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From fix to fit into the autoptic human brains
2152PDF: 1393HTML: 55 -
75 | Β-SITOSTEROL-D-GLUCOSIDE TRIGGERS INTESTINAL INFLAMMATION IN ZEBRAFISH LARVAE POSSIBLY LEADING TO NEURODEGENERATION THROUGH THE GUT-BRAIN AXIS Francesca Terrin1, Sofia Faggin2|3, Chiara Consorti4, Stefania Marcotti5, Paolo Bonaldo4, Maria Cecilia Giron2, Nicoletta Plotegher1, Luisa Dalla Valle1 | 1Department of Biology, University of Padova, Italy; 2Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy; 3Institute of Digestive Health Research (IRSD), Toulouse University, France; 4Department of Molecular Medicine, University of Padova, Italy; 5Randall Centre for Cell and Molecular Biophysics, King's College London, London; UK
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CHANGE IN AQUAPORIN-4 EXPRESSION AND LOCALIZATION DURING AMYOTROPHIC LATERAL SCLEROSIS AND SPINAL MUSCULAR ATROPHY PROGRESSION Tuninetti A1, Boido M1, Vercelli A1 and Pacca P1 | 1Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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Expression of S100β during mouse cochlear development
1488PDF: 416Supplementary: 82HTML: 9 -
ON THE WAY TO A NEW MODEL OF NEURODEGENERATION? FIRST EVIDENCE OF THE EXPRESSION OF GATA1 IN THE BRAIN: CORRELATIONS WITH AGING, MITOCHONDRIAL DAMAGE AND SYNUCLEINOPATHY C. Caturano1, F. E. Bellomi1, F. Arciprete1, V. Velardi1, L. La Barbera2, M. Falchi3, M. Bacioglu4, R. Mancinelli5, M. D’Amelio2, M. Spillantini4, M. Zingariello1, G. Vivacqua1,6 | 1Laboratory of Microscopic and Ultrastructural Anatomy, Campus Biomedico University of Rome, Italy; 2Laboratory of Molecular Neuroscience - Campus Biomedico University of Rome, Italy; 3National Centre for HIV/AIDS Research, Istituto Superior di Sanità, Rome, Italy; 4Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK; 5Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy; 6Department of Clinical Neuroscience, The University of Cambridge, Cambridge, UK
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GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy
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P05 | ENTERIC NERVOUS SYSTEM NEUROPLASTICITY IN COLON OF ANIMAL MODELS OF OBESITY V. Bellitto1, I. Martinelli2, G. Nittari2, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
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P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto1, F. Grasselli1, L. Lucernoni1, I. Martinelli2, E. Vittadini1, A.M. Eleuteri1, L. Bonfili1, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy
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Lipofuscin, lipofuscin-like pigments and autofluorescence
4355PDF: 1883HTML: 524 -
P01 | BET PROTEIN INHIBITION ATTENUATES MICROGLIAL ACTIVATION AND OXIDATIVE STRESS IN A CELLULAR MODEL OF PARKINSON’S DISEASE E. Bisesto1, D. Pensabene1, M. Colardo1, M. Varone1, M. Segatto1 | 1Dept. of Biosciences and territory, University of Molise, Pesche (IS), Italy
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THE FACETED S100B PROTEIN: THE JEKYLL/HYDE SIDE F. Michetti | LUM University Casamassima, Genes Company, Roma, Italy
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CONNECTOME-BASED BRAIN FINGERPRINTS PREDICT ART THERAPY RESPONSE IN PARKINSON’S DISEASE Ielo A1,§, Genovese D2,3,§, Falcó-Roget J4, Amico E5,6, Norcini M7, Quartarone A1, Ghilardi MF8 and Cacciola A9,10 | 1IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy; 2Institute of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; 4Computational Neuroscience Group, Sano Centre for Computational Medicine, Kraków, Poland; 5School of Mathematics, University of Birmingham, Birmingham, UK; 6Centre for Human Brain Health, University of Birmingham, Birmingham, UK; 7NYU Langone Health, Department of Neurology, New York, USA; 8Department of Molecular, Cellular & Biomedical Sciences, School of Medicine, City University of New York, New York, USA; 9Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; 10IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. §Shared co-first authorship
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61 | ROTENONE-INDUCED OXIDATIVE STRESS TRIGGERS PEROXISOMAL ALTERATIONS IN BV-2 MICROGLIAL CELLS F. Rendina1, A. Valenza1, M. Muzzi2, D. Pensabene2, A. Fracassi3, M. Segatto2, S. Moreno1|3 | 1Dept. of Science, University Roma Tre, Rome, Italy. 2Dept. of Biosciences and Territory, University of Molise, Pesche, Italy. 3Dept. of Neurology, UTMB, Galveston, TX, USA
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy
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MULTI SCAFFOLD 3D-BIOPRINTED MODEL OF SPINAL CORD ARCHITECTURE IN VITRO Chasseur S1, Traldi C2,3,4, Chiappini V1, Tonda-Turo C2,3,4 and Boido M1 | 1Department of Neuroscience «Rita Levi Montalcini», Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, Italy; 2Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; 3POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy; 4Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy
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P03 | ALTERED NEUROTRANSMISSION AND METABOLISM IN A GFAP R239C ZEBRAFISH MODEL OF ALEXANDER DISEASE S. Candiani1|2, M. Bozzo1, V. Bazzurro1, D. Bellitto3, A. Tripi1, S. Ferrando1, G. Rosa1, T. Bacchetti3 | 1Dept. of Biology, University of Genova, Italy; 2RCCS Azienda Ospedaliera Metropolitana, Genova, Italy; 3UO Proteomica e Spettrometria di Massa, IRCCS Ospedale Policlinico San Martino, Genova, Italy
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A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL 5xFAD Chicote J1, Rosano V1, Mezzanotte M1, Bertinaria M2, Marini E2, Vercelli A1 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Drug Science and Technology, University of Turin, Italy
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P13 | NEURODEGENERATION AND DNA DAMAGE FOLLOWING CO-EXPOSURE TO POLYSTYRENE MICROPLASTICS AND BISPHENOL A IN ZEBRAFISH EMBRYOS A. La Pietra, A.R. Bianchi, B. Berman, A. Petito, A. Chirico, A. Cacace, B. Cozzolino, P. Venditti, A. De Maio, I. Ferrandino | Dept. of Biology, University of Naples Federico II, Italy
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IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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FLVCR1a REGULATES CORTICAL INTERNEURON DEVELOPMENT AND MIGRATION IN THE EMBRYONIC CORTEX Metani L1, Zanin Venturini DI1, Abalai RE1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Torino, Italy
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Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells
2698PDF: 855Supplementary: 371HTML: 45 -
Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1
1821PDF: 896Supplementary: 172HTML: 20 -
02 | MODELING NON-CELL AUTONOMOUS MECHANISMS IN THE ALS PERIPHERAL NERVOUS SYSTEM A. Romano1|2|3 | 1Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 2Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3CNR NANOTEC - Institute of Nanotechnology, Lecce, Italy
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A PILOT STUDY TO INVESTIGATE THE ANTIAGING EFFECTS OF THE OLIVE POMACE BY-PRODUCT ON THE BRAIN OF DROSOPHILA MELANOGASTER Makladissi S1†, Tomassoni D2†*, Nardin T3, Bellitto V2, Cappelli A2, Di Cara F1‡ and Beghelli D2‡ | 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; 2School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, MC, Italy ; 3Chemical Unit Oenological Vines Agri-food - Technology Transfer Centre Foundation Edmund Mach, TN, Italy †These authors equally contributed. ‡These authors share the authorship
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