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P82 | PROINFLAMMATORY BONE MARROW NICHES AND NEUTROPHIL ACTIVATION ARE ASSOCIATED WITH TIGIT EXPRESSION IN MULTIPLE MYELOMA V. Velardi1, F. Arciprete1, V. Tomarchio2, G. Vivacqua1, M.A. Tafuri2, M. Di Cecca2, L. Rigacci2, A. Crescenzi3, R. Rana1, O. Annibali2, M. Zingariello1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Unit of Hematology, Stem Cell Transplantation, University Hospital Campus Bio-Medico Rome, Italy; 3Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy
276 -
miR-199a-5p inhibited HIF-1α to suppress the proliferation, migration, and differentiation of cardiac stem cells
520PDF: 358Supplementary: 58HTML: 21 -
P59 | IMMUNOHISTOCHEMISTRY ANALYSIS TO DETECT A MOLECULAR SIGNATURE IN INTERVERTEBRAL DISC DEGENERATION L. Penolazzi1, R. Nadalini1, C. Sief1, E. Lambertini2, C. Angelini3, R. Piva1 | 1Department of Neurosciences and rehabilitation, University of Ferrara, Italy; 2Laboratorio Centralizzato di ricerca preclinica, University of Ferrara, Italy; 3Department of Translational Medicine, University of Ferrara, Italy
278 -
Interindividual variability in the expression of surfactant protein A and B in the human lung during development
2086PDF: 789Supplementary: 261HTML: 387 -
Lectins as versatile tools to explore cellular glycosylation
2896PDF: 1243HTML: 52 -
ECRG4 expression in normal rat tissues: expression study and literature review
3093PDF: 1187Supplementary: 393HTML: 1018 -
NO-tryptophan: a new small molecule located in the rat brain
2099PDF: 591HTML: 245 -
P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
324 -
Functional topography of the fully grown human oocyte
2139PDF: 882HTML: 264 -
PERICYTE INVOLVEMENT IN THE PATHOGENESIS OF COLVI-RELATED MYOPATHIES: INSIGHTS INTO NG2–COLVI AXIS A. Fazio1, C. Evangelisti1, P. Sabatelli2, A. Cappellini1, A. Di Martino3, C. Faldini3, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, University of Bologna, DIBINEM, Bologna, Italy; 2CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza”, Unit of Bologna, Bologna, Italy; 3IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
167 -
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy
3131PDF: 1718Video 1: 250Video 2: 297HTML: 27 -
PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS L. Morello1, G. Stati1, V. Giansante1, S. Lattanzio1, P. Cerritelli1, D. Bruni1, S. Cinti2, R. Di Pietro1,3,4 | 1Department of Medicine and Aging Sciences, “G. d’ Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Experimental and Clinical Medicine, Center of Obesity, Polytechnic University of Marche, Ancona, Italy; 3StemTeCh Group, G. d’ Annunzio Foundation, “G. d’ Annunzio” University of Chieti Pescara, Chieti, Italy; 4Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
308 -
Galunisertib enhances chimeric antigen receptor-modified T cell function
2100PDF: 1115Supplementary: 171HTML: 20 -
P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy
381 -
ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS S. Alberti | University of Messina, Messina, Italy
185 -
P30 | NEW INSIGHT IN THE IN VITRO-GENERATION OF INSULIN-PRODUCING CELLS: VAV1 AS A REGULATOR OF PDX1 AND MIR-375 LEVELS DURING DIFFERENTIATION OF HIPSCS INTO Β-CELLS M. Pierantoni1, F. Brugnoli1, V. Zamarian2, M. Dell’Aira1, V. Sordi2, V. Bertagnolo1, S. Grassilli3 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Department of Environmental and Prevention Sciences and LTTA Centre, University of Ferrara, Ferrara, Italy
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Immunohistochemical localization of periostin in human gingiva
2241PDF: 809HTML: 498 -
FROM CLOUD TO BEDSIDE C. Tacchetti1,2 | 1Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; 2Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy
209 -
Is there still room for novelty, in histochemical papers?
2925PDF: 727HTML: 283 -
CONNECTOME-BASED BRAIN FINGERPRINTS PREDICT ART THERAPY RESPONSE IN PARKINSON’S DISEASE Ielo A1,§, Genovese D2,3,§, Falcó-Roget J4, Amico E5,6, Norcini M7, Quartarone A1, Ghilardi MF8 and Cacciola A9,10 | 1IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy; 2Institute of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; 4Computational Neuroscience Group, Sano Centre for Computational Medicine, Kraków, Poland; 5School of Mathematics, University of Birmingham, Birmingham, UK; 6Centre for Human Brain Health, University of Birmingham, Birmingham, UK; 7NYU Langone Health, Department of Neurology, New York, USA; 8Department of Molecular, Cellular & Biomedical Sciences, School of Medicine, City University of New York, New York, USA; 9Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; 10IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. §Shared co-first authorship
525 -
Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling
1876PDF: 965Supplementary: 171HTML: 27 -
EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy
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P11 | DOMINO TRANSPLANTATION IN MNGIE: IS THE LIVER A SUITABLE GRAFT? E. Boschetti1, I. Neri1, S. Blando1, C. Malagelada2, L. Caporali3, R. D’Angelo4, R. Rinaldi4, S. Mongiorgi1, V. Carelli3, R. De Giorgio5, L. Manzoli1, S. Ratti1 | 1Center of Clinical Surgical Molecular and Experimental Anatomy Alma Mater Studiorum – University of Bologna, Italy; 2Digestive System Research Unit, University Hospital Vall d’Hebron; Barcelona, Spain; 3IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 4IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
227 -
P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti1, F. Liccardo2, L. Pace1, M. Marcotulli3, L. Lafrate3, G. Cidonio3, T. Ottone4, S. Travaglini4, M.T. Voso4, V. Fulci5, M. Sampaolesi1, F. Fazi1, S. Masciarelli1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; 2Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; 3Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; 4Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; 5Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy
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Lorenzo Gotte (1926-1991): a pioneer of elastin
1468PDF: 691HTML: 207 -
CONTRIBUTION OF MAGNETIC RESONANCE IMAGING ASSOCIATED WITH MACHINE LEARNING TO AN EARLY ASSESSMENT OF THE CONVERSION OF MILD COGNITIVE IMPAIRMENT IN OVERT DEMENTIA Amenta F, Battineni G, Chintalapudi N and Traini E | Clinical Research Centre, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
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