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P29 | AUTOPHAGY IS IMPAIRED IN GSCS-ENRICHED GLIOBLASTOMA MODELS G. Trotto1, M. Calvitto1, N. Martella1, D.Gargano1, M. Cillo2, E. Sgambati1, F. Nazio3, P. Grumati2|4, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy; 3Dept. of Biology, "Tor Vergata" University, Rome, Italy; 4Dept. of Clinical Medicine and Surgery, Federico II University, Naples, Italy
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NEUROBIOLOGY OF SUICIDE: MORPHOLOGICAL ASSESSMENT OF MICROGLIAL NETWORK IN HUMAN POST-MORTEM PREFRONTAL CORTEX Tambuzzi S1, Bertolotto N2, Massari S2, Madaschi L3, Alini M2, Brandolese D2, Ubezio MC1, Cattaneo C1 and Amadeo A2 | 1Institute of Forensic Medicine, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; 2Department of Biosciences, Università degli Studi di Milano, Milan, Italy; 3UNITECH NOLIMITS, Università degli Studi di Milano, Milan, Italy
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IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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P39 | NEW PERSPECTIVES FOR THE EXPLOITATION OF FEMALE REPRODUCTIVE POTENTIAL IN MAMMALS: GENERATION OF GRANULOSA-LIKE CELLS FROM HUMAN ADIPOSE MESENCHYMAL STEM CELLS Y. Lacapra1, D. Farini1, G. Salvatore1, M.A. Ucci1, F.G. Klinger2, M. De Felici1, A. Camaio1 | 1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy: 2Saint Camillus International University of Health Sciences, Rome, Italy
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MODULATION OF EXTRACELLULAR SIGNAL-RELATED KINASE, CYCLIN D1, GLIAL FIBRILLARY ACIDIC PROTEIN, AND VIMENTIN EXPRESSION IN ESTRADIOL-PRETREATED ASTROCYTE CULTURES TREATED WITH COMPETENCE AND PROGRESSION GROWTH FACTORS Barbagallo A1, Barbagallo F1, Rapisarda G1 and Avola R1 | 1Department of Biometec (Biochemistry Section), University of Catania, Italy
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07 | FROM GUT MICROBIOTA TO GONADS: BUTYRATE MITIGATES PFAS–PESTICIDE MIXTURE TOXICITY IN ZEBRAFISH SPERMATOGENESIS M. Lombó, N. Baldoni, C. Giommi, O. Carnevali | Dept. of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy
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MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F1, Russo L2, Jorkesh A2, Khodaparast S1, Gambarotta G1, Ronchi G1 and Cescon M2 | 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy
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Expression of acetylated tubulin in the postnatal developing mouse cochlea
2107PDF: 795Supplementary: 323HTML: 34 -
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Immuno- and glyco-histochemistry as a tool to evaluate the oregano supplemented feed effects in pig gut
1793PDF: 837Supplementary: 202HTML: 16 -
14 | NR2F1 MODULATES ACTIVATION DYNAMICS AND MAINTENANCE OF THE ADULT MURINE HIPPOCAMPAL NEURAL STEM CELL POOL S. Bonzano1|2, A. Lippolis1|2, S. Quaresima3, V. Manzini3, E. Dallorto1|2, E. Cacci3, P. Peretto1|2, M. Studer4, V. Licursi5, G. Lupo3, S. De Marchis1|2 | 1Dept. of Life Sciences and Systems Biology (DBIOS), Univ. of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (Turin), Italy; 3Dept. of Biology and Biotechnologies Charles Darwin, Sapienza Univ. of Rome, Italy; 4Univ. Côte d'Azur, CNRS, Inserm, iBV, Nice, France; 5Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy
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Mouse development - From oocyte to stem cells
2281PDF: 612HTML: 112 -
MULTI SCAFFOLD 3D-BIOPRINTED MODEL OF SPINAL CORD ARCHITECTURE IN VITRO Chasseur S1, Traldi C2,3,4, Chiappini V1, Tonda-Turo C2,3,4 and Boido M1 | 1Department of Neuroscience «Rita Levi Montalcini», Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, Italy; 2Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; 3POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy; 4Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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P78 | THE ROLE OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STROMAL CELLS IN MYOFIBER REGENERATION A. Longhin1, V. Gatta2, G. Teti2, C. Sassoli3, F. Chellini3, A. Tani3, M. Parigi3, R. Garella3, F. Palmieri3, R. Squecco3, M. Mattioli Belmonte4, C. Licini4, A. La Contana4, S. Zecchi Orlandini3, M. Falconi1 | 1Dep. Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Dep. Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy; 3Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 4Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy
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