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P58 | VITAMIN D ATTENUATES LIVER INJURY BY REDUCING APOTOSIS, PYROPTOSIS, FERROPTOSIS AND PROMOTING REGENERATION IN TYPE 2 DIABETES S. Rzeyeva1, N. Bayromava2, T. Ozbilenler1, A. Akdemir3, M. Anapalı Aykaç4, D. Aydemir5, F. Kaya Dagistanli1, T. Ulutin1, O. Uysal1, M. Ozturk6 | 1Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; 2Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul, Türkiye; 3Karabuk University, Faculty of Medicine, Karabük, Türkiye; 4Ataturk University, Faculty of Medicine, Erzurum, Türkiye; 5Istanbul University, Faculty of Medicine, Istanbul, Türkiye; 6Istanbul University-Cerrahpasa, Faculty of Medicine, Istanbul Türkiye
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GPX4 and GPX7 over-expression in human hepatocellular carcinoma tissues
4171PDF: 1311Supplementary: 517HTML: 677 -
NANOVESICLES IN THE GUT–BRAIN AXIS: INSIGHTS FROM PROBIOTIC SUPPLEMENTATION IN IRRITABLE BOWEL SYNDROME C. Caruso Bavisotto, F. Cappello | Section of Human Anatomy, Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, Palermo, Italy
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THE ESTABLISHMENT OF A HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED IN VITRO MODEL TO STUDY DIABETIC PERIPHERAL NEUROPATHY Rando S1,2, Muratori L1,2, Contato A2,3, Lorenzati M2,3, Dotta S2,3, Marvaldi L2,3, Buffo A2,3 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Turin, Italy; 3Department of Neuroscience “Rita Levi Montalcini” University of Turin, Turin, Italy
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60 | CELLULAR DYSHOMEOSTASIS AND REDOX IMBALANCE INDUCED BY CANTHARIDIN IN GLIOBLASTOMA MODELS R. Proietti, V. D’Ezio, A. Presaghi, L. Salsedo, A. Sperati, M.A. Bologna, M. Colasanti, T. Persichini | Dept. of Science, Roma Tre University, Rome, Italy
163PDF: 90 -
Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci
2947PDF: 1457Supplementary: 294HTML: 81 -
P24 | NUTRACEUTICAL-MEDIATED EFFECTS IN THE MODULATION OF INFLAMMATORY PROCESSES IN AN IN VITRO MODEL OF HUMAN ENDOMETRIAL STROMAL CELLS L. Pietrobelli1, V.C. Divincenzo1, L. Sileo1, G. Scanavino1, E. Vicini2, L. Campagnolo3, V. Corsetti4, A.M. Tata1 | 1Dept. of Biology and Biotechnology “C. Darwin”, Sapienza University of Rome, Italy; 2Dept. of SAIMAL, Section of Histology, Sapienza University of Rome, Italy; 3Dept. of Biomedicine and Prevention, University of Rome Tor Vergata, Italy; 4Institute of Translational Pharmacology (IFT)-CNR, Rome, Italy
130PDF: 82 -
08 | HUMAN ADIPOSE STEM CELLS: IMPACT OF DONORS’ AGE ON CELL PROPERTIES AND BEHAVIOUR Ludovica Barone1, Federica Rossi1, Federico Tamborini1, Christina Pagiatakis1|2, Roberto Papait1|2, Rosalba Gornati1 | 1Dept of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; 2Dept of Cardiovascular Medicine, IRCCS Humanitas Research Hospital, Rozzano (MI), Italy
256PDF: 79 -
P27 | THE ECHINOCHROME FROM ARBACIA LIXULA: CHARACTERIZATION AND BIOACTIVE EFFECTS ON ZEBRAFISH EMBRYOS Andrea Claudio Stetco1, Patrizia Pagliara1, Laura Pecoraro1, Aurora Mazzei1, Roberta Schiavone1, Amilcare Barca2, Tiziano Verri1 | 1Dept of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy; 2Dept of Experimental Medicine, University of Salento, Lecce, Italy
157PDF: 86 -
P45 | TARGETING PRELAMIN A PROCESSING TO SENSITIZE GLIOBLASTOMA CELLS TO OXIDATIVE STRESS M.V. Marvi1, C. Evangelisti1, I. Rusciano1, I. Neri1, L.I. Cocco1, L. Manzoli1, C. Capanni2, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum-University of Bologna, Bologna, Italy; 2CNR Institute of Molecular Genetics «Luigi Luca Cavalli-Sforza», Unit of Bologna, Bologna, Italy / IRCCS Rizzoli Orthopedi, Institute, Bologna, Italy
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THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS M. Micucci | Department of Biomolecular Sciences, Urbino University “Carlo Bo”, Urbino, Italy
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77 | TARGETING P75NTR CORRECTS OXIDATIVE AND INFLAMMATORY IMBALANCES IN A CELLULAR MODEL OF RETT SYNDROME M. Varone, M. Colardo, N. Martella, D. Pensabene, E. Bisesto, M. Segatto | Dept of Biosciences and Territory, University of Molise, Pesche, Italy
182PDF: 75 -
AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
2171PDF: 1072Supplementary Figures: 368Supplementary Table: 264HTML: 527 -
P05 | COMBINED EMBRYOTOXIC EFFECTS OF MICROPLASTICS AND HEAVY METALS IN XENOPUS LAEVIS S. Di Marino, C. Fogliano, C.M. Motta, B. Avallone, R. Carotenuto | Dept. of Biology, University of Naples Federico II, Italy
148PDF: 96 -
SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS D’Aprile C1, Naghshbandieh A1,3, Fabbro V1, Turano E2, Scambi I2, Virla F2, Caprioli M2, Mariotti R2, Scuteri A1 and Meregalli C1 | 1Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Italy; 2Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 3PhD Program in Neuroscience, University of Milano- Bicocca, Italy
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P25 | THE INVASIVE ALGAE CAULERPA RACEMOSA POSES A THREAT TO MUSSEL VIABILITY AND REPRODUCTION S. Balsamo, T. Chianese, A. Allocca, M. Prisco, R. Scudiero, M. De Falco, L. Rosati | Dept. of Biology, University of Naples Federico II, Italy
179PDF: 75 -
68 | RESILIENCE ASSOCIATED WITH DEFECTS IN VITAMIN B12 METABOLISM: BALANCING BETWEEN HOMEOSTASIS AND DISEASE E. Selita1, E. Tomaselli2, G. Di Matteo3, L. Mannina3, M. Rossi2|4, D. Passeri2|4, L. Angeloni2|4, M. Fidaleo1|4 | 1Dept of Biology and Biotechnology, Charles Darwin, University of Rome Sapienza, Italy; 2Dept of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Italy; 3Dept of Chemistry and Technology of Drugs, Sapienza University of Rome, Italy; 4Research Centre for Nanotechnology for Engineering of Sapienza (CNIS), Sapienza University of Rome, Italy
143PDF: 89 -
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway
341PDF: 362Supplementary: 65HTML: 26 -
P10 | BIOLOGICAL ACTIVITIES OF CITRUS LIMON-, VITIS VINIFERA- AND ACTINIDIA DELICIOSA-DERIVED EXTRACELLULAR VESICLES ON HUMAN CACO-2 CELLS M. Destino, E. Carata, B.A. Tenuzzo, E. Panzarini | Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), University of Salento, Lecce, Italy
150PDF: 81 -
P57 | SELONSERTIB (ASK1 INHIBITOR) IN SKIN TISSUE REPAIR OF OBESE MICE V. Oliveira Collares Barbos, B. Romana de Souza | Department of Histology and Embriology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
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P12 | NEUROBIOLOGICAL IMPACT OF CITRUS BERGAMIA IN THE IDIOPHATIC AUTISM MODEL BTBR D. Minervini1, I. Olivito1, A. Vivacqua2|3, L. Bartella4|5, L. Di Donna4|5, R. Alò1, R.M. Facciolo1 | 1Comparative Neuroanatomy Lab; Biology, Ecology and Earth Sciences Dept., University of Calabria, Rende (CS), Italy; 2Dept. of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy; 3Centro Sanitario, University of Calabria, Rende (CS), Italy; 4QUASIORA Lab., AGRINFRA Research Net, University of Calabria, Rende (CS), Italy; 5Chimica and Tecnologie Chimiche Dept., University of Calabria, Rende (CS), Italy
139PDF: 85 -
A PILOT STUDY TO INVESTIGATE THE ANTIAGING EFFECTS OF THE OLIVE POMACE BY-PRODUCT ON THE BRAIN OF DROSOPHILA MELANOGASTER Makladissi S1†, Tomassoni D2†*, Nardin T3, Bellitto V2, Cappelli A2, Di Cara F1‡ and Beghelli D2‡ | 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; 2School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, MC, Italy ; 3Chemical Unit Oenological Vines Agri-food - Technology Transfer Centre Foundation Edmund Mach, TN, Italy †These authors equally contributed. ‡These authors share the authorship
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P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti1, F. Liccardo2, L. Pace1, M. Marcotulli3, L. Lafrate3, G. Cidonio3, T. Ottone4, S. Travaglini4, M.T. Voso4, V. Fulci5, M. Sampaolesi1, F. Fazi1, S. Masciarelli1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; 2Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; 3Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; 4Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; 5Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy
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THE ROLE OF RETINAL mTOR IN RETINAL DEGENERATION Lazzeri G1, Lenzi P1, Ferrucci M1, Biagioni F2, Busceti CL2, Giambelluca M1, Puglisi-Allegra S2 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa; 2IRCCS, Neuromed, Pozzilli, Italy
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A PRECLINICAL STUDY ON THE MODULATION OF THE MICROBIOTA–GUT–BRAIN AXIS BY A FUNCTIONAL SNACK PROMOTING HEALTHY AGING Bellitto V1, Grasselli F1, Martinelli I2, Nittari G2, Vittadini E1, Eleuteri AM1, Tayebati SK2, Bonfili L1 and Tomassoni D1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Italy
414 -
04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE G. Abruscato1, L. Sileo2, G. Scanavino2, C. Guerriero2, M. Mauro1, M. Vazzana1|3, V. Arizza1|3, C. Luparello1|3, A.M.Tata2 | 1Dept. of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Italy; 2Dept. of Biology and Biotechnologies Charles Darwin, Sapienza- University of Rome, Italy; 3National Biodiversity Future Center (NBFC), Italy
346PDF: 99 -
P17 | INTERMITTENT FASTING AND FUCOIDAN ADMINISTRATION AMELIORATE THE EFFECT OF TYPE 2 DIABETES ON ENTERIC NERVOUS SYSTEM IN RATS A.M. Cırık¹, B. Erdem¹, E. Akar ¹, E. Akkuş¹, Ö. İleri-Meşe², H. Maraş², Z.N. Özdemir-Kumral³, M. Yüksel⁴, Ö.T. Çilingir-Kaya² | 1Marmara Uni School of Medicine, Istanbul, Türkiye; 2Department of Histology and Embryology, Marmara Uni School of Medicine, Türkiye; 3Department of Physiology, Marmara Uni Faculty of Medicine, Türkiye; 4Department of Medical Laboratory Techniques, Vocational School of Health Services, Marmara Uni, Türkiye
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NEUROPROTECTIVE POTENTIAL OF ADIPOSE MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES ON DAMAGED MOTONEURONS Caprioli M1, Sganzerla D1, Scambi I1, Virla F1, Grazioli N2, Greco N2, Turano E1 and Mariotti R1 | 1Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 2Department of Engineering for Innovation Medicine, University of Verona, Italy
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47 | SYNERGISTIC LUNG TOXICITY OF PM2.5 AND ENNIATIN B1 IN A CO-CULTURE MODEL S. Marchetti1, F. Caloni2, P. Mantecca1, M. Gualtieri1 | 1POLARIS Research Centre, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Italy; 2Dept. of Environmental Science and Policy, Università degli Studi di Milano, Italy
146PDF: 79 -
26 | ASSESSING DEVELOPMENTAL TOXICITY OF PSYCHOACTIVE POLLUTANTS USING XENOPUS LAEVIS AS A MODEL S. Di Marino, C. Fogliano, C.M. Motta, B. Avallone, R. Carotenuto | Dept. of Biology, University of Naples Federico II, Italy
159PDF: 84
