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Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway

Yuhan Wang, Gang Wang, Xiaojun Liu, Dong Yun, Qing Cui, Xiaoting Wu, Wenfeng Lu, Xiwen Yang, Ming Zhang

03-08-2022

https://doi.org/10.4081/ejh.2022.3336

1435

PDF: 721

HTML: 41
Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model

Juan Fan, Yu Ma, Liying Sun, Suhua Miao, Jianghong He

20-04-2026

https://doi.org/10.4081/ejh.2026.4533

194

PDF: 154

HTML: 9
Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

Jun Pan, Yi Zhao, Yu Zhang, Yuhe Zhou, Fengxuan Zhang, Yitian Chen, Xiaoyuan Chu

24-04-2025

https://doi.org/10.4081/ejh.2025.4203

697

PDF: 281

HTML: 49
Effects of the lncRNA ENST00000623984 on colon cancer and the biological characteristics of colon cancer cells

Zhi-bao Liu, Jing-hua Zhang, Jing-hua Gao, Jian Shi

12-07-2021

https://doi.org/10.4081/ejh.2021.3215

2134

PDF: 552

HTML: 27
Continuous cyclic mechanical tension increases ank expression in endplate chondrocytes through the TGF-Î²1 and p38 pathway

H. Xu, X. Zhang, H. Wang, Y. Zhang, Y. Shi, X. Zhang

e28

25-09-2013

https://doi.org/10.4081/ejh.2013.e28

2344

PDF: 655

HTML: 218
Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang

29-04-2024

https://doi.org/10.4081/ejh.2024.4019

1814

PDF: 575

HTML: 21
MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells

J. Zhang, J. Luo, J. Ni, L. Tang, H.P. Zhang, L. Zhang, J.F. Xu, D. Zheng

18-02-2014

https://doi.org/10.4081/ejh.2014.2262

3396

PDF: 1007

HTML: 320
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1051

PDF: 480

HTML: 17
Characterization of the role of RILP in cell migration

Azzurra Margiotta, Cinzia Progida, Oddmund Bakke, Cecilia Bucci

31-05-2017

https://doi.org/10.4081/ejh.2017.2783

2461

PDF: 948

Supplementary: 243

Movie 1: 331

Movie 2: 374

HTML: 102
DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells

Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu

03-05-2017

https://doi.org/10.4081/ejh.2017.2775

2657

PDF: 986

HTML: 175
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway

Peipei Lu, Shuxiang Li, Caoyang Zhang, Xinyi Jiang, Jinghua Xiang, Hong Xu, Jian Dong, Kun Wang, Yuhua Shi

22-05-2024

https://doi.org/10.4081/ejh.2024.4033

1116

PDF: 488

HTML: 15
Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye

30-09-2021

https://doi.org/10.4081/ejh.2021.3224

3420

PDF: 1859

HTML: 38
Regulatory roles of ACSL5 in the anti-tumor function of palmitic acid (C16:0) via the ERK signaling pathway

Jiapei Lv, Wang Yanting, Shan Wei

08-11-2023

https://doi.org/10.4081/ejh.2023.3867

1935

PDF: 942

HTML: 45
Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma

Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li

22-07-2024

https://doi.org/10.4081/ejh.2024.4048

1308

PDF: 381

HTML: 14
Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway

Y. Zhang, J. Wang, X. Cheng, B. Yi, X. Zhang, Q. Li

13-04-2015

https://doi.org/10.4081/ejh.2015.2467

3488

PDF: 1548

HTML: 887
Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan

13-05-2024

https://doi.org/10.4081/ejh.2024.3917

1825

PDF: 674

HTML: 37
NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway

Xuanjin Zhu, Weilu Jia, Yong Yan, Yong Huang, Bailin Wang

02-07-2021

https://doi.org/10.4081/ejh.2021.3246

2727

PDF: 738

HTML: 36
High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma

Yin Pan, Di Qiu, Shu Chen, Xiaoxue Han, Ruiman Li

11-05-2023

https://doi.org/10.4081/ejh.2023.3691

1231

PDF: 857

HTML: 21
The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study

Roberta Sferra, Simona Pompili, Claudio Festuccia, Francesco Marampon, Giovanni L. Gravina, Luca Ventura, Ernesto Di Cesare, Sara Cicchinelli, Eugenio Gaudio, Antonella Vetuschi

16-05-2017

https://doi.org/10.4081/ejh.2017.2732

2661

PDF: 985

HTML: 153
Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages

Jun Lin, Liping Jiang, Kun Guo, Ning Feng

22-12-2022

https://doi.org/10.4081/ejh.2023.3528

1925

PDF: 1179

Supplementary: 122

HTML: 37
Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis

Jinbi Xie, Yong Ning, Lihang Zhang, Yuan Lin, Runsheng Guo, Shanjuan Wang

03-10-2022

https://doi.org/10.4081/ejh.2022.3477

1935

PDF: 626

HTML: 34
The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

Huyi Liu, Xiangdao Cai , Jia Liu, Fengxiang Zhang , Andong He, Ruiman Li

25-11-2021

https://doi.org/10.4081/ejh.2021.3323

1813

PDF: 666

HTML: 31
Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway

Suwei Dong, Yanbin Xiao, Ziqiang Zhu, Xiang Ma, Zhuohui Peng, Jianping Kang, Jianqiang Wang, Yunqing Wang, Zhen Li

17-05-2023

https://doi.org/10.4081/ejh.2023.3612

1304

PDF: 878

Supplementary: 86

HTML: 21
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo

21-06-2022

https://doi.org/10.4081/ejh.2022.3426

1418

PDF: 798

HTML: 25
MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS

Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Gao

31-05-2022

https://doi.org/10.4081/ejh.2022.3342

1101

PDF: 690

HTML: 28
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway

Hongmei Yin, Xiumei Han, Qun Zhang, Duojie Li, Fan Wang

26-01-2026

https://doi.org/10.4081/ejh.2026.4422

573

PDF: 324

Supplementary: 38

Original gels: 35

HTML: 10
Transient receptor potential canonical 3/5 attenuate endothelial damage-induced neointima formation without affecting endothelial cell proliferation

Wenjun Zeng, Bei Liu, Lixia Yang, Ruiwei Guo

19-11-2025

https://doi.org/10.4081/ejh.2025.4311

368

PDF: 185

HTML: 16
Comparison between Lipofectamine RNAiMAX and GenMute transfection agents in two cellular models of human hepatoma

Clarissa Berardo, Veronica Siciliano, Laura G. Di Pasqua, Plinio Richelmi, Mariapia Vairetti, Andrea Ferrigno

06-08-2019

https://doi.org/10.4081/ejh.2019.3048

2986

PDF: 1784

HTML: 33
Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

Guangbao He, Yibo He, Hongwei Ni, Kai Wang, Yijun Zhu, Yang Bao

26-07-2023

https://doi.org/10.4081/ejh.2023.3766

1885

PDF: 1209

HTML: 14
Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study

M. Di Rosa, M.A. Szychlinska, D. Tibullo, L. Malaguarnera, G. Musumeci

16-09-2014

https://doi.org/10.4081/ejh.2014.2423

2919

PDF: 1153

HTML: 1609
Knockdown of VEGFR2 inhibits proliferation and induces apoptosis in hemangioma-derived endothelial cells

J.M. Ou, Z.Y. Yu, M.K. Qiu, Y.X. Dai, Q. Dong, J. Shen, X.F. Wang, Y.B. Liu, Z.W. Quan, Z.W. Fei

17-03-2014

https://doi.org/10.4081/ejh.2014.2263

3436

PDF: 981

HTML: 585
Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

Chixian Zhang, Kai Bai, Dexu Li

14-04-2025

https://doi.org/10.4081/ejh.2025.4186

1226

PDF: 453

HTML: 28
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway

Yong Jiang, Chun-hui Xu, Ying Zhao, Yun-han Ji, Xin-tao Wang, Ying Liu

16-01-2023

https://doi.org/10.4081/ejh.2023.3526

1659

PDF: 775

HTML: 53
Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

14-04-2016

https://doi.org/10.4081/ejh.2016.2640

3124

PDF: 1316

HTML: 597
Tumor cells-derived exosomal PD-L1 promotes the growth and invasion of lung cancer cells in vitro via mediating macrophages M2 polarization

Xiangjun Lu, Jian Shen, Siyuan Huang, Dongdong Liu, Haitao Wang

01-08-2023

https://doi.org/10.4081/ejh.2023.3784

1849

PDF: 838

HTML: 20
ECRG4 expression in normal rat tissues: expression study and literature review

A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro

18-05-2015

https://doi.org/10.4081/ejh.2015.2458

2925

PDF: 1145

Supplementary: 377

HTML: 1013
RNA therapeutics - Function, design and delivery

Carlo Alberto Redi

br7

17-06-2011

https://doi.org/10.4081/ejh.2011.br7

905

PDF: 432

HTML: 169
Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis

Jindong Li, Jie Kang, Weiyan Liu, Jiazhe Liu, Gaofeng Pan, Anwei Mao, Qing Zhang, Jingfeng Lu, Junbin Ding, Hongchang Li

25-10-2022

https://doi.org/10.4081/ejh.2022.3529

1648

PDF: 788

HTML: 36
P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR M. Hałas-Wiśniewska¹, W. Arendt¹, M. Gagat^1,2, M. Izdebska¹ | ¹Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Poland; ²Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4352

172
Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis

Manuel Scimeca, Simone Bischetti, Harpreet Kaur Lamsira, Rita Bonfiglio, Elena Bonanno

15-03-2018

https://doi.org/10.4081/ejh.2018.2841

14307

PDF: 7006

HTML: 432
Subcellular localization and distribution of the reduced folate carrier in normal rat tissues

M. Hinken, S. Halwachs, C. Kneuer, W. Honscha

e3

27-01-2011

https://doi.org/10.4081/ejh.2011.e3

1821

PDF: 693

HTML: 5641
Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai

14-10-2022

https://doi.org/10.4081/ejh.2022.3510

1261

PDF: 664

HTML: 35
SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells via activating TGF-β/Smad2/3 signaling

Yiyu Qin, Jian Li, Hongchao Han, Yongliang Zheng, Haiming Lei, Yang Zhou, Hongyan Wu, Guozhe Zhang, Xiang Chen, Zhengping Chen

28-12-2023

https://doi.org/10.4081/ejh.2023.3899

1052

PDF: 302

HTML: 6
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu

03-03-2026

https://doi.org/10.4081/ejh.2026.4530

409

PDF: 319

HTML: 6
Ion channels alterations in the forebrain of high-fat diet fed rats

Proshanta Roy, Ilenia Martinelli, Michele Moruzzi, Federica Maggi, Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni

23-11-2021

https://doi.org/10.4081/ejh.2021.3305

2118

PDF: 1066

HTML: 35
Knockdown of RAGE inhibits growth and invasion of gastric cancer cells

X.C. Xu, X. Abuduhadeer, W.B. Zhang, T. Li, H. Gao, Y.H. Wang

e36

18-11-2013

https://doi.org/10.4081/ejh.2013.e36

4270

PDF: 819

HTML: 257
Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu

11-11-2024

https://doi.org/10.4081/ejh.2024.4063

1523

PDF: 464

HTML: 11
Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine

Flavia Carton, Manuela Malatesta

24-11-2022

https://doi.org/10.4081/ejh.2022.3603

999

PDF: 443

HTML: 19
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy

Valentina Alda Carozzi, Chiara Salio, Virginia Rodriguez-Menendez, Elisa Ciglieri, Francesco Ferrini

19-10-2021

https://doi.org/10.4081/ejh.2021.3276

2954

PDF: 1661

Video 1: 230

Video 2: 273

HTML: 25
MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9

Qingwen Li, Jiao Zhang, Shougang Liu, Fangfei Zhang, Jiayi Zhuang, Yongfeng Chen

12-01-2022

https://doi.org/10.4081/ejh.2022.3275

1889

PDF: 784

Supplementary: 144

HTML: 34

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