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• 

  Lipid droplets characterization in adipocyte differentiated 3T3-L1 cells: size and optical density distribution

  V. Rizzatti, F. Boschi, M. Pedrotti, E. Zoico, A. Sbarbati, M. Zamboni

  e24

  06-08-2013

  https://doi.org/10.4081/ejh.2013.e24

  4199

  PDF: 1700

  HTML: 385
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  Folic acid promotes autophagy to relieve metabolism-associated fatty liver disease by regulating NRF2

  Yu Wen, Juan Luo, Chunjing Shi, Jie Wu

  03-11-2025

  https://doi.org/10.4081/ejh.2025.4309

  268

  PDF: 240

  HTML: 4
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  Investigation of seasonal changes in lipid synthesis and metabolism-related genes in the oviduct of Chinese brown frog (Rana dybowskii)

  Yankun Wang, Yuning Liu, Yawei Wang, Ao Zhang, Wenqian Xie, Haolin Zhang, Qiang Weng, Meiyu Xu

  20-12-2023

  https://doi.org/10.4081/ejh.2023.3890

  898

  PDF: 503

  HTML: 13
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  Lipids: Evergreen autofluorescent biomarkers for the liver functional profiling

  Anna Cleta Croce, Giovanni Bottiroli

  01-06-2017

  https://doi.org/10.4081/ejh.2017.2808

  1513

  PDF: 744

  HTML: 126
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  Polydatin reverses oxidation low lipoprotein (oxLDL)-induced apoptosis of human umbilical vein endothelial cells via regulating the miR-26a-5p/BID axis

  Dajie Wang, Zhaofeng Zhou, Liang Yuan

  20-09-2022

  https://doi.org/10.4081/ejh.2022.3505

  1039

  PDF: 513

  HTML: 33
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  Carotenoids co-localize with hydroxyapatite, cholesterol, and other lipids in calcified stenotic aortic valves. Ex vivo Raman maps compared to histological patterns

  A. Bonetti, A. Bonifacio, A. Della Mora, U. Livi, M. Marchini, F. Ortolani

  20-04-2015

  https://doi.org/10.4081/ejh.2015.2505

  1868

  PDF: 1080

  HTML: 379
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  Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

  Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferra

  21-06-2022

  https://doi.org/10.4081/ejh.2022.3391

  2784

  PDF: 1704

  HTML: 40
• 

  Autofluorescence spectroscopy and imaging: a tool for biomedical research and diagnosis

  A.C. Croce, G. Bottiroli

  12-12-2014

  https://doi.org/10.4081/ejh.2014.2461

  12381

  PDF: 5253

  HTML: 7937

• Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α)

  Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan

  13-05-2024

  https://doi.org/10.4081/ejh.2024.3917

  1300

  PDF: 483

  HTML: 25
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  Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

  M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

  14-04-2016

  https://doi.org/10.4081/ejh.2016.2640

  2697

  PDF: 1226

  HTML: 585
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  Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

  Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye

  30-09-2021

  https://doi.org/10.4081/ejh.2021.3224

  2789

  PDF: 1715

  HTML: 32
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  Study on the mechanism of Shenling Baizhu powder on the pathogenesis of pregnancy complicated with non-alcoholic fatty liver, based on PI3K/AKT/mTOR signal pathway

  Yao Le, Zhijun Wang, Qian Zhang, Ling Miao, Xiaohong Wang, Guorong Han

  17-09-2024

  https://doi.org/10.4081/ejh.2024.4093

  1660

  PDF: 414

  HTML: 35
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  Effects of lead pollution on Ammonia parkinsoniana (foraminifera): ultrastructural and microanalytical approaches

  F. Frontalini, D. Curzi, F.M. Giordano, J.M. Bernhard, E. Falcieri, R. Coccioni

  30-01-2015

  https://doi.org/10.4081/ejh.2015.2460

  2288

  PDF: 802

  HTML: 1113
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  Calcium-induced alteration of mitochondrial morphology and mitochondrial-endoplasmic reticulum contacts in rat brown adipocytes

  I. Golic, K. Velickovic, M. Markelic, A. Stancic, A. Jankovic, M. Vucetic, V. Otasevic, B. Buzadzic, B. Korac, A. Korac

  09-09-2014

  https://doi.org/10.4081/ejh.2014.2377

  3177

  PDF: 1010

  HTML: 1543
• 

  Forever particles: histochemistry in the plasticene age

  Beatrice Camia, Andrea Casasco, Manuela Monti

  01-08-2025

  https://doi.org/10.4081/ejh.2025.4226

  498

  PDF: 252

  HTML: 3
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  Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis

  Manuel Scimeca, Simone Bischetti, Harpreet Kaur Lamsira, Rita Bonfiglio, Elena Bonanno

  15-03-2018

  https://doi.org/10.4081/ejh.2018.2841

  12516

  PDF: 6397

  HTML: 263
• 

  Effects of Notch signaling on proliferation, angiogenesis, and adipogenesis of hemangioma-derived stem cells

  Weidong Wang, Sheng Chen, Yuan Wang, Cui Jie, Weimin Shen

  01-09-2025

  https://doi.org/10.4081/ejh.2025.4241

  224

  PDF: 179

  HTML: 0
• 

  In vivo imaging techniques: a new era for histochemical analysis

  A. Busato, P. Fumene Feruglio, P.P. Parnigotto, P. Marzola, A. Sbarbati

  28-11-2016

  https://doi.org/10.4081/ejh.2016.2725

  1797

  PDF: 816

  HTML: 277
• 

  A spectrofluorometric analysis to evaluate transcutaneous biodistribution of fluorescent nanoparticulate gel formulations

  Enrica Cappellozza, Federico Boschi, Maddalena Sguizzato, Elisabetta Esposito, Rita Cortesi, Manuela Malatesta, Laura Calderan

  07-02-2022

  https://doi.org/10.4081/ejh.2022.3321

  1390

  PDF: 578

  HTML: 18
• 

  Transmission electron microscopy for nanomedicine: novel applications for long-established techniques

  Manuela Malatesta

  09-12-2016

  https://doi.org/10.4081/ejh.2016.2751

  2074

  PDF: 1413

  HTML: 252
• 

  Autofluorescence in freshly isolated adult human liver sinusoidal cells

  Anett Kristin Larsen, Jaione Simón-Santamaría, Kjetil Elvevold, Bo Göran Ericzon, Kim Erlend Mortensen, Peter McCourt, Bård Smedsrød, Karen Kristine Sørensen

  13-12-2021

  https://doi.org/10.4081/ejh.2021.3337

  2085

  PDF: 820

  HTML: 52
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  Seasonal expressions of GPR41 and GPR43 in the colon of the wild ground squirrels (Spermophilus dauricus)

  Xiaoying Yang, Xuhao Liu, Fengcheng Song, Hao Wei, Fuli Gao, Haolin Zhang, Yingying Han, Qiang Weng, Zhengrong Yuan

  21-01-2022

  https://doi.org/10.4081/ejh.2022.3351

  1490

  PDF: 681

  HTML: 28
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  Morphological and histochemical characterization of the secretory epithelium in the canine lacrimal gland

  Tadashi Yasui, Kenya Miyata, Chie Nakatsuka, Azuma Tsukise, Hiroshi Gomi

  02-11-2021

  https://doi.org/10.4081/ejh.2021.3320

  1518

  PDF: 655

  HTML: 21

• PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS L. Morello¹, G. Stati¹, V. Giansante¹, S. Lattanzio¹, P. Cerritelli¹, D. Bruni¹, S. Cinti², R. Di Pietro^1,3,4 | ¹Department of Medicine and Aging Sciences, “G. d’ Annunzio” University of Chieti-Pescara, Chieti, Italy; ²Department of Experimental and Clinical Medicine, Center of Obesity, Polytechnic University of Marche, Ancona, Italy; ³StemTeCh Group, G. d’ Annunzio Foundation, “G. d’ Annunzio” University of Chieti Pescara, Chieti, Italy; ⁴Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4379

  167
• 

  Lipofuscin, lipofuscin-like pigments and autofluorescence

  G. Di Guardo

  06-02-2015

  https://doi.org/10.4081/ejh.2015.2485

  3853

  PDF: 1710

  HTML: 490
• 

  Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry

  Claudio Casali, Stella Siciliani, Lorena Zannino, Marco Biggiogera

  20-04-2022

  https://doi.org/10.4081/ejh.2022.3409

  1538

  PDF: 826

  HTML: 21
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  Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine

  Flavia Carton, Manuela Malatesta

  24-11-2022

  https://doi.org/10.4081/ejh.2022.3603

  806

  PDF: 368

  HTML: 15
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  An ex vivo experimental system to track fluorescent nanoparticles inside skeletal muscle

  Laura Calderan, Flavia Carton, Ilaria Andreana, Valeria Bincoletto, Silvia Arpicco, Barbara Stella, Manuela Malatesta

  22-12-2022

  https://doi.org/10.4081/ejh.2023.3596

  995

  PDF: 546

  HTML: 30
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  Guilu Erxian oral liquid mitigates oxidative damage in spermatogonial cells via miR-6739-5p modulation and PI3K/AKT pathway activation: a functional histocytochemical study

  Zefeng Sun, Xinrong Fan, Zhenquan Liu

  02-10-2025

  https://doi.org/10.4081/ejh.2025.4253

  174

  PDF: 154

  HTML: 16
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  Histochemistry as an irreplaceable approach for investigating functional cytology and histology

  C. Pellicciari

  e41

  19-12-2013

  https://doi.org/10.4081/ejh.2013.e41

  3217

  PDF: 772

  HTML: 404
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  Visualizing endocytotic pathways at transmission electron microscopy via diaminobenzidine photo-oxidation by a fluorescent cell-membrane dye

  S. Grecchi, M. Malatesta

  22-10-2014

  https://doi.org/10.4081/ejh.2014.2449

  2334

  PDF: 903

  Supplementary: 252

  HTML: 705
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  Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands

  Tadashi Yasui, Hiroshi Gomi, Taishi Kitahara, Azuma Tsukise

  08-08-2017

  https://doi.org/10.4081/ejh.2017.2828

  1562

  PDF: 616

  HTML: 146
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  Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

  Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

  27-07-2023

  https://doi.org/10.4081/ejh.2023.3506

  1263

  PDF: 844

  HTML: 13

• THE ROLE OF RETINAL mTOR IN RETINAL DEGENERATION Lazzeri G¹, Lenzi P¹, Ferrucci M¹, Biagioni F², Busceti CL², Giambelluca M¹, Puglisi-Allegra S² and Fornai F^1,2 | ¹Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa; ²IRCCS, Neuromed, Pozzilli, Italy

  12-12-2025

  https://doi.org/10.4081/ejh.2025.4458

  167

• P43 | NEW INSIGHTS IN THE ACTIVATION OF FERROPTOSIS PROCESS DURING LIVER FIBROSIS R. Mancinelli¹, S. Leone¹, A. Casini¹, R. Vaccaro¹, M. Tagliafierro¹, F.M. Bassi¹, E. Bocci¹, S. Vitale¹, A. Franchitto², L. Pannarale¹, P. Onori¹, E. Gaudio¹ | ¹Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; ²Division of Health Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4365

  133
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  Maternal dietary loads of alpha-tocopherol increase synapse density and glial synaptic coverage in the hippocampus of adult offspring

  S. Salucci, P. Ambrogini, D. Lattanzi, M. Betti, P. Gobbi, C. Galati, F. Galli, R. Cuppini, A. Minelli

  02-05-2014

  https://doi.org/10.4081/ejh.2014.2355

  1960

  PDF: 856

  HTML: 460
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  Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction

  Jinshuang Li, Dawei Xu, Ce Shi, Chunqi Cheng, Ziheng Xu, Xingjuan Gao, Yong Cheng

  28-10-2024

  https://doi.org/10.4081/ejh.2024.4122

  1015

  PDF: 389

  HTML: 7

• Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

  Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

  29-02-2024

  https://doi.org/10.4081/ejh.2024.3977

  1647

  PDF: 905

  Supplementary: 83

  HTML: 44
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  MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS

  Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Gao

  31-05-2022

  https://doi.org/10.4081/ejh.2022.3342

  900

  PDF: 570

  HTML: 23
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  Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

  C. Pellicciari

  30-12-2014

  https://doi.org/10.4081/ejh.2014.2474

  1965

  PDF: 628

  HTML: 802
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  circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes

  Ziyang Yu, Wenbo Xu, Yirong Teng, Tingting Li, Ren Guo, Ju Li, Xichen Li, Yanping Li, Yinglu Hao

  22-08-2025

  https://doi.org/10.4081/ejh.2025.4230

  214

  PDF: 167

  HTML: 1
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  Localization of avβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

  G. Latella, A. Vetuschi, R. Sferra, S. Speca, E. Gaudio

  e40

  04-12-2013

  https://doi.org/10.4081/ejh.2013.e40

  3344

  PDF: 889

  HTML: 620
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  Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

  Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

  06-08-2025

  https://doi.org/10.4081/ejh.2025.4228

  516

  PDF: 257

  HTML: 4
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  Irisin suppresses PDGF-BB-induced proliferation of vascular smooth muscle cells in vitro by activating AMPK/mTOR-mediated autophagy

  Fenqiang Qi, Yuxin Deng, Wei Huang, Yanli Cai, Kelin Hong, Shui Xiang

  15-10-2024

  https://doi.org/10.4081/ejh.2024.4104

  1664

  PDF: 379

  HTML: 1
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  Oxygen tension-independent protection against hypoxic cell killing in rat liver by low sodium

  Andrea Ferrigno, Laura G. Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti

  30-05-2017

  https://doi.org/10.4081/ejh.2017.2798

  1789

  PDF: 636

  HTML: 70
• 

  LOX-1 deficient mice show resistance to zymosan-induced arthritis

  Kazuhiko Hashimoto, Yutaka Oda, Koichi Nakagawa, Terumasa Ikeda, Kazuhiro Ohtani, Masao Akagi

  22-01-2018

  https://doi.org/10.4081/ejh.2018.2847

  1761

  PDF: 791

  HTML: 63
• 

  Role of water in chromosome spreading and swelling induced by acetic acid treatment: a FTIR spectroscopy study

  D. Ami, M. Di Segni, M. Forcella, V. Meraviglia, M. Baccarin, S.M. Doglia, G. Terzoli

  11-02-2014

  https://doi.org/10.4081/ejh.2014.2330

  3581

  PDF: 918

  Supplementary: 249

  HTML: 712
• 

  High glucose inhibits neural differentiation by excessive autophagy via peroxisome proliferator-activated receptor gamma

  Yin Pan, Di Qiu, Shu Chen, Xiaoxue Han, Ruiman Li

  11-05-2023

  https://doi.org/10.4081/ejh.2023.3691

  1059

  PDF: 742

  HTML: 18
• 

  Neurodegeneration in zebrafish embryos and adults after cadmium exposure

  Antonio Monaco, Teresa Capriello, Maria C. Grimaldi, Valentina Schiano, Ida Ferrandino

  19-10-2017

  https://doi.org/10.4081/ejh.2017.2833

  2862

  PDF: 1129

  HTML: 140

• P41 | INVOLVEMENT OF THE DOLPHIN’S MELON IN IMMUNE FUNCTION G.P. Lombardo¹, A. Miller², L. Spiccia¹, V. Natale¹, F. Pellicanò¹, G. Squadrito¹, E. R. Lauriano¹ | ¹Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina; ²Department of Veterinary Sciences, University of Messina, Messina, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4363

  123
• 

  Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma

  Zhiyang Wang, Jing Li, Ziwei Liu, Ling Yue

  20-03-2023

  https://doi.org/10.4081/ejh.2023.3622

  908

  PDF: 605

  HTML: 28
• 

  Vitamin D and vitamin D receptor in patients with ophthalmic pterygium

  Cristina Maxia, Daniela Murtas, Michela Corrias, Ignazio Zucca, Luigi Minerba, Franca Piras, Cristiana Marinelli, Maria Teresa Perra

  30-10-2017

  https://doi.org/10.4081/ejh.2017.2837

  1742

  PDF: 927

  HTML: 62
• 

  Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway

  Hui Yang, Yunlong Zhang, Desheng Zhang, Liping Qian, Tianxing Yang, Xiaocheng Wu

  12-09-2023

  https://doi.org/10.4081/ejh.2023.3697

  968

  PDF: 542

  HTML: 8
• 

  Clathrin-dependent endocytosis of membrane-bound RANKL in differentiated osteoclasts

  P. Narducci, R. Bortul, R. Bareggi, V. Nicolin

  e6

  08-03-2010

  https://doi.org/10.4081/ejh.2010.e6

  1431

  PDF: 507

  HTML: 6016
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  Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study

  Sabrina Giacoppo, Agnese Gugliandolo, Oriana Trubiani, Federica Pollastro, Gianpaolo Grassi, Placido Bramanti, Emanuela Mazzon

  23-01-2017

  https://doi.org/10.4081/ejh.2017.2749

  5689

  PDF: 1241

  HTML: 385
• 

  Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis

  F. Rappa, E. Unti, P. Baiamonte, F. Cappello, N. Scibetta

  e20

  28-06-2013

  https://doi.org/10.4081/ejh.2013.e20

  2668

  PDF: 620

  HTML: 337

• P11 | DOMINO TRANSPLANTATION IN MNGIE: IS THE LIVER A SUITABLE GRAFT? E. Boschetti¹, I. Neri¹, S. Blando¹, C. Malagelada², L. Caporali³, R. D’Angelo⁴, R. Rinaldi⁴, S. Mongiorgi¹, V. Carelli³, R. De Giorgio⁵, L. Manzoli¹, S. Ratti¹ | ¹Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum – University of Bologna, Italy; ²Digestive System Research Unit, University Hospital Vall d’Hebron; Barcelona, Spain; ³IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; ⁴IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; ⁵Department of Translational Medicine, University of Ferrara, Ferrara, Italy

  21-08-2025

  https://doi.org/10.4081/ejh.2025.4331

  133
• 

  Histochemistry in biology and medicine: a message from the citing journals

  Carlo Pellicciari

  23-12-2015

  https://doi.org/10.4081/ejh.2015.2610

  2844

  PDF: 812

  HTML: 881
• 

  Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve

  A. Arcucci, M.R. Ruocco, F. Albano, G. Granato, V. Romano, G. Corso, C. Bancone, E. De Vendittis, A. Della Corte, S. Montagnani

  18-07-2014

  https://doi.org/10.4081/ejh.2014.2383

  1951

  PDF: 2078

  HTML: 340

• Atorvastatin reduces calcification in valve interstitial cells via the NF-κB signalling pathway by promoting Atg5-mediated autophagy

  Menghui Chen, Su Liu

  12-04-2024

  https://doi.org/10.4081/ejh.2024.3983

  997

  PDF: 435

  HTML: 8