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65 | EFFECTS OF ENVIRONMENTAL TEMPERATURE VARIATION AND BDNF MODULATION ON THE SPATIO-TEMPORAL SHOALING BEHAVIOUR OF ADULT ZEBRAFISH (DANIO RERIO) REVEALED BY TWO- AND THREE-DIMENSIONAL ANALYSIS A.S. Sanchez Garcia1, F. Frabetti2, G. Brighi2, G. Tedeschi3|4, A. Racca5, E. Alleva5, M. Toni1 | 1Dept. of Biology and Biotechnologies “Charles Darwin”, Rome, Italy; 2Dept. of Medical and Surgical Sciences, Bologna, Italy; 3Dept. of Veterinary Medicine and Animal Science, University of Milan, Italy; 4CRC “Innovation for Well-Being and Environment”, University of Milan, Italy; 5Centre for Behavioural Sciences and Mental Health, Rome, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE G. Abruscato1, L. Sileo2, G. Scanavino2, C. Guerriero2, M. Mauro1, M. Vazzana1|3, V. Arizza1|3, C. Luparello1|3, A.M.Tata2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Dept. of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center (NBFC), Italy
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INSIGHTS INTO THE EVOLUTION OF DOPAMINERGIC CONTROL OF REPRODUCTION: THE BRAIN-PITUITARY-GONADAL AXIS OF THE SMALL-SPOTTED CATSHARK SCYLIORHINUS CANICULA Porceddu R1,2, Mulas G1, Porcu C1 and Follesa MC1,2 | 1Sezione di Biologia Animale ed Ecologia, Dipartimento di Scienze della Vita e dell’Ambiente, Università degli Studi di Cagliari, Cagliari, Italy; 2CoNISMa Consorzio Nazionale Interuniversitario per le Scienze Mare, Rome, Italy
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PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS L. Morello1, G. Stati1, V. Giansante1, S. Lattanzio1, P. Cerritelli1, D. Bruni1, S. Cinti2, R. Di Pietro1,3,4 | 1Department of Medicine and Aging Sciences, “G. d’ Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Experimental and Clinical Medicine, Center of Obesity, Polytechnic University of Marche, Ancona, Italy; 3StemTeCh Group, G. d’ Annunzio Foundation, “G. d’ Annunzio” University of Chieti Pescara, Chieti, Italy; 4Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
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68 | RESILIENCE ASSOCIATED WITH DEFECTS IN VITAMIN B12 METABOLISM: BALANCING BETWEEN HOMEOSTASIS AND DISEASE E. Selita1, E. Tomaselli2, G. Di Matteo3, L. Mannina3, M. Rossi2|4, D. Passeri2|4, L. Angeloni2|4, M. Fidaleo1|4 | 1Dept of Biology and Biotechnology, Charles Darwin, University of Rome Sapienza, Italy; 2Dept of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Italy; 3Dept of Chemistry and Technology of Drugs, Sapienza University of Rome, Italy; 4Research Centre for Nanotechnology for Engineering of Sapienza (CNIS), Sapienza University of Rome, Italy
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Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway
1893PDF: 613Supplementary Figure: 95HTML: 61 -
P15 | PHB/JAK/H3Y41PH AXIS REGULATES MEIOTIC RECOMBINATION IN SPERMATOGENESIS H. Chen1, L. Zhang1, W. Tan-Tai1, M. Liu2, H. Shi3, W. O4, P.A. Martin-DeLeon5 | 1Department of Anatomy, Histology & Embryology, Shanghai Medical College, Fudan University, Shanghai, China; 2State Key Laboratory of Molecular Biology, Chinese Academy of Sciences-University of Chinese Academy of Sciences, Shanghai, China; 3NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China; 4School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China; 5Department of Biological Sciences, University of Delaware, Newark, USA
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Transgenic mouse - Methods and protocols, 2nd edition
1388PDF: 499HTML: 240 -
P05 | COMBINED EMBRYOTOXIC EFFECTS OF MICROPLASTICS AND HEAVY METALS IN XENOPUS LAEVIS S. Di Marino, C. Fogliano, C.M. Motta, B. Avallone, R. Carotenuto | Dept. of Biology, University of Naples Federico II, Italy
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16 | EXTRACELLULAR VESICLES RELEASED BY CUMULUS CELLS CONTRIBUTE TO THE ACQUISITION OF MOUSE OOCYTE’S DEVELOPMENTAL COMPETENCE Giulia Brazzale1, Mario Zanoni1, Valeria Merico1, Giulia Fiorentino1, Paola Rebuzzini1, Andrea Fantinato1, Margherita Isernia1, Sergio Comincini1, Danilo Cimadomo1|2, Maurizio Zuccotti1 | 1Dept. of Biology and Biotechnology, University of Pavia, Italy; 2IVIRMA Global Research Alliance, IVIRMA Italia, Rome, Italy
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THE EFFECT OF ANTIBIOTIC-INDUCED DYSBIOSIS ON PERIPHERAL NERVE REPAIR Pellegrino D1, El Soury M1, Farzin S1, Elmelgy AA1, Muratori L1, Calabrò S2, Ferrocino I3, Ferrero G1, Camandona A1, Haastert- Talini K4, Cescon M2, Gambarotta G1 and Ronchi G1 | 1Department of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Orbassano, (Torino), Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy; 3Department of Scienze Agrarie, Forestali e Alimentari, DISAFA, University of Torino, Grugliasco, (Torino), Italy; 4Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Carl-Neuberg-Str.1, Hannover, Lower-Saxony, Germany
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RNA therapeutics - Function, design and delivery
936PDF: 459HTML: 175 -
Two-dimensional electrophoresis protocols
783PDF: 450HTML: 166 -
P03 | ALTERED NEUROTRANSMISSION AND METABOLISM IN A GFAP R239C ZEBRAFISH MODEL OF ALEXANDER DISEASE S. Candiani1|2, M. Bozzo1, V. Bazzurro1, D. Bellitto3, A. Tripi1, S. Ferrando1, G. Rosa1, T. Bacchetti3 | 1Dept. of Biology, University of Genova, Italy; 2RCCS Azienda Ospedaliera Metropolitana, Genova, Italy; 3UO Proteomica e Spettrometria di Massa, IRCCS Ospedale Policlinico San Martino, Genova, Italy
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ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy
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19 | ADRENERGIC MODULATION OF THE HYPOTHALAMIC-PITUITARY-THYROID AXIS IN THE LIZARD PODARCIS SICULUS Francesca Carrella1, Assunta Lallo1, Stefania Boccia2, Maria De Falco3|4, Rosaria Sciarrillo1 | 1Department of Science and Technologies, University of Sannio, Benevento, Italy; 2Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Department of Biology, University of Naples “Federico II”, Naples, Italy; 4National Institute of Biostructures and Biosystems (INBB), Rome, Italy
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EX VIVO MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS Cirillo G1, Montella M2, La Mantia E2, Tedesco I2, De Luca C1, Virtuoso A1, De Angelis F1, Riccio L1, Esposito F3, Cirillo M3, Franco R2 and Papa M1 | 1Division of Human Anatomy, Neuronal Networks Morphology & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 3Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania Luigi Vanvitelli, Naples, Italy
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Peribiliary gland damage due to liver transplantation involves peribiliary vascular plexus and vascular endothelial growth factor
2516PDF: 805Supplementary: 294HTML: 17 -
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67 | DYNAMICS AND INTRACELLULAR TRAFFICKING OF M2R-DUALSTERIC AGONIST COMPLEX INTO GLIOBLASTOMA CELLS G. Scanavino1, C. Metelli1, L. Sileo1, C. Dallanoce2, Matera2, AM. Tata1 | 1Dept. of Biology and Biotechnology, University of Rome “Sapienza”, Italy; 2Dept. of Pharmaceutical Sciences, University of Milan, Italy
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P19 | IDENTIFICATION OF MIR-129-5P AS A COMMON REGULATOR OF E3 UBIQUITIN LIGASES WITH A POTENTIAL ROLE IN GLIOBLASTOMA PROGRESSION N. Martella1, A.B. Díaz Méndez2, G. Regazzo2, G.F. Bufalieri3, A. Frati4, A. Arcella4, L. Di Marcotullio3, M.G. Rizzo2, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Research, Advanced Diagnostics and Technological Innovation, Translational Oncology Research Unit, IRCCS -Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 4IRCCS Neuromed, Pozzilli (IS), Italy
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MicroRNA-29b-3p promotes 5-fluorouracil resistance via suppressing TRAF5-mediated necroptosis in human colorectal cancer
2117PDF: 1042Supplementary: 208HTML: 21 -
Species diversity regarding the presence of proximal tubular progenitor cells of the kidney
2043PDF: 789Supplementary: 313HTML: 372 -
Cell-penetrating peptides - Methods and protocols
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29 | IL-17 FAMILY IN POMACEA CANALICULATA: FIRST EVIDENCE OF A EXCLUSIVE NEURAL-SPECIFIC MEMBER A. Ferri1, S. Sacchi1, C. Losi2, N. Franchi1, U. Rosani3, D. Malagoli1|4 | 1Dept. of Life Science, University of Modena and Reggio Emilia, Italy; 2Dept. of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Italy; 3Dept. of Biology, University of Padova, Italy; 4NBFC, National Biodiversity Future Center, Italy
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12 | IMPACT OF COCAINE ON GASTROINTESTINAL BARRIER INTEGRITY S. Boccia1, B. Sgangarella Valvano2, A. Mileo3, A. Nebbioso4, A. De Luca1, A. Capaldo5, M. De Falco5|6 | 1Dept. of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy; 3Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 4Dept. of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 5Dept. of Biology, University of Naples Federico II, Naples, Italy
175PDF: 35
