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FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
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PARP-1 protein expression in glioblastoma multiforme
3608PDF: 1442HTML: 1889 -
P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante1, L. Leanza2, E. Guerra3, F. Vianello4, C. Iacovino1, S. Lattanzio1, L. Morello1, G. Stati1, P. Simeone3, P. Lanuti3, S. Alberti5, M. Reichert6, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Biology, University of Padua, Padua, Italy; 3Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; 4Department of Biology, University of Padua, Padua, Italy; 5Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; 6Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany
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BEYOND THE SPINAL CORD: MORPHOLOGICAL ALTERATIONS OF CORTICAL PROJECTION NEURON IN SPINAL MUSCULAR ATROPHY La Rocca F1,2, Schellino R1,2, Iezzi G1,2, Caretto A1,2, Boido B1,2 and Vercelli A1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri, Ottolenghi, University of Turin, Turin, Italy
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy
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WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
1734PDF: 1038Supplementary: 131HTML: 37 -
Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway
3324PDF: 723Supplementary: 332HTML: 313 -
P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti1,2, F. Beretti2, M. Malenchini2, M. Y. Follo1, F. Mancarella3, F. Bonafè3, F. Gherardini4, T. Maraldi2 | 1Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; 4Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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Lipofuscin, lipofuscin-like pigments and autofluorescence
4500PDF: 1954HTML: 546 -
IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling
2004PDF: 1074Supplementary: 207HTML: 47 -
EX VIVO MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS Cirillo G1, Montella M2, La Mantia E2, Tedesco I2, De Luca C1, Virtuoso A1, De Angelis F1, Riccio L1, Esposito F3, Cirillo M3, Franco R2 and Papa M1 | 1Division of Human Anatomy, Neuronal Networks Morphology & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 3Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania Luigi Vanvitelli, Naples, Italy
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ECRG4 expression in normal rat tissues: expression study and literature review
3262PDF: 1303Supplementary: 475HTML: 1047 -
P56 | HISTOLOGICAL PROFILE OF INACTIVE UNILATERAL CONDYLAR HYPERPLASIA: EVIDENCE OF BORDERLINE TISSUE ACTIVITY F. Nicita1, G. Vermiglio1, J. Freni1, A. Centofanti1, D. Labellarte1, R. Briganti1, G.P. Anastasi1, G. Cutroneo1, A. Favaloro1, M. Runci Anastasi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy; 2Department of Maxillo-Facial Surgery, University of Rome, La Sapienza, Italy
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MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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P04 | CYTOCHEMICAL AND BIOLOGICAL EFFECT OF BIORESONANCE IN IRRITABLE BOWEL SYNDROME G. Barassi1, M. Panunzio2, P.E. Gallenga1 | 1Center for Physiotherapy, Rehabilitation and Re-Education (Ce.Fi.R.R.), Venue “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Responsible Research Hospital, Campobasso, Italy
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The penetration of methanol into bovine cardiac and hepatic tissues is faster than ethanol and formalin
2236PDF: 949Supplementary: 254HTML: 75 -
Decreased expression of Met during differentiation in rat lung
1768PDF: 884Supplementary: 367HTML: 301 -
ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN EXPRESSION IS REGIONALLY UPREGULATED BY MODERATE AEROBIC EXERCISE IN THE RAT BRAIN Palmeri N1, D’Amico AG2, Pricoco E3, D’Agata V2 and Maugeri G1 | 1Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 2Department of Drug and Health Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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02 | MODELING NON-CELL AUTONOMOUS MECHANISMS IN THE ALS PERIPHERAL NERVOUS SYSTEM A. Romano1|2|3 | 1Dept. of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy; 2Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3CNR NANOTEC - Institute of Nanotechnology, Lecce, Italy
306PDF: 106 -
P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto1, F. Grasselli1, L. Lucernoni1, I. Martinelli2, E. Vittadini1, A.M. Eleuteri1, L. Bonfili1, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy
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Expression of S100β during mouse cochlear development
1601PDF: 513Supplementary: 112HTML: 23 -
P23 | CALRETININ IMMUNOREACTIVE NON-TRADITIONAL LARGE NEURONS IN THE GRANULAR LAYER OF THE HUMAN CEREBELLAR CORTEX P. Flace1, M. E. Caringella2, D. Galletta3, G. Santangelo3, C. Caporusso2, M. Stolfa2, A. Cacciola4, J.J.V. Branca5, G. Agazzino2, R. Gradini6, P. Livrea7, A. Marzullo2 | 1Medical School, University of Bari ‘Aldo Moro’, Bari, Italy; 2Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, Italy; 3Department of Psychology, Specialization School of Neuropsychology. University of Campania ‘Luigi Vanvitelli’, Caserta, Italy; 4Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 5Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy; 6Department of Experimental Medicine, Sapienza University, Roma, Italy; 7University of Bari ‘Aldo Moro’, Bari, Italy
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MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices
2704PDF: 1286MIAQuant user Manual: 326MIAQuant source code: 397HTML: 94 -
SHORT-TERM EXPOSURE TO PARTICULATE MATTER TRIGGERS SELECTIVE MOLECULAR AND BEHAVIORAL ALTERATIONS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS Bonato M1,2, Montarolo F1,2, Cerrato V1,2, Parolisi R1,2, Abbadessa G3, Caudana M3, Di Cintio N1,2, De Francia S3, Bertolotto A2,4, Buffo A1,2, and Boda E1,2 | 1Dept. of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (Turin), Italy; 3Department of Clinical and Biological Sciences, University of Turin, Orbassano (Turin), Italy; 4Koelliker Hospital, Turin, Italy
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Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances
2551PDF: 910Supplementary: 238HTML: 43 -
62 | APPLICATION OF AN AI-BASED WORKFLOW FOR THE ASSESSMENT OF TESTICULAR DAMAGE IN DOGS Lorenzo Riccio1|2, Maria De Falco2, Nicola Ambrosio3, Angelo Spada3, Francesca Del Porto2, Cristina Marchetti2, Orlando Paciello1, Luigi Rosati2 | 1Dept. of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy; 2Dept. of Biology, University of Naples Federico II, Italy; 3ASL Napoli 2 Nord, Italy
128PDF: 96 -
AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
2175PDF: 1075Supplementary Figures: 368Supplementary Table: 264HTML: 528 -
VGF AS BIOMARKER OF PRE-SYMPTOMATIC PHASE OF PARKINSON’S DISEASE Manai AL1, Modi A2, Noli B1, Choudhary SM2, Ruda-Kucerova J3, Dražanová E3,4, Khairnar A2,5, Cocco C1 | 1Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy; 2International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; 3Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 4Institute of Scientific Instruments of the CAS, v. v. i., Brno, Czech Republic; 5Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL 5xFAD Chicote J1, Rosano V1, Mezzanotte M1, Bertinaria M2, Marini E2, Vercelli A1 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Drug Science and Technology, University of Turin, Italy
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