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Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma

Yan Wang, Jie Sun, Ninghua Yao

16-11-2021

https://doi.org/10.4081/ejh.2021.3304

1401

PDF: 541

HTML: 21
Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy

Fenqiang Qi, Yuxin Deng, Wei Huang, Yanli Cai, Kelin Hong, Shui Xiang

15-10-2024

https://doi.org/10.4081/ejh.2024.4104

1759

PDF: 395

HTML: 1
Localization of avβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

G. Latella, A. Vetuschi, R. Sferra, S. Speca, E. Gaudio

e40

04-12-2013

https://doi.org/10.4081/ejh.2013.e40

3401

PDF: 895

HTML: 620
Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway

Xiaoyan Chu, Jun Lou, Yun Yi, Linlin Zhong, Ouping Huang

11-05-2023

https://doi.org/10.4081/ejh.2023.3653

925

PDF: 505

HTML: 27
NR4A3 suppresses bladder cancer progression by modulating autophagy via the PI3K/AKT/mTOR pathway

Li Fan, Feng Xu, Shouyong Liu, Ding Wu, Suchun Wang, Xin Pan, Yulin Zhou, Le Qu, Wenquan Zhou

30-06-2025

https://doi.org/10.4081/ejh.2025.4221

435

PDF: 243

HTML: 5
microRNA-16-5p suppresses cell proliferation and angiogenesis in colorectal cancer by negatively regulating forkhead box K1 to block the PI3K/Akt/mTOR pathway

Xin Huang, Xuan Xu, Huajing Ke, Xiaolin Pan, Jiaoyu Ai, Ruyi Xie, Guilian Lan, Yang Hu, Yao Wu

10-05-2022

https://doi.org/10.4081/ejh.2022.3333

1377

PDF: 796

HTML: 24
Study on the mechanism of Shenling Baizhu powder on the pathogenesis of pregnancy complicated with non-alcoholic fatty liver, based on PI3K/AKT/mTOR signal pathway

Yao Le, Zhijun Wang, Qian Zhang, Ling Miao, Xiaohong Wang, Guorong Han

17-09-2024

https://doi.org/10.4081/ejh.2024.4093

1785

PDF: 434

HTML: 35
Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway

Yuhan Wang, Gang Wang, Xiaojun Liu, Dong Yun, Qing Cui, Xiaoting Wu, Wenfeng Lu, Xiwen Yang, Ming Zhang

03-08-2022

https://doi.org/10.4081/ejh.2022.3336

1216

PDF: 632

HTML: 31
THE ROLE OF RETINAL mTOR IN RETINAL DEGENERATION Lazzeri G¹, Lenzi P¹, Ferrucci M¹, Biagioni F², Busceti CL², Giambelluca M¹, Puglisi-Allegra S² and Fornai F^1,2 | ¹Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa; ²IRCCS, Neuromed, Pozzilli, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4458

177
P25 | RESPONSE TO HEDGEHOG AND PI3K/AKT/MTOR PATHWAY INHIBITORS IN PREB-ALL: ANALYSIS OF THE INTRACELLULAR DISTRIBUTION OF PATHWAY ENZYMES AND OF THE AUTOPHAGY PROCESS M. Sicurella¹, M. De Chiara², E. Battaglia², F. Franco², M. De Vita², L.M. Neri² | ¹Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy; ²Department of Translational Medicine, University of Ferrara, Ferrara, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4345

133
Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway

Liyuan Yang, Chunfu Du, Hui Chen, Zhengwen Diao

17-11-2021

https://doi.org/10.4081/ejh.2021.3255

1010

PDF: 550

HTML: 36
Lobetyolin suppressed lung cancer in a mouse model by inhibiting epithelial-mesenchymal transition

Lu Liu, Zhankui Liu, Liu Yang, Xue Wu, Jiaying Zhu, Lili Liu, Yang Liu

04-07-2022

https://doi.org/10.4081/ejh.2022.3423

1851

PDF: 784

HTML: 57
AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells

L. Fassina, G. Magenes, A. Inzaghi, S. Palumbo, G. Allavena, C. Miracco, L. Pirtoli, M. Biggiogera, S. Comincini

e44

11-10-2012

https://doi.org/10.4081/ejh.2012.e44

1841

PDF: 903

Supplementary Figures: 287

Supplementary Table: 206

HTML: 494
Erratum - Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

Giovanni Latella, Antonella Vetuschi, Roberta Sferra, Silvia Speca, Eugenio Gaudio

13-10-2025

https://doi.org/10.4081/ejh.2025.4428

95

PDF: 76

HTML: 1
Morphology, clearing efficacy, and mTOR dependency of the organelle autophagoproteasome

Fiona Limanaqi, Francesca Biagioni, Alessandra Salvetti, Stefano Puglisi-Allegra, Paola Lenzi, Francesco Fornai

01-06-2021

https://doi.org/10.4081/ejh.2021.3220

1197

PDF: 470

HTML: 14
Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells

Weidong Wang, Sheng Chen, Yuan Wang, Cui Jie, Weimin Shen

01-09-2025

https://doi.org/10.4081/ejh.2025.4241

243

PDF: 194

HTML: 0
SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells via activating TGF-β/Smad2/3 signaling

Yiyu Qin, Jian Li, Hongchao Han, Yongliang Zheng, Haiming Lei, Yang Zhou, Hongyan Wu, Guozhe Zhang, Xiang Chen, Zhengping Chen

28-12-2023

https://doi.org/10.4081/ejh.2023.3899

927

PDF: 243

HTML: 3
Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi

22-04-2022

https://doi.org/10.4081/ejh.2022.3393

1061

PDF: 636

HTML: 18
Pretreatment with geniposide mitigates myocardial ischemia/reperfusion injury by modulating inflammatory response through TLR4/NF-κB pathway

Yanmei Yao, Leqing Lin, Wenxue Tang, Yueliang Shen, Fayu Chen, Ning Li, Baiyong Wang

08-09-2023

https://doi.org/10.4081/ejh.2023.3742

841

PDF: 405

HTML: 16
Knockdown of VEGFR2 inhibits proliferation and induces apoptosis in hemangioma-derived endothelial cells

J.M. Ou, Z.Y. Yu, M.K. Qiu, Y.X. Dai, Q. Dong, J. Shen, X.F. Wang, Y.B. Liu, Z.W. Quan, Z.W. Fei

17-03-2014

https://doi.org/10.4081/ejh.2014.2263

3201

PDF: 882

HTML: 577
Significance and relationship between DJ-1 gene and survivin gene expression in laryngeal carcinoma

Z. Shen, Y. Ren, D. Ye, J. Guo, C. Kang, H. Ding

e9

21-03-2011

https://doi.org/10.4081/ejh.2011.e9

1465

PDF: 446

HTML: 1649
The role of miRNA-29b1 on the hypoxia-induced apoptosis in mammalian cardiomyocytes

Bo Dai, Hailin Liu, Dingmin Juan, Kaize Wu, Ruhao Cao

27-06-2024

https://doi.org/10.4081/ejh.2024.4021

841

PDF: 379

HTML: 8
Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway

Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou

22-06-2022

https://doi.org/10.4081/ejh.2022.3394

1542

PDF: 995

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Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway

Suwei Dong, Yanbin Xiao, Ziqiang Zhu, Xiang Ma, Zhuohui Peng, Jianping Kang, Jianqiang Wang, Yunqing Wang, Zhen Li

17-05-2023

https://doi.org/10.4081/ejh.2023.3612

1002

PDF: 768

Supplementary: 68

HTML: 15
Expression and role of cocaine-amphetamine regulated transcript (CART) in the proliferation of biliary epithelium

Arianna Casini, Giorgio Vivacqua, Rosa Vaccaro, Anastasia Renzi, Stefano Leone, Luigi Pannarale, Antonio Franchitto, Paolo Onori, Romina Mancinelli, Eugenio Gaudio

19-10-2023

https://doi.org/10.4081/ejh.2023.3846

1508

PDF: 566

HTML: 14
Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

C. Pellicciari

30-12-2014

https://doi.org/10.4081/ejh.2014.2474

2028

PDF: 632

HTML: 803
Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi

23-06-2022

https://doi.org/10.4081/ejh.2022.3377

1439

PDF: 743

HTML: 20
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

17-09-2024

https://doi.org/10.4081/ejh.2024.4034

824

PDF: 381

HTML: 3
Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye

30-09-2021

https://doi.org/10.4081/ejh.2021.3224

2842

PDF: 1750

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Cellular and tissue expression of DAPIT, a phylogenetically conserved peptide

H. Kontro, J.J. Hulmi, P. Rahkila, H. Kainulainen

e18

22-05-2012

https://doi.org/10.4081/ejh.2012.18

1454

PDF: 651

HTML: 4794
Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan

17-06-2025

https://doi.org/10.4081/ejh.2025.4168

352

PDF: 188

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CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis

Yangying Peng, Shaojie Ding, Ping Xu, Xueyan Zhang, Jianzhang Wang, Tiantian Li, Liyun Liao, Xinmei Zhang

06-08-2024

https://doi.org/10.4081/ejh.2024.4052

770

PDF: 519

HTML: 23
Ion channels alterations in the forebrain of high-fat diet fed rats

Proshanta Roy, Ilenia Martinelli, Michele Moruzzi, Federica Maggi, Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni

23-11-2021

https://doi.org/10.4081/ejh.2021.3305

1934

PDF: 1001

HTML: 26
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

993

PDF: 585

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Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

07-04-2025

https://doi.org/10.4081/ejh.2025.4182

857

PDF: 468

HTML: 26
Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

Rong Tian, Gengsheng Mao

12-01-2022

https://doi.org/10.4081/ejh.2022.3350

1610

PDF: 779

HTML: 28
Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway

Zhongzhu Tang, Lei Wang, Yunwang Chen, Xiaomin Zheng, Runyu Wang, Bingxue Liu, Shiqi Zhang, Huimin Wang

07-08-2023

https://doi.org/10.4081/ejh.2023.3719

1245

PDF: 738

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P37 | THE ROLE OF ACTIN-BINDING PROTEINS IN ENDOMETRIOSIS W. Arendt¹, M. Hałas-Wiśniewska¹, M. Gagat², M. Izdebska¹ | ¹Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; ²Department of Histology and Embryology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Poland; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4359

135
Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication in vitro by reinforcing miR-192-5p/ATG7-induced autophagy

Minkai Cao, Deping Yuan, Hongxiu Jiang, Guanlun Zhou, Chao Chen, Guorong Han

02-09-2022

https://doi.org/10.4081/ejh.2022.3438

1302

PDF: 777

HTML: 27
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways

Zhi Wang, Guihua Jian, Teng Chen, Yiping Chen, Junhui Li, Niansong Wang

01-03-2023

https://doi.org/10.4081/ejh.2023.3648

1944

PDF: 872

HTML: 37
Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu

11-11-2024

https://doi.org/10.4081/ejh.2024.4063

1264

PDF: 354

HTML: 3
MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9

Qingwen Li, Jiao Zhang, Shougang Liu, Fangfei Zhang, Jiayi Zhuang, Yongfeng Chen

12-01-2022

https://doi.org/10.4081/ejh.2022.3275

1722

PDF: 707

Supplementary: 127

HTML: 30
Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

27-07-2023

https://doi.org/10.4081/ejh.2023.3506

1310

PDF: 876

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Histochemistry as an irreplaceable approach for investigating functional cytology and histology

C. Pellicciari

e41

19-12-2013

https://doi.org/10.4081/ejh.2013.e41

3227

PDF: 775

HTML: 404
P84 | OMOMYC PEPTIDE LOCALIZES IN THE NUCLEUS AND DISPLAYS ANTIPROLIFERATIVE EFFECTS ON CELLULAR MODELS OF HUMAN OSTEOSARCOMA I. Versari¹, S. Salucci¹, A. Bavelloni², M. Traversari³, I. Faenza¹ | ¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; ²Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4410

174
Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan

13-05-2024

https://doi.org/10.4081/ejh.2024.3917

1352

PDF: 510

HTML: 25
Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis

Manuel Scimeca, Simone Bischetti, Harpreet Kaur Lamsira, Rita Bonfiglio, Elena Bonanno

15-03-2018

https://doi.org/10.4081/ejh.2018.2841

12724

PDF: 6466

HTML: 280
DPY30 promotes the growth and survival of osteosarcoma cell by regulating the PI3K/AKT signal pathway

Gong Cheng, Fengmin An, Zhilin Cao, Mingdi Zheng, Zhongyuan Zhao, Hao Wu

22-12-2022

https://doi.org/10.4081/ejh.2023.3413

1073

PDF: 564

Supplementary: 74

HTML: 15
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment

Tao Wu, Shikui Wu, Hui Gao, Haolei Liu, Jun Feng, Ge Yin

23-10-2024

https://doi.org/10.4081/ejh.2024.4098

1694

PDF: 324

HTML: 7
LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

Yiming Zhang, Wanqiong Zheng, Liang Zhang, Yechun Gu, Lihe Zhu, Yingpeng Huang

20-06-2023

https://doi.org/10.4081/ejh.2023.3667

963

PDF: 522

Supplementary: 70

HTML: 12
Continuous cyclic mechanical tension increases ank expression in endplate chondrocytes through the TGF-Î²1 and p38 pathway

H. Xu, X. Zhang, H. Wang, Y. Zhang, Y. Shi, X. Zhang

e28

25-09-2013

https://doi.org/10.4081/ejh.2013.e28

2244

PDF: 629

HTML: 214
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

29-02-2024

https://doi.org/10.4081/ejh.2024.3977

1703

PDF: 927

Supplementary: 86

HTML: 47
Protective effect of different antioxidant agents in UVB-irradiated keratinocytes

Sara Salucci, Sabrina Burattini, Francesca Buontempo, Alberto Maria Martelli, Elisabetta Falcieri, Michela Battistelli

18-09-2017

https://doi.org/10.4081/ejh.2017.2784

2189

PDF: 940

HTML: 170
Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis

Jinbi Xie, Yong Ning, Lihang Zhang, Yuan Lin, Runsheng Guo, Shanjuan Wang

03-10-2022

https://doi.org/10.4081/ejh.2022.3477

1733

PDF: 551

HTML: 25
The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

Huyi Liu, Xiangdao Cai , Jia Liu, Fengxiang Zhang , Andong He, Ruiman Li

25-11-2021

https://doi.org/10.4081/ejh.2021.3323

1613

PDF: 598

HTML: 25
High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma

Yin Pan, Di Qiu, Shu Chen, Xiaoxue Han, Ruiman Li

11-05-2023

https://doi.org/10.4081/ejh.2023.3691

1076

PDF: 748

HTML: 18
STAT3 and SOCS3 expression patterns during murine placenta development

S. San Martin, J. Fitzgerald, M. Weber, M. PÃ¡rraga, T. SÃ¡ez, T.M. Zorn, U.R. Markert

e19

28-06-2013

https://doi.org/10.4081/ejh.2013.e19

3402

PDF: 766

HTML: 302
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

570

PDF: 292

HTML: 8
MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS

Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Gao

31-05-2022

https://doi.org/10.4081/ejh.2022.3342

926

PDF: 574

HTML: 23
Histochemistry in biology and medicine: a message from the citing journals

Carlo Pellicciari

23-12-2015

https://doi.org/10.4081/ejh.2015.2610

2869

PDF: 816

HTML: 881
Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai

14-10-2022

https://doi.org/10.4081/ejh.2022.3510

1141

PDF: 612

HTML: 28

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