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CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti1, V. Serafin1, L. Antolini1, S. Bresolin2, L. Reggiani Bonetti3, S. Marmiroli1 | 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; 3Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy
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MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F1, Russo L2, Jorkesh A2, Khodaparast S1, Gambarotta G1, Ronchi G1 and Cescon M2 | 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy
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LOCUS COERULEUS STRUCTURAL INTEGRITY IS ASSOCIATED WITH CIRCULATING SOLUBLE AXL IN ALZHEIMER’S DISEASE Galgani A1, Scotto M2, Mary A3, Lombardo F4, Martini N4, Siciliano G5, Ceravolo R5, Heneka MT3,6 and Giorgi FS1,7 | 1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy; 2Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; 3Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; 4Department of Radiology, Fondazione Toscana “G. Monasterio”, Pisa, Italy; 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; 7I.R.C.C.S. Stella Maris, Calambrone, Pisa, Italy
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P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira1, S. Grassilli2, M. Pierantoni1, V. Bertagnolo1, F. Brugnoli1 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy
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Fine structural detection of calcium ions by photoconversion
1686PDF: 736Supplementary: 291HTML: 137 -
ROLE OF MITOCHONDRIAL METABOLISM AND CONTACT SITES IN CANCER CELL DEATH AND SURVIVAL F. Severin, A. Ruzza, F. Vianello, E. Zaltron, I. Celotti, M. Scavezzon, S. Toffanin, C. Bastianello, L. Leanza | Department of Biology, University of Padova, Padova, Italy
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THERAPEUTIC VERSUS PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY Iseppon F1, Tonelli E1,2, Fabbro V1, Chiorazzi A1, Canta A1, Alberti P1, Carozzi VA1, Pozzi E1, Cherchi L1,2, Fermi S1,2, Segmani I1,2, Fantoni L1, Rodriguez-Menendez V1, Ballarini E1, Cavaletti G1 and Meregalli C1 | 1University of Milano-Bicocca, Department of Medicine and Surgery, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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NEUROACTIVE STEROIDS PROTECT FROM BORTEZOMIB-INDUCED TOXICITY: EVIDENCE FROM IN VITRO MODELS Fabbro V1, Tonelli E1,2, Scuteri A1,3, D’Aprile C1, Naghshbandieh A1,2, Lim D4, Distasi C4, Giatti S5 and Meregalli C1 | 1School of Medicine and Surgery, Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano- Bicocca, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy; 3Milan Center for Neuroscience (NeuroMI); 4University of Piemonte Orientale, Department of Pharmaceutical Sciences, Novara, Italy; 5University of Milan, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Milan, Italy
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P36 | BIOLOGICAL ROLE OF DNA G-QUADRUPLEX DURING LIVER REGENERATION AFTER PARTIAL HEPATECTOMY T. Ishizuka, K. M. Aung, T. Kubota, B. Lkham-Erdene, K. Kai, Y. Hishikawa | Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
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LABELING EXTRACELLULAR VESICLES FOR HIGHLY SENSITIVE FLOW CYTOMETRY ANALYSES P. Simeone1,2, D. Brocco3, F. D’Ascanio1,2,4, D. De Bellis1,2, G. Colasante1,2, A. Aquilini-Mummolo1,2, T. Esmail1,2, A. Younas2, M. Filoso2, C. Cichella2, M. C. Cufaro5, A. Di Sebastiano5, D. Pieragostino6, S. Burattini7, M. Battistelli7, P. Del Boccio5, A. Fontana8, R. Di Pietro1, P. Lanuti1,2 | 1Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, Italy; 2Flow Cytometry Core Facility, Center for Advanced Studies and Technology (CAST), University “G. d’Annunzio” of Chieti-Pescara, Italy; 3Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy; 4Department of Humanities, Law and Economics, Leonardo da Vinci University, Torrevecchia Teatina, Italy: 5Department of Science, University “G. d’Annunzio”, Chieti Pescara, Italy; 6Department of Innovative Technologies in Medicine and Dentistry, G. d’Annunzio University of Chieti-Pescara, Italy; 7Department of Biomolecular Sciences, University of Urbino, Urbino, Italy; 8Department of Pharmacy, University “G. d’Annunzio”, Chieti Pescara, Italy
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GAIT CHARACTERIZATION IN A MOUSE MODEL OF CHRONIC MILD STRESS- AND 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROINFLAMMATION Serinelli FC1, Kashyrina M2, De Nuccio F2, Panaro MA3, Cianciulli A3, Ruggiero M3, Porro C4, Ichas F5, Nicolardi N1 and Lofrumento DD1 | 1Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy; 2Department of Experimental Medicine, University of Salento, Lecce, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 4Department of Clinical and Experimental Medicine, University of Foggia, Italy; 5Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, France
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NO-tryptophan: a new small molecule located in the rat brain
1991PDF: 570HTML: 244 -
Paul Nakane Prize Lecture | FROM NUCLEOLAR MORPHOLOGY TO MOLECULAR REGULATION OF GENE EXPRESSION BY PHASE SEPARATION P. Hozák | Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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Decreased expression of Met during differentiation in rat lung
1601PDF: 742Supplementary: 294HTML: 272 -
P43 | NEW INSIGHTS IN THE ACTIVATION OF FERROPTOSIS PROCESS DURING LIVER FIBROSIS R. Mancinelli1, S. Leone1, A. Casini1, R. Vaccaro1, M. Tagliafierro1, F.M. Bassi1, E. Bocci1, S. Vitale1, A. Franchitto2, L. Pannarale1, P. Onori1, E. Gaudio1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopaedics Sciences, Sapienza University of Rome, Italy; 2Division of Health Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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Effects of cadmium on the glial architecture in lizard brain
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Forever particles: histochemistry in the plasticene age
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Cartilage canals in newborn dogs: histochemical and immunohistochemical findings
1426PDF: 699Supplementary: 282HTML: 214 -
NADPH-d activity in rat thymus after the application of retinoid acid
1401PDF: 512HTML: 1281
