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Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally

Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariotti

04-07-2024

https://doi.org/10.4081/ejh.2024.4040

2194

PDF: 732

HTML: 30
Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

27-07-2023

https://doi.org/10.4081/ejh.2023.3506

1943

PDF: 1180

HTML: 30
Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway

Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou

22-06-2022

https://doi.org/10.4081/ejh.2022.3394

2179

PDF: 1408

HTML: 34
Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study

Giada Remoli, Chiara Rita Inguscio, Federico Boschi, Gabriele Tabaracci, Manuela Malatesta, Barbara Cisterna

26-01-2026

https://doi.org/10.4081/ejh.2026.4440

1370

PDF: 320

HTML: 20
Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl

Hao Li, Junliang Chen, Wenjun You, Yizhen Xu, Yaqiong Ye, Haiquan Zhao, Junxing Li, Hui Zhang

15-10-2024

https://doi.org/10.4081/ejh.2024.4089

1839

PDF: 463

HTML: 21
Expression profile of the zinc transporter ZnT3 in taste cells of rat circumvallate papillae and its role in zinc release, a potential mechanism for taste stimulation

Kentaro Nishida, Saho Bansho, Akiko Ikukawa, Teruyo Kubota, Akihiro Ohishi, Kazuki Nagasawa

10-11-2022

https://doi.org/10.4081/ejh.2022.3534

1425

PDF: 820

Supplementary: 206

HTML: 39
Tumor cells-derived exosomal PD-L1 promotes the growth and invasion of lung cancer cells in vitro via mediating macrophages M2 polarization

Xiangjun Lu, Jian Shen, Siyuan Huang, Dongdong Liu, Haitao Wang

01-08-2023

https://doi.org/10.4081/ejh.2023.3784

2251

PDF: 975

HTML: 27
Fine structural detection of calcium ions by photoconversion

V. Poletto, V. Galimberti, G. Guerra, V. Rosti, F. Moccia, M. Biggiogera

10-08-2016

https://doi.org/10.4081/ejh.2016.2695

1886

PDF: 803

Supplementary: 321

HTML: 144
Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging

Dmitrii E. Korzhevskii, Olga V. Kirik, Valeriia V. Guselnikova, Darya L. Tsyba, Elena A. Fedorova, Igor P. Grigorev

01-09-2021

https://doi.org/10.4081/ejh.2021.3283

2093

PDF: 747

HTML: 25
Molecules implicated in glucose homeostasis are differentially expressed in the trachea of lean and obese Zucker rats

F. Merigo, F. Boschi, C. Lasconi, D. Benati, A. Sbarbati

01-02-2016

https://doi.org/10.4081/ejh.2016.2557

2856

PDF: 828

HTML: 728
MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney

D. Fanni, N. Iacovidou, A. Locci, C. Gerosa, S. Nemolato, P. Van Eyken, G. Monga, S. Mellou, G. Faa, V. Fanos

e40

26-10-2012

https://doi.org/10.4081/ejh.2012.e40

1669

PDF: 688

HTML: 358
Bovine pericardium membrane, gingival stem cells, and ascorbic acid: a novel team in regenerative medicine

Jacopo Pizzicannella, Guya D. Marconi, Sante D. Pierdomenico, Marcos F.X.B. Cavalcanti, Francesca Diomede, Oriana Trubiani

25-09-2019

https://doi.org/10.4081/ejh.2019.3064

1804

PDF: 890

HTML: 28
Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma

Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta

10-10-2023

https://doi.org/10.4081/ejh.2023.3879

4852

PDF: 848

HTML: 33
Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

Kui Long, Xiang Kui, Qingbin Zeng, Wenzhi Dong

17-04-2025

https://doi.org/10.4081/ejh.2025.4176

1583

PDF: 700

Supplementary: 143

HTML: 50
Essential Current Concepts in Stem Cell Biology

Manuela Monti

18-11-2020

https://doi.org/10.4081/ejh.2020.3201

2879

PDF: 532

HTML: 12
P10 | BIOLOGICAL ACTIVITIES OF CITRUS LIMON-, VITIS VINIFERA- AND ACTINIDIA DELICIOSA-DERIVED EXTRACELLULAR VESICLES ON HUMAN CACO-2 CELLS M. Destino, E. Carata, B.A. Tenuzzo, E. Panzarini | Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4706

111

PDF: 42
What happens to an acellular dermal matrix after implantation in the human body? A histological and electron microscopic study

Martin Boháč, Ľuboš Danišovič, Ján Koller, Jana Dragúňová, Ivan Varga

22-01-2018

https://doi.org/10.4081/ejh.2018.2873

3568

PDF: 1520

HTML: 120
Altered alkaline phosphatase activity in obese Zucker rats liver respect to lean Zucker and Wistar rats discussed in terms of all putative roles ascribed to the enzyme

V. Bertone, E. Tarantola, A. Ferrigno, E. Gringeri, S. Barni, M. Vairetti, I. Freitas

e5

08-02-2011

https://doi.org/10.4081/ejh.2011.e5

1550

PDF: 842

HTML: 3580
Immunohistochemistry as a paramount tool in research of normal urothelium, bladder cancer and bladder pain syndrome

Daša Zupančič, Rok Romih

24-03-2021

https://doi.org/10.4081/ejh.2021.3242

2350

PDF: 1361

HTML: 22
Visualizing endocytotic pathways at transmission electron microscopy via diaminobenzidine photo-oxidation by a fluorescent cell-membrane dye

S. Grecchi, M. Malatesta

22-10-2014

https://doi.org/10.4081/ejh.2014.2449

2594

PDF: 1080

Supplementary: 334

HTML: 721
Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu

17-11-2025

https://doi.org/10.4081/ejh.2025.4426

1159

PDF: 566

HTML: 22
The role of mutated SOD1 gene in synaptic stripping and MHC class I expression following nerve axotomy in ALS murine model

Roman M. Kassa, Roberta Bonafede, Federico Boschi, Manuela Malatesta, Raffaella Mariotti

17-05-2018

https://doi.org/10.4081/ejh.2018.2904

2223

PDF: 781

HTML: 34
Simultaneous ultrastructural analysis of fluorochrome-photoconverted diaminobenzidine and gold immunolabeling in cultured cells

M. Malatesta, C. Zancanaro, M. Costanzo, B. Cisterna, C. Pellicciari

e26

16-09-2013

https://doi.org/10.4081/ejh.2013.e26

2504

PDF: 721

HTML: 308
Histochemistry for nanomedicine: Novelty in tradition

Manuela Malatesta

27-12-2021

https://doi.org/10.4081/ejh.2021.3376

1241

PDF: 560

HTML: 24
Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis

Jindong Li, Jie Kang, Weiyan Liu, Jiazhe Liu, Gaofeng Pan, Anwei Mao, Qing Zhang, Jingfeng Lu, Junbin Ding, Hongchang Li

25-10-2022

https://doi.org/10.4081/ejh.2022.3529

1882

PDF: 922

HTML: 47
FLOW CYTOMETRY IN THE DEVELOPMENT AND CHARACTERIZATION OF PRECLINICAL TUMOR MODELS BASED ON THE ANALYSIS OF EXTRACELLULAR VESICLES AS CANDIDATE LIQUID BIOMARKERS I. D’Agnano | Institute of Biomedical Technologies, CNR, Segrate, Milan, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4303

216
Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis

A.C. Croce, G. Bottiroli

12-12-2014

https://doi.org/10.4081/ejh.2014.2461

15252

PDF: 6284

HTML: 8019
Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading

D. Curzi, D. Lattanzi, S. Ciuffoli, S. Burattini, R.E. Grindeland, V.R. Edgerton, R.R. Roy, J.G. Tidball, E. Falcieri

e37

13-11-2013

https://doi.org/10.4081/ejh.2013.e37

3385

PDF: 872

HTML: 634
Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina

Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel

27-04-2022

https://doi.org/10.4081/ejh.2022.3373

2036

PDF: 936

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P78 | THE ROLE OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS IN MYOFIBER REGENERATION A. Longhin¹, V. Gatta², G. Teti², C. Sassoli³, F. Chellini³, A. Tani³, M. Parigi³, R. Garella³, F. Palmieri³, R. Squecco³, M. Mattioli Belmonte⁴, C. Licini⁴, A. La Contana⁴, S. Zecchi Orlandini³, M. Falconi¹ | ¹Dep. Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ²Dep. Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; ⁴Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4404

309
LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES P. Simeone^1,2, D. Brocco³, F. D’Ascanio^1,2,4, D. De Bellis^1,2, G. Colasante^1,2, A. Aquilini-Mummolo^1,2, T. Esmail^1,2, A. Younas², M. Filoso², C. Cichella², M. C. Cufaro⁵, A. Di Sebastiano⁵, D. Pieragostino⁶, S. Burattini⁷, M. Battistelli⁷, P. Del Boccio⁵, A. Fontana⁸, R. Di Pietro¹, P. Lanuti^1,2 | ¹Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; ²Flow Cytometry Core Facility, Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” of Chieti-Pescara, Italy; ³Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; ⁴Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy: ⁵Department of Science, University “G. d’Annunzio”, Chieti Pescara, Italy; ⁶Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, Italy; ⁷Department of Biomolecular Sciences, University of Urbino, Urbino, Italy; ⁸Department of Pharmacy, University “G. d’Annunzio”, Chieti Pescara, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4302

246
SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS D’Aprile C¹, Naghshbandieh A^1,3, Fabbro V¹, Turano E², Scambi I², Virla F², Caprioli M², Mariotti R², Scuteri A¹ and Meregalli C¹ | ¹Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Italy; ²Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; ³PhD Program in Neuroscience, University of Milano- Bicocca, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4466

376
Carotenoids co-localize with hydroxyapatite, cholesterol, and other lipids in calcified stenotic aortic valves. Ex vivo Raman maps compared to histological patterns

A. Bonetti, A. Bonifacio, A. Della Mora, U. Livi, M. Marchini, F. Ortolani

20-04-2015

https://doi.org/10.4081/ejh.2015.2505

2253

PDF: 1267

HTML: 391
Autofluorescence in freshly isolated adult human liver sinusoidal cells

Anett Kristin Larsen, Jaione Simón-Santamaría, Kjetil Elvevold, Bo Göran Ericzon, Kim Erlend Mortensen, Peter McCourt, Bård Smedsrød, Karen Kristine Sørensen

13-12-2021

https://doi.org/10.4081/ejh.2021.3337

2523

PDF: 1021

HTML: 69
Diaminobenzidine photoconversion is a suitable tool for tracking the intracellular location of fluorescently labelled nanoparticles at transmission electron microscopy

M. Malatesta, M. Giagnacovo, M. Costanzo, B. Conti, I. Genta, R. Dorati, V. Galimberti, M. Biggiogera, C. Zancanaro

e20

16-04-2012

https://doi.org/10.4081/ejh.2012.20

1953

PDF: 1053

HTML: 4424
57 | PUNICA GRANATUM-DERIVED EXTRACELLULAR VESICLES EFFECTS ON AN IN VITRO GASTROINTESTINAL BARRIER MODEL OF INTESTINAL INFLAMMATION Mariano Stefania¹, Carata Elisabetta², Moris Destino², Bernardetta Anna Tenuzzo², Panzarini Elisa² | ¹Department of Mathematics and Physics “E. De Giorgi”, University of Salento, Lecce, Italy; ²Department of Biological Sciences and Technologies, University of Salento, Lecce, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4675

94

PDF: 96
Characterization of the role of RILP in cell migration

Azzurra Margiotta, Cinzia Progida, Oddmund Bakke, Cecilia Bucci

31-05-2017

https://doi.org/10.4081/ejh.2017.2783

2680

PDF: 1050

Supplementary: 268

Movie 1: 377

Movie 2: 425

HTML: 116
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo

21-06-2022

https://doi.org/10.4081/ejh.2022.3426

1572

PDF: 1003

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ECRG4 expression in normal rat tissues: expression study and literature review

A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro

18-05-2015

https://doi.org/10.4081/ejh.2015.2458

3152

PDF: 1244

Supplementary: 421

HTML: 1028
Ultrastructural analysis of different human mesenchymal stem cells after in vitro expansion: a technical review

M. Miko, L. Danisovic, A. Majidi, I. Varga

26-10-2015

https://doi.org/10.4081/ejh.2015.2528

2741

PDF: 916

HTML: 844
16 | EXTRACELLULAR VESICLES RELEASED BY CUMULUS CELLS CONTRIBUTE TO THE ACQUISITION OF MOUSE OOCYTE’S DEVELOPMENTAL COMPETENCE Giulia Brazzale¹, Mario Zanoni¹, Valeria Merico¹, Giulia Fiorentino¹, Paola Rebuzzini¹, Andrea Fantinato¹, Margherita Isernia¹, Sergio Comincini¹, Danilo Cimadomo^1|2, Maurizio Zuccotti¹ | ¹Dept. of Biology and Biotechnology, University of Pavia, Italy; ²IVIRMA Global Research Alliance, IVIRMA Italia, Rome, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4634

195

PDF: 56
NEUROPROTECTIVE POTENTIAL OF ADIPOSE MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES ON DAMAGED MOTONEURONS Caprioli M¹, Sganzerla D¹, Scambi I¹, Virla F¹, Grazioli N², Greco N², Turano E¹ and Mariotti R¹ | ¹Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; ²Department of Engineering for Innovation Medicine, University of Verona, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4473

311
The trochanteric fat pad

P. Panettiere, D. Accorsi, L. Marchetti, A.M. Minicozzi, G. Orsini, P. Bernardi, D. Benati, G. Conti, A. Sbarbati

e16

24-05-2011

https://doi.org/10.4081/ejh.2011.e16

2742

PDF: 769

HTML: 7522
Expression, localization and synthesis of small leucine-rich proteoglycans in developing mouse molar tooth germ

Angammana Randilini, Kaoru Fujikawa, Shunichi Shibata

10-02-2020

https://doi.org/10.4081/ejh.2020.3092

1770

PDF: 1195

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Subcellular localization and distribution of the reduced folate carrier in normal rat tissues

M. Hinken, S. Halwachs, C. Kneuer, W. Honscha

e3

27-01-2011

https://doi.org/10.4081/ejh.2011.e3

1993

PDF: 768

HTML: 5833
Histochemistry as an irreplaceable approach for investigating functional cytology and histology

C. Pellicciari

e41

19-12-2013

https://doi.org/10.4081/ejh.2013.e41

3465

PDF: 968

HTML: 414
P71 | THE EXTRACELLULAR VESICLE POPULATIONS UNDERWENT ALTERATIONS SUBSEQUENT TO THE PRETREATMENT OF ADIPOSE-DERIVED STEM CELLS WITH MELATONIN RECEPTOR AGONIST B. Sikora, K. Pogoda-Mieszczak, E. Bogunia, A. Skubis-Sikora, P. Czekaj | Department of Cytophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4396

348
Guilu Erxian oral liquid mitigates oxidative damage in spermatogonial cells via miR-6739-5p modulation and PI3K/AKT pathway activation: a functional histocytochemical study

Zefeng Sun, Xinrong Fan, Zhenquan Liu

02-10-2025

https://doi.org/10.4081/ejh.2025.4253

475

PDF: 472

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Histochemistry in biology and medicine: a message from the citing journals

Carlo Pellicciari

23-12-2015

https://doi.org/10.4081/ejh.2015.2610

3304

PDF: 932

HTML: 903
Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling

Kaizheng Liu, Jinyu Pan, Quan Liu, Yang Huang, Liqun Shang, Yi Zhang, Jinming Wen, Huayang Li, Zhongkai Wu

15-06-2026

https://doi.org/10.4081/ejh.2026.4569

256

PDF: 199

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Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons

Andrea Conz, Clara Alice Musi, Luca Russo, Tiziana Borsello, Luca Colnaghi

11-08-2021

https://doi.org/10.4081/ejh.2021.3241

1782

PDF: 799

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LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury

Guoyue Liu, Cunzhi Yin, Mingjiang Qian, Xuan Xiao, Hang Wu, Fujian Fu

31-05-2023

https://doi.org/10.4081/ejh.2023.3535

1349

PDF: 774

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Is there still room for novelty, in histochemical papers?

Carlo Pellicciari

16-12-2016

https://doi.org/10.4081/ejh.2016.2758

3038

PDF: 756

HTML: 284
P21 | EARLY BIOLOGICAL EFFECTS ON CELL PROLIFERATION AND DIFFERENTIATION INDUCED BY EXTRACELLULAR MICROVESICLES (EVS) DERIVED FROM HUMAN KERATINOCYTES IN PSORIATIC MICROENVIRONMENT D. Daluiso¹, B. Barco¹, C. Porro², E. Donetti³, F. Riva¹ | ¹Department of Publich Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, Pavia, Italy; ²Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; ³Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4341

215
Excitatory Amino Acid Transporter 5 is widely expressed in peripheral tissues

A. Lee, A.R. Anderson, M. Stevens, S. Beasley, N.L. Barnett, D.V. Pow

e11

12-03-2013

https://doi.org/10.4081/ejh.2013.e11

3050

PDF: 811

Supplementary: 257

HTML: 440
Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai

14-10-2022

https://doi.org/10.4081/ejh.2022.3510

1444

PDF: 741

HTML: 44
Ferritin expression in the periodontal tissues of primates

Wenxue Huang, Wei Li, Juan Liu, Jianxia Hou, Huanxin Meng

03-09-2019

https://doi.org/10.4081/ejh.2019.3046

1390

PDF: 775

HTML: 24
P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante¹, L. Leanza², E. Guerra³, F. Vianello⁴, C. Iacovino¹, S. Lattanzio¹, L. Morello¹, G. Stati¹, P. Simeone³, P. Lanuti³, S. Alberti⁵, M. Reichert⁶, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Biology, University of Padua, Padua, Italy; ³Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; ⁴Department of Biology, University of Padua, Padua, Italy; ⁵Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; ⁶Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany

21-08-2025

https://doi.org/10.4081/ejh.2025.4348

236
Organotypic spinal cord cultures: An in vitro 3D model to preliminary screen treatments for spinal muscular atrophy

Marina Boido, Elena De Amicis, Katia Mareschi, Franca Fagioli, Alessandro Vercelli

04-11-2021

https://doi.org/10.4081/ejh.2021.3294

2339

PDF: 1024

HTML: 29
Clathrin-dependent endocytosis of membrane-bound RANKL in differentiated osteoclasts

P. Narducci, R. Bortul, R. Bareggi, V. Nicolin

e6

08-03-2010

https://doi.org/10.4081/ejh.2010.e6

1821

PDF: 598

HTML: 6113
Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells

Weidong Wang, Sheng Chen, Yuan Wang, Cui Jie, Weimin Shen

01-09-2025

https://doi.org/10.4081/ejh.2025.4241

622

PDF: 566

HTML: 18
Depot-dependent peroxisome response in the rat white adipose tissue under hypothyroidism

Ahsein Addloli, Marija Ilic, Tamara Zakic, Bato Korac, Aleksandra Cvoro, Aleksandra Jankovic, Aleksandra Korac

23-07-2026

https://doi.org/10.4081/ejh.2026.4574

235

PDF: 110

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P13 | MORPHO-FUNCTIONAL DIFFERENCES IN THE GUT OF AGED MICE WITH THE POSSIBLE EFFECTS OF ANTI-INFLAMMATORY TREATMENTS A. Casini¹, S. Leone¹, R. Mancinelli¹, R. Vaccaro¹, M. Catalano², G. D’Alessandro², A. Rinaldi², A. Reccagni², G. Vivacqua³, A. Franchitto⁴, P. Onori¹, C. Limatola², E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Department of Physiology and Pharmacology, Sapienza University of Rome, Italy; ³Department of Medicine and Surgery, University Campus BioMedico of Rome, Italy; ⁴Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome «Foro Italico», Rome,Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4333

197
SHORT-TERM EXPOSURE TO PARTICULATE MATTER TRIGGERS SELECTIVE MOLECULAR AND BEHAVIORAL ALTERATIONS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS Bonato M^1,2, Montarolo F^1,2, Cerrato V^1,2, Parolisi R^1,2, Abbadessa G³, Caudana M³, Di Cintio N^1,2, De Francia S³, Bertolotto A^2,4, Buffo A^1,2, and Boda E^1,2 | ¹Dept. of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy; ²Neuroscience Institute Cavalieri Ottolenghi, Orbassano (Turin), Italy; ³Department of Clinical and Biological Sciences, University of Turin, Orbassano (Turin), Italy; ⁴Koelliker Hospital, Turin, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4482

343
FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4301

239
DPY30 promotes the growth and survival of osteosarcoma cell by regulating the PI3K/AKT signal pathway

Gong Cheng, Fengmin An, Zhilin Cao, Mingdi Zheng, Zhongyuan Zhao, Hao Wu

22-12-2022

https://doi.org/10.4081/ejh.2023.3413

1415

PDF: 721

Supplementary: 120

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Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang

29-04-2024

https://doi.org/10.4081/ejh.2024.4019

2090

PDF: 807

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Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

07-04-2025

https://doi.org/10.4081/ejh.2025.4182

1319

PDF: 798

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Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

14-04-2016

https://doi.org/10.4081/ejh.2016.2640

3361

PDF: 1465

HTML: 604
Effects of lead pollution on Ammonia parkinsoniana (foraminifera): ultrastructural and microanalytical approaches

F. Frontalini, D. Curzi, F.M. Giordano, J.M. Bernhard, E. Falcieri, R. Coccioni

30-01-2015

https://doi.org/10.4081/ejh.2015.2460

2722

PDF: 946

HTML: 1130
Optimization of the autophagy measurement in a human cell line and primary cells by flow cytometry

Tonino Alonzi, Elisa Petruccioli, Valentina Vanini, Gian Maria Fimia, Delia Goletti

26-06-2019

https://doi.org/10.4081/ejh.2019.3044

2227

PDF: 1289

Supplementary: 209

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EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES D. Jerka¹, P. Antosik², K. Bonowicz^1,3, D. Grzanka⁴, M. Gagat^1,3 | ¹Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland; ²Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; ³Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland; ⁴Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4304

271
18 | EARLY-DIFFERENTIATED C2C12 MYOTUBES RELEASE A PRO-TROPHIC SECRETOME THAT MODULATES NSC-34 MATURATION: IMPLICATIONS FOR NEUROMUSCULAR CROSSTALK IN AMYOTROPHIC LATERAL SCLEROSIS E. Carata, M. Muci, E. Panzarini | Dept. of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4636

109

PDF: 64
IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini^1,2 | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4266

416
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

17-09-2024

https://doi.org/10.4081/ejh.2024.4034

1368

PDF: 758

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Immunolocalization of succinate dehydrogenase in the esophagus epithelium of domesticated mammals

W. Meyer, J. Kacza, I. N. Hornickel, B. Schoennagel

e18

10-05-2013

https://doi.org/10.4081/ejh.2013.e18

2700

PDF: 1226

HTML: 573
TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti¹, M. C. Gagliani², G. Bellese², M. Crippa³, A. Abbona⁴, M. Paccagnella⁴, P. Arnaldi⁵, M. C. Merlano⁶, O. Garrone⁷, A.M. Porcelli⁸, M. Matteoli¹, P. Falletta⁹, P. Castagnola¹⁰, K. Cortese² | ¹IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; ²DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; ³Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; ⁴Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; ⁵IRCCS Ospedale Policlinico San Martino, Genova, Italy; ⁶Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; ⁷Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; ⁸FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; ⁹Vita-Salute San Raffaele University, Milan, Italy; ¹⁰IRCCS Ospedale Policlinico San Martino, Genova, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4305

390
P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri¹, M.V. Marvi¹, V. Righi², V. Papa³, E. Boschetti¹, S. Blando¹, E. Franceschi⁴, M. Zoli⁴, D. Mazzatenta⁴, N. Neri⁴, A. Vignaroli⁴, L. Cocco¹, L. Manzoli¹, S. Ratti¹ | ¹Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ²Department of Life Quality Sciences, University of Bologna, Bologna, Italy; ³IRCCS St. Orsola, Bologna, Italy; ⁴IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4389

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