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Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
1751PDF: 1052Supplementary: 146HTML: 54 -
Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances
2566PDF: 924Supplementary: 253HTML: 55 -
LncRNA RP11-708J19.2 promotes colorectal cancer progression by binding to SIRT7 via regulating H3K18ac
458PDF: 183Supplementary: 128HTML: 43 -
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy
3319PDF: 1859Video 1: 333Video 2: 378HTML: 54 -
LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira1, S. Grassilli2, M. Pierantoni1, V. Bertagnolo1, F. Brugnoli1 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy
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P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS M.V. Marvi1, C. Evangelisti1, I. Rusciano1, I. Neri1, L.I. Cocco1, L. Manzoli1, C. Capanni2, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy; 2CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza», Unit of Bologna, Bologna, Italy / IRCCS Rizzoli Orthopedi, Institute, Bologna, Italy
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24 | ADMINISTRATION OF BRANCHED-CHAIN AMINO ACIDS AND DI-ALANINE MITIGATES MUSCLE ATROPHY IN A MOUSE MODEL OF CANCER CACHEXIA M. Colardo1, N. Martella1, M. Varone1, D. Pensabene1, G. Caretti2, G. Bianchini3, A. Aramini3, M. Segatto1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Biosciences, University of Milan, Italy; 3Research & Early Development, Dompé Farmaceutici S.p.A., L’Aquila, Italy
181PDF: 110 -
RNA interference - From Biology to clinical applications
1186PDF: 552HTML: 370 -
In vivo imaging techniques: a new era for histochemical analysis
2247PDF: 1009HTML: 314 -
NEUROPROTECTIVE POTENTIAL OF ADIPOSE MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES ON DAMAGED MOTONEURONS Caprioli M1, Sganzerla D1, Scambi I1, Virla F1, Grazioli N2, Greco N2, Turano E1 and Mariotti R1 | 1Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 2Department of Engineering for Innovation Medicine, University of Verona, Italy
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IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft1, L. Tratnjek1, A. Janev1, N. Resnik1, U. Cerkvenik1, U. D. Jerman1, G. Markovič1, T.Ž. Ramuta1, T. Višnjar1, Ž. Sardoč1, A.Punčuh1, S. Kralj2, M. Čemažar3, P. Veranič1 |1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 2Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; 3Institute of Oncology Ljubljana, Ljubljana, Slovenia
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ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA
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Optimization of the autophagy measurement in a human cell line and primary cells by flow cytometry
2299PDF: 1342Supplementary: 242HTML: 64 -
P30 | P75NTR MODULATION IMPROVES RESILIENCE TO OXIDATIVE DAMAGE IN A MICROGLIAL CELL MODEL OF PARKINSON’S DISEASE A. Valenza1, D. Pensabene2, F. Rendina1, M. Muzzi2, A. Fracassi3, M. Segatto2, S. Moreno1|3 | 1Dept. of Science, University Roma Tre, Rome, Italy; 2Dept. of Biosciences and Territory, University of Molise, Pesche, Italy; 3Dept. of Neurology, UTMB, Galveston, TX, USA
182PDF: 92 -
P80 | MITOCHONDRIA-LYSOSOME INTERACTIONS: EMERGING PLAYERS IN GLIOMA L. Zeppa1, M.B. Morelli2, C. Aguzzi2, M. Giangrossi2, M. Nabissi2, G. Cameli2, G. Santoni2, S.K. Tayebati2, V. Bellitto1, D. Tomassoni1, C. Amantini1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Pharmacy, University of Camerino, Camerino, Italy
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P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri1, M.V. Marvi1, V. Righi2, V. Papa3, E. Boschetti1, S. Blando1, E. Franceschi4, M. Zoli4, D. Mazzatenta4, N. Neri4, A. Vignaroli4, L. Cocco1, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Sciences, University of Bologna, Bologna, Italy; 3IRCCS St. Orsola, Bologna, Italy; 4IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
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31 | LOSS OF IMPG2 PARALOGS LEADS TO RETINAL DEGENERATION IN ZEBRAFISH DOUBLE KNOCK-OUT MODEL C. Fogliano1, A. Cumplido Mayoral2, L. Balasco2, S. Casarosa2|3, B. Avallone1 | 1Dept. of Biology, University of Naples Federico II, Italy 2Dept. of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Italy; 3Center for Medical Sciences, University of Trento, Italy
203PDF: 94 -
HUMAN INDUCED PLURIPOTENT STEM CELLS-DERIVED CEREBRAL ORGANOIDS AS A MODEL FOR C9ORF72-LINKED FRONTO-TEMPORAL DEMENTIA: INSIGHTS INTO NEURONAL AND GLIAL DIFFERENTIATION DYNAMICS Ferrero C1,2,3, Pacca P1,2, Vercelli A1,2 and Boido M1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Italy 3University School for Advanced Studies IUSS Pavia, Pavia, Italy
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Mistletoe - From mythology to evidence-based medicine
1603PDF: 697HTML: 165 -
Elastofibroma dorsi: a histochemical and immunohistochemical study
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P68 | EARLY EFFECTS OF MECHANOACUSTIC FOCUSED VIBRATION (MFV) ON PRIMARY HUMAN SATELLITE CELLS ISOLATED FROM YOUNG AND OLDER INDIVIDUALS S. Sancilio1, G. Stati1, E.S. Di Filippo2, S. Fulle2, R. Di Pietro1 | 1Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neuroscience Imaging and Clinical Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
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P83 | INFLAMMATORY PROFILE IN SKIN, LUNG, AND KIDNEY OF A HOCL-INDUCED MURINE MODEL OF SYSTEMIC SCLEROSIS: AN IMMUNOHISTOCHEMICAL STUDY G. Vermiglio1, J. Freni1, F. Nicita1, A. Centofanti1, D. Labellarte1, E. Rizzuto1, A. Favaloro1, M. Runci Anastasi2, G.P. Anastasi1, G. Cutroneo1 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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17 | EXPLORING THE FUNCTIONAL ROLE OF THE PROTEOGLYCAN ESM1 IN THE BREAST CANCER TUMOR MICROENVIRONMENT E. Peri1, S. Feo1|2, E. Roz3, A. D’Ascola4, P. Cancemi1|2 | 1Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy; 2Experimental Center of Onco Biology (COBS), Palermo, Italy; 3La Maddalena Hospital III Level Oncological Department, Palermo, Italy; 4Department of Clinical and Experimental Medicine, University of Messina, Italy
193PDF: 136 -
44 | CHARACTERIZATION OF IMMUNE CELLS IN THE ADIPOSE TISSUE OF OBESE MICE TREATED WITH ANTI-OBESITY THERAPIES G.P. Lombardo1, A. Nunnari1, A. Miller2, M. Kotańska3, S. Fiorentino1, E.R. Lauriano1 | 1Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 2Department for the Promotion of Human Sciences and Quality of Life, San Raffaele University, Rome, Italy; 3Department of Pharmacodynamics, Jagiellonian University, Medical College, Medyczna 9, Krakow, Poland
178PDF: 99 -
MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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UNRAVELING GLIAL REMODELING IN SPACE AND TIME DURING GLIOBLASTOMA EVOLUTION Riccio L1, De Luca C1, Rega C1, Papa M1 and Virtuoso A1 | 1Laboratory of Neuronal Networks Morphology and System Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR M. Hałas-Wiśniewska1, W. Arendt1, M. Gagat1,2, M. Izdebska1 | 1Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Poland; 2Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland
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Essential Current Concepts in Stem Cell Biology
3004PDF: 580HTML: 48 -
38 | NATURAL ANTIOXIDANTS IN THE FIGHT AGAINST OVARIAN CANCER: IN VITRO EFFECTS OF POLYPHENOLS Lorenzo Ibello, Filomena Mottola, Maria Teresa Gentile, Ilaria Palmieri, Lucia Rocco | Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy
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P19 | LOQANT: IMAGEJ SCRIPT FOR ANALYSING NUCLEO-CYTOPLASMIC PROTEIN TRANSLOCATION K. Cizkova | Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic
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P21 | INVOLVEMENT OF TELOCYTES IN CARDIAC INFLAMMATION CAUSED BY LPS IN MICE AND THE POTENTIAL ANTI-INFLAMMATORY ROLE OF CANNABIS SATIVA L. A. Miller1, G.P. Lombardo2, A. Nunnari2, G. Pirracchio2, M. Kotańska3, C. Condurso4, E.R. Lauriano2, S. Pergolizzi2 | 1Dept. for the Promotion of Human Sciences and Quality of life, San Raffaele University, Rome, Italy; 2Dept. of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Italy; 3Dept. of Pharmacological Screening, Jagiellonian University Medical; College, Kraków, Poland; 4Dept of Veterinary Sciences, University of Messina, Italy
184PDF: 113 -
GENERATION AND CHARACTERIZATION OF A KNOCK-IN MOUSE MODEL FOR FLVCR1-RELATED SENSORY NEUROPATHY Abalai RE1, Marvaldi L2, Ferrini F3, Riganti C1, Zanin Venturini DI1, Metani L1, Tolosano E1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (TO), Italy; 3Dipartimento di Morfofisiologia Veterinaria and Rita Levi Montalcini Center for Brain Repair, Grugliasco (TO), Italy
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