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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Carlo Pellicciari, Italy

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  • Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7

    Tianliang Bai, Ping Li, Yabin Liu, Bindan Cai, Gang Li, Wenbin Wang, Rui Yan, Xiangkui Zheng, Shangkun Du
    05-05-2025
    https://doi.org/10.4081/ejh.2025.4178
    542
    PDF: 235
    Supplementary: 18
    HTML: 26
  • Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

    Kui Long, Xiang Kui, Qingbin Zeng, Wenzhi Dong
    17-04-2025
    https://doi.org/10.4081/ejh.2025.4176
    985
    PDF: 368
    Supplementary: 57
    HTML: 27
  • Tumor cells-derived exosomal PD-L1 promotes the growth and invasion of lung cancer cells in vitro via mediating macrophages M2 polarization

    Xiangjun Lu, Jian Shen, Siyuan Huang, Dongdong Liu, Haitao Wang
    01-08-2023
    https://doi.org/10.4081/ejh.2023.3784
    1474
    PDF: 683
    HTML: 11
  • Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages

    Jun Lin, Liping Jiang, Kun Guo, Ning Feng
    22-12-2022
    https://doi.org/10.4081/ejh.2023.3528
    1614
    PDF: 1034
    Supplementary: 89
    HTML: 27
  • Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

    Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu
    17-11-2025
    https://doi.org/10.4081/ejh.2025.4426
    165
    PDF: 123
    HTML: 5
  • Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

    Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang
    17-09-2024
    https://doi.org/10.4081/ejh.2024.4034
    755
    PDF: 362
    HTML: 3
  • Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

    Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai
    14-10-2022
    https://doi.org/10.4081/ejh.2022.3510
    1124
    PDF: 601
    HTML: 28
  • Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

    Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin
    23-10-2024
    https://doi.org/10.4081/ejh.2024.4098
    1604
    PDF: 304
    HTML: 5
  • Characterization of the role of RILP in cell migration

    Azzurra Margiotta, Cinzia Progida, Oddmund Bakke, Cecilia Bucci
    31-05-2017
    https://doi.org/10.4081/ejh.2017.2783
    2158
    PDF: 887
    Supplementary: 223
    Movie 1: 290
    Movie 2: 337
    HTML: 95
  • Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

    Rong Tian, Gengsheng Mao
    12-01-2022
    https://doi.org/10.4081/ejh.2022.3350
    1577
    PDF: 754
    HTML: 27
  • Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling

    Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng
    17-06-2025
    https://doi.org/10.4081/ejh.2025.4218
    458
    PDF: 215
    HTML: 12
  • P65 | (YS) INVESTIGATING THE EFFECTS OF THE SECRETOME FROM HUMAN AMNIOTIC MESENCHYMAL STROMAL CELLS ON INFLAMMASOME ACTIVATION M. Rossi1, M. Magatti2, P. Romele2, E. Vertua2, E. Giuzzi2, S. Farigu2, L. Marelli2, B. Rapuzzi2, S. De Munari2, A. Silini2, O. Parolini3 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, and Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 2Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 3Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy & Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4390
    155
  • Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

    Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan
    17-06-2025
    https://doi.org/10.4081/ejh.2025.4168
    316
    PDF: 167
    HTML: 9
  • In vitro reparative dentin: a biochemical and morphological study

    G. Teti, V. Salvatore, A. Ruggeri, L. Manzoli, M. Gesi, G. Orsini, M. Falconi
    e23
    06-08-2013
    https://doi.org/10.4081/ejh.2013.e23
    3035
    PDF: 731
    HTML: 929
  • MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

    Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo
    21-06-2022
    https://doi.org/10.4081/ejh.2022.3426
    1263
    PDF: 707
    HTML: 18
  • Image by <a href="https://pixabay.com/users/spotsoflight-6345617/?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=2744729">Monika Robak</a> from <a href="https://pixabay.com//?utm_source=link-attribution&amp;utm_medium=referral&amp;utm_campaign=image&amp;utm_content=2744729">Pixabay</a>

    The contribution of immunohistochemistry to the development of hydrogels for skin repair and regeneration

    Flavia Carton
    23-02-2023
    https://doi.org/10.4081/ejh.2023.3679
    1501
    PDF: 762
    HTML: 23
  • miR-29a-3p enhances the radiosensitivity of oral squamous cell carcinoma cells by inhibiting ADAM12

    Cuihong Jiang, Feng Liu , Shuai Xiao, Lili He, Wenqiong Wu, Qi Zhao
    27-09-2021
    https://doi.org/10.4081/ejh.2021.3295
    1106
    PDF: 658
    HTML: 20
  • Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

    Chixian Zhang, Kai Bai, Dexu Li
    14-04-2025
    https://doi.org/10.4081/ejh.2025.4186
    812
    PDF: 258
    HTML: 23
  • Differentiation of monocytic U937 cells under static magnetic field exposure

    P Pagliara, R Lanubile, M Dwikat, L Abbro, L Dini
    75-86
    29-06-2009
    https://doi.org/10.4081/930
    1523
    PDF: 3063
  • Wheat germ agglutinin staining as a suitable method for detection and quantification of fibrosis in cardiac tissue after myocardial infarction

    B. Emde, A. Heinen, A. Gödecke, K. Bottermann
    17-12-2014
    https://doi.org/10.4081/ejh.2014.2448
    8446
    PDF: 4646
    HTML: 2165
  • Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

    Jacopo J.V. Branca, Donatello Carrino, Ferdinando Paternostro, Massimo Gulisano, Matteo Becatti, Lorenzo Di Cesare Mannelli, Alessandra Pacini
    10-11-2021
    https://doi.org/10.4081/ejh.2021.3285
    1261
    PDF: 687
    HTML: 6
  • Imaging and spectral analysis of autofluorescence patterns in larval head structures of mosquito vectors

    Francesca Scolari, Alessandro Girella, Anna Cleta Croce
    20-09-2022
    https://doi.org/10.4081/ejh.2022.3462
    1181
    PDF: 508
    HTML: 51
  • Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma

    Zhiyang Wang, Jing Li, Ziwei Liu, Ling Yue
    20-03-2023
    https://doi.org/10.4081/ejh.2023.3622
    905
    PDF: 601
    HTML: 28
  • CONNEXIN 43 HEMICHANNELS CAN DRIVE THE GLIOBLASTOMA SPREADING Virtuoso A1, De Luca C1, Altieri R2, Milior G3, Moulard J3, Huberfeld J3, Cirillo G1, Barbarisi M2, Rouach N3 and Papa M1 | 1Laboratory of Neural Network Morphology and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy; 3Interdisciplinary Research Center in Biology, College de France, CNRS, INSERM, Labex Memolife, Université PSL, Paris, France

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4517
    97
  • Bile duct ligature in young rats: A revisited animal model for biliary atresia

    Matias Garrido, Camila Escobar, Constanza Zamora, Carolina Rejas, Juan Varas, Mario Párraga, Sebastián San Martin, Sandra Montedonico
    13-09-2017
    https://doi.org/10.4081/ejh.2017.2803
    1743
    PDF: 869
    HTML: 133
  • Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study

    A. Santoro, G. Pannone, M.E. Errico, D. Bifano, G. Lastilla, P. Bufo, C. Loreto, V. Donofrio
    e25
    02-07-2012
    https://doi.org/10.4081/ejh.2012.e25
    1318
    PDF: 543
    HTML: 5355
  • The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways

    Zhi Wang, Guihua Jian, Teng Chen, Yiping Chen, Junhui Li, Niansong Wang
    01-03-2023
    https://doi.org/10.4081/ejh.2023.3648
    1772
    PDF: 851
    HTML: 35
  • Immunofluorescent characterization of non-myelinating Schwann cells and their interactions with immune cells in mouse mesenteric lymph node

    Zhongli Shi, Wayne K. Greene, Philip K. Nicholls, Dailun Hu, Janina E.E. Tirnitz-Parker, Qionglan Yuan, Changfu Yin, Bin Ma
    07-08-2017
    https://doi.org/10.4081/ejh.2017.2827
    2177
    PDF: 871
    HTML: 154
  • Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl

    Hao Li, Junliang Chen, Wenjun You, Yizhen Xu, Yaqiong Ye, Haiquan Zhao, Junxing Li, Hui Zhang
    15-10-2024
    https://doi.org/10.4081/ejh.2024.4089
    1238
    PDF: 238
    HTML: 2
  • microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

    Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu
    10-05-2022
    https://doi.org/10.4081/ejh.2022.3333
    1344
    PDF: 779
    HTML: 24
  • E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway

    Zhijing Wang, Xiaohua Qin, Shanshan Liu, Yilei Wen, Bikan Lan, Hantao Liao, Haixian Wei
    26-05-2025
    https://doi.org/10.4081/ejh.2025.4196
    529
    PDF: 244
    HTML: 4
  • Immunolocalization of endocan during the endothelial-mesenchymal transition process

    L. M. Carrillo, E. Arciniegas, H. R. Rojas, R. E. Ramirez
    e13
    01-06-2011
    https://doi.org/10.4081/ejh.2011.e13
    1146
    PDF: 498
    HTML: 1321
  • miR-199a-5p inhibited HIF-1α to suppress the proliferation, migration, and differentiation of cardiac stem cells

    Sha Li, Cuigai Zhang, Yanping Liu, Cuiqiao Meng, Yang Xie, Shuren Li
    22-09-2025
    https://doi.org/10.4081/ejh.2025.4239
    208
    PDF: 156
    Supplementary: 13
    HTML: 3
  • Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes

    Christian Zuppinger, George Gibbons, Priyanka Dutta-Passecker, Adrian Segiser, Henriette Most, Thomas M. Suter
    21-06-2017
    https://doi.org/10.4081/ejh.2017.2763
    4610
    PDF: 1972
    HTML: 282
  • Subcellular localization and distribution of the reduced folate carrier in normal rat tissues

    M. Hinken, S. Halwachs, C. Kneuer, W. Honscha
    e3
    27-01-2011
    https://doi.org/10.4081/ejh.2011.e3
    1596
    PDF: 621
    HTML: 5605
  • IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4266
    199
  • CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis

    Yangying Peng, Shaojie Ding, Ping Xu, Xueyan Zhang, Jianzhang Wang, Tiantian Li, Liyun Liao, Xinmei Zhang
    06-08-2024
    https://doi.org/10.4081/ejh.2024.4052
    741
    PDF: 489
    HTML: 21
  • Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

    Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou
    02-12-2021
    https://doi.org/10.4081/ejh.2021.3331
    2233
    PDF: 1304
    HTML: 30
  • MiR-122-5p inhibits the epithelial mesenchymal transition of liver cancer cells by inducing hiPSCs to differentiate into hepatocyte-like cells

    Qianzhe Xing, Yanjie Xu, Ying Luo, Chenglong Li, Peng Wang, Bin Kang, Chengjun Lu
    06-05-2025
    https://doi.org/10.4081/ejh.2025.4190
    438
    PDF: 224
    HTML: 22
  • Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney

    S. Ćirović, J. Marković-Lipkovski, J. Todorović, J. Nešović-Ostojić, M. Jović, S. Ilić, S. Tatić, D. Čemerikić
    e7
    08-02-2010
    https://doi.org/10.4081/ejh.2010.e7
    1436
    PDF: 429
    HTML: 3615
  • SerpinB3 administration protects liver against ischemia-reperfusion injury

    Cristian Turato, Mariapia Vairetti, Marta Cagna, Alessandra Biasiolo, Andrea Ferrigno, Santina Quarta, Mariagrazia Ruvoletto, Silvia De Siervi, Patrizia Pontisso, Laura Giuseppina Di Pasqua
    28-10-2022
    https://doi.org/10.4081/ejh.2022.3561
    1070
    PDF: 646
    HTML: 31
  • TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4305
    174
  • Stem/progenitor cells in the developing human cerebellum: an immunohistochemical study

    V. Pibiri, A. Ravarino, C. Gerosa, M.C. Pintus, V. Fanos, G. Faa
    19-09-2016
    https://doi.org/10.4081/ejh.2016.2686
    2195
    PDF: 821
    HTML: 269
  • Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway

    Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu Xu
    12-12-2023
    https://doi.org/10.4081/ejh.2023.3908
    1329
    PDF: 405
    HTML: 12
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Vol. 69 No. 4 (2025)
Transient receptor potential canonical 3/5 attenuate endothelial damage-induced neointima formation without affecting endothelial cell proliferation
Wenjun Zeng et al.
19 November 2025
Vol. 69 No. 4 (2025)
Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia
Xiaoli Liu et al.
17 November 2025
Vol. 69 No. 4 (2025)
Immunohistochemical analysis of YB-1 expression in the developing mouse eye
Alexander Forian Nass et al.
3 November 2025

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European Journal of Histochemistry

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