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Galunisertib enhances chimeric antigen receptor-modified T cell function
2232PDF: 1185Supplementary: 214HTML: 31 -
WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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P55 | ENDOTHELIAL THYMIDINE PHOSPHORYLASE DEFICIENCY TRIGGERS MORPHO-FUNCTIONAL DEGE-NERATION OF ENTERIC NEURONS AND REDUCES INTESTINAL STEM CELL PROLIFERATION I. Neri1, E. Boschetti1, T. Saha2, S. Rommel2, S. Schulte2, M. Gries2, R. De Giorgio3, L. Manzoli1, S. Ratti1, K. Schäfer2 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Workgroup Enteric Nervous System (AGENS), Department of Informatics and Microsystems Technology, University of Applied, Sciences Kaiserslautern, Zweibrücken, Germany; 3Department of Translational Medicine, University of Ferrara, Ferrara, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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P56 | HISTOLOGICAL PROFILE OF INACTIVE UNILATERAL CONDYLAR HYPERPLASIA: EVIDENCE OF BORDERLINE TISSUE ACTIVITY F. Nicita1, G. Vermiglio1, J. Freni1, A. Centofanti1, D. Labellarte1, R. Briganti1, G.P. Anastasi1, G. Cutroneo1, A. Favaloro1, M. Runci Anastasi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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Visualizing endocytotic pathways at transmission electron microscopy via diaminobenzidine photo-oxidation by a fluorescent cell-membrane dye
2634PDF: 1115Supplementary: 361HTML: 740 -
P23 | CALRETININ IMMUNOREACTIVE NON-TRADITIONAL LARGE NEURONS IN THE GRANULAR LAYER OF THE HUMAN CEREBELLAR CORTEX P. Flace1, M. E. Caringella2, D. Galletta3, G. Santangelo3, C. Caporusso2, M. Stolfa2, A. Cacciola4, J.J.V. Branca5, G. Agazzino2, R. Gradini6, P. Livrea7, A. Marzullo2 | 1Medical School, University of Bari ‘Aldo Moro’, Bari, Italy; 2Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, Italy; 3Department of Psychology, Specialization School of Neuropsychology. University of Campania ‘Luigi Vanvitelli’, Caserta, Italy; 4Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 5Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy; 6Department of Experimental Medicine, Sapienza University, Roma, Italy; 7University of Bari ‘Aldo Moro’, Bari, Italy
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Excitatory Amino Acid Transporter 5 is widely expressed in peripheral tissues
3089PDF: 854Supplementary: 285HTML: 451 -
EXPLORING NEURON–GLIOMA SIGNALING THROUGH IN VITRO CO-CULTURES Nicorvo E¹, Ferraro A¹, Pacca P¹, Boido M¹, Di Cunto F¹ and Vercelli A¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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SUMOYLATION AS AN EARLY ADAPTIVE MECHANISM IN THE PROTEOMIC RESPONSE OF HUMAN GERM CELLS TO SIMULATED MICROGRAVITY A. Di Pauli1, G. Ricci2, M. Crescenzi3, M. A. Mariggiò4, C. Morabito4, L. Gesualdi1, M. Berardini1, F. Ferranti5, M. Signore6, A. Catizone1 | 1Department of Anatomy, Histology, Forensic-Medicine and Orthopedics, Section of Histology and Embryology, «Sapienza» University, Rome, Italy; 2Department of Experimental Medicine, University «Luigi Vanvitelli», Naples, Italy; 3Core Facilities, Italian National Institute of Health, Rome, Italy; 4Department of Neuroscience, Imaging and Clinical Sciences CAST, «G. d’Annunzio» University, Chieti, Italy; 5Human Spaceflight and Scientific Research Unit, Italian Space Agency, Rome, Italy; 6RPPA unit, Proteomics, Italian National Institute of Health, Rome, Italy
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P68 | EARLY EFFECTS OF MECHANOACUSTIC FOCUSED VIBRATION (MFV) ON PRIMARY HUMAN SATELLITE CELLS ISOLATED FROM YOUNG AND OLDER INDIVIDUALS S. Sancilio1, G. Stati1, E.S. Di Filippo2, S. Fulle2, R. Di Pietro1 | 1Department of Medicine and Aging Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Neuroscience Imaging and Clinical Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy
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04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE G. Abruscato1, L. Sileo2, G. Scanavino2, C. Guerriero2, M. Mauro1, M. Vazzana1|3, V. Arizza1|3, C. Luparello1|3, A.M.Tata2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Dept. of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center (NBFC), Italy
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P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION J. Freni1, M. Crescenti2, E. Bertuccio3, A. Fittipaldi1, P. Carrega2, E. Di Carlo4, G. Ferlazzo3, G. Vermiglio1, I. Bonaccorsi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy: 2Department Human Pathology, «G. Barresi», University of Messina, Messina, Italy; 3Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy; 4Department of Medicine and Sciences of Aging, «G. D’Annunzio» University of Chieti-Pescara, Chieti, Italy
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MITOCHONDRIAL DYSFUNCTION AS A KEY FACTOR OF MOTOR NEURON DEGENERATION: INSIGHTS FROM AMYOTROPHIC LATERAL SCLEROSIS CELLULAR MODELS Scimia N¹, Carletti RM², Rasà MD¹, Ferrari D3, Boido M¹ and Stanga S¹ | ¹Neuroscience Institute Cavalieri Ottolenghi, Orbassano (TO), Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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