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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi¹, V. Righi², A. Mucci³, I. Rusciano¹, S. Mongiorgi¹, M. Shin⁴, Y. Kosodo⁴, I. Cani⁵, P. Cortelli⁶, E. Giorgio⁷, G. Ramazzotti¹, L. Manzoli¹, S. Ratti¹ | ¹ Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ²Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; ³Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; ⁴Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; ⁵Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; ⁶IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; ⁷Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.

21-08-2025

https://doi.org/10.4081/ejh.2025.4312

288
Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

C. Pellicciari

30-12-2014

https://doi.org/10.4081/ejh.2014.2474

2315

PDF: 675

HTML: 814
Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers

K Hirai, M Kumakiri, K Ueda, Y Imamura, S Noriki, Y Nishi, H Kato, M Fukuda

319-32

30-12-2009

https://doi.org/10.4081/1641

765

PDF: 723
Expression of S100β during mouse cochlear development

Wenjing Liu, Yongchun Zhang, Cheng Liang, Lizhong Su

10-03-2025

https://doi.org/10.4081/ejh.2025.4189

1363

PDF: 362

Supplementary: 68

HTML: 6
Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine

Flavia Carton, Manuela Malatesta

24-11-2022

https://doi.org/10.4081/ejh.2022.3603

1005

PDF: 447

HTML: 19
Vitamin D and vitamin D receptor in patients with ophthalmic pterygium

Cristina Maxia, Daniela Murtas, Michela Corrias, Ignazio Zucca, Luigi Minerba, Franca Piras, Cristiana Marinelli, Maria Teresa Perra

30-10-2017

https://doi.org/10.4081/ejh.2017.2837

1903

PDF: 992

HTML: 73
MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo

21-06-2022

https://doi.org/10.4081/ejh.2022.3426

1428

PDF: 803

HTML: 25
Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells

Y. Asara, J. A. Marchal, P. Bandiera, V. Mazzarello, L. G. Delogu, M. A. Sotgiu, A. Montella, R. Madeddu

e1

20-01-2012

https://doi.org/10.4081/ejh.2012.e1

1804

PDF: 904

HTML: 4526
Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway

Xiaoyan Chu, Jun Lou, Yun Yi, Linlin Zhong, Ouping Huang

11-05-2023

https://doi.org/10.4081/ejh.2023.3653

1150

PDF: 605

HTML: 38
Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome

A.K. Lindström, D. Hellberg

15-04-2014

https://doi.org/10.4081/ejh.2014.2227

3182

PDF: 1090

HTML: 289
Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model

Qichao Yin, Hua Xiong

03-10-2022

https://doi.org/10.4081/ejh.2022.3541

1052

PDF: 629

HTML: 37
DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells

Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu

03-05-2017

https://doi.org/10.4081/ejh.2017.2775

2660

PDF: 991

HTML: 177
Radioprotective potential of histamine on rat small intestine and uterus

E. Carabajal, N. Massari, M. Croci, D. J. Martinel Lamas, J. P. Prestifilippo, R. M. Bergoc, E. S. Rivera, V. A. Medina

e48

18-12-2012

https://doi.org/10.4081/ejh.2012.e48

1292

PDF: 712

HTML: 911
P07 | DISRUPTED GUT-VASCULAR BARRIER AND INFLAMMATORY REMODELING IN MNGIE: A SPATIAL TRANSCRIPTOMIC AND HISTOLOGICAL STUDY S. Blando¹, E. Boschetti¹, I. Neri¹, L. Caporali², C. Fiorini², D. Ormanbekova², C. Malagelada³, I. Rusciano¹, V. Carelli², R. De Giorgio⁴, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum, University of Bologna, Italy; ²IRCCS Institute of Neurological Sciences of Bologna, Neurogenetics Program, Bologna, Italy; ³Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain; ⁴Department of Translational Medicine, University of Ferrara, Ferrara, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4327

158
Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

Rong Tian, Gengsheng Mao

12-01-2022

https://doi.org/10.4081/ejh.2022.3350

1780

PDF: 857

HTML: 36
Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

E. Guerriero, M. Accardo, F. Capone, G. Colonna, G. Castello, S. Costantini

01-12-2014

https://doi.org/10.4081/ejh.2014.2433

3893

PDF: 808

HTML: 418
A new monoclonal antibody against DNA ligase I is a suitable marker of cell proliferation in cultured cell and tissue section samples

B Vitolo, MR Lidonnici, C Montecucco, A Montecucco

349-354

30-06-2009

https://doi.org/10.4081/962

969

PDF: 664
Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis

Jinbi Xie, Yong Ning, Lihang Zhang, Yuan Lin, Runsheng Guo, Shanjuan Wang

03-10-2022

https://doi.org/10.4081/ejh.2022.3477

1947

PDF: 632

HTML: 36
MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices

Elena Casiraghi, Mara Cossa, Veronica Huber, Licia Rivoltini, Matteo Tozzi, Antonello Villa, Barbara Vergani

02-11-2017

https://doi.org/10.4081/ejh.2017.2838

2409

PDF: 1173

MIAQuant user Manual: 255

MIAQuant source code: 327

HTML: 73
Knockdown of RAGE inhibits growth and invasion of gastric cancer cells

X.C. Xu, X. Abuduhadeer, W.B. Zhang, T. Li, H. Gao, Y.H. Wang

e36

18-11-2013

https://doi.org/10.4081/ejh.2013.e36

4276

PDF: 827

HTML: 259
microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu

10-05-2022

https://doi.org/10.4081/ejh.2022.3333

1679

PDF: 891

HTML: 28
High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis

G. Goteri, E. Altobelli, G. Tossetta, A. Zizzi, C. Avellini, C. Licini, T. Lorenzi, M. Castellucci, A. Ciavattini, D. Marzioni

09-12-2015

https://doi.org/10.4081/ejh.2015.2570

2633

PDF: 805

HTML: 410
E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway

Zhijing Wang, Xiaohua Qin, Shanshan Liu, Yilei Wen, Bikan Lan, Hantao Liao, Haixian Wei

26-05-2025

https://doi.org/10.4081/ejh.2025.4196

1061

PDF: 484

HTML: 14
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

1185

PDF: 703

HTML: 24
Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling

You-Jie Liu, Hua-Jun Wang, Zhao-Wen Xue, Lek-Hang Cheang, Man-Seng Tam, Ri-Wang Li, Jie-Ruo Li, Hui-Ge Hou, Xiao-Fei Zheng

07-09-2021

https://doi.org/10.4081/ejh.2021.3297

1752

PDF: 928

Supplementary: 162

HTML: 24
VGF AS BIOMARKER OF PRE-SYMPTOMATIC PHASE OF PARKINSON’S DISEASE Manai AL¹, Modi A², Noli B¹, Choudhary SM², Ruda-Kucerova J³, Dražanová E^3,4, Khairnar A^2,5, Cocco C¹ | ¹Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy; ²International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; ³Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; ⁴Institute of Scientific Instruments of the CAS, v. v. i., Brno, Czech Republic; ⁵Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

12-12-2025

https://doi.org/10.4081/ejh.2025.4456

305
Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma

Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li

22-07-2024

https://doi.org/10.4081/ejh.2024.4048

1312

PDF: 386

HTML: 14
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer

J. Ning, J. Zhang, W. Liu, Y. Lang, Y. Xue, S. Xu

e46

30-11-2012

https://doi.org/10.4081/ejh.2012.e46

2492

PDF: 721

HTML: 509
Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway

Hui Yang, Yunlong Zhang, Desheng Zhang, Liping Qian, Tianxing Yang, Xiaocheng Wu

12-09-2023

https://doi.org/10.4081/ejh.2023.3697

1270

PDF: 636

HTML: 17
miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma via targeting cingulin

Yang Liu, Weichun Guo, Shuo Fang, Bin He, Xiaohai Li, Li Fan

07-12-2021

https://doi.org/10.4081/ejh.2021.3237

1460

PDF: 562

HTML: 25
Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway

Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

21-01-2025

https://doi.org/10.4081/ejh.2025.4158

1743

PDF: 564

Supplementary Figure: 79

HTML: 53
Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice

Fengqin Yan, Hong Zhu, Yingxia He, Qinqin Wu, Xiaoyu Duan

11-11-2022

https://doi.org/10.4081/ejh.2022.3563

1565

PDF: 842

Supplementary: 116

HTML: 33
An ex vivo study on immunohistochemical localization of MMP-7 and MMP-9 in temporomandibular joint discs with internal derangement

C. Loreto, R. Leonardi, G. Musumeci, G. Pannone, S. Castorina

e12

15-04-2013

https://doi.org/10.4081/ejh.2013.e12

2819

PDF: 838

HTML: 435
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

29-02-2024

https://doi.org/10.4081/ejh.2024.3977

2179

PDF: 1097

Supplementary: 103

HTML: 116
Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi

22-04-2022

https://doi.org/10.4081/ejh.2022.3393

1255

PDF: 706

HTML: 23
CONTRIBUTION OF MAGNETIC RESONANCE IMAGING ASSOCIATED WITH MACHINE LEARNING TO AN EARLY ASSESSMENT OF THE CONVERSION OF MILD COGNITIVE IMPAIRMENT IN OVERT DEMENTIA Amenta F, Battineni G, Chintalapudi N and Traini E | Clinical Research Centre, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4469

266
Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally

Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariotti

04-07-2024

https://doi.org/10.4081/ejh.2024.4040

1973

PDF: 575

HTML: 18
Expression of parafibromin in major renal cell tumors

C. Cui, P. Lal, S. Master, Y. Ma, T. Baradet, Z. Bing

e39

23-10-2012

https://doi.org/10.4081/ejh.2012.e39

1462

PDF: 638

HTML: 220
P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu¹, C.G. Lison², F. Etzi³, A. Pisano³, C. Farace³, A. Sabalic³, D. Tutedde³, J.A. Marchal⁴, R. Madeddu⁵ | ¹Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; ²Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ³Department of Biomedical Science, University of Sassari, Sassari, Italy; ⁴Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ⁵Department of Biomedical Science, University of Sassari, Sassari, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4364

174
Deletion of osteopontin in non-small cell lung cancer cells affects bone metabolism by regulating miR-34c/Notch1 axis: a clue to bone metastasis

Jing Guo, Chang-Yong Tong, Jian-Guang Shi, Xin-Jian Li, Xue-Qin Chen

26-07-2023

https://doi.org/10.4081/ejh.2023.3631

1305

PDF: 729

HTML: 24
Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou

02-12-2021

https://doi.org/10.4081/ejh.2021.3331

2529

PDF: 1444

HTML: 38
Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis

Jindong Li, Jie Kang, Weiyan Liu, Jiazhe Liu, Gaofeng Pan, Anwei Mao, Qing Zhang, Jingfeng Lu, Junbin Ding, Hongchang Li

25-10-2022

https://doi.org/10.4081/ejh.2022.3529

1665

PDF: 793

HTML: 36
Overview of the optical properties of fluorescent nanoparticles for optical imaging

Federico Boschi, Francesco De Sanctis

29-08-2017

https://doi.org/10.4081/ejh.2017.2830

1739

PDF: 797

HTML: 73
USE OF HIGH-DEFINITION IMAGING FLOW CYTOMETRY AND A.I. TO ENUMERATE AND CHARACTERISE CIRCULATING TUMOUR CELLS S. Saravi¹, S. Panfilov², E. Karteris² | ¹College of Health, Medicine and Life Sciences, Brunel University of London, UK; ²College of Health, Medicine and Life Sciences, Brunel University of London, UK

21-08-2025

https://doi.org/10.4081/ejh.2025.4295

165
Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry

A.M. SchlÃ¤fli, S. Berezowska, O. Adams, R. Langer, M.P. Tschan

05-05-2015

https://doi.org/10.4081/ejh.2015.2481

8046

PDF: 3239

HTML: 2146
Luminescence and fluorescence of essential oils. Fluorescence imaging in vivo of wild chamomile oil

F. Boschi, M. Fontanella, L. Calderan, A. Sbarbati

e18

16-06-2011

https://doi.org/10.4081/ejh.2011.e18

1213

PDF: 945

HTML: 1473

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