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Characterization of PD-1/PD-L1 immune checkpoint expression in soft tissue sarcomas

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Masao Akagi

02-07-2021

https://doi.org/10.4081/ejh.2021.3203

3100

PDF: 932

HTML: 32
Histopathological and immunofluorescent characterization of post-sepsis immune dysregulation in a clinically relevant mouse model

Haoran Tang, Chen Liao, Ning Tang, Hui Li, Yi Liu, Lingling Wang, Zongfang Ren

12-02-2026

https://doi.org/10.4081/ejh.2026.4435

464

PDF: 330

HTML: 11
Pretreatment with interleukin-15 attenuates inflammation and apoptosis by inhibiting NF-κB signaling in sepsis-induced myocardial dysfunction

Chaojie He, Yi Yu, Feifan Wang, Wudi Li, Hui Ni, Meixiang Xiang

29-04-2024

https://doi.org/10.4081/ejh.2024.4019

1870

PDF: 598

HTML: 23
Placental mesenchymal stem cell exosomes drive macrophage M2 polarization via the miR-146a-5p/TRAF6 axis to ameliorate preeclampsia

Xiaoli Liu, Ruiyue Li, Junjie Sun, Yuanpei Yang, Lina Hu

17-11-2025

https://doi.org/10.4081/ejh.2025.4426

875

PDF: 487

HTML: 16
Swertianolin ameliorates immune dysfunction in sepsis via blocking the immunosuppressive function of myeloid-derived suppressor cells

Zongfang Ren, Haoren Tang, Linjun Wan, Xing Liu, Ning Tang, Lingling Wang, Zhenhui Guo

01-09-2021

https://doi.org/10.4081/ejh.2021.3292

1466

PDF: 948

HTML: 37
Leptin affects filopodia and cofilin in NK-92 cells in a dose- and time-dependent manner

Jana Oswald, Maximilian Büttner, Simon Jasinski-Bergner, Roland Jacobs, Philip Rosenstock, Heike Kielstein

26-01-2018

https://doi.org/10.4081/ejh.2018.2848

3320

PDF: 1199

HTML: 114
Pretreatment with geniposide mitigates myocardial ischemia/reperfusion injury by modulating inflammatory response through TLR4/NF-κB pathway

Yanmei Yao, Leqing Lin, Wenxue Tang, Yueliang Shen, Fayu Chen, Ning Li, Baiyong Wang

08-09-2023

https://doi.org/10.4081/ejh.2023.3742

1129

PDF: 475

HTML: 21
Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis via the AMPK signaling pathway

Chaoyi Yang, Shujun Wang, Mengru Li, Xiangli Pang, Aili Tan

17-06-2025

https://doi.org/10.4081/ejh.2025.4168

546

PDF: 338

HTML: 15
Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis

Shicheng Jiao, Lijun Deng, Mu Niu, Jie Yang

21-01-2025

https://doi.org/10.4081/ejh.2025.4147

4225

PDF: 824

HTML: 52
Reliable hexokinase 3 protein detection in human cell lines and primary tissue

Yasmeen H. Mady, Carmen G. Kalbermatter, Maarij Khan, Anna M. Schläfli, Rina Mehmeti, Inti Zlobec, Lucine Christe, Mario P. Tschan

12-03-2025

https://doi.org/10.4081/ejh.2025.4175

1877

PDF: 446

Supplementary: 58

Uncropped Western blots: 56

HTML: 12
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function

Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng

21-06-2022

https://doi.org/10.4081/ejh.2022.3412

2465

PDF: 1403

HTML: 31
Adipose-derived stem cells promote the recovery of intestinal barrier function by inhibiting the p38 MAPK signaling pathway

Mei Yang, Wangbin Xu, Chaofu Yue, Rong Li, Xian Huang, Yongjun Yan, Qinyong Yan, Shisheng Liu, Yuan Liu, Qiaolin Li

21-01-2025

https://doi.org/10.4081/ejh.2025.4158

1807

PDF: 575

Supplementary Figure: 84

HTML: 55
From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease

Carolina Pellegrini, Vanessa D'Antongiovanni, Chiara Ippolito, Cristina Segnani, Luca Antonioli, Matteo Fornai, Nunzia Bernardini

22-11-2021

https://doi.org/10.4081/ejh.2021.3278

1520

PDF: 835

HTML: 40
Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation

Lin Liu, Wei Huang, Yu Wu, Guanlong Ye, Jing Zhang, Tong Shen, Changjuan Ouyang

19-02-2026

https://doi.org/10.4081/ejh.2026.4436

513

PDF: 303

HTML: 10
Colchicine alleviates severe acute pancreatitis in rats by inhibiting acinar cell ferroptosis via LCN2/MAPK/ERK signaling axis

Liu Yang, Xiaoyi Zheng, Yang Zhang, Yue Li, Lei Li, Feng Liu

11-05-2026

https://doi.org/10.4081/ejh.2026.4557

246

PDF: 414

Supplementary: 30

HTML: 3
Ion channels alterations in the forebrain of high-fat diet fed rats

Proshanta Roy, Ilenia Martinelli, Michele Moruzzi, Federica Maggi, Consuelo Amantini, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati, Daniele Tomassoni

23-11-2021

https://doi.org/10.4081/ejh.2021.3305

2191

PDF: 1089

HTML: 38
Independent and interactive roles of hirudin and HMGB1 interference in protecting renal function by regulating autophagy, apoptosis, and kidney injury in chronic kidney disease

Ying Li, Xuan Gao, Yao Chen, Huihui Li, Jing Tang, Wei Sun

07-04-2025

https://doi.org/10.4081/ejh.2025.4182

1163

PDF: 702

HTML: 44
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway

Shengwen Wang, Gang Yang, Qian Zhang, Yanbei Zhang

18-05-2026

https://doi.org/10.4081/ejh.2026.4544

125

PDF: 103

Supplementary: 16

HTML: 3
Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study

V.N. Karavana, H. Gakiopoulou, E.A. Lianos

15-04-2014

https://doi.org/10.4081/ejh.2014.2308

2214

PDF: 889

HTML: 645
Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Antonella Vetuschi, Alfredo Cappariello, Paolo Onori, Eugenio Gaudio, Giovanni Latella, Simona Pompili, Roberta Sferra

21-06-2022

https://doi.org/10.4081/ejh.2022.3391

3619

PDF: 1892

HTML: 58
Pre-treatment with galectin-1 attenuates lipopolysaccharide-induced myocarditis by regulating the Nrf2 pathway

Liying Shen, Kongjie Lu, Zhenfeng Chen, Yingwei Zhu, Cong Zhang, Li Zhang

07-12-2023

https://doi.org/10.4081/ejh.2023.3816

1186

PDF: 687

HTML: 35
Forever particles: histochemistry in the plasticene age

Beatrice Camia, Andrea Casasco, Manuela Monti

01-08-2025

https://doi.org/10.4081/ejh.2025.4226

955

PDF: 479

HTML: 51
Umbilical cord mesenchymal stem cells inhibited inflammation of bronchial epithelial cells by regulating Hedgehog pathway

Qiong Lin, Tianxing Yu, Xiaohua Li, Xin Lin, Yong Fan, Liyu Xu

12-12-2023

https://doi.org/10.4081/ejh.2023.3908

1598

PDF: 499

HTML: 24
Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis

Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang

17-09-2024

https://doi.org/10.4081/ejh.2024.4034

1157

PDF: 576

HTML: 10
2D vs 3D morphological analysis of dorsal root ganglia in health and painful neuropathy

Valentina Alda Carozzi, Chiara Salio, Virginia Rodriguez-Menendez, Elisa Ciglieri, Francesco Ferrini

19-10-2021

https://doi.org/10.4081/ejh.2021.3276

3040

PDF: 1684

Video 1: 238

Video 2: 284

HTML: 25
Folic acid promotes autophagy to relieve metabolism-associated fatty liver disease by regulating NRF2

Yu Wen, Juan Luo, Chunjing Shi, Jie Wu

03-11-2025

https://doi.org/10.4081/ejh.2025.4309

811

PDF: 534

HTML: 33
Gemst: a taylor-made combination that reverts neuroanatomical changes in stroke

Arturo Mangas, Javier Yajeya, Noelia González, Isabel Ruiz, Marianny Pernía, Michel Geffard, Rafael Coveñas

25-05-2017

https://doi.org/10.4081/ejh.2017.2790

1823

PDF: 689

HTML: 195
Therapeutic effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on ovarian functions through the PI3K/Akt cascade in mice with premature ovarian failure

Nan Li, Xue Fan, Lihong Liu, Yanbing Liu

27-07-2023

https://doi.org/10.4081/ejh.2023.3506

1704

PDF: 1050

HTML: 22
Genetic deletion of P-selectin prevents fibrosis development by inhibiting the neutrophil megakaryocyte emperipolesis in the Gata1^low mouse model for myelofibrosis

Francesca Arciprete, Viola Velardi, Antonio Di Virgilio, Paola Verachi, Claudio Carta, Giulia Pozzi, Vincenzo Roberti, Giorgio Vivacqua, Rosalba Rana, Maria Zingariello

16-12-2025

https://doi.org/10.4081/ejh.2025.4427

657

PDF: 335

HTML: 5
Spatio-temporal course of macrophage-like cell accumulation after experimental embolic stroke depending on treatment with tissue plasminogen activator and its combination with hyperbaric oxygenation

D. Michalski, M. Heindl, J. Kacza, F. Laignel, L. KÃ¼ppers-Tiedt, D. Schneider, J. Grosche, J. Boltze, M. LÃ¶hr, C. Hobohm, W. HÃ¤rtig

e14

09-05-2012

https://doi.org/10.4081/ejh.2012.14

6678

PDF: 785

HTML: 10451
Cannabinoid CB2 receptors are involved in the protection of RAW264.7 macrophages against the oxidative stress: an in vitro study

Sabrina Giacoppo, Agnese Gugliandolo, Oriana Trubiani, Federica Pollastro, Gianpaolo Grassi, Placido Bramanti, Emanuela Mazzon

23-01-2017

https://doi.org/10.4081/ejh.2017.2749

6013

PDF: 1355

HTML: 400
The hematopoietic stem cells supportive megakaryocytes as shapers of the bone marrow niche

Francesca Arciprete, Viola Velardi, Paola Verachi, Claudio Carta, Antonio Di Virgilio, Vincenzo Roberti, Giorgio Vivacqua, Rosalba Rana, Maria Zingariello

16-12-2025

https://doi.org/10.4081/ejh.2025.4424

687

PDF: 284

HTML: 13
Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages

Rong Tian, Gengsheng Mao

12-01-2022

https://doi.org/10.4081/ejh.2022.3350

1809

PDF: 865

HTML: 37
Mucin1 relieves acute lung injury by inhibiting inflammation and oxidative stress

Chunlin Ye, Bin Xu, Jie Yang, Yunkun Liu, Zhikai Zeng, Lingchun Xia, Quanjin Li, Guowen Zou

02-12-2021

https://doi.org/10.4081/ejh.2021.3331

2573

PDF: 1456

HTML: 38
Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway

Yan Yan Li, Ya Ping Feng, Li Liu, Jin Ke, Xing Long

21-06-2022

https://doi.org/10.4081/ejh.2022.3357

1878

PDF: 1101

HTML: 31
Immunohistochemical detection of putative pathogenetic factors in adhesions of infants: a pilot study

Arvis Pauliņš, Anna Junga, Māra Pilmane

10-02-2026

https://doi.org/10.4081/ejh.2026.4438

264

PDF: 211

HTML: 3
Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation

Hongkai Xiao, Jinghu Liu, Qinhong Cai, Siyu Liang, Zhitao Hu, Xiaochao Chen

13-10-2025

https://doi.org/10.4081/ejh.2025.4254

610

PDF: 378

HTML: 39
miR-199a-5p inhibited HIF-1α to suppress the proliferation, migration, and differentiation of cardiac stem cells

Sha Li, Cuigai Zhang, Yanping Liu, Cuiqiao Meng, Yang Xie, Shuren Li

22-09-2025

https://doi.org/10.4081/ejh.2025.4239

470

PDF: 324

Supplementary: 52

HTML: 18
Expression of hyaluronan synthase 3 in deformed human temporomandibular joint discs: in vivo and in vitro studies

T. Matsumoto, M. Inayama, I. Tojyo, N. Kiga, S. Fujita

e50

15-12-2010

https://doi.org/10.4081/ejh.2010.e50

1672

PDF: 690

HTML: 1290
SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma

Bohu Liu, Xiaoran Zhang, Jintao Tian, Xiaobin Huang, Xuhui Li, Jinxi Zhao, Zhenghu Xu, Jun Pu

03-03-2026

https://doi.org/10.4081/ejh.2026.4530

462

PDF: 367

HTML: 8
Aloe-emodin ameliorates chronic kidney disease fibrosis by inhibiting PI3K-mediated signaling pathway

Ming Chen, Wenhui Zhu, Yao Chen, Jingying Shang, Wenfan Wang, Xiaoming Yan, Peng Liu, Yabin Zhou

06-08-2025

https://doi.org/10.4081/ejh.2025.4228

1142

PDF: 514

HTML: 18
The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes

R. Song, W. Xu, Y. Chen, Z. Li, Y. Zeng, Y. Fu

e10

21-03-2011

https://doi.org/10.4081/ejh.2011.e10

1992

PDF: 650

HTML: 934
Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma

Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li

22-07-2024

https://doi.org/10.4081/ejh.2024.4048

1734

PDF: 729

HTML: 17
P70 | TRICHOSANTHIN TARGETS WNT/NF-KB PATHWAYS TO ATTENUATE PSORIATIC INFLAMMATION AND KERATINOCYTE HYPERPROLIFERATION K. Wang¹, W. Li¹, Z. Ying¹, C. Li², O. Sha¹ | ¹Department of Anatomy and Histology, School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China; ²Department of Anatomy, Shantou University Medical College, Shantou, China

21-08-2025

https://doi.org/10.4081/ejh.2025.4395

291
High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis

G. Goteri, E. Altobelli, G. Tossetta, A. Zizzi, C. Avellini, C. Licini, T. Lorenzi, M. Castellucci, A. Ciavattini, D. Marzioni

09-12-2015

https://doi.org/10.4081/ejh.2015.2570

2667

PDF: 813

HTML: 410
Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl

Hao Li, Junliang Chen, Wenjun You, Yizhen Xu, Yaqiong Ye, Haiquan Zhao, Junxing Li, Hui Zhang

15-10-2024

https://doi.org/10.4081/ejh.2024.4089

1677

PDF: 369

HTML: 10
VEGF promotes diabetic retinopathy by upregulating the PKC/ET/NF-κB/ICAM-1 signaling pathway

Meiying Zhang, Min Zhou, Xia Cai, Yan Zhou, Xueling Jiang, Yan Luo, Yue Hu, Rong Qiu, Yanrong Wu, Yuejin Zhang, Yan Xiong

27-10-2022

https://doi.org/10.4081/ejh.2022.3522

2117

PDF: 1006

HTML: 43
Downregulation of S100 calcium-binding A4 (S100A4) ameliorates hepatic fibrosis via regulating Wnt/β-catenin signaling pathway

Chixian Zhang, Kai Bai, Dexu Li

14-04-2025

https://doi.org/10.4081/ejh.2025.4186

1278

PDF: 472

HTML: 29
Senescence-associated ß-galactosidase staining over the lifespan differs in a short- and a long-lived fish species

Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E. Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer

29-02-2024

https://doi.org/10.4081/ejh.2024.3977

2210

PDF: 1124

Supplementary: 106

HTML: 138
NEUROBIOLOGY OF SUICIDE: MORPHOLOGICAL ASSESSMENT OF MICROGLIAL NETWORK IN HUMAN POST-MORTEM PREFRONTAL CORTEX Tambuzzi S¹, Bertolotto N², Massari S², Madaschi L³, Alini M², Brandolese D², Ubezio MC¹, Cattaneo C¹ and Amadeo A² | ¹Institute of Forensic Medicine, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; ²Department of Biosciences, Università degli Studi di Milano, Milan, Italy; ³UNITECH NOLIMITS, Università degli Studi di Milano, Milan, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4459

292
Distribution of NADPH-diaphorase and AChE activity in the anterior leaflet of rat mitral valve

K. Lovasova, D. Kluchova, A. Bolekova, F. Dorko, T. Spakovska

e5

04-02-2010

https://doi.org/10.4081/ejh.2010.e5

1168

PDF: 478

HTML: 3101
Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally

Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariotti

04-07-2024

https://doi.org/10.4081/ejh.2024.4040

2027

PDF: 605

HTML: 20
Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway

Hui Yang, Yunlong Zhang, Desheng Zhang, Liping Qian, Tianxing Yang, Xiaocheng Wu

12-09-2023

https://doi.org/10.4081/ejh.2023.3697

1319

PDF: 651

HTML: 18
Premature senescence in primary muscle cultures of myotonic dystrophy type 2 is not associated with p16 induction

L.V. Renna, R. Cardani, A. Botta, G. Rossi, B. Fossati, E. Costa, G. Meola

22-10-2014

https://doi.org/10.4081/ejh.2014.2444

2412

PDF: 1053

HTML: 498
P72 | A SWAB NEGATIVE PATIENT AFTER SARS-COV-2 INFECTION DISPLAYS INCREASE OF VEGF AND FIBRONECTIN ASSOCIATED WITH ALTERATIONS OF INTERCELLULAR JUNCTIONS C. Simioni¹, J.M. Sanz², R. Gafà³, G. Cenacchi⁴, S. Occhionorelli³, R. Rizzo⁵, D. Bortolotti⁵, A. Passaro³, L.M. Neri³ | ¹Department of Life Sciences and Biotechnology, University of Ferrara, Italy; ²Department of Chemical, Pharmaceutical and Agricultural, Sciences, University of Ferrara, Italy; ³Department of Translational Medicine, University of Ferrara, Italy; ⁴Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Italy; ⁵Department of Environmental and Prevention Sciences, University of Ferrara, Italy

21-08-2025

https://doi.org/10.4081/ejh.2025.4397

283
The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization

R. M. Ruggeri, E. Vitarelli, G. Barresi, F. Trimarchi, S. Benvenga, M. Trovato

e24

03-06-2010

https://doi.org/10.4081/ejh.2010.e24

1445

PDF: 667

HTML: 2599
Effects of piperlonguminine on lung injury in severe acute pancreatitis via the TLR4/NF-κB pathway

Qian Hu, Ran Tao, Xiaoyun Hu, Haibo Wu, Jianjun Xu

20-03-2023

https://doi.org/10.4081/ejh.2023.3639

1228

PDF: 718

HTML: 24
Dipeptidylpeptidase-IV activity and expression reveal decreased damage to the intrahepatic biliary tree in fatty livers submitted to subnormothermic machine-perfusion respect to conventional cold storage

E. Tarantola, V. Bertone, G. Milanesi, C. Gruppi, A. Ferrigno, M. Vairetti, S. Barni, I. Freitas

17-07-2014

https://doi.org/10.4081/ejh.2014.2414

1875

PDF: 797

HTML: 572
pPKCÎ± mediated-HIF-1Î± activation related to the morphological modifications occurring in neonatal myocardial tissue in response to severe and mild hyperoxia

S. Zara, V. Macchi, R. De Caro, M. Rapino, A. Cataldi, A. Porzionato

e2

31-01-2012

https://doi.org/10.4081/ejh.2012.e2

1736

PDF: 2431

HTML: 2507
Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. A morphological study

M. Di Rosa, M.A. Szychlinska, D. Tibullo, L. Malaguarnera, G. Musumeci

16-09-2014

https://doi.org/10.4081/ejh.2014.2423

2968

PDF: 1173

HTML: 1609
STAT3 and SOCS3 expression patterns during murine placenta development

S. San Martin, J. Fitzgerald, M. Weber, M. PÃ¡rraga, T. SÃ¡ez, T.M. Zorn, U.R. Markert

e19

28-06-2013

https://doi.org/10.4081/ejh.2013.e19

3636

PDF: 846

HTML: 315
MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F¹, Russo L², Jorkesh A², Khodaparast S¹, Gambarotta G¹, Ronchi G¹ and Cescon M² | ¹Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; ²Department of Molecular Medicine, University of Padova, Padova, Italy

12-12-2025

https://doi.org/10.4081/ejh.2025.4481

289
Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats

Jun Liu, Linbin Cai, Yuanyuan He, Jun Yang

07-08-2017

https://doi.org/10.4081/ejh.2017.2706

2399

PDF: 785

HTML: 213

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