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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou^1-6, M. Najajreh^1-4, D.P. Cook⁷, C.H. Maurer^1,2, S. Bärthel⁸, P. Putze⁸, H.A. Messal⁹, S.K. Ravichandran^1-3, T. Richter¹⁰, M. Knolle¹¹, T. Metzler¹², A.R. Shastri^1,2,3, R. Öllinger¹³, J. Jasper^1,2,3, L. Schmidleitner^1,2,3, C.Schneeweis⁸, H. Ishikawa-Ankerhold¹⁴, T. Engleitner¹³, S. Dobiasch¹⁵, I. Heid, M.D. Luecken¹⁶, K. Steiger¹², G. Kaissis¹¹, J. Van Rheenen⁹, F.J. Theis¹⁰, D. Saur⁸, R. Rad¹³, M. Reichert^{1,2,3,4,5,17,18} | ¹Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ²Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; ³Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; ⁴Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; ⁵Bavarian Cancer Research Center (BZKF), Munich, Germany; ⁶Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; ⁷University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; ⁸Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; ⁹Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. ¹⁰Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; ¹¹Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; ¹²Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; ¹³Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; ¹⁴Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; ¹⁵Department of Radiation Oncology, Technical University of Munich, Germany; ¹⁶Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); ¹⁷German Cancer Consortium (DKTK), Munich, Germany; ¹⁸Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany

21-08-2025

https://doi.org/10.4081/ejh.2025.4289

390
Swertianolin ameliorates immune dysfunction in sepsis via blocking the immunosuppressive function of myeloid-derived suppressor cells

Zongfang Ren, Haoren Tang, Linjun Wan, Xing Liu, Ning Tang, Lingling Wang, Zhenhui Guo

01-09-2021

https://doi.org/10.4081/ejh.2021.3292

1694

PDF: 1114

HTML: 52
Astragalus Ⅳ ameliorates the dry eye injury in rabbit model via MUC1-ErbB1 pathway

Li Chu, Suhong Ma, Zhiwei Chen, Wenfu Cao

01-04-2021

https://doi.org/10.4081/ejh.2021.3198

1982

PDF: 1081

HTML: 40
17 | EXPLORING THE FUNCTIONAL ROLE OF THE PROTEOGLYCAN ESM1 IN THE BREAST CANCER TUMOR MICROENVIRONMENT E. Peri¹, S. Feo^1|2, E. Roz³, A. D’Ascola⁴, P. Cancemi^1|2 | ¹Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Italy; ²Experimental Center of Onco Biology (COBS), Palermo, Italy; ³La Maddalena Hospital III Level Oncological Department, Palermo, Italy; ⁴Department of Clinical and Experimental Medicine, University of Messina, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4635

175

PDF: 111
Overview of the optical properties of fluorescent nanoparticles for optical imaging

Federico Boschi, Francesco De Sanctis

29-08-2017

https://doi.org/10.4081/ejh.2017.2830

1961

PDF: 902

HTML: 96
P32 | BLOCKING CANCER CELL MOVEMENT: THE ROLE OF PAXILLIN AND EZRIN IN CERVICAL TUMOR M. Hałas-Wiśniewska¹, W. Arendt¹, M. Gagat^1,2, M. Izdebska¹ | ¹Department of Histology and Embryology, Nicolaus Copernicus University in Toruń, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Poland; ²Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4352

244
Hepatocyte growth factor intervention to reduce myocardial injury and improve cardiac function on diabetic myocardial infarction rats

Zaiyong Zhang, Cheng Long, Yufeng Guan, Mingcai Song

30-07-2020

https://doi.org/10.4081/ejh.2020.3142

1520

PDF: 825

HTML: 32
Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine

Flavia Carton, Manuela Malatesta

24-11-2022

https://doi.org/10.4081/ejh.2022.3603

1309

PDF: 570

HTML: 46
Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

07-04-2025

https://doi.org/10.4081/ejh.2025.4182

1413

PDF: 839

HTML: 73
Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery

M. Costanzo, F. Carton, A. Marengo, G. Berlier, B. Stella, S. Arpicco, M. Malatesta

14-04-2016

https://doi.org/10.4081/ejh.2016.2640

3419

PDF: 1501

HTML: 613
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu

03-03-2026

https://doi.org/10.4081/ejh.2026.4530

659

PDF: 542

HTML: 28
Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling

Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng

17-06-2025

https://doi.org/10.4081/ejh.2025.4218

1870

PDF: 728

HTML: 54
MiR-550a-3p restores damaged vascular smooth muscle cells by inhibiting thrombomodulin in an in vitro atherosclerosis model

Shiyuan Chen, Longfei Zhang, Benchi Feng, Wei Wang, Delang Liu, Xinyu Zhao, Chaowen Yu, Xiaogao Wang, Yong Gao

19-07-2022

https://doi.org/10.4081/ejh.2022.3429

1429

PDF: 780

Supplementary: 176

HTML: 59
Quantification of morphology of canine circumanal gland tumors: a fractal based study

I.C. Šoštarić-Zuckermann, K. Severin, M. Huzak, M. Hohšteter, A. Gudan Kurilj, B. Artuković, A. Džaja, Ž. Grabarević

11-04-2016

https://doi.org/10.4081/ejh.2016.2609

2021

PDF: 819

HTML: 398
Seasonal expressions of androgen receptor, estrogen receptors and cytochrome P450 aromatase in the uteri of the wild Daurian ground squirrels (Spermophilus dauricus)

Yu Wang, Ziyi Wang, Wenyang Yu, Xia Sheng, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng

07-02-2018

https://doi.org/10.4081/ejh.2018.2889

2435

PDF: 689

HTML: 91
HLA-G expression and role in advanced-stage classical Hodgkin lymphoma

G. Caocci, M. Greco, D. Fanni, G. Senes, R. Littera, S. Lai, P. Risso, C. Carcassi, G. Faa, G. La Nasa

11-04-2016

https://doi.org/10.4081/ejh.2016.2606

2934

PDF: 943

HTML: 253
Chemotherapy-induced nephrotoxicity was improved by crocin in mouse model

Qichao Yin, Hua Xiong

03-10-2022

https://doi.org/10.4081/ejh.2022.3541

1226

PDF: 768

HTML: 69
SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS A. Chytła¹, E. H. Lagunar¹, R. Gonül¹, B. Šalovská², J. Červenka³, A. Miladinović⁴, L. Antiga⁴, P. Hozák⁴, M. Sztacho¹ | ¹Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; ²Yale Cancer Biology Institute, Yale University School of Medicine, West Haven, USA; ³Laboratory of proteomics, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; ⁴Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic

21-08-2025

https://doi.org/10.4081/ejh.2025.4306

367
Species diversity regarding the presence of proximal tubular progenitor cells of the kidney

J. Hansson, A.E. Ericsson, H. Axelson, M.E. Johansson

05-02-2016

https://doi.org/10.4081/ejh.2016.2567

2168

PDF: 849

Supplementary: 349

HTML: 393
SerpinB3 administration protects liver against ischemia-reperfusion injury

Cristian Turato, Mariapia Vairetti, Marta Cagna, Alessandra Biasiolo, Andrea Ferrigno, Santina Quarta, Mariagrazia Ruvoletto, Silvia De Siervi, Patrizia Pontisso, Laura Giuseppina Di Pasqua

28-10-2022

https://doi.org/10.4081/ejh.2022.3561

1513

PDF: 864

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Koilocytes are enriched for alkaline-labile sites

E. I. CortÃ©s-GutiÃ©rrez, M. I. DÃ¡vila-RodrÃguez, J. L. FernÃ¡ndez, C. LÃ³pez-FernÃ¡ndez, J. GosÃ¡lvez

e32

13-10-2010

https://doi.org/10.4081/ejh.2010.e32

1431

PDF: 720

HTML: 2457
Muc5ac mucin expression during rat skin development

V. Ferretti, Ã. Segal-Eiras, C.G. Barbeito, M.V. Croce

20-02-2015

https://doi.org/10.4081/ejh.2015.2462

2674

PDF: 932

HTML: 741
Nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (T4) breast cancer

F. Piras, M.T. Ionta, S. Lai, M.T. Perra, F. Atzori, L. Minerba, V. Pusceddu, C. Maxia, D. Murtas, P. Demurtas, B. Massidda, P. Sirigu

e39

14-11-2011

https://doi.org/10.4081/ejh.2011.e39

1481

PDF: 692
P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS W. Arendt¹, P. Zawadka¹, M. Hałas-Wiśniewska¹, M. Gagat², M. Izdebska¹ | ¹ Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń, Poland; ²Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4323

246
Interaction between sphingosine kinase/sphingosine 1 phosphate and transforming growth factor-β/Smads pathways in experimental intestinal fibrosis. An in vivo immunohistochemical study

Roberta Sferra, Simona Pompili, Luca Ventura, Caroline Dubuquoy, Silvia Speca, Eugenio Gaudio, Giovanni Latella, Antonella Vetuschi

31-07-2018

https://doi.org/10.4081/ejh.2018.2956

2127

PDF: 1081

Supplementary: 266

HTML: 63
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

1429

PDF: 854

HTML: 45
OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas

Cristina Pirrone, Anna M. Chiaravalli, Alessandro Marando, Andrea Conti, Alessia Rainero, Andrea Pistochini, Francesco Lo Curto, Francesco Pasquali, Paolo Castelnuovo, Carlo Capella, Giovanni Porta

09-02-2017

https://doi.org/10.4081/ejh.2017.2730

3029

PDF: 1218

HTML: 371
P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER P. Chiodelli¹, J. Romoli¹, P. Bonassi Signoroni², E. Vertua², C. Ferrari³, E. Giuzzi², A. Paini², E. Scalvini², A. Papait¹, F.R. Stefani², A. R. Silini², O. Parolini¹ | ¹Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; ²Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; ³Research and Clinical Trials Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4336

231
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

17-09-2024

https://doi.org/10.4081/ejh.2024.4034

1438

PDF: 801

HTML: 35
Impact of Histochemistry on biomedical research: looking through the articles published in a long-established histochemical journal

C. Pellicciari

30-12-2014

https://doi.org/10.4081/ejh.2014.2474

2588

PDF: 763

HTML: 846
The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization

R. M. Ruggeri, E. Vitarelli, G. Barresi, F. Trimarchi, S. Benvenga, M. Trovato

e24

03-06-2010

https://doi.org/10.4081/ejh.2010.e24

1620

PDF: 735

HTML: 2662
Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration

Roberto Ghiselli, Guendalina Lucarini, Monica Ortenzi, Eleonora Salvolini, Stefania Saccomanno, Fiorenza Orlando, Mauro Provinciali, Fabio Casciani, Mario Guerrieri

10-01-2020

https://doi.org/10.4081/ejh.2020.3085

2139

PDF: 939

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Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication in vitro by reinforcing miR-192-5p/ATG7-induced autophagy

Minkai Cao, Deping Yuan, Hongxiu Jiang, Guanlun Zhou, Chao Chen, Guorong Han

02-09-2022

https://doi.org/10.4081/ejh.2022.3438

1687

PDF: 1039

HTML: 68
Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferra

21-06-2022

https://doi.org/10.4081/ejh.2022.3391

4381

PDF: 2041

HTML: 84
VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas

Ana Silvia Corlan, Anca Maria Cîmpean, Eugen Melnic, Marius Raica, Simona Sarb

05-03-2019

https://doi.org/10.4081/ejh.2019.3010

1851

PDF: 882

HTML: 46
Intracellular distribution of Tankyrases as detected by multicolor immunofluorescence techniques

M.G. Bottone, G. Santin, C. Soldani, P. Veneroni, A.I. Scovassi, C. Alpini

e4

20-01-2012

https://doi.org/10.4081/ejh.2012.e4

1524

PDF: 766

HTML: 5240
Detection of cancer clones in human gastric adenoma by increased DNA-instability and other biomarkers

A Sun, S Noriki, Y Imamura, M Fukuda

111-122

26-06-2009

https://doi.org/10.4081/815

843

PDF: 764
Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea

Wenjing Liu, Shanshan Ming, Xiaobing Zhao, Xin Zhu, Yuxiang Gong

01-09-2023

https://doi.org/10.4081/ejh.2023.3704

1371

PDF: 1103

HTML: 41
Detection of cancer clones in human colorectal adenoma as revealed by increased DNA instability and other bio-markers

Y Jin, A Sun, S Noriki, Y Imamura, M Fukuda

1-10

30-06-2009

https://doi.org/10.4081/1005

616

PDF: 458
Immunohistochemical study for relationship between vessel and lymphatic properties and tooth marks in human oral mucosa

Toru Inomata, Yoko Miwa, Shinichi Kawata, Takuya Omotehara, Iwao Sato, Masahiro Itoh

26-02-2020

https://doi.org/10.4081/ejh.2020.3095

1315

PDF: 776

HTML: 43
Dipeptidylpeptidase-ÂIV, a key enzyme for the degradation of incretins and neuropeptides: activity and expression in the liver of lean and obese rats

E. Tarantola, V. Bertone, G. Milanesi, E. Capelli, A. Ferrigno, D. Neri, M. Vairetti, S. Barni, I. Freitas

e41

08-10-2012

https://doi.org/10.4081/ejh.2012.e41

1900

PDF: 955

HTML: 1113
KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion

A. Porzionato, G. Fenu, M. Rucinski, V. Macchi, A. Montella, L. K. Malendowicz, R. De Caro

e14

04-05-2011

https://doi.org/10.4081/ejh.2011.e14

1412

PDF: 612

HTML: 1172
Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway

Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu Xu

12-12-2023

https://doi.org/10.4081/ejh.2023.3908

1833

PDF: 620

HTML: 38
ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION C. Giampietri¹, E. Pizzichini¹, F. Somma¹, S. Petrungaro¹, A. Facchiano², A. Filippini¹, C. Fabrizi¹, E. Gaudio¹ | ¹Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; ²Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4276

263
High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis

G. Goteri, E. Altobelli, G. Tossetta, A. Zizzi, C. Avellini, C. Licini, T. Lorenzi, M. Castellucci, A. Ciavattini, D. Marzioni

09-12-2015

https://doi.org/10.4081/ejh.2015.2570

2834

PDF: 958

HTML: 434
Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis

Tao Wu, Shikui Wu, Hailu Jiao, Jun Feng, Xiang Zeng

02-10-2023

https://doi.org/10.4081/ejh.2023.3839

1676

PDF: 914

HTML: 61
Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells

D Waltregny, B North, F Van Mellaert, J de Leval, E Verdin, V Castronovo

273-290

29-06-2009

https://doi.org/10.4081/897

1083

PDF: 1568
Histochemistry through the years, browsing a long-established journal: novelties in traditional subjects

C. Pellicciari

e51

16-12-2010

https://doi.org/10.4081/ejh.2010.e51

1669

PDF: 815

HTML: 4066
Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro

Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen

09-09-2024

https://doi.org/10.4081/ejh.2024.4101

1525

PDF: 518

HTML: 36
P67 | EMERGING ROLE OF NUCLEAR PHOSPHOLIPASE C BETA 1 AS POTENTIAL BIOMARKER IN LUNG CANCER S. Salucci¹, I. Versari¹, S. Burattini², D. Montecchio³, I. Faenza¹ | ¹Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; ²Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy; ³Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4392

403
Histochemistry as an irreplaceable approach for investigating functional cytology and histology

C. Pellicciari

e41

19-12-2013

https://doi.org/10.4081/ejh.2013.e41

3520

PDF: 1013

HTML: 435
P33 | IMPACT OF CYCLIN C EXPRESSION ON THE AGGRESSIVENESS OF A549 NON-SMALL CELL LUNG CANCER CELLS V. Havryliuk | Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4353

262
FILAMIN A IN BREAST CANCER: FROM LITERATURE TO FUNCTIONAL INSIGHTS P. Zawadka¹, W. Arendt¹, M. Gagat^1,2, M. Izdebska¹ | ¹Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland. ²Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland

21-08-2025

https://doi.org/10.4081/ejh.2025.4278

249
Three-dimensional apoptotic nuclear behavior analyzed by means of Field Emission in Lens Scanning Electron Microscope

S. Salucci, S. Burattini, E. Falcieri, P. Gobbi

15-09-2015

https://doi.org/10.4081/ejh.2015.2539

1742

PDF: 1080

HTML: 397
Mistletoe - From mythology to evidence-based medicine

Manuela Monti

26-10-2015

https://doi.org/10.4081/ejh.2015.2577

1589

PDF: 688

HTML: 155
Assessment of proliferating cell nuclear antigen and its relationship with proinflammatory cytokines and parameters of disease activity in multiple myeloma patients

G. Tsirakis, C. A. Pappa, M. Kaparou, V. Katsomitrou, A. Hatzivasili, T. Alegakis, A. Xekalou, E. N. Stathopoulos, M. Alexandrakis

e21

01-08-2011

https://doi.org/10.4081/ejh.2011.e21

1461

PDF: 648

HTML: 1225
Erratum - Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

Jun Pan, Yi Zhao, Yu Zhang, Yuhe Zhou, Fengxuan Zhang, Yitian Chen, Xiaoyuan Chu

20-05-2025

https://doi.org/10.4081/ejh.2025.4235

611

PDF: 338

HTML: 84
Lipofuscin, lipofuscin-like pigments and autofluorescence

G. Di Guardo

06-02-2015

https://doi.org/10.4081/ejh.2015.2485

4493

PDF: 1953

HTML: 546
Fluorescence properties of the Na+/H+exchanger inhibitor HMA (5-(N,N-hexamethylene)amiloride) are modulated by intracellular pH

V. Giansanti, G. Santamaria, A. Torriglia, F. Aredia, A.I. Scovassi, G. Bottiroli, A.C. Croce

e3

20-01-2012

https://doi.org/10.4081/ejh.2012.e3

1772

PDF: 749

HTML: 2936
Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages

Jun Lin, Liping Jiang, Kun Guo, Ning Feng

22-12-2022

https://doi.org/10.4081/ejh.2023.3528

2239

PDF: 1363

Supplementary: 169

HTML: 54
Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas

D.G.B. AraÃºjo, L. Nakao, P. Gozzo, C.D.A. Souza, V. Balderrama, E.S. Gugelmin, A.P. Kuczynski, M. Olandoski, L. de Noronha

06-03-2014

https://doi.org/10.4081/ejh.2014.2228

3254

PDF: 1344

HTML: 385
Sodium nitroprusside induces cell death and cytoskeleton degradation in adult rat cardiomyocytes in vitro: implications for anthracycline-induced cardiotoxicity

M. Chiusa, F. Timolati, J.C. Perriard, T.M. Suter, C. Zuppinger

e15

16-04-2012

https://doi.org/10.4081/ejh.2012.15

1772

PDF: 1425

HTML: 4594
Detection of non-papillary, non-invasive transitional cell G1 carcinoma as revealed by increased DNA instability and other cancer markers

M Hirose, A Sun, T Okubo, S Noriki, Y Imamura, M Fukuda

199-210

29-06-2009

https://doi.org/10.4081/944

789

PDF: 465
38 | NATURAL ANTIOXIDANTS IN THE FIGHT AGAINST OVARIAN CANCER: IN VITRO EFFECTS OF POLYPHENOLS Lorenzo Ibello, Filomena Mottola, Maria Teresa Gentile, Ilaria Palmieri, Lucia Rocco | Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4656

114

PDF: 80
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

29-02-2024

https://doi.org/10.4081/ejh.2024.3977

2429

PDF: 1367

Supplementary: 170

HTML: 271
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1589

PDF: 819

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Cell Migration - Methods and Protocols

Manuela Monti

17-01-2019

https://doi.org/10.4081/ejh.2019.3013

1135

PDF: 666

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Growth hormone inhibits the JAK/STAT3 pathway by regulating SOCS1 in endometrial cells in vitro: a clue to enhance endometrial receptivity in recurrent implantation failure

Haixia Li, Ning Sun, Yaqiao Zhu, Wei Wang, Meihong Cai, Xiaohuan Luo, Wei Xia, Song Quan

22-12-2022

https://doi.org/10.4081/ejh.2023.3580

1832

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Is there still room for novelty, in histochemical papers?

Carlo Pellicciari

16-12-2016

https://doi.org/10.4081/ejh.2016.2758

3202

PDF: 798

HTML: 302
24 | ADMINISTRATION OF BRANCHED-CHAIN AMINO ACIDS AND DI-ALANINE MITIGATES MUSCLE ATROPHY IN A MOUSE MODEL OF CANCER CACHEXIA M. Colardo¹, N. Martella¹, M. Varone¹, D. Pensabene¹, G. Caretti², G. Bianchini³, A. Aramini³, M. Segatto¹ | ¹Dept. of Biosciences and Territory, University of Molise, Italy; ²Dept. of Biosciences, University of Milan, Italy; ³Research & Early Development, Dompé Farmaceutici S.p.A., L’Aquila, Italy

GEI - SOCIETÀ ITALIANA DI BIOLOGIA DELLO SVILUPPO E DELLA CELLULA

22-06-2026

https://doi.org/10.4081/ejh.2026.4642

170

PDF: 93
High-level detection of gene amplification and chromosome aneuploidy in extracted nuclei from paraffin-embedded tissue of human cancer using FISH: a new approach for retrospective studies

E Rossi, A Ubiali, P Balzarini, M Cadei, F Alpi, PG Grigolato

53-58

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https://doi.org/10.4081/927

766

PDF: 1086
The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways

Zhi Wang, Guihua Jian, Teng Chen, Yiping Chen, Junhui Li, Niansong Wang

01-03-2023

https://doi.org/10.4081/ejh.2023.3648

5344

PDF: 1235

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Endoplasmic reticulum stress contributed to inflammatory bowel disease by activating p38 MAPK pathway

Yan Long, Yan Zhao, Xiaoqing Ma, Ya Zeng, Tian Hu, Weijie Wu, Chongtian Deng, Jinyue Hu, Yueming Shen

23-05-2022

https://doi.org/10.4081/ejh.2022.3415

2670

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MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney

D. Fanni, N. Iacovidou, A. Locci, C. Gerosa, S. Nemolato, P. Van Eyken, G. Monga, S. Mellou, G. Faa, V. Fanos

e40

26-10-2012

https://doi.org/10.4081/ejh.2012.e40

1717

PDF: 714

HTML: 371
The lncRNA MEG3 promotes trophoblastic cell growth and invasiveness in preeclampsia by acting as a sponge for miR-21, which regulates BMPR2 levels

Huyi Liu, Xiangdao Cai , Jia Liu, Fengxiang Zhang , Andong He, Ruiman Li

25-11-2021

https://doi.org/10.4081/ejh.2021.3323

2095

PDF: 816

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Immunohistochemical and ultrastructural visualization of different routes of oocyte elimination in adult rats

M.L. Escobar SÃ¡nchez, O.M. EcheverrÃa MartÃnez, G.H. VÃ¡zquez-Nin

e17

16-04-2012

https://doi.org/10.4081/ejh.2012.17

2006

PDF: 892

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Expression of S100β during mouse cochlear development

Wenjing Liu, Yongchun Zhang, Cheng Liang, Lizhong Su

10-03-2025

https://doi.org/10.4081/ejh.2025.4189

1597

PDF: 509

Supplementary: 110

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Efficacy of immunohistochemical staining in detecting Helicobacter pylori in Saudi patients with minimal and atypical infection

Mohammed Akeel, Ahmed Elhafey , Atef Shehata , Erwa Elmakki , Thanaa Aboshouk, Hussein Ageely , Mohammed Salih Mahfouz

20-07-2021

https://doi.org/10.4081/ejh.2021.3222

3369

PDF: 1092

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Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma

Caterina L. Mammola, Antonella Vetuschi, Luigi Pannarale, Roberta Sferra, Romina Mancinelli

30-11-2018

https://doi.org/10.4081/ejh.2018.2971

1623

PDF: 877

Supplementary: 230

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Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis

F. Aredia, M. Malatesta, P. Veneroni, M.G. Bottone

01-12-2015

https://doi.org/10.4081/ejh.2015.2571

2556

PDF: 860

HTML: 791
Immunohistochemical analysis of YB-1 expression in the developing mouse eye

Alexander Forian Nass, Hella Wolf, Saadettin Sel , Thomas Kalinski, Norbert Nass

03-11-2025

https://doi.org/10.4081/ejh.2025.4244

2036

PDF: 329

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Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou

02-12-2021

https://doi.org/10.4081/ejh.2021.3331

2853

PDF: 1639

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Autofluorescence in freshly isolated adult human liver sinusoidal cells

Anett Kristin Larsen, Jaione Simón-Santamaría, Kjetil Elvevold, Bo Göran Ericzon, Kim Erlend Mortensen, Peter McCourt, Bård Smedsrød, Karen Kristine Sørensen

13-12-2021

https://doi.org/10.4081/ejh.2021.3337

2616

PDF: 1051

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Digital PCR - Methods and Protocols

Paolo Catarsi

18-10-2019

https://doi.org/10.4081/ejh.2019.3074

2161

PDF: 1022

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Seasonal expressions of prolactin, prolactin receptor and STAT5 in the scented glands of the male muskrats (Ondatra zibethicus)

Wenqian Xie, Hong Liu, Qian Liu, Qiong Gao, Fuli Gao, Yingying Han, Zhengrong Yuan, Haolin Zhang, Qiang Weng

17-01-2019

https://doi.org/10.4081/ejh.2019.2991

2064

PDF: 885

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P42 | PANCREATIC CANCER STEM CELLS AND FUNCTIONAL CHARACTERIZATION OF MIR-216A-5P G. Fenu¹, C.G. Lison², F. Etzi³, A. Pisano³, C. Farace³, A. Sabalic³, D. Tutedde³, J.A. Marchal⁴, R. Madeddu⁵ | ¹Department of Biomedical Science, University of Sassari, 07100 Sassari, Italy; ²Instituto de Investigación Biosanitaria ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ³Department of Biomedical Science, University of Sassari, Sassari, Italy; ⁴Instituto de Investigación Biosanitaria ibs. GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain; ⁵Department of Biomedical Science, University of Sassari, Sassari, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4364

246
Histochemistry in biology and medicine: a message from the citing journals

Carlo Pellicciari

23-12-2015

https://doi.org/10.4081/ejh.2015.2610

3415

PDF: 963

HTML: 919
P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira¹, S. Grassilli², M. Pierantoni¹, V. Bertagnolo¹, F. Brugnoli¹ | ¹Department of Translational Medicine, University of Ferrara, Ferrara, Italy; ²Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4342

308
Genetic deletion of P-selectin prevents fibrosis development by inhibiting the neutrophil megakaryocyte emperipolesis in the Gata1^low mouse model for myelofibrosis

Francesca Arciprete, Viola Velardi, Antonio Di Virgilio, Paola Verachi, Claudio Carta, Giulia Pozzi, Vincenzo Roberti, Giorgio Vivacqua, Rosalba Rana, Maria Zingariello

16-12-2025

https://doi.org/10.4081/ejh.2025.4427

932

PDF: 459

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P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo¹, S. Boccia², E. Del Genio¹, R. Pastore¹, M. De Falco³, I. Belviso⁴ | ¹Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; ²Dept. of Biology, University of Naples Federico II, Naples, Italy; ³Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; ⁴Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4373

377
Developmental expression of calretinin in the mouse cochlea

Wenjing Liu, Yongchun Zhang, Cheng Liang, Xuefang Jiang

06-11-2024

https://doi.org/10.4081/ejh.2024.4137

1950

PDF: 716

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Prognostic factors affecting disease-free survival rate following surgical resection of primary breast cancer

K Horita, A Yamaguchi, K Hirose, M Ishida, S Noriki, Y Imamura, M Fukuda

73-84

24-12-2009

https://doi.org/10.4081/ejh.2001.1616

1011

PDF: 967
DNA breakage detection-fluorescence in situ hybridization (DBD-FISH) in buccal cells

E. I. CortÃ©s-GutiÃ©rrez, M. I. Davila-RodrÃguez, J. L. FernÃ¡ndez, C. LÃ³pez-FernÃ¡ndez, J. Gosalvez

e49

28-12-2012

https://doi.org/10.4081/ejh.2012.e49

1724

PDF: 611

HTML: 238
ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA

21-08-2025

https://doi.org/10.4081/ejh.2025.4270

404
Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

Chixian Zhang, Kai Bai, Dexu Li

14-04-2025

https://doi.org/10.4081/ejh.2025.4186

1598

PDF: 588

HTML: 58
Effects of rutin on osteoblast MC3T3-E1 differentiation, ALP activity and Runx2 protein expression

Xin-Wei Liu, Bin Ma, Ying Zi, Liang-Bi Xiang, Tian-Yu Han

20-01-2021

https://doi.org/10.4081/ejh.2021.3195

3761

PDF: 1797

HTML: 52
Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang

29-04-2024

https://doi.org/10.4081/ejh.2024.4019

2182

PDF: 833

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P31 | MORPHOLOGICAL AND ULTRASTRUCTURAL MARKERS OF RADIATION-INDUCED ADIPOSE TISSUE DAMAGE E. Guerra¹, S. Lattanzio¹, G. Furini², G. Scabia², E. Mota-Silva², M. Maffei², S. Cinti³, R. Di Pietro¹ | ¹Department of Medicine and Ageing Sciences, “G. d’Annunzio” University of Chieti-Pescara, Chieti, Italy; ²CNR Institute of Clinical Physiology, Pisa, Italy; ³Department of Experimental and Clinical Medicine, Center of Obesity, Università Politecnica delle Marche (Polytechnic University of Marche), Ancona, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4351

261
Seasonal changes of androgen receptor, estrogen receptors and aromatase expression in the medial preoptic area of the wild male ground squirrels (Citellus dauricus Brandt)

F. Zhang, J. Wang, Y. Jiao, L. Zhang, H. Zhang, X. Sheng, Y. Han, Z. Yuan, Q. Weng

02-05-2016

https://doi.org/10.4081/ejh.2016.2621

1715

PDF: 815

HTML: 253
On the future contents of a small journal of histochemistry

C. Pellicciari

e51

10-12-2012

https://doi.org/10.4081/ejh.2012.e51

2723

PDF: 1065

HTML: 964

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