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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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Expression of the endocannabinoid receptors in human fascial tissue
3453PDF: 1783HTML: 2360 -
Developmental expression of calretinin in the mouse cochlea
1667PDF: 520HTML: 16 -
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species
2200PDF: 1118Supplementary: 106HTML: 130 -
Interindividual variability in the expression of surfactant protein A and B in the human lung during development
2027PDF: 770Supplementary: 254HTML: 386 -
Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea
1042PDF: 715Supplementary: 89HTML: 16 -
STRESS GRANULES AND α-SYNUCLEIN: INTERPLAY BETWEEN CELLULAR STRESS AND PROTEIN AGGREGATION IN PARKINSON’S DISEASE Zanchi G1, Novello C1, Calogero AM2, Mazzetti S2, Bonaldo B1, Gomez MCL1, Rolando C1, Calandrella D2,3, Pezzoli G2 and Cappelletti G1 | 1Department of Biosciences, University of Milan, Milan, Italy 2Fondazione Pezzoli per la Malattia di Parkinson, Milan, Italy 3Parkinson Institute, ASST G. Pini-CTO, Milan, Milan, Italy
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LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling
1188PDF: 632Supplementary: 91HTML: 22 -
P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION J. Freni1, M. Crescenti2, E. Bertuccio3, A. Fittipaldi1, P. Carrega2, E. Di Carlo4, G. Ferlazzo3, G. Vermiglio1, I. Bonaccorsi2 | 1Department of Biomedical, Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy: 2Department Human Pathology, «G. Barresi», University of Messina, Messina, Italy; 3Department of Experimental Medicine (DIMES), University of Genoa, Genova, Italy; 4Department of Medicine and Sciences of Aging, «G. D’Annunzio» University of Chieti-Pescara, Chieti, Italy
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CALRETININ IMMUNOREACTIVITY IN NERVE CELLS OF THE HUMAN MIDBRAIN AND THEIR POTENTIAL ROLE IN NEURODEGENERATIVE DISORDERS Flace P1, Caporusso C2, Galletta D3, Stolfa M2, Cacciola A4,5, Scarcella VS2, Branca JJV6, Gulisano M6, Milardi D7, Gradini R8, Livrea P9 and Marzullo A2 | 1Medical School, University of Bari Aldo Moro, Bari, Italy; 2Department of Precision and Regenerative Medicine and Ionian Area, Pathology Unit, University of Bari Aldo Moro, Bari, Italy; 3Specialization School Neuropsychology, University of Campania Luigi Vanvitelli, Caserta, Italy; 4IRCCS Humanitas Research Hospital, Milan, Italy; 5Department of Biomedical Sciences, Humanotas University, Milan, Italy; 6Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 7Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 8Department of Experimental Medicine, Sapienza University, Roma, Italy; 9University of Bari Aldo Moro, Bari, Italy
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ASTROCYTE DYSFUNCTION IN AUTOSOMAL DOMINANT LEUKODYSTROPHY (ADLD): INSIGHTS FROM 2D AND 3D IN VITRO SYSTEMS AND EX VIVO CEREBROSPINAL FLUID METABOLOMICS F.D. Koufi1, V. Righi2, A. Mucci3, I. Rusciano1, S. Mongiorgi1, M. Shin4, Y. Kosodo4, I. Cani5, P. Cortelli6, E. Giorgio7, G. Ramazzotti1, L. Manzoli1, S. Ratti1 | 1 Cellular Signaling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, Italy; 3Department of Geological and Chemical Sciences, University of Modena and Reggio Emilia, Modena, Italy; 4Korea Brain Research Institute (KBRI), Daegu, Republic of Korea; 5Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 6IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; 7Department of Molecular Medicine, University of Pavia, Pavia, Italy; Medical Genetics Unit, IRCCS Mondino Foundation, Pavia, Italy.
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GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy
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Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
1366PDF: 913Supplementary: 96HTML: 21 -
Peribiliary gland damage due to liver transplantation involves peribiliary vascular plexus and vascular endothelial growth factor
2445PDF: 780Supplementary: 279HTML: 15 -
P28 | EXPLORING THE POTENTIAL LINK BETWEEN MITOCHONDRIAL DYSFUNCTION AND MITO-EVS IN PANCREATIC DUCTAL ADENOCARCINOMA (PDAC) V. Giansante1, L. Leanza2, E. Guerra3, F. Vianello4, C. Iacovino1, S. Lattanzio1, L. Morello1, G. Stati1, P. Simeone3, P. Lanuti3, S. Alberti5, M. Reichert6, R. Di Pietro1 | 1Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; 2Department of Biology, University of Padua, Padua, Italy; 3Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; Laboratory of Cancer Pathology, Center for Advanced Studies and Technology (CAST)G. d’Annunzio” University of Chieti-Pescara, Italy; 4Department of Biology, University of Padua, Padua, Italy; 5Unit of Medical Genetics, Department of Biomedical Sciences, University of Messina, Messina, Italy; 6Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany; Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany
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ECRG4 expression in normal rat tissues: expression study and literature review
3006PDF: 1161Supplementary: 381HTML: 1014 -
BEYOND THE SPINAL CORD: MORPHOLOGICAL ALTERATIONS OF CORTICAL PROJECTION NEURON IN SPINAL MUSCULAR ATROPHY La Rocca F1,2, Schellino R1,2, Iezzi G1,2, Caretto A1,2, Boido B1,2 and Vercelli A1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri, Ottolenghi, University of Turin, Turin, Italy
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AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
2033PDF: 981Supplementary Figures: 308Supplementary Table: 227HTML: 500 -
HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES G. Di Sante1, A. M. Stabile1, A. Pistilli1, M. Ruggirello1,2, F. Michetti3,4, F. Ria2, M. Rende1 | 1 Department of Surgery and Medicine, Sect. of Human, Clinical and Forensic Anatomy, University of Perugia, Perugia, Italy; 2Department of Translational Medicine and Surgery, Section of General Pathology, University “Cattolica del Sacro Cuore” of Rome, Roma, Italy; 3Department of Medicine, LUM University, Casamassima, Bari, Italy; 4Italy Genes, Rome, Italy
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Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway
3144PDF: 632Supplementary: 273HTML: 285 -
WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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FROM SEEING TO BELIEVING: A 43-YEAR LONG JOURNEY IN IMMUNOSTAINING G. Cattoretti | UNIMIB Pathology, Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
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P44 | CROSSTALK AMONG NEURONS, MUSCLE AND BONE: HUMAN NEUROMUSCULAR JUNCTION ON A CHIP M. Gatti1,2, F. Beretti2, M. Malenchini2, M. Y. Follo1, F. Mancarella3, F. Bonafè3, F. Gherardini4, T. Maraldi2 | 1Department of Biomedical and Neuromotor Science, Cellular Signalling Laboratory, University of Bologna, Italy; 2Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 3Istituto per lo Studio dei Materiali Nanostrutturati (ISMN), National Research Council (CNR), Bologna, Italy; 4Department of Engineering “Enzo Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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Expression of S100β during mouse cochlear development
1398PDF: 375Supplementary: 72HTML: 7 -
On the future contents of a small journal of histochemistry
2520PDF: 967HTML: 939 -
IMPAIRMENT OF HERP E3 LIGASE ACTIVITY BY MUTANT POLYGLUTAMINE PROTEINS: A NOVEL MECHANISM IN POLYGLUTAMINE DISEASE NEUROPATHOLOGY T. Peng, B. Zhang, M. Yang, H. Li | Department of Histology and Embryology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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