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Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1654

PDF: 860

HTML: 63
Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

Yan Wang, Jie Sun, Ninghua Yao

16-11-2021

https://doi.org/10.4081/ejh.2021.3304

1970

PDF: 768

HTML: 96
Guilu Erxian oral liquid mitigates oxidative damage in spermatogonial cells via miR-6739-5p modulation and PI3K/AKT pathway activation: a functional histocytochemical study

Zefeng Sun, Xinrong Fan, Zhenquan Liu

02-10-2025

https://doi.org/10.4081/ejh.2025.4253

565

PDF: 550

HTML: 75
Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway

Xiaoyan Chu, Jun Lou, Yun Yi, Linlin Zhong, Ouping Huang

11-05-2023

https://doi.org/10.4081/ejh.2023.3653

1695

PDF: 846

HTML: 76
Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells

Weidong Wang, Sheng Chen, Yuan Wang, Cui Jie, Weimin Shen

01-09-2025

https://doi.org/10.4081/ejh.2025.4241

719

PDF: 702

HTML: 42
DPY30 promotes the growth and survival of osteosarcoma cell by regulating the PI3K/AKT signal pathway

Gong Cheng, Fengmin An, Zhilin Cao, Mingdi Zheng, Zhongyuan Zhao, Hao Wu

22-12-2022

https://doi.org/10.4081/ejh.2023.3413

1517

PDF: 780

Supplementary: 167

HTML: 73
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway

Li Fan, Feng Xu, Shouyong Liu, Ding Wu, Suchun Wang, Xin Pan, Yulin Zhou, Le Qu, Wenquan Zhou

30-06-2025

https://doi.org/10.4081/ejh.2025.4221

1384

PDF: 630

HTML: 56
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway

Shengwen Wang, Gang Yang, Qian Zhang, Yanbei Zhang

18-05-2026

https://doi.org/10.4081/ejh.2026.4544

379

PDF: 414

Supplementary: 90

HTML: 41
Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling

Kaizheng Liu, Jinyu Pan, Quan Liu, Yang Huang, Liqun Shang, Yi Zhang, Jinming Wen, Huayang Li, Zhongkai Wu

15-06-2026

https://doi.org/10.4081/ejh.2026.4569

349

PDF: 294

HTML: 52
E-cadherin inhibits the proliferation and migration of human colorectal cancer cells through Hippo signaling pathway

Zhijing Wang, Xiaohua Qin, Shanshan Liu, Yilei Wen, Bikan Lan, Hantao Liao, Haixian Wei

26-05-2025

https://doi.org/10.4081/ejh.2025.4196

1737

PDF: 757

HTML: 59
Astragaloside IV inhibits nasopharyngeal carcinoma progression by inhibiting SATB2/Wnt/PD-L1 pathway and enhancing the killing activity of T cells

Yinping Zeng, Jiajun Huang, Tingting Duan, Xiaofeng Wang

28-05-2026

https://doi.org/10.4081/ejh.2026.4540

522

PDF: 392

HTML: 46
Expression of bone morphogenetic protein signaling pathway players in the jejunum and colon of adult rats

Emma Cogo, Edwin Fouché, Charline Buisson, Adenike Omotoyinbo, Fabrice Pierre, Françoise Guéraud, Pascale Plaisancié

21-08-2025

https://doi.org/10.4081/ejh.2025.4174

837

PDF: 624

HTML: 62
Study on the mechanism of Shenling Baizhu powder on the pathogenesis of pregnancy complicated with non-alcoholic fatty liver, based on PI3K/AKT/mTOR signal pathway

Yao Le, Zhijun Wang, Qian Zhang, Ling Miao, Xiaohong Wang, Guorong Han

17-09-2024

https://doi.org/10.4081/ejh.2024.4093

2679

PDF: 751

HTML: 95
Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Diao

17-11-2021

https://doi.org/10.4081/ejh.2021.3255

1452

PDF: 779

HTML: 82
miR-19a targeting CLCA4 to regulate the proliferation, migration, and invasion of colorectal cancer cells

Huiwen Li, Bo Huang

10-03-2022

https://doi.org/10.4081/ejh.2022.3381

2451

PDF: 874

HTML: 61
Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou

02-12-2021

https://doi.org/10.4081/ejh.2021.3331

2901

PDF: 1668

HTML: 76
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway

Hongmei Yin, Xiumei Han, Qun Zhang, Duojie Li, Fan Wang

26-01-2026

https://doi.org/10.4081/ejh.2026.4422

904

PDF: 517

Supplementary: 109

Original gels: 121

HTML: 58
Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway

Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou

22-06-2022

https://doi.org/10.4081/ejh.2022.3394

2305

PDF: 1475

HTML: 64
Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway

Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu Xu

12-12-2023

https://doi.org/10.4081/ejh.2023.3908

1880

PDF: 657

HTML: 59
Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

Chixian Zhang, Kai Bai, Dexu Li

14-04-2025

https://doi.org/10.4081/ejh.2025.4186

1651

PDF: 635

HTML: 68
Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway

Zhongzhu Tang, Lei Wang, Yunwang Chen, Xiaomin Zheng, Runyu Wang, Bingxue Liu, Shiqi Zhang, Huimin Wang

07-08-2023

https://doi.org/10.4081/ejh.2023.3719

2547

PDF: 1210

HTML: 57
Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study

Sonia Fantone, Giovanni Tossetta, Rodolfo Montironi, Martina Senzacqua , Daniela Marzioni, Roberta Mazzucchelli

19-10-2020

https://doi.org/10.4081/ejh.2020.3147

2335

PDF: 943

HTML: 60
Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway

Yuhan Wang, Gang Wang, Xiaojun Liu, Dong Yun, Qing Cui, Xiaoting Wu, Wenfeng Lu, Xiwen Yang, Ming Zhang

03-08-2022

https://doi.org/10.4081/ejh.2022.3336

1898

PDF: 951

HTML: 91
Pretreatment with geniposide mitigates myocardial ischemia/reperfusion injury by modulating inflammatory response through TLR4/NF-κB pathway

Yanmei Yao, Leqing Lin, Wenxue Tang, Yueliang Shen, Fayu Chen, Ning Li, Baiyong Wang

08-09-2023

https://doi.org/10.4081/ejh.2023.3742

1515

PDF: 589

HTML: 65
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin

23-10-2024

https://doi.org/10.4081/ejh.2024.4098

2940

PDF: 667

HTML: 64
Sinensetin ameliorates osteoarthritis progression by modulating the NF-κB/NLRP3 signaling pathway and suppressing chondrocyte pyroptosis

Zhendong Liu, Ruizhou Liu, Hongwei Yue, Peilai Liu, Rui Wang

07-10-2026

https://doi.org/10.4081/ejh.2026.4587

806

PDF: 248

HTML: 4
Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway

Hui Yang, Yunlong Zhang, Desheng Zhang, Liping Qian, Tianxing Yang, Xiaocheng Wu

12-09-2023

https://doi.org/10.4081/ejh.2023.3697

1578

PDF: 821

HTML: 51
Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells

J. Feng, S. Ge, L. Zhang, H. Che, C. Liang

16-12-2016

https://doi.org/10.4081/ejh.2016.2711

2812

PDF: 1284

HTML: 353
STAT3 and SOCS3 expression patterns during murine placenta development

S. San Martin, J. Fitzgerald, M. Weber, M. PÃ¡rraga, T. SÃ¡ez, T.M. Zorn, U.R. Markert

e19

28-06-2013

https://doi.org/10.4081/ejh.2013.e19

3965

PDF: 1013

HTML: 352
MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9

Qingwen Li, Jiao Zhang, Shougang Liu, Fangfei Zhang, Jiayi Zhuang, Yongfeng Chen

12-01-2022

https://doi.org/10.4081/ejh.2022.3275

2451

PDF: 960

Supplementary: 211

HTML: 73
Localization of avβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

G. Latella, A. Vetuschi, R. Sferra, S. Speca, E. Gaudio

e40

04-12-2013

https://doi.org/10.4081/ejh.2013.e40

3956

PDF: 1141

HTML: 670
The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

Huyi Liu, Xiangdao Cai , Jia Liu, Fengxiang Zhang , Andong He, Ruiman Li

25-11-2021

https://doi.org/10.4081/ejh.2021.3323

2155

PDF: 852

HTML: 74
Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway

Suwei Dong, Yanbin Xiao, Ziqiang Zhu, Xiang Ma, Zhuohui Peng, Jianping Kang, Jianqiang Wang, Yunqing Wang, Zhen Li

17-05-2023

https://doi.org/10.4081/ejh.2023.3612

1796

PDF: 1072

Supplementary: 152

HTML: 54
The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization

R. M. Ruggeri, E. Vitarelli, G. Barresi, F. Trimarchi, S. Benvenga, M. Trovato

e24

03-06-2010

https://doi.org/10.4081/ejh.2010.e24

1669

PDF: 771

HTML: 2699
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function

Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng

21-06-2022

https://doi.org/10.4081/ejh.2022.3412

2830

PDF: 1601

HTML: 66
Seasonal expressions of VEGF and its receptors VEGFR1 and VEGFR2 in the prostate of the wild ground squirrels (Spermophilus dauricus)

Yuchen Yao, Wenqian Xie, Di Chen, Yingying Han, Zhengrong Yuan, Haolin Zhang, Qiang Weng

24-03-2021

https://doi.org/10.4081/ejh.2021.3219

1737

PDF: 719

HTML: 78
Knockdown of VEGFR2 inhibits proliferation and induces apoptosis in hemangioma-derived endothelial cells

J.M. Ou, Z.Y. Yu, M.K. Qiu, Y.X. Dai, Q. Dong, J. Shen, X.F. Wang, Y.B. Liu, Z.W. Quan, Z.W. Fei

17-03-2014

https://doi.org/10.4081/ejh.2014.2263

4151

PDF: 1160

HTML: 652
SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells via activating TGF-β/Smad2/3 signaling

Yiyu Qin, Jian Li, Hongchao Han, Yongliang Zheng, Haiming Lei, Yang Zhou, Hongyan Wu, Guozhe Zhang, Xiang Chen, Zhengping Chen

28-12-2023

https://doi.org/10.4081/ejh.2023.3899

1410

PDF: 476

HTML: 41
Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea

Wenjing Liu, Shanshan Ming, Xiaobing Zhao, Xin Zhu, Yuxiang Gong

01-09-2023

https://doi.org/10.4081/ejh.2023.3704

1451

PDF: 1148

HTML: 49
Solamargine inhibited the progression of non-small cell lung cancer in vitro by activating T cells

Changchun Zhang, Yichen Sun, Wei Jiang, Lin Wu, Qi Fang, Qikun Wang

01-09-2025

https://doi.org/10.4081/ejh.2025.4217

721

PDF: 354

HTML: 44
LncRNA gadd7 promotes mitochondrial membrane potential decrease and apoptosis of alveolar type II epithelial cells by positively regulating MFN1 in an in vitro model of hyperoxia-induced acute lung injury

Guoyue Liu, Cunzhi Yin, Mingjiang Qian, Xuan Xiao, Hang Wu, Fujian Fu

31-05-2023

https://doi.org/10.4081/ejh.2023.3535

1479

PDF: 848

HTML: 82
LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

Yiming Zhang, Wanqiong Zheng, Liang Zhang, Yechun Gu, Lihe Zhu, Yingpeng Huang

20-06-2023

https://doi.org/10.4081/ejh.2023.3667

1485

PDF: 878

Supplementary: 172

HTML: 66
Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen

13-10-2025

https://doi.org/10.4081/ejh.2025.4254

1105

PDF: 569

HTML: 79
Significance and relationship between DJ-1 gene and survivin gene expression in laryngeal carcinoma

Z. Shen, Y. Ren, D. Ye, J. Guo, C. Kang, H. Ding

e9

21-03-2011

https://doi.org/10.4081/ejh.2011.e9

2030

PDF: 621

HTML: 1736
Expressions of IL-6, TNF-α and NF-κB in the skin of Chinese brown frog (Rana dybowskii)

Liqin Xi, Chen Wang, Pengyu Chen, Qi Yang, Ruiqi Hu, Haolin Zhang, Qiang Weng, Meiyu Xu

19-10-2017

https://doi.org/10.4081/ejh.2017.2834

2715

PDF: 1027

HTML: 129
Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis

Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang

11-01-2023

https://doi.org/10.4081/ejh.2023.3570

1714

PDF: 808

HTML: 60
Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7

Tianliang Bai, Ping Li, Yabin Liu, Bindan Cai, Gang Li, Wenbin Wang, Rui Yan, Xiangkui Zheng, Shangkun Du

05-05-2025

https://doi.org/10.4081/ejh.2025.4178

1310

PDF: 550

Supplementary: 119

HTML: 99
miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma via targeting cingulin

Yang Liu, Weichun Guo, Shuo Fang, Bin He, Xiaohai Li, Li Fan

07-12-2021

https://doi.org/10.4081/ejh.2021.3237

1977

PDF: 710

HTML: 65
Effects of miR-939 and miR-376A on ulcerative colitis using a decoy strategy to inhibit NF-κB and NFAT expression

Yongwei Lin, Zhipeng Zhou, Lang Xie, Yongsheng Huang, Zhenghua Qiu, Lili Ye, Chunhui Cui

15-02-2022

https://doi.org/10.4081/ejh.2022.3316

2128

PDF: 851

HTML: 62

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