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P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE V. Bellitto1, F. Grasselli1, L. Lucernoni1, I. Martinelli2, E. Vittadini1, A.M. Eleuteri1, L. Bonfili1, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal Sciences and Health Products, University of Camerino, Camerino, Italy
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Expression of S100β during mouse cochlear development
1433PDF: 391Supplementary: 75HTML: 9 -
P23 | CALRETININ IMMUNOREACTIVE NON-TRADITIONAL LARGE NEURONS IN THE GRANULAR LAYER OF THE HUMAN CEREBELLAR CORTEX P. Flace1, M. E. Caringella2, D. Galletta3, G. Santangelo3, C. Caporusso2, M. Stolfa2, A. Cacciola4, J.J.V. Branca5, G. Agazzino2, R. Gradini6, P. Livrea7, A. Marzullo2 | 1Medical School, University of Bari ‘Aldo Moro’, Bari, Italy; 2Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari ‘Aldo Moro’, Italy; 3Department of Psychology, Specialization School of Neuropsychology. University of Campania ‘Luigi Vanvitelli’, Caserta, Italy; 4Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 5Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy; 6Department of Experimental Medicine, Sapienza University, Roma, Italy; 7University of Bari ‘Aldo Moro’, Bari, Italy
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MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices
2448PDF: 1198MIAQuant user Manual: 267MIAQuant source code: 340HTML: 75 -
SHORT-TERM EXPOSURE TO PARTICULATE MATTER TRIGGERS SELECTIVE MOLECULAR AND BEHAVIORAL ALTERATIONS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS Bonato M1,2, Montarolo F1,2, Cerrato V1,2, Parolisi R1,2, Abbadessa G3, Caudana M3, Di Cintio N1,2, De Francia S3, Bertolotto A2,4, Buffo A1,2, and Boda E1,2 | 1Dept. of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (Turin), Italy; 3Department of Clinical and Biological Sciences, University of Turin, Orbassano (Turin), Italy; 4Koelliker Hospital, Turin, Italy
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Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances
2310PDF: 822Supplementary: 187HTML: 19 -
AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
2046PDF: 994Supplementary Figures: 314Supplementary Table: 230HTML: 504 -
VGF AS BIOMARKER OF PRE-SYMPTOMATIC PHASE OF PARKINSON’S DISEASE Manai AL1, Modi A2, Noli B1, Choudhary SM2, Ruda-Kucerova J3, Dražanová E3,4, Khairnar A2,5, Cocco C1 | 1Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy; 2International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; 3Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 4Institute of Scientific Instruments of the CAS, v. v. i., Brno, Czech Republic; 5Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL 5xFAD Chicote J1, Rosano V1, Mezzanotte M1, Bertinaria M2, Marini E2, Vercelli A1 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Drug Science and Technology, University of Turin, Italy
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TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy
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Imaging techniques in nanomedical research
2017PDF: 816HTML: 20 -
On the future contents of a small journal of histochemistry
2529PDF: 980HTML: 940 -
P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION J. Freni1, M. Crescenti2, E. Bertuccio3, A. Fittipaldi1, P. Carrega2, E. Di Carlo4, G. Ferlazzo3, G. Vermiglio1, I. Bonaccorsi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy: 2Department Human Pathology, «G. Barresi», University of Messina, Messina, Italy; 3Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy; 4Department of Medicine and Sciences of Aging, «G. D’Annunzio» University of Chieti-Pescara, Chieti, Italy
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CALRETININ IMMUNOREACTIVITY IN NERVE CELLS OF THE HUMAN MIDBRAIN AND THEIR POTENTIAL ROLE IN NEURODEGENERATIVE DISORDERS Flace P1, Caporusso C2, Galletta D3, Stolfa M2, Cacciola A4,5, Scarcella VS2, Branca JJV6, Gulisano M6, Milardi D7, Gradini R8, Livrea P9 and Marzullo A2 | 1Medical School, University of Bari Aldo Moro, Bari, Italy; 2Department of Precision and Regenerative Medicine and Ionian Area, Pathology Unit, University of Bari Aldo Moro, Bari, Italy; 3Specialization School Neuropsychology, University of Campania Luigi Vanvitelli, Caserta, Italy; 4IRCCS Humanitas Research Hospital, Milan, Italy; 5Department of Biomedical Sciences, Humanotas University, Milan, Italy; 6Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 7Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 8Department of Experimental Medicine, Sapienza University, Roma, Italy; 9University of Bari Aldo Moro, Bari, Italy
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62 | APPLICATION OF AN AI-BASED WORKFLOW FOR THE ASSESSMENT OF TESTICULAR DAMAGE IN DOGS Lorenzo Riccio1|2, Maria De Falco2, Nicola Ambrosio3, Angelo Spada3, Francesca Del Porto2, Cristina Marchetti2, Orlando Paciello1, Luigi Rosati2 | 1Dept. of Veterinary Medicine and Animal Productions, University of Naples Federico II, Italy; 2Dept. of Biology, University of Naples Federico II, Italy; 3ASL Napoli 2 Nord, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy
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Antigen retrieval pre-treatment causes a different expression pattern of Cav3.2 in rat and mouse spinal dorsal horn
2063PDF: 875Supplementary: 228HTML: 37 -
FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
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P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante1, L. Leanza2, E. Guerra3, F. Vianello4, C. Iacovino1, S. Lattanzio1, L. Morello1, G. Stati1, P. Simeone3, P. Lanuti3, S. Alberti5, M. Reichert6, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Biology, University of Padua, Padua, Italy; 3Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; 4Department of Biology, University of Padua, Padua, Italy; 5Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; 6Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany
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PARP-1 protein expression in glioblastoma multiforme
3273PDF: 1299HTML: 1815 -
BEYOND THE SPINAL CORD: MORPHOLOGICAL ALTERATIONS OF CORTICAL PROJECTION NEURON IN SPINAL MUSCULAR ATROPHY La Rocca F1,2, Schellino R1,2, Iezzi G1,2, Caretto A1,2, Boido B1,2 and Vercelli A1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri, Ottolenghi, University of Turin, Turin, Italy
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14 | NR2F1 MODULATES ACTIVATION DYNAMICS AND MAINTENANCE OF THE ADULT MURINE HIPPOCAMPAL NEURAL STEM CELL POOL S. Bonzano1|2, A. Lippolis1|2, S. Quaresima3, V. Manzini3, E. Dallorto1|2, E. Cacci3, P. Peretto1|2, M. Studer4, V. Licursi5, G. Lupo3, S. De Marchis1|2 | 1Dept. of Life Sciences and Systems Biology (DBIOS), Univ. of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (Turin), Italy; 3Dept. of Biology and Biotechnologies Charles Darwin, Sapienza Univ. of Rome, Italy; 4Univ. Côte d'Azur, CNRS, Inserm, iBV, Nice, France; 5Institute of Molecular Biology and Pathology (IBPM), National Research Council (CNR), Rome, Italy
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy
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WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
1398PDF: 924Supplementary: 100HTML: 24 -
Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway
3162PDF: 643Supplementary: 277HTML: 287 -
P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti1,2, F. Beretti2, M. Malenchini2, M. Y. Follo1, F. Mancarella3, F. Bonafè3, F. Gherardini4, T. Maraldi2 | 1Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; 4Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
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