan, Italy 2Fondazione Pezzoli per la Malattia di Parkinson, Milan, Italy 3Parkinson Institute, ASST G. Pini-CTO, Milan, Milan, Italy
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Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea
1202PDF: 774Supplementary: 105HTML: 25 -
Transgenic mouse - Methods and protocols, 2nd edition
1398PDF: 507HTML: 243 -
Developmental expression of calretinin in the mouse cochlea
1808PDF: 654HTML: 21 -
Diagnosis of sudden cardiac death due to early myocardial ischemia: An ultrastructural and immunohistochemical study
2843PDF: 1347Supplementary: 264HTML: 83 -
P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti1,2, F. Beretti2, M. Malenchini2, M. Y. Follo1, F. Mancarella3, F. Bonafè3, F. Gherardini4, T. Maraldi2 | 1Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; 4Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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Lipofuscin, lipofuscin-like pigments and autofluorescence
4378PDF: 1904HTML: 526 -
14 | NR2F1 MODULATES ACTIVATION DYNAMICS AND MAINTENANCE OF THE ADULT MURINE HIPPOCAMPAL NEURAL STEM CELL POOL S. Bonzano1|2, A. Lippolis1|2, S. Quaresima3, V. Manzini3, E. Dallorto1|2, E. Cacci3, P. Peretto1|2, M. Studer4, V. Licursi5, G. Lupo3, S. De Marchis1|2 | 1Dept. of Life Sciences and Systems Biology (DBIOS), Univ. of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (Turin), Italy; 3Dept. of Biology and Biotechnologies Charles Darwin, Sapienza Univ. of Rome, Italy; 4Univ. Côte d'Azur, CNRS, Inserm, iBV, Nice, France; 5Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy
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IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling
1899PDF: 988Supplementary: 183HTML: 29 -
EX VIVO MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS Cirillo G1, Montella M2, La Mantia E2, Tedesco I2, De Luca C1, Virtuoso A1, De Angelis F1, Riccio L1, Esposito F3, Cirillo M3, Franco R2 and Papa M1 | 1Division of Human Anatomy, Neuronal Networks Morphology & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 3Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania Luigi Vanvitelli, Naples, Italy
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ECRG4 expression in normal rat tissues: expression study and literature review
3116PDF: 1216Supplementary: 413HTML: 1021 -
P56 | HISTOLOGICAL PROFILE OF INACTIVE UNILATERAL CONDYLAR HYPERPLASIA: EVIDENCE OF BORDERLINE TISSUE ACTIVITY F. Nicita1, G. Vermiglio1, J. Freni1, A. Centofanti1, D. Labellarte1, R. Briganti1, G.P. Anastasi1, G. Cutroneo1, A. Favaloro1, M. Runci Anastasi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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37 | INVESTIGATING THE ROLE OF NR2F1 IN NEURAL STEM CELL QUIESCENCE AND ACTIVATION IN THE ADULT SUBVENTRICULAR ZONE Iacono F.1, Licursi V.2, Quaresima S.1, Manzini V.2, Felli A.1, Lippolis A.3|4, Miranda Banos M.E.1, Cacci E.1, Peretto P.3|4, Studer M.5, De Marchis S.3|4, Lupo G.1, Bonzano S.3|4 | 1Department of Biology e Biotechnologies Charles Darwin, Sapienza University of Rome, Italy; 2Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy; 3Department of Life Sciences and Systems Biology (DBIOS), University of Turin, Italy; 4Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano (TO), Italy; 5Univ. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France
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P04 | CYTOCHEMICAL AND BIOLOGICAL EFFECT OF BIORESONANCE IN IRRITABLE BOWEL SYNDROME G. Barassi1, M. Panunzio2, P.E. Gallenga1 | 1Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Responsible Research Hospital, Campobasso, Italy
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