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P06 | MODELING THE COMPLEXITY OF THE CENTRAL NERVOUS SYSTEM WITH PATIENT IPSC-DERIVED CEREBRAL ORGANOIDS L. Carpinelli1, D. Sibilia1, P.N. Doronzio2, F. Giacalone1, C. Lisciandrello2, E. Guadagni2, A. Conte3, S. Lattante4, M. Magatti5, A. Silini5, Facility Biobanca6, Facility Citometria a Flusso6, L. Di Pietro1|2, M. Sabatelli3, O. Parolini1|2 | 1Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy; 2Dipartimento di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy; 3Centro Clinico NEMO, Fondazione Policlinico Gemelli IRCCS, Rome, Italy; 4Department of Experimental Medicine, University of Salento, Lecce, Italy; 5Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 6Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy
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PRENATAL N-ACETYL-CYSTEINE PREVENTS NEURONAL, EMOTIONAL AND METABOLIC IMPAIRMENTS IN AN ANIMAL MODEL OF ADVERSE EXPERIENCES Cirulli F | Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy
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IMMUNOLOGICAL MECHANISMS IN REGENERATIVE MEDICINE: A LESSON FROM THE HUMAN PLACENTA O. Parolini1,2 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
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Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea
1078PDF: 728Supplementary: 94HTML: 20 -
The synovial surface of the articular cartilage
1366PDF: 701HTML: 15 -
08 | HUMAN ADIPOSE STEM CELLS: IMPACT OF DONORS’ AGE ON CELL PROPERTIES AND BEHAVIOUR Ludovica Barone1, Federica Rossi1, Federico Tamborini1, Christina Pagiatakis1|2, Roberto Papait1|2, Rosalba Gornati1 | 1Dept of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; 2Dept of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
34PDF: 6 -
CRAFTING THE MICROVASCULAR CANVAS: BIOENGINEERED MATERIALS OR NATIVE EXTRACELLULAR MATRIX FOR THE CENTRAL NERVOUS SYSTEM De Luca C1, Virtuoso A1, Cirillo G1, De Angelis F1, Guedán A2, Maduna T3, Morin A4, Sepulveda Diaz J4, Vlachos A3,5,6, Panetsos F7, Pérez-Rigueiro J8 and Papa M1,9 | 1Laboratory of Morphology of Neuronal Networks and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Bioactive Surfaces S.L., Madrid, Spain; 3Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 4Microfluidics Innovation Center, Paris, France; 5Center for Basics in Neuromodulation (NeuroModulBasics), Faculty of Medicine. University of Freiburg, Freiburg, Germany 6Center BrainLinks-BrainTools, University of Freiburg, Freiburg, Germany; 7Universidad Complutense de Madrid, Madrid, Spain 8Universidad Politécnica de Madrid, Spain; 9SYSBIO Centre of Systems Biology ISBE-IT, Milan, Italy
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RNA therapeutics - Function, design and delivery
928PDF: 446HTML: 174 -
18 | EARLY-DIFFERENTIATED C2C12 MYOTUBES RELEASE A PRO-TROPHIC SECRETOME THAT MODULATES NSC-34 MATURATION: IMPLICATIONS FOR NEUROMUSCULAR CROSSTALK IN AMYOTROPHIC LATERAL SCLEROSIS E. Carata, M. Muci, E. Panzarini | Dept. of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
20PDF: 14 -
FLOW CYTOMETRY FOR THE ANALYSIS OF MICRO/ NANOPARTICLES: CURRENT APPLICATIONS AND CHALLENGES S. Amalfitano | National Research Council of Italy - Water Research Institute (CNR-IRSA) – Montelibretti, Rome, Italy
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52 | EFFECTS OF DIETARY FRUCTOSE ON DUODENAL MUCIN GLYCOSYLATION AND MUCUS PRODUCTION IN MICE FED A HIGH-FAT DIET D. Mentino1, A. Provera2, C. Vecchio2, A. Antonioli2, A.N. Sheferaw2, N. Taldone1, R. Vitale3, C. Passamonti4, S. Fensore5, F. Prodam2, S. Sutti2, M. Mastrodonato1|6, M. F. Faienza3 | 1Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, Italy; 2Department of Health Sciences, University of Piemonte Orientale, Novara, Italy; 3 Department of Mathematics, University of Luxembourg, Belval Esch-sur-Alzette, Luxembourg; 4Department of Socio-Economic, Managerial and Statistical Studies, University of Chieti-Pescara, 3Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Italy; 6National Research Council of Italy (CNR) - Water Research Institute (IRSA),Taranto, Italy
19PDF: 11 -
P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | 1Marmara Uni School of Medicine, Istanbul, Türkiye; 2Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; 3Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; 4Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye
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NEUROBIOLOGY OF SUICIDE: MORPHOLOGICAL ASSESSMENT OF MICROGLIAL NETWORK IN HUMAN POST-MORTEM PREFRONTAL CORTEX Tambuzzi S1, Bertolotto N2, Massari S2, Madaschi L3, Alini M2, Brandolese D2, Ubezio MC1, Cattaneo C1 and Amadeo A2 | 1Institute of Forensic Medicine, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; 2Department of Biosciences, Università degli Studi di Milano, Milan, Italy; 3UNITECH NOLIMITS, Università degli Studi di Milano, Milan, Italy
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CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti1, V. Serafin1, L. Antolini1, S. Bresolin2, L. Reggiani Bonetti3, S. Marmiroli1 | 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; 3Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy
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P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy
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Expression of parafibromin in major renal cell tumors
1486PDF: 654HTML: 225 -
10 | ASSESSING RECOVERY FROM HYDROCARBON SPILL EXPOSURE IN MEDITERRANEAN MUSSEL MYTILUS GALLOPROVINCIALIS: A MULTI-BIOMARKER APPROACH F. Bertini1, L. Scirè Calabrisotto1, L. Bisanti1, C. La Corte1, M. Dara1, M. Staropoli1, L. T. Marcianò2, G. Santaluna2, L. Greco1, R. Chiarelli3, V. Catania1, D. Parrinello1, M. Cammarata1, M.G. Parisi1 | 1Dept. of Earth and Marine Sciences, University of Palermo, Italy; 2Dept. of Earth and Marine Sciences, University of Palermo, Italy; 3Dept. of Biological, Chemical and Pharmaceutical Sciences and Technology, University of Palermo, Italy
39PDF: 8 -
EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy
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P01 | PUTATIVE EFFECTS OF THE HYDROGEL-STEM CELL-MELATONIN COMBINATION WITH OR WITHOUT A SCAFFOLD TO TREAT THIOACETAMIDE-INDUCED LIVER DEGENERATION IN RAT G. Ozgun1, D. Yucel2, M. Kolgazi3, S. Ozer4, N. Tozun5, S. Arbak6 | 1Dept of Medical Biotechnology, Institute of health sciences, Acibadem Univ, Istanbul, Türkiye; 2Dept. of Histology and Embryology, School of Medicine, Acibadem Univ, Istanbul, Türkiye; 3Dept. of Physiology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; 4Animal Application and Research Center, Acibadem Univ. Istanbul, Türkiye; 5Dept. of Gastroenterology, School of Medicine, Acibadem Univ., Istanbul, Türkiye; 6Dept. of Histology and Embryology, School of Medicine, Acibadem Univ., Istanbul, Türkiye
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Expression of the endocannabinoid receptors in human fascial tissue
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Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway
662PDF: 384Supplementary: 49Original gels: 49HTML: 14 -
P49 | DEVELOPMENT OF AN INJECTABLE AND SELFASSEMBLING SCAFFOLD FOR THE DIRECT DELIVERY OF CARDIAC EXTRACELLULAR MATRIX AND CARDIAC PROGENITOR CELLS A. Menini1, V. Romano1, A. M. Sacco1, D. Nurzynska2, G. Ricci3, C. Amarelli4, C. Castaldo1, F. Di Meglio1 | 1Department of Public Health, University of Naples «Federico II», Naples, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi; 3Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy; 4Department of Cardiac Surgery and Transplants, Monaldi Hospital, Naples, Italy
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Combination of tolvaptan and valsartan improves cardiac and renal functions in doxorubicin-induced heart failure in mice
1654PDF: 872Supplementary: 129HTML: 35 -
ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion
2942PDF: 1087Supplementary: 275HTML: 107 -
19 | ADRENERGIC MODULATION OF THE HYPOTHALAMIC-PITUITARY-THYROID AXIS IN THE LIZARD PODARCIS SICULUS Francesca Carrella1, Assunta Lallo1, Stefania Boccia2, Maria De Falco3|4, Rosaria Sciarrillo1 | 1Department of Science and Technologies, University of Sannio, Benevento, Italy; 2Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 3Department of Biology, University of Naples “Federico II”, Naples, Italy; 4National Institute of Biostructures and Biosystems (INBB), Rome, Italy
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IMAGING THE LYSOSOME IN CELLULAR SYSTEMS FOR DRUG DISCOVERY AND SCREENING V.A. Baldassarro1, M. Galeotti2, E. Satanassi3, L. Giardino1, L. Calzà4, C. Quadalti4 | 1DIMEVET, University of Bologna, Italy; 2IRET Foundation, Ozzano dell’Emilia, Bologna, Italy; 3Interdepartmental Centre for Industrial Research in Health Sciences and Technology ICIR-HST, University of Bologna, Ozzano dell’Emilia, Bologna, Italy; 4Fabit, University of Bologna, Italy
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43 | OVERVIEW OF EFFECTS OF ENDOCRINE-DISRUPTING CHEMICALS (EDCS) ON THE MORPHOPHYSIOLOGY OF THE THYROID GLAND IN REPTILES: EVIDENCE FROM LACERTIDE PODARCIS SICULUS Assunta Lallo1, Francesca Carrella1, Roberta Imperatore1, Benedetta Sangarella Valvano4, Maria De Falcob3, Rosaria Sciarrillo1 | 1Department of Science and Technologies, University of Sannio, Benevento, Italy; 2Department of Biology, University of Naples “Federico II”, Naples, Italy; 3National Institute of Biostructures and Biosystems (INBB), Rome, Italy; 4Dept. of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, Italy
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CONNEXIN 43 HEMICHANNELS CAN DRIVE THE GLIOBLASTOMA SPREADING Virtuoso A1, De Luca C1, Altieri R2, Milior G3, Moulard J3, Huberfeld J3, Cirillo G1, Barbarisi M2, Rouach N3 and Papa M1 | 1Laboratory of Neural Network Morphology and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy; 3Interdisciplinary Research Center in Biology, College de France, CNRS, INSERM, Labex Memolife, Université PSL, Paris, France
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STANDARDIZING LIGHT SHEET IMAGING AND 3D IMAGE ANALYSIS FOR WHOLE BRAIN VASCULAR NET QUANTIFICATION Zanella L1, Moretti M1, Quadalti C2, Giardino L1,3,4, Calzà L2,3,4, Baldassarro VA1,4 and Lorenzini L1,4 | 1Department of Veterinary Medical Science, University of Bologna, Ozzano dell’Emilia, Bologna, Italy; 2Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; 3IRET Foundation, Ozzano dell’Emilia, Bologna, Italy; 4Interdepartmental Centre for Industrial Research in Health Sciences and Technology ICIR-HST, University of Bologna, Ozzano dell’Emilia, Bologna, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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P75 | MICROBIOTA-GUT-BRAIN AXIS IN AN AUTISM SPECTRUM DISORDER ANIMAL MODEL F. Sulas1, G. Cominelli1, G. Favero1,2, D. Pinto2,3, F. Rinaldi2,3, R. Rezzani1,2,4 | 1Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; 2Interdepartmental University Center of Research Adaption and Regeneration of Tissues and Organs (ARTO), University of Brescia, Brescia, Italy; 3Human Microbiome Advanced Project Institute, Milan, Italy; 4Italian Society for the Study of Orofacial Pain (Società Italiana Studio Dolore Orofacciale - SISDO), Brescia, Italy
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MiR-550a-3p restores damaged vascular smooth muscle cells by inhibiting thrombomodulin in an in vitro atherosclerosis model
1223PDF: 661Supplementary: 141HTML: 39 -
Imaging techniques in nanomedical research
2021PDF: 816HTML: 21 -
Immunohistochemical localization of periostin in human gingiva
2185PDF: 788HTML: 497 -
FLVCR1a REGULATES CORTICAL INTERNEURON DEVELOPMENT AND MIGRATION IN THE EMBRYONIC CORTEX Metani L1, Zanin Venturini DI1, Abalai RE1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Torino, Italy
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Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7
927PDF: 400Supplementary: 52HTML: 50 -
Muc5ac mucin expression during rat skin development
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75 | Β-SITOSTEROL-D-GLUCOSIDE TRIGGERS INTESTINAL INFLAMMATION IN ZEBRAFISH LARVAE POSSIBLY LEADING TO NEURODEGENERATION THROUGH THE GUT-BRAIN AXIS Francesca Terrin1, Sofia Faggin2|3, Chiara Consorti4, Stefania Marcotti5, Paolo Bonaldo4, Maria Cecilia Giron2, Nicoletta Plotegher1, Luisa Dalla Valle1 | 1Department of Biology, University of Padova, Italy; 2Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy; 3Institute of Digestive Health Research (IRSD), Toulouse University, France; 4Department of Molecular Medicine, University of Padova, Italy; 5Randall Centre for Cell and Molecular Biophysics, King's College London, London; UK
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P50 | OPTIMIZATION OF A RAPID AND EFFICIENT DECELLULARIZATION PROTOCOL FOR COMPOSITE VASCULARIZED FACIAL GRAFT FABRICATION A. Menini1, A. M. Sacco1, V. Romano1, D. Nurzynska2, G. Ricci3, S. La Padula1, F. Schonauer1, C. Castaldo1, F. Di Meglio1 | 1Department of Public Health, University of Naples «Federico II», Naples, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy; 3Department of Experimental Medicine, University of Campania «Luigi Vanvitelli», Naples, Italy
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The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis
1912PDF: 972Supplementary: 195HTML: 31
