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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Marco Biggiogera, Italy

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  • SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

    Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu
    03-03-2026
    https://doi.org/10.4081/ejh.2026.4530
    549
    PDF: 451
    HTML: 13
  • ECRG4 expression in normal rat tissues: expression study and literature review

    A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro
    18-05-2015
    https://doi.org/10.4081/ejh.2015.2458
    3113
    PDF: 1214
    Supplementary: 412
    HTML: 1021
  • PARP-1 protein expression in glioblastoma multiforme

    A. Galia, A.E. Calogero, R. Condorelli, F. Fraggetta, A. La Corte, F. Ridolfo, P. Bosco, R. Castiglione, M. Salemi
    e9
    27-02-2012
    https://doi.org/10.4081/ejh.2012.e9
    3414
    PDF: 1376
    HTML: 1824
  • P80 | MITOCHONDRIA-LYSOSOME INTERACTIONS: EMERGING PLAYERS IN GLIOMA L. Zeppa1, M.B. Morelli2, C. Aguzzi2, M. Giangrossi2, M. Nabissi2, G. Cameli2, G. Santoni2, S.K. Tayebati2, V. Bellitto1, D. Tomassoni1, C. Amantini1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Pharmacy, University of Camerino, Camerino, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4406
    346
  • P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri1, M.V. Marvi1, V. Righi2, V. Papa3, E. Boschetti1, S. Blando1, E. Franceschi4, M. Zoli4, D. Mazzatenta4, N. Neri4, A. Vignaroli4, L. Cocco1, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Sciences, University of Bologna, Bologna, Italy; 3IRCCS St. Orsola, Bologna, Italy; 4IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4389
    348
  • Galunisertib enhances chimeric antigen receptor-modified T cell function

    Zhixiong Wang, Qian Liu, Na Risu, Jiayu Fu, Yan Zou, Jiaxing Tang, Long Li, Hui Liu, Guomin Zhou, Xuekai Zhu
    19-06-2020
    https://doi.org/10.4081/ejh.2020.3122
    2132
    PDF: 1135
    Supplementary: 190
    HTML: 22
  • LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

    Yiming Zhang, Wanqiong Zheng, Liang Zhang, Yechun Gu, Lihe Zhu, Yingpeng Huang
    20-06-2023
    https://doi.org/10.4081/ejh.2023.3667
    1287
    PDF: 770
    Supplementary: 110
    HTML: 30
  • The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study

    Roberta Sferra, Simona Pompili, Claudio Festuccia, Francesco Marampon, Giovanni L. Gravina, Luca Ventura, Ernesto Di Cesare, Sara Cicchinelli, Eugenio Gaudio, Antonella Vetuschi
    16-05-2017
    https://doi.org/10.4081/ejh.2017.2732
    2749
    PDF: 1073
    HTML: 157
  • Dipeptidyl peptidase IV in two human glioma cell lines

    A Sedo, R Malík, K Drbal, V Lisá, K Vlasicová, V Mares
    57-64
    24-12-2009
    https://doi.org/10.4081/ejh.2001.1614
    858
    PDF: 903
  • EXPLORING NEURON–GLIOMA SIGNALING THROUGH IN VITRO CO-CULTURES Nicorvo E¹, Ferraro A¹, Pacca P¹, Boido M¹, Di Cunto F¹ and Vercelli A¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4504
    349
  • MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4510
    251
  • Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances

    Zhi Chen, Na Cui, Ji-sen Zhao, Jian-fei Wu, Fang Ma, Cong Li, Xian-yi Liu
    20-01-2021
    https://doi.org/10.4081/ejh.2021.3173
    2389
    PDF: 851
    Supplementary: 201
    HTML: 22
  • Varying effects of EGF, HGF and TGFβ on formation of invadopodia and invasiveness of melanoma cell lines of different origin

    A. Makowiecka, A. Simiczyjew, D. Nowak, A.J. Mazur
    09-12-2016
    https://doi.org/10.4081/ejh.2016.2728
    2347
    PDF: 989
    Supplementary: 310
    HTML: 424
  • Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis

    Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang
    11-01-2023
    https://doi.org/10.4081/ejh.2023.3570
    1544
    PDF: 738
    HTML: 42
  • Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome

    A.K. Lindström, D. Hellberg
    15-04-2014
    https://doi.org/10.4081/ejh.2014.2227
    3314
    PDF: 1155
    HTML: 293
  • AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells

    L. Fassina, G. Magenes, A. Inzaghi, S. Palumbo, G. Allavena, C. Miracco, L. Pirtoli, M. Biggiogera, S. Comincini
    e44
    11-10-2012
    https://doi.org/10.4081/ejh.2012.e44
    2091
    PDF: 1023
    Supplementary Figures: 326
    Supplementary Table: 238
    HTML: 507
  • miRNA-877-5p inhibits malignant progression of prostate cancer by directly targeting SSFA2

    Wanchun Wang, Jun Yi, Degang Dong, Wenli Mao, Xuanyu Wang, Zhangren Yan
    20-09-2021
    https://doi.org/10.4081/ejh.2021.3243
    1450
    PDF: 731
    HTML: 43
  • miR-627-5p inhibits malignant progression of cervical cancer by targeting ANGPTL4

    Xinghua Wu, Kai Lin, Chen Gao, Yinfang Ni, Li Zhang, Tailai Yang, Jinguo Chen
    07-04-2025
    https://doi.org/10.4081/ejh.2025.4161
    1588
    PDF: 507
    HTML: 34
  • Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7

    Tianliang Bai, Ping Li, Yabin Liu, Bindan Cai, Gang Li, Wenbin Wang, Rui Yan, Xiangkui Zheng, Shangkun Du
    05-05-2025
    https://doi.org/10.4081/ejh.2025.4178
    1039
    PDF: 433
    Supplementary: 60
    HTML: 55
  • In vivo imaging techniques: a new era for histochemical analysis

    A. Busato, P. Fumene Feruglio, P.P. Parnigotto, P. Marzola, A. Sbarbati
    28-11-2016
    https://doi.org/10.4081/ejh.2016.2725
    2126
    PDF: 932
    HTML: 286
  • Reliable hexokinase 3 protein detection in human cell lines and primary tissue

    Yasmeen H. Mady, Carmen G. Kalbermatter, Maarij Khan, Anna M. Schläfli, Rina Mehmeti, Inti Zlobec, Lucine Christe, Mario P. Tschan
    12-03-2025
    https://doi.org/10.4081/ejh.2025.4175
    1995
    PDF: 497
    Supplementary: 72
    Uncropped Western blots: 71
    HTML: 16
  • Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

    Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Diao
    17-11-2021
    https://doi.org/10.4081/ejh.2021.3255
    1285
    PDF: 676
    HTML: 51
  • Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

    Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin
    23-10-2024
    https://doi.org/10.4081/ejh.2024.4098
    2513
    PDF: 528
    HTML: 38
  • Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue

    M. Salemi, A. Galia, F. Fraggetta, C. La Corte, P. Pepe, S. La Vignera, G. Improta, P. Bosco, A.E. Calogero
    e13
    15-04-2013
    https://doi.org/10.4081/ejh.2013.e13
    2995
    PDF: 3337
    HTML: 232
  • Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

    Yan Wang, Jie Sun, Ninghua Yao
    16-11-2021
    https://doi.org/10.4081/ejh.2021.3304
    1742
    PDF: 654
    HTML: 48
  • The knee joint loose body as a source of viable autologous human chondrocytes

    J. Melrose
    10-06-2016
    https://doi.org/10.4081/ejh.2016.2645
    2373
    PDF: 828
    HTML: 422
  • Effects of the lncRNA ENST00000623984 on colon cancer and the biological characteristics of colon cancer cells

    Zhi-bao Liu, Jing-hua Zhang, Jing-hua Gao, Jian Shi
    12-07-2021
    https://doi.org/10.4081/ejh.2021.3215
    2267
    PDF: 590
    HTML: 34
  • Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication in vitro by reinforcing miR-192-5p/ATG7-induced autophagy

    Minkai Cao, Deping Yuan, Hongxiu Jiang, Guanlun Zhou, Chao Chen, Guorong Han
    02-09-2022
    https://doi.org/10.4081/ejh.2022.3438
    1579
    PDF: 945
    HTML: 51
  • The substance P and neurokinin-1 receptor system in human thyroid cancer: an immunohistochemical study

    Inmaculada Isorna, Francisco Esteban, Juan Solanellas, Rafael Coveñas, Miguel Muñoz
    28-04-2020
    https://doi.org/10.4081/ejh.2020.3117
    1424
    PDF: 750
    HTML: 15
  • The role of galanin in the progression and prognosis of colorectal cancer: the unfinished story

    Zbigniew Kmiec, Jacek Kieżun, Bartlomiej E. Krazinski, Przemyslaw Kwiatkowski, Janusz Godlewski
    06-03-2024
    https://doi.org/10.4081/ejh.2024.3990
    1658
    PDF: 505
    HTML: 19
  • Maternal dietary loads of alpha-tocopherol increase synapse density and glial synaptic coverage in the hippocampus of adult offspring

    S. Salucci, P. Ambrogini, D. Lattanzi, M. Betti, P. Gobbi, C. Galati, F. Galli, R. Cuppini, A. Minelli
    02-05-2014
    https://doi.org/10.4081/ejh.2014.2355
    2200
    PDF: 970
    HTML: 469
  • microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

    Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu
    10-05-2022
    https://doi.org/10.4081/ejh.2022.3333
    2063
    PDF: 949
    HTML: 34
  • Regulatory roles of ACSL5 in the anti-tumor function of palmitic acid (C16:0) via the ERK signaling pathway

    Jiapei Lv, Wang Yanting, Shan Wei
    08-11-2023
    https://doi.org/10.4081/ejh.2023.3867
    2156
    PDF: 1067
    HTML: 59
  • P29 | AUTOPHAGY IS IMPAIRED IN GSCS-ENRICHED GLIOBLASTOMA MODELS G. Trotto1, M. Calvitto1, N. Martella1, D.Gargano1, M. Cillo2, E. Sgambati1, F. Nazio3, P. Grumati2|4, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy; 3Dept. of Biology, "Tor Vergata" University, Rome, Italy; 4Dept. of Clinical Medicine and Surgery, Federico II University, Naples, Italy

    GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
    22-06-2026
    https://doi.org/10.4081/ejh.2026.4725
    96
    PDF: 28
  • MicroRNA-29b-3p promotes 5-fluorouracil resistance via suppressing TRAF5-mediated necroptosis in human colorectal cancer

    Shuimei Wu, Yun Zhou, Ping Liu, Hui Zhang, Wanliang Wang, Yuan Fang, Xiang Shen
    22-06-2021
    https://doi.org/10.4081/ejh.2021.3247
    2133
    PDF: 1056
    Supplementary: 215
    HTML: 22
  • MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells

    J. Zhang, J. Luo, J. Ni, L. Tang, H.P. Zhang, L. Zhang, J.F. Xu, D. Zheng
    18-02-2014
    https://doi.org/10.4081/ejh.2014.2262
    3530
    PDF: 1064
    HTML: 334
  • MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9

    Qingwen Li, Jiao Zhang, Shougang Liu, Fangfei Zhang, Jiayi Zhuang, Yongfeng Chen
    12-01-2022
    https://doi.org/10.4081/ejh.2022.3275
    2141
    PDF: 847
    Supplementary: 168
    HTML: 38
  • CONNEXIN 43 HEMICHANNELS CAN DRIVE THE GLIOBLASTOMA SPREADING Virtuoso A1, De Luca C1, Altieri R2, Milior G3, Moulard J3, Huberfeld J3, Cirillo G1, Barbarisi M2, Rouach N3 and Papa M1 | 1Laboratory of Neural Network Morphology and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy; 3Interdisciplinary Research Center in Biology, College de France, CNRS, INSERM, Labex Memolife, Université PSL, Paris, France

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4517
    293
  • Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway

    Hui Yang, Yunlong Zhang, Desheng Zhang, Liping Qian, Tianxing Yang, Xiaocheng Wu
    12-09-2023
    https://doi.org/10.4081/ejh.2023.3697
    1408
    PDF: 704
    HTML: 24
  • TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study

    C. Loreto, L. E. Almeida, M.R. Migliore, M. Caltabiano, R. Leonardi
    e40
    13-09-2010
    https://doi.org/10.4081/ejh.2010.e40
    2698
    PDF: 653
    HTML: 1616
  • P19 | IDENTIFICATION OF MIR-129-5P AS A COMMON REGULATOR OF E3 UBIQUITIN LIGASES WITH A POTENTIAL ROLE IN GLIOBLASTOMA PROGRESSION N. Martella1, A.B. Díaz Méndez2, G. Regazzo2, G.F. Bufalieri3, A. Frati4, A. Arcella4, L. Di Marcotullio3, M.G. Rizzo2, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Research, Advanced Diagnostics and Technological Innovation, Translational Oncology Research Unit, IRCCS -Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 4IRCCS Neuromed, Pozzilli (IS), Italy

    GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA
    22-06-2026
    https://doi.org/10.4081/ejh.2026.4715
    67
    PDF: 30
  • Knockdown of RAGE inhibits growth and invasion of gastric cancer cells

    X.C. Xu, X. Abuduhadeer, W.B. Zhang, T. Li, H. Gao, Y.H. Wang
    e36
    18-11-2013
    https://doi.org/10.4081/ejh.2013.e36
    4383
    PDF: 897
    HTML: 272
  • Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

    Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu
    17-11-2025
    https://doi.org/10.4081/ejh.2025.4426
    1048
    PDF: 532
    HTML: 22
  • Subcellular distribution and expression of cofilin and ezrin in human colon adenocarcinoma cell lines with different metastatic potential

    D. Nowak, A. J. Mazur, A. Popow-Woźniak, A. Radwańska, H. G. Mannherz, M. Malicka-Błaszkiewicz
    e14
    13-04-2010
    https://doi.org/10.4081/ejh.2010.e14
    1819
    PDF: 680
    HTML: 2709
  • Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells

    Yinping Zeng, Jiajun Huang, Tingting Duan, Xiaofeng Wang
    28-05-2026
    https://doi.org/10.4081/ejh.2026.4540
    351
    PDF: 263
    HTML: 11
  • IncRNA MAPKAPK5-AS1 promotes proliferation and migration of thyroid cancer cell lines by targeting miR-519e-5p/YWHAH

    Yan Zhou, Shanshan Liu, Yan Luo, Meiying Zhang, Xueling Jiang, Yan Xiong
    03-12-2020
    https://doi.org/10.4081/ejh.2020.3177
    2325
    PDF: 913
    HTML: 17
  • LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway

    Yong Jiang, Chun-hui Xu, Ying Zhao, Yun-han Ji, Xin-tao Wang, Ying Liu
    16-01-2023
    https://doi.org/10.4081/ejh.2023.3526
    1975
    PDF: 873
    HTML: 68
  • Microgravity-induced apoptosis in cultured glial cells

    BM Uva, MA Masini, M Sturla, F Bruzzone, M Giuliani, G Tagliafierro, F Strollo
    209-14
    23-01-2010
    https://doi.org/10.4081/1681
    1700
    PDF: 1269
  • Immunohistochemical detection of putative pathogenetic factors in adhesions of infants: a pilot study

    Arvis Pauliņš, Anna Junga, Māra Pilmane
    10-02-2026
    https://doi.org/10.4081/ejh.2026.4438
    313
    PDF: 438
    HTML: 12
  • Effect of carboplatin injection on Bcl-2 protein expression and apoptosis induction in Raji cells

    Peng Lin, Boliang Zhou, Haiying Yao, Ya-ping Guo
    09-07-2020
    https://doi.org/10.4081/ejh.2020.3134
    2177
    PDF: 616
    HTML: 31
  • The role of miRNA-29b1 on the hypoxia-induced apoptosis in mammalian cardiomyocytes

    Bo Dai, Hailin Liu, Dingmin Juan, Kaize Wu, Ruhao Cao
    27-06-2024
    https://doi.org/10.4081/ejh.2024.4021
    1092
    PDF: 573
    HTML: 35
  • Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis

    F. Rappa, E. Unti, P. Baiamonte, F. Cappello, N. Scibetta
    e20
    28-06-2013
    https://doi.org/10.4081/ejh.2013.e20
    2927
    PDF: 764
    HTML: 359
  • Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma

    Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li
    22-07-2024
    https://doi.org/10.4081/ejh.2024.4048
    2461
    PDF: 1392
    HTML: 24
  • CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure

    S. Huang, S. Guo, F. Guo, Q. Yang, X. Xiao, M. Murata, S. Ohnishi, S. Kawanishi, N. Ma
    e1
    14-01-2013
    https://doi.org/10.4081/ejh.2013.e1
    2113
    PDF: 915
    HTML: 895
  • Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

    Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye
    30-09-2021
    https://doi.org/10.4081/ejh.2021.3224
    3774
    PDF: 1939
    HTML: 42
  • Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

    Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun
    07-04-2025
    https://doi.org/10.4081/ejh.2025.4182
    1252
    PDF: 743
    HTML: 50
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European Journal of Histochemistry

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