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HUMAN AMNIOTIC EPITHELIAL CELLS FOR RETINAL REGENERATION: INVESTIGATING THEIR DIFFERENTIATIVE POTENTIAL IN VITRO R. Pisu1, S. Saponara2, S. Angioni2, E. Peiretti2, S.G. Vitale2, F. Marongiu1 | 1Department of Biomedical Sciences, University of Cagliari, Cagliari; 2Department of Surgical Sciences, University of Cagliari, Cagliari, Italy
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HIGH RESOLUTION MAGNETIC RESONANCE IMAGING TO ASSESS AXONAL DAMAGE IN NEUROPATHY MODELS Bontempi P1, Mastropietro A2, Rizzo G2, Taccogna M2, Napolitano A3, Gerevini S4, Kraus MF5,6, Di Girolamo S5,7, Cavaletti G5,7, Tamburin S8 and Alberti P5,7 | 1Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy; 2Institute for Biomedical Technologies, National Research Council (ITB-CNR), Segrate, Italy; 3Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy; 4Department of Neuroradiology, ASST Papa Giovanni XXIII, Bergamo, Italy; 5Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy 6S.C. Neuroscienze, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle D’Aosta, Torino, Italy; 7NeuroMI (Milan Center for Neuroscience), Milan, Italy; 8Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
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P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES I. Atasoy1, S. Yilmazer2, D. Gezen Ak3, E. Dursun3 | 1Medical Biology Department, İstabul University-Cerrahpasa Faculty of Medicine Istanbul, Türkiye; 2Department of Medical Biology Halic University, Faculty of Medicine, Istanbul, Türkiye; 3Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Türkiye
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Cell-penetrating peptides - Methods and protocols
1441PDF: 370HTML: 126 -
PRENATAL N-ACETYL-CYSTEINE PREVENTS NEURONAL, EMOTIONAL AND METABOLIC IMPAIRMENTS IN AN ANIMAL MODEL OF ADVERSE EXPERIENCES Cirulli F | Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy
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P10 | ELECTRON MICROSCOPY-ADAPTED PHTHALOCYANINE AND VON KOSSA HISTOCHEMISTRY: A POWERFUL TOOL TO STUDY AORTIC VALVE CALCIFICATION IN AD HOC MODELS AND ACTUAL DISEASE A. Bonetti, M. Contin, M. Marchini, F. Ortolani | Department of Medicine, University of Udine, Udine, Italy
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RNA interference - From Biology to clinical applications
990PDF: 455HTML: 348 -
CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti1, V. Serafin1, L. Antolini1, S. Bresolin2, L. Reggiani Bonetti3, S. Marmiroli1 | 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; 3Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy
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MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F1, Russo L2, Jorkesh A2, Khodaparast S1, Gambarotta G1, Ronchi G1 and Cescon M2 | 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy
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LOCUS COERULEUS STRUCTURAL INTEGRITY IS ASSOCIATED WITH CIRCULATING SOLUBLE AXL IN ALZHEIMER’S DISEASE Galgani A1, Scotto M2, Mary A3, Lombardo F4, Martini N4, Siciliano G5, Ceravolo R5, Heneka MT3,6 and Giorgi FS1,7 | 1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy; 2Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; 3Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; 4Department of Radiology, Fondazione Toscana “G. Monasterio”, Pisa, Italy; 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; 7I.R.C.C.S. Stella Maris, Calambrone, Pisa, Italy
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P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira1, S. Grassilli2, M. Pierantoni1, V. Bertagnolo1, F. Brugnoli1 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy
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Fine structural detection of calcium ions by photoconversion
1686PDF: 736Supplementary: 291HTML: 137 -
ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy
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THERAPEUTIC VERSUS PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY Iseppon F1, Tonelli E1,2, Fabbro V1, Chiorazzi A1, Canta A1, Alberti P1, Carozzi VA1, Pozzi E1, Cherchi L1,2, Fermi S1,2, Segmani I1,2, Fantoni L1, Rodriguez-Menendez V1, Ballarini E1, Cavaletti G1 and Meregalli C1 | 1University of Milano-Bicocca, Department of Medicine and Surgery, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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