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European Journal of Histochemistry

eISSN 2038-8306 - pISSN 1121-760X

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Editor-in-Chief: Marco Biggiogera, Italy

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  • THE ROLE OF RETINAL mTOR IN RETINAL DEGENERATION Lazzeri G1, Lenzi P1, Ferrucci M1, Biagioni F2, Busceti CL2, Giambelluca M1, Puglisi-Allegra S2 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa; 2IRCCS, Neuromed, Pozzilli, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4458
    183
  • Solamargine inhibited the progression of non-small cell lung cancer in vitro by activating T cells

    Changchun Zhang, Yichen Sun, Wei Jiang, Lin Wu, Qi Fang, Qikun Wang
    01-09-2025
    https://doi.org/10.4081/ejh.2025.4217
    349
    PDF: 103
    HTML: 2
  • Quercetin reverses 5-fluorouracil resistance in colon cancer cells by modulating the NRF2/HO-1 pathway

    Zhongzhu Tang, Lei Wang, Yunwang Chen, Xiaomin Zheng, Runyu Wang, Bingxue Liu, Shiqi Zhang, Huimin Wang
    07-08-2023
    https://doi.org/10.4081/ejh.2023.3719
    1284
    PDF: 752
    HTML: 16
  • Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats

    Zhen Wang, Xiaoyan Du, Daoyang Yu, Yang Yang, Gaoen Ma, Xueli Jia, Lulu Cheng
    12-01-2022
    https://doi.org/10.4081/ejh.2022.3328
    1928
    PDF: 1076
    HTML: 77
  • Carotenoids co-localize with hydroxyapatite, cholesterol, and other lipids in calcified stenotic aortic valves. Ex vivo Raman maps compared to histological patterns

    A. Bonetti, A. Bonifacio, A. Della Mora, U. Livi, M. Marchini, F. Ortolani
    20-04-2015
    https://doi.org/10.4081/ejh.2015.2505
    1940
    PDF: 1089
    HTML: 380
  • Co-transplantation of bone marrow mesenchymal stem cells and monocytes in the brain stem to repair the facial nerve axotomy

    Li Wu, Dan Han, Jie Jiang, Xiaojie Xie, Xunran Zhao, Tengfei Ke, Wen Zhao, Liu Liu, Wei Zhao
    19-06-2020
    https://doi.org/10.4081/ejh.2020.3136
    1461
    PDF: 739
    HTML: 10
  • Expression pattern of thymosin beta 4 in the adult human liver

    S. Nemolato, P. Van Eyken, T. Cabras, F. Cau, M.U. Fanari, A. Locci, D. Fanni, C.L.P. Gerosa, I. Messana, M. Castagnola, G. Faa
    e25
    07-09-2011
    https://doi.org/10.4081/ejh.2011.e25
    1366
    PDF: 664
    HTML: 1302
  • P59 | IMMUNOHISTOCHEMISTRY ANALYSIS TO DETECT A MOLECULAR SIGNATURE IN INTERVERTEBRAL DISC DEGENERATION L. Penolazzi1, R. Nadalini1, C. Sief1, E. Lambertini2, C. Angelini3, R. Piva1 | 1Department of Neurosciences and rehabilitation, University of Ferrara, Italy; 2Laboratorio Centralizzato di ricerca preclinica, University of Ferrara, Italy; 3Department of Translational Medicine, University of Ferrara, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4384
    178
  • Histochemistry in biology and medicine: a message from the citing journals

    Carlo Pellicciari
    23-12-2015
    https://doi.org/10.4081/ejh.2015.2610
    2876
    PDF: 820
    HTML: 882
  • Histochemistry as an irreplaceable approach for investigating functional cytology and histology

    C. Pellicciari
    e41
    19-12-2013
    https://doi.org/10.4081/ejh.2013.e41
    3233
    PDF: 779
    HTML: 404
  • THERAPEUTIC VERSUS PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY Iseppon F1, Tonelli E1,2, Fabbro V1, Chiorazzi A1, Canta A1, Alberti P1, Carozzi VA1, Pozzi E1, Cherchi L1,2, Fermi S1,2, Segmani I1,2, Fantoni L1, Rodriguez-Menendez V1, Ballarini E1, Cavaletti G1 and Meregalli C1 | 1University of Milano-Bicocca, Department of Medicine and Surgery, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4494
    124
  • Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma

    Zhiyang Wang, Jing Li, Ziwei Liu, Ling Yue
    20-03-2023
    https://doi.org/10.4081/ejh.2023.3622
    945
    PDF: 615
    HTML: 30
  • Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

    Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye
    30-09-2021
    https://doi.org/10.4081/ejh.2021.3224
    2860
    PDF: 1754
    HTML: 32
  • Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway

    Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou
    22-06-2022
    https://doi.org/10.4081/ejh.2022.3394
    1573
    PDF: 1022
    HTML: 24
  • GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4460
    184
  • Immunohistochemical localization and functional characterization of somatostatin receptor subtypes in a corticotropin releasing hormonesecreting adrenal phaeochromocytoma: review of the literature and report of a case

    RM Ruggeri, F Ferraù, A Campennì, A Simone, V Barresi, G Giuffrè, G Tuccari, S Baldari, F Trimarchi
    e1
    17-08-2009
    https://doi.org/10.4081/ejh.2009.e1
    1008
    PDF: 642
  • Tumor cell-derived exosomal lncRNA LOC441178 inhibits the tumorigenesis of esophageal carcinoma through suppressing macrophage M2 polarization

    Jiangmu Chen, Zongchi Chen, Weitao Hu, Daxing Cai
    14-10-2022
    https://doi.org/10.4081/ejh.2022.3510
    1148
    PDF: 613
    HTML: 29
  • RXRα is upregulated in first trimester endometrial glands of spontaneous abortions unlike LXR and PPARγ

    J. Knabl, A. Vattai, R. Hüttenbrenner, S. Hutter, M. Karsten, U. Jeschke
    02-11-2016
    https://doi.org/10.4081/ejh.2016.2665
    1917
    PDF: 992
    HTML: 309
  • Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve

    A. Arcucci, M.R. Ruocco, F. Albano, G. Granato, V. Romano, G. Corso, C. Bancone, E. De Vendittis, A. Della Corte, S. Montagnani
    18-07-2014
    https://doi.org/10.4081/ejh.2014.2383
    2003
    PDF: 2100
    HTML: 341
  • NADPH-diaphorase expression in the rat jejunum after intestinal ischemia/reperfusion

    A. Bolekova, T. Spakovska, D. Kluchova, S. Toth, J. Vesela
    e23
    13-07-2011
    https://doi.org/10.4081/ejh.2011.e23
    1368
    PDF: 581
    HTML: 1301
  • A semiquantitative scoring tool to evaluate eccentric exercise-induced muscle damage in trained rats

    D. Rizo-Roca, J.G. Ríos-Kristjánsson, C. Núñez-Espinosa, A. Ascensão, J. Magalhães, J.R. Torrella, T. Pagès, G. Viscor
    02-11-2015
    https://doi.org/10.4081/ejh.2015.2544
    2045
    PDF: 788
    HTML: 447
  • Three-dimensional scaffold-free fusion culture: the way to enhance chondrogenesis of in vitro propagated human articular chondrocytes

    M. Lehmann, F. Martin, K. Mannigel, K. Kaltschmidt, U. Sack, U. Anderer
    e31
    05-11-2013
    https://doi.org/10.4081/ejh.2013.e31
    4567
    PDF: 980
    HTML: 960
  • Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes

    G. Perrone, S. Morini, D. Santini, C. Rabitti, B. Vincenzi, R. Alloni, A. Antinori, P. Magistrelli, R. Lai, C. Cass, J. R. Mackey, R. Coppola, G. Tonini, A. Onetti Muda
    e38
    13-09-2010
    https://doi.org/10.4081/ejh.2010.e38
    1266
    PDF: 620
    HTML: 1714
  • EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4496
    117
  • Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

    Jun Pan, Yi Zhao, Yu Zhang, Yuhe Zhou, Fengxuan Zhang, Yitian Chen, Xiaoyuan Chu
    24-04-2025
    https://doi.org/10.4081/ejh.2025.4203
    546
    PDF: 201
    HTML: 32
  • Effect of carboplatin injection on Bcl-2 protein expression and apoptosis induction in Raji cells

    Peng Lin, Boliang Zhou, Haiying Yao, Ya-ping Guo
    09-07-2020
    https://doi.org/10.4081/ejh.2020.3134
    1865
    PDF: 531
    HTML: 19
  • Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation

    Mariko Kawai, Yu-Ki Ohmori, Mai Nishino, Masayo Yoshida, Kaori Tabata, Do-Saku Hirota, Ayako Ryu-Mon, Hiromitsu Yamamoto, Junya Sonobe, Yo-Hei Kataoka, Noriko Shiotsu, Mika Ikegame, Hiroki Maruyama, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura
    05-05-2017
    https://doi.org/10.4081/ejh.2017.2772
    1911
    PDF: 676
    HTML: 196
  • Visualizing endocytotic pathways at transmission electron microscopy via diaminobenzidine photo-oxidation by a fluorescent cell-membrane dye

    S. Grecchi, M. Malatesta
    22-10-2014
    https://doi.org/10.4081/ejh.2014.2449
    2356
    PDF: 910
    Supplementary: 259
    HTML: 706
  • P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4344
    128
  • Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function

    Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng
    21-06-2022
    https://doi.org/10.4081/ejh.2022.3412
    2057
    PDF: 1231
    HTML: 27
  • SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS D’Aprile C1, Naghshbandieh A1,3, Fabbro V1, Turano E2, Scambi I2, Virla F2, Caprioli M2, Mariotti R2, Scuteri A1 and Meregalli C1 | 1Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Italy; 2Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 3PhD Program in Neuroscience, University of Milano- Bicocca, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4466
    189
  • In vitro exposure of human chondrocytes to pulsed electromagnetic fields

    V Nicolin, C Ponti, G Baldini, D Gibellini, R Bortul, M Zweyer, B Martinelli, P Narducci
    203-212
    10-08-2009
    https://doi.org/10.4081/1143
    673
    PDF: 893
  • HUMAN AMNIOTIC MEMBRANE POTENTIAL FOR BONE REPAIR: FROM THE LAB TO THE CLINIC - ROLE OF ITS IMMUNOGENICITY F. Gindraux1,2 | 1CHU Besançon, Service de Chirurgie Maxillo-Faciale et Stomatologie, Besançon, France; 2Université Marie et Louis Pasteur, SINERGIES UR 4662, Besançon, France

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4271
    123
  • Dipeptidylpeptidase-IV activity and expression reveal decreased damage to the intrahepatic biliary tree in fatty livers submitted to subnormothermic machine-perfusion respect to conventional cold storage

    E. Tarantola, V. Bertone, G. Milanesi, C. Gruppi, A. Ferrigno, M. Vairetti, S. Barni, I. Freitas
    17-07-2014
    https://doi.org/10.4081/ejh.2014.2414
    1673
    PDF: 745
    HTML: 564
  • P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME L. Sallicandro1, R. Gentile2, B. Filová3, S. Polakovičová3, A. Biagini1, F. Ballarino4, D. Del Bianco4, I. Varga5, A. Malvasi6, B. Fioretti2 | 1Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 3Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 4Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 5Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 6Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Unit, University of Bari Aldo Moro, Bari, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4391
    202
  • Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

    C. Pellicciari
    30-12-2014
    https://doi.org/10.4081/ejh.2014.2474
    2041
    PDF: 634
    HTML: 804
  • NEUROACTIVE STEROIDS PROTECT FROM BORTEZOMIB-INDUCED TOXICITY: EVIDENCE FROM IN VITRO MODELS Fabbro V1, Tonelli E1,2, Scuteri A1,3, D’Aprile C1, Naghshbandieh A1,2, Lim D4, Distasi C4, Giatti S5 and Meregalli C1 | 1School of Medicine and Surgery, Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano- Bicocca, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy; 3Milan Center for Neuroscience (NeuroMI); 4University of Piemonte Orientale, Department of Pharmaceutical Sciences, Novara, Italy; 5University of Milan, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Milan, Italy

    12-12-2025
    https://doi.org/10.4081/ejh.2025.4471
    182
  • miR-1270 enhances the proliferation, migration, and invasion of osteosarcoma via targeting cingulin

    Yang Liu, Weichun Guo, Shuo Fang, Bin He, Xiaohai Li, Li Fan
    07-12-2021
    https://doi.org/10.4081/ejh.2021.3237
    1268
    PDF: 507
    HTML: 21
  • Quantity of AgNOR in gastric endocrine carcinoid tumours as a potential prognostic tool

    G Giuffrè, F Mormandi, V Barresi, C Bordi, G Tuccari, G Barresi
    45-50
    30-06-2009
    https://doi.org/10.4081/974
    1480
    PDF: 478
  • FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4279
    134
  • Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study

    M. Di Rosa, M.A. Szychlinska, D. Tibullo, L. Malaguarnera, G. Musumeci
    16-09-2014
    https://doi.org/10.4081/ejh.2014.2423
    2746
    PDF: 1078
    HTML: 1600
  • P69 | MICROPLASTICS AND ATHEROSCLEROSIS: EVIDENCE OF MICROPLASTICS IN CAROTID ATHEROSCLEROTIC PLAQUES R. Sciarrillo1, V. Gallicchio1, A. Lallo1, F. Carrella1, D. Barbarisi2, A. Falzarano1, M. De Falco3, F. Flora2, A. Peluso2, S. Piccolo2, L. Flora2 | 1Department of Science and Technologies, University of Sannio, Italy; 2Vascular Surgery, Hospital of National Importance San Giuseppe Moscati, Italy; 3Department of Biology, University of Naples, Italy

    21-08-2025
    https://doi.org/10.4081/ejh.2025.4394
    189
  • Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis

    Guangbao He, Yibo He, Hongwei Ni, Kai Wang, Yijun Zhu, Yang Bao
    26-07-2023
    https://doi.org/10.4081/ejh.2023.3766
    1492
    PDF: 1019
    HTML: 10
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European Journal of Histochemistry

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