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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Marco Biggiogera, Italy

1.9
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1.9
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3.7
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  • Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

    Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye
    30-09-2021
    https://doi.org/10.4081/ejh.2021.3224
    3919
    PDF: 1993
    HTML: 51
  • Characterizing the activation of the Wnt signaling pathway in hilar cholangiocarcinoma using a tissue microarray approach

    W. Chen, J. Liang, L. Huang, J. Cai, Y. Lei, J. Lai, L. Liang, K. Zhang
    09-02-2016
    https://doi.org/10.4081/ejh.2016.2536
    1990
    PDF: 917
    HTML: 351
  • LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

    Hu Li, Zheng Zeng, Xiang Yang, Ye Chen, Lei He, Ting Wan
    10-11-2020
    https://doi.org/10.4081/ejh.2020.3166
    1120
    PDF: 714
    HTML: 26
  • Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway

    Yanhong Xiao, Zhengdao Liu, Yougang Feng, Han Zhu, Bo Wang, Shulian Chen, Guobiao Liang
    23-07-2026
    https://doi.org/10.4081/ejh.2026.4575
    278
    PDF: 122
    HTML: 9
  • Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation, migration, and invasiveness by suppressing the PI3K/AKT/mTOR signaling pathway

    Xiaoyan Chu, Jun Lou, Yun Yi, Linlin Zhong, Ouping Huang
    11-05-2023
    https://doi.org/10.4081/ejh.2023.3653
    1590
    PDF: 767
    HTML: 49
  • Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

    Chixian Zhang, Kai Bai, Dexu Li
    14-04-2025
    https://doi.org/10.4081/ejh.2025.4186
    1563
    PDF: 562
    HTML: 42
  • Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma

    Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi
    23-06-2022
    https://doi.org/10.4081/ejh.2022.3377
    1902
    PDF: 1056
    HTML: 33
  • Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway

    Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li
    21-01-2025
    https://doi.org/10.4081/ejh.2025.4158
    1987
    PDF: 676
    Supplementary Figure: 120
    HTML: 69
  • SPRR2B knockdown inhibits the proliferation and inflammatory response in M5-treated human HaCaT keratinocytes

    Zhenzhen Ding, Chengchi Wang, Mingfeng Lv
    06-08-2026
    https://doi.org/10.4081/ejh.2026.4606
    200
    PDF: 167
    HTML: 12
  • Histopathological evaluation of RPL5 expression in triple-negative breast cancer: an integrated immunohistochemical and transcriptomic study

    Bing Zhao, Peiyuan Yu, Li Li , Zhenhui Zhao, Xiner Zhang
    23-07-2026
    https://doi.org/10.4081/ejh.2026.4599
    273
    PDF: 17
    HTML: 12
  • Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

    Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang
    29-04-2024
    https://doi.org/10.4081/ejh.2024.4019
    2099
    PDF: 809
    HTML: 35
  • CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure

    S. Huang, S. Guo, F. Guo, Q. Yang, X. Xiao, M. Murata, S. Ohnishi, S. Kawanishi, N. Ma
    e1
    14-01-2013
    https://doi.org/10.4081/ejh.2013.e1
    2215
    PDF: 930
    HTML: 898
  • Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress

    ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu
    11-11-2024
    https://doi.org/10.4081/ejh.2024.4063
    1745
    PDF: 670
    HTML: 29
  • SNORA38B promotes proliferation, migration, invasion and epithelial-mesenchymal transition of gallbladder cancer cells via activating TGF-β/Smad2/3 signaling

    Yiyu Qin, Jian Li, Hongchao Han, Yongliang Zheng, Haiming Lei, Yang Zhou, Hongyan Wu, Guozhe Zhang, Xiang Chen, Zhengping Chen
    28-12-2023
    https://doi.org/10.4081/ejh.2023.3899
    1269
    PDF: 409
    HTML: 13
  • Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

    Nan Li, Xue Fan, Lihong Liu, Yanbing Liu
    27-07-2023
    https://doi.org/10.4081/ejh.2023.3506
    1961
    PDF: 1183
    HTML: 31
  • LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway

    Yong Jiang, Chun-hui Xu, Ying Zhao, Yun-han Ji, Xin-tao Wang, Ying Liu
    16-01-2023
    https://doi.org/10.4081/ejh.2023.3526
    2092
    PDF: 904
    HTML: 70
  • Downregulation of GMPS inhibited the proliferation of hepatocellular cancer cells via the regulation of STAT3/c-Myc pathway

    Zhibin Guo, Juan Yu, Jing Sun, Sheng Yang, Jiang Pu
    15-06-2026
    https://doi.org/10.4081/ejh.2026.4541
    215
    PDF: 227
    Supplementary: 42
    HTML: 11
  • Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages

    Kui Long, Xiang Kui, Qingbin Zeng, Wenzhi Dong
    17-04-2025
    https://doi.org/10.4081/ejh.2025.4176
    1601
    PDF: 708
    Supplementary: 144
    HTML: 52
  • Aberrant expression of CCDC69 in breast cancer and its clinicopathologic significance

    Jinjiao Li, Panshi Zhang, Yun Xia
    22-02-2021
    https://doi.org/10.4081/ejh.2021.3207
    1698
    PDF: 922
    HTML: 42
  • Regulatory roles of ACSL5 in the anti-tumor function of palmitic acid (C16:0) via the ERK signaling pathway

    Jiapei Lv, Wang Yanting, Shan Wei
    08-11-2023
    https://doi.org/10.4081/ejh.2023.3867
    2239
    PDF: 1128
    HTML: 68
  • NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway

    Xuanjin Zhu, Weilu Jia, Yong Yan, Yong Huang, Bailin Wang
    02-07-2021
    https://doi.org/10.4081/ejh.2021.3246
    3185
    PDF: 838
    HTML: 45
  • Role of β-catenin expression in paediatric mesenchymal lesions: a tissue microarray-based immunohistochemical study

    A. Santoro, G. Pannone, M.E. Errico, D. Bifano, G. Lastilla, P. Bufo, C. Loreto, V. Donofrio
    e25
    02-07-2012
    https://doi.org/10.4081/ejh.2012.e25
    1643
    PDF: 711
    HTML: 5503
  • miR-19a targeting CLCA4 to regulate the proliferation, migration, and invasion of colorectal cancer cells

    Huiwen Li, Bo Huang
    10-03-2022
    https://doi.org/10.4081/ejh.2022.3381
    2302
    PDF: 805
    HTML: 33
  • The possible prognostic role of histone deacetylase and transforming growth factor β/Smad signaling in high grade gliomas treated by radio-chemotherapy: a preliminary immunohistochemical study

    Roberta Sferra, Simona Pompili, Claudio Festuccia, Francesco Marampon, Giovanni L. Gravina, Luca Ventura, Ernesto Di Cesare, Sara Cicchinelli, Eugenio Gaudio, Antonella Vetuschi
    16-05-2017
    https://doi.org/10.4081/ejh.2017.2732
    2802
    PDF: 1093
    HTML: 163
  • Morphological and immunohistochemical study of ovarian and tubal dysplasia associated with tamoxifen

    G. Chene, N. Radosevic-Robin, A.S. Tardieu, A. Cayre, I. Raoelfils, P. Dechelotte, J. Dauplat, F. Penault Llorca
    15-04-2014
    https://doi.org/10.4081/ejh.2014.2251
    2465
    PDF: 932
    HTML: 480
  • Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1

    Chuanchao Wei, Jiayue Wu, Weiyan Liu, Jingfeng Lu, Hongchang Li, Benjun Hai
    10-03-2021
    https://doi.org/10.4081/ejh.2021.3214
    1908
    PDF: 963
    Supplementary: 195
    HTML: 27
  • Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model

    Qichao Yin, Hua Xiong
    03-10-2022
    https://doi.org/10.4081/ejh.2022.3541
    1186
    PDF: 740
    HTML: 51
  • The clinical significance of UBE2C gene in progression of renal cell carcinoma

    Zhiping Chen, Lanfeng Wang
    29-03-2021
    https://doi.org/10.4081/ejh.2021.3196
    2026
    PDF: 970
    HTML: 40
  • Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma

    Sikuan Zheng, Yue Liu, Haohe Sun, Jingyu Jia, Tianlong Wu, Rui Ding, Xigao Cheng
    03-09-2021
    https://doi.org/10.4081/ejh.2021.3264
    2128
    PDF: 801
    Supplementary: 162
    HTML: 34
  • Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells

    Huina Su, Ruiqiong Ma, Dehui Su, Cheng Tan, Ye Zhu, Xin Yang
    21-04-2026
    https://doi.org/10.4081/ejh.2026.4537
    1130
    PDF: 664
    HTML: 37
  • Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

    Guangbao He, Yibo He, Hongwei Ni, Kai Wang, Yijun Zhu, Yang Bao
    26-07-2023
    https://doi.org/10.4081/ejh.2023.3766
    2345
    PDF: 1455
    HTML: 25
  • Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway

    Suwei Dong, Yanbin Xiao, Ziqiang Zhu, Xiang Ma, Zhuohui Peng, Jianping Kang, Jianqiang Wang, Yunqing Wang, Zhen Li
    17-05-2023
    https://doi.org/10.4081/ejh.2023.3612
    1694
    PDF: 1001
    Supplementary: 118
    HTML: 29
  • Vitamin D and vitamin D receptor in patients with ophthalmic pterygium

    Cristina Maxia, Daniela Murtas, Michela Corrias, Ignazio Zucca, Luigi Minerba, Franca Piras, Cristiana Marinelli, Maria Teresa Perra
    30-10-2017
    https://doi.org/10.4081/ejh.2017.2837
    2070
    PDF: 1072
    HTML: 84
  • MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

    Francesca Diomede, Maria Zingariello, Marcos F.X.B. Cavalcanti, Ilaria Merciaro, Jacopo Pizzicannella, Natalia de Isla, Sergio Caputi, Patrizia Ballerini, Oriana Trubiani
    24-05-2017
    https://doi.org/10.4081/ejh.2017.2791
    3490
    PDF: 1453
    HTML: 158
  • MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway

    Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo
    21-06-2022
    https://doi.org/10.4081/ejh.2022.3426
    1581
    PDF: 1005
    HTML: 39
  • Nuclear damages and oxidative stress: new perspectives for laminopathies

    G. Lattanzi, S. Marmiroli, A. Facchini, N.M. Maraldi
    e45
    18-10-2012
    https://doi.org/10.4081/ejh.2012.e45
    2179
    PDF: 996
    HTML: 212
  • miR-26b regulates cell proliferation and apoptosis of CD117+CD44+ ovarian cancer stem cells by targeting PTEN

    Zubiao Gao, Xiaofeng Ye, Anne Bordeaux, Stanka Hettich, Siyao Lin, Fang Han, Yan Jia
    04-02-2021
    https://doi.org/10.4081/ejh.2021.3186
    2430
    PDF: 800
    HTML: 29
  • Immunohistochemistry as a paramount tool in research of normal urothelium, bladder cancer and bladder pain syndrome

    Daša Zupančič, Rok Romih
    24-03-2021
    https://doi.org/10.4081/ejh.2021.3242
    2375
    PDF: 1366
    HTML: 24
  • Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea

    Wenjing Liu, Shanshan Ming, Xiaobing Zhao, Xin Zhu, Yuxiang Gong
    01-09-2023
    https://doi.org/10.4081/ejh.2023.3704
    1317
    PDF: 1075
    HTML: 33
  • Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by PAC1-immunopositive retinal ganglion cells in the postnatal rat retina

    Viktória Dénes, Kármen Kovacs, Ákos Lukáts, Adrienn Mester, Gergely Berta, Arnold Szabó, Robert Gabriel
    27-04-2022
    https://doi.org/10.4081/ejh.2022.3373
    2044
    PDF: 943
    HTML: 48
  • Visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis

    Hai-rong Fu, Xiao-shan Li, Yong-hui Zhang, Bin-bin Feng, Lian-hong Pan
    07-09-2020
    https://doi.org/10.4081/ejh.2020.3131
    1393
    PDF: 992
    HTML: 20
  • Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis

    Tao Wu, Shikui Wu, Hailu Jiao, Jun Feng, Xiang Zeng
    02-10-2023
    https://doi.org/10.4081/ejh.2023.3839
    1636
    PDF: 890
    HTML: 52
  • LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4 expression by sponging miR-873-5p in hepatocellular carcinoma

    Nuobei Zhang, Hao Shen, Shenan Huang, Fenfen Wang, Huifang Liu, Fen Xie, Lei Jiang, Xin Chen
    16-11-2021
    https://doi.org/10.4081/ejh.2021.3300
    1399
    PDF: 765
    HTML: 64
  • Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity

    Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Seyed-Moayed Alavian, Kamran B. Lankarani, Parisa Farrokh, Jens Randel Nyengaard
    29-01-2018
    https://doi.org/10.4081/ejh.2018.2859
    2466
    PDF: 1130
    HTML: 88
  • Docetaxel-resistant triple-negative breast cancer cell-derived exosomal lncRNA LINC00667 reduces the chemosensitivity of breast cancer cells to docetaxel via targeting miR-200b-3p/Bcl-2 axis

    Jindong Li, Jie Kang, Weiyan Liu, Jiazhe Liu, Gaofeng Pan, Anwei Mao, Qing Zhang, Jingfeng Lu, Junbin Ding, Hongchang Li
    25-10-2022
    https://doi.org/10.4081/ejh.2022.3529
    1897
    PDF: 924
    HTML: 47
  • Angiotensin II: immunohistochemical study in Sardinian pterygium

    P. Demurtas, M. Corrias, I. Zucca, C. Maxia, F. Piras, P. Sirigu, M.T. Perra
    28-07-2014
    https://doi.org/10.4081/ejh.2014.2426
    2260
    PDF: 835
    HTML: 368
  • Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

    M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta
    14-04-2016
    https://doi.org/10.4081/ejh.2016.2640
    3372
    PDF: 1466
    HTML: 605
  • Downregulation of SRPK2 promotes cell cycle arrest though E2F1 in non-small cell lung cancer

    Xin Li, Shaoyu Yang, Minna Zhang, Shuhuan Xie, Zefeng Xie
    11-12-2019
    https://doi.org/10.4081/ejh.2019.3067
    2200
    PDF: 1192
    HTML: 28
  • Twenty years of histochemistry in the third millennium, browsing the scientific literature

    Carlo Pellicciari
    29-12-2020
    https://doi.org/10.4081/ejh.2020.3213
    1494
    PDF: 574
    HTML: 17
  • Three-dimensional apoptotic nuclear behavior analyzed by means of Field Emission in Lens Scanning Electron Microscope

    S. Salucci, S. Burattini, E. Falcieri, P. Gobbi
    15-09-2015
    https://doi.org/10.4081/ejh.2015.2539
    1700
    PDF: 1057
    HTML: 382
  • Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry

    E. Guerriero, M. Accardo, F. Capone, G. Colonna, G. Castello, S. Costantini
    01-12-2014
    https://doi.org/10.4081/ejh.2014.2433
    4363
    PDF: 868
    HTML: 428
  • Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas

    Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi
    22-04-2022
    https://doi.org/10.4081/ejh.2022.3393
    1491
    PDF: 811
    HTML: 32
  • Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry

    Claudio Casali, Stella Siciliani, Lorena Zannino, Marco Biggiogera
    20-04-2022
    https://doi.org/10.4081/ejh.2022.3409
    1928
    PDF: 1028
    HTML: 36
  • Clinicopathological assessment of PD-1/PD-L1 immune checkpoint expression in desmoid tumors

    Kazuhiko Hashimoto, Shunji Nishimura, Yu Shinyashiki, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi
    26-04-2023
    https://doi.org/10.4081/ejh.2023.3688
    1014
    PDF: 724
    HTML: 28
  • P53 | CIRCADIAN DEPENDENT MOTILITY: THE ROLE FOR THE PERINUCLEAR ACTIN CAP E. Montacci1, M. Sgarzi2, L. Dall’Olio3, E. Giampieri4, D. Romaniello4, M. Lauriola5 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Laboratory of Data Science and Bioinformatics, IRCSS Institute of Neurological Sciences, Bellaria Hospital, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 5Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4375
    332
  • Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters

    Michael Williams Leal Quirino, Michelly Cristiny Pereira, Maria de Fátima Deodato de Souza, Ivan da Rocha Pitta, Antônio Felix da Silva Filho, Mario S. de Souza Albuquerque, Amanda Pinheiro de Barros Albuquerque, Mário Rino Martins, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo
    04-03-2021
    https://doi.org/10.4081/ejh.2021.3174
    8928
    PDF: 1327
    Supplementary: 249
    HTML: 22
  • Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis

    Liyun Guan, Shifa Yuan, Jing Ma, Hong Liu, Lizhen Huang, Fengzhen Zhang
    11-01-2023
    https://doi.org/10.4081/ejh.2023.3570
    1611
    PDF: 761
    HTML: 44
  • GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

    Mário S. de Souza Albuquerque, Antônio F. da Silva-filho, Marina Ferraz Cordeiro, Maria de Fátima Deodato de Souza, Michael W.L. Quirino, Luiza R. Amorim Lima, Maira G. da Rocha Pitta, Mario R. Martins, Moacyr J.B. de Melo Rêgo
    14-06-2018
    https://doi.org/10.4081/ejh.2018.2931
    3650
    PDF: 645
    Supplementary: 257
    HTML: 40
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Vol. 70 No. 2 (2026)
Ketogenic diet regulates Uch-L1(C) to improve cerebral energy metabolism and cognitive function in Alzheimer's disease mice
Nana Bao et al.
20 April 2026
Vol. 70 No. 2 (2026)
Senolytics alleviate cyclophosphamide-induced premature ovarian insufficiency by eliminating senescent cells
Huina Su et al.
21 April 2026
Vol. 70 No. 2 (2026)
Electroacupuncture combined with rTMS promotes neuronal regeneration via DNMT1-mediated PI3K-AKT pathway in cerebral palsy model
Juan Fan et al.
20 April 2026

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European Journal of Histochemistry

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