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MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices
2450PDF: 1200MIAQuant user Manual: 267MIAQuant source code: 340HTML: 75 -
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway
662PDF: 384Supplementary: 49Original gels: 49HTML: 14 -
Metformin sensitises osteosarcoma to chemotherapy via the IGF-1R/miR-610/FEN1 pathway
1400PDF: 928Supplementary: 100HTML: 24 -
Hormone receptor expression in human fascial tissue
4182PDF: 1727HTML: 264 -
Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci
2693PDF: 1349Supplementary: 243HTML: 56 -
SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS A. Chytła1, E. H. Lagunar1, R. Gonül1, B. Šalovská2, J. Červenka3, A. Miladinović4, L. Antiga4, P. Hozák4, M. Sztacho1 | 1Laboratory of Cancer Cell Architecture, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; 2Yale Cancer Biology Institute, Yale University School of Medicine, West Haven, USA; 3Laboratory of proteomics, Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic; 4Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic
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P24 | DEVELOPMENT OF HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT-DERIVED XENOGRAFTS (PDXS) AND ORGANOIDS (PDXOS) FOR MORPHOLOGICAL ANALYSIS AND DRUG SCREENING A. Francia1, C. Girone1, D.M. Filippini2, G. Querzoli3, M. Fermi4, S. Venturoli5, A. Degiovanni6, C. Miroglio1, E. Montacci1, A. Ardizzoni7, M. Lauriola8, D. Romaniello8 | 1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS; Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 4Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Department of Otorhinolaryngology-Head and Neck Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 5Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Bologna, Italy; 6Pathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna,Bologna, Italy; 7Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; 8Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
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LEVERAGING ORGANOID TECHNOLOGIES TO CHARACTERIZE DYNAMIC TUMOR CELL STATES DRIVING TREATMENT RESISTANCE IN PANCREATIC CANCER A. Papargyriou1-6, M. Najajreh1-4, D.P. Cook7, C.H. Maurer1,2, S. Bärthel8, P. Putze8, H.A. Messal9, S.K. Ravichandran1-3, T. Richter10, M. Knolle11, T. Metzler12, A.R. Shastri1,2,3, R. Öllinger13, J. Jasper1,2,3, L. Schmidleitner1,2,3, C.Schneeweis8, H. Ishikawa-Ankerhold14, T. Engleitner13, S. Dobiasch15, I. Heid, M.D. Luecken16, K. Steiger12, G. Kaissis11, J. Van Rheenen9, F.J. Theis10, D. Saur8, R. Rad13, M. Reichert1,2,3,4,5,17,18 | 1Translational Pancreatic Cancer Research Center, Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 2Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Germany; 3Center for Functional Protein Assemblies, Technical University of Munich, Garching, Germany; 4Center for Organoid Systems (COS), Technical University of Munich, Garching, Germany; 5Bavarian Cancer Research Center (BZKF), Munich, Germany; 6Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany; 7University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 8Chair for Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany; 9Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands. 10Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; 11Institute of Diagnostic and Interventional Radiology, Klinikum rechts der Isar München, Technical University of Munich, Germany; 12Comparative Experimental Pathology, Institut für Allgemeine Pathologie und Pathologische Anatomie, School of Medicine, Technical University of Munich, Germany; 13Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Germany; 14Department of Medicine I, University Hospital of the LudwigMaximilians-University Munich, Germany; 15Department of Radiation Oncology, Technical University of Munich, Germany; 16Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Germany; Member of the German Center for Lung Research (DZL); 17German Cancer Consortium (DKTK), Munich, Germany; 18Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich, Germany
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P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME L. Sallicandro1, R. Gentile2, B. Filová3, S. Polakovičová3, A. Biagini1, F. Ballarino4, D. Del Bianco4, I. Varga5, A. Malvasi6, B. Fioretti2 | 1Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 3Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 4Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 5Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 6Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Unit, University of Bari Aldo Moro, Bari, Italy
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Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1
1753PDF: 858Supplementary: 167HTML: 19 -
AUTOCOUNTER, an ImageJ JavaScript to analyze LC3B-GFP expression dynamics in autophagy-induced astrocytoma cells
2049PDF: 994Supplementary Figures: 314Supplementary Table: 230HTML: 504 -
SUSD2 suppresses lung adenocarcinoma tumorigenesis by inducing autophagy via inhibiting PI3K/AKT/mTOR signaling pathway
163PDF: 126Supplementary: 21HTML: 6 -
Expression of the HPV18/E6 oncoprotein induces DNA damage
1927PDF: 789HTML: 213 -
EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES D. Jerka1, P. Antosik2, K. Bonowicz1,3, D. Grzanka4, M. Gagat1,3 | 1Department of Histology and Embryology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland; 2Department of Dermatology and Venerology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland; 3Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Płock, Poland; 4Department of Clinical Pathomorphology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland
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A method for semi-automated image analysis of HLA class I tumour epithelium expression in rectal cancer
1629PDF: 771Supplementary: 218HTML: 20 -
P84 | OMOMYC PEPTIDE LOCALIZES IN THE NUCLEUS AND DISPLAYS ANTIPROLIFERATIVE EFFECTS ON CELLULAR MODELS OF HUMAN OSTEOSARCOMA I. Versari1, S. Salucci1, A. Bavelloni2, M. Traversari3, I. Faenza1 | 1Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy; 2Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy; 3Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
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TRACKING HER2 TRAFFICKING AND ORGANELLE CROSSTALK IN TRASTUZUMAB-DERUXTECAN–TREATED BREAST CANCER CELLS USING MULTIMODAL IMAGING E. Tagliatti1, M. C. Gagliani2, G. Bellese2, M. Crippa3, A. Abbona4, M. Paccagnella4, P. Arnaldi5, M. C. Merlano6, O. Garrone7, A.M. Porcelli8, M. Matteoli1, P. Falletta9, P. Castagnola10, K. Cortese2 | 1IRCCS Humanitas Research Hospital, Laboratory of Pharmacology and Brain Pathology, Rozzano, Milano, Italy; 2DIMES, Department of Experimental Medicine, Cellular Electron Microscopy Lab, University of Genoa, Genoa, Italy; 3Experimental Imaging Center, IRCCS Ospedale San Raffaele, Milan, Italy; 4Health Department S. Croce e Carle Teaching Hospital, Cuneo, Italy; 5IRCCS Ospedale Policlinico San Martino, Genova, Italy; 6Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy; 7Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy; 8FABIT, Department of Pharmacy and Biotechnology and CIRI, Interdepartmental Centre for Industrial Research ‘Scienze Della Vita e Tecnologie per La Salute’, University of Bologna, Bologna, Italy; 9Vita-Salute San Raffaele University, Milan, Italy; 10IRCCS Ospedale Policlinico San Martino, Genova, Italy
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Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma
1983PDF: 729Supplementary: 149HTML: 31 -
Immunohistochemical localization of periostin in human gingiva
2185PDF: 788HTML: 497 -
PARP-1 protein expression in glioblastoma multiforme
3289PDF: 1304HTML: 1816 -
UNRAVELING GLIAL REMODELING IN SPACE AND TIME DURING GLIOBLASTOMA EVOLUTION Riccio L1, De Luca C1, Rega C1, Papa M1 and Virtuoso A1 | 1Laboratory of Neuronal Networks Morphology and System Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
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CAPTURE-CAPIVASERTIB AND PROSTATE CANCER TARGETING: UNRAVELING RESISTANCE ELEMENTS M. Zavatti1, V. Serafin1, L. Antolini1, S. Bresolin2, L. Reggiani Bonetti3, S. Marmiroli1 | 1Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Pediatric Hematology, Oncology and Stem Cell Transplant Division, Women and Child Health Department, Padua University, Padua, Italy; 3Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia, Modena, Italy
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PURKINJE CELL INTEGRITY IS PRESERVED BY EXERCISE IN PARANEOPLASTIC CEREBELLAR DEGENERATION: EVIDENCE FROM A CANCER CACHEXIA MOUSE MODEL Zummo FP1, Saqagandomabadi V1, Barone R1, Macaluso F1, D’Amico D1, Sausa M1, Carini F1, Di Felice V1 and David S1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy
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P22 | EXPLORING THE UNEXPECTED DUAL ROLE OF GARLIC DERIVATIVES IN REGULATING INVASIVENESS IN BREAST CANCER SUBTYPES M. Dell’Aira1, S. Grassilli2, M. Pierantoni1, V. Bertagnolo1, F. Brugnoli1 | 1Department of Translational Medicine, University of Ferrara, Ferrara, Italy; 2Department of Environmental Sciences and Prevention and LTTA Centre, University of Ferrara, Ferrara, Italy
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THE USE OF BIOMIMETIC 2D AND 3D UROTHELIAL IN VITRO MODELS WITH MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL CHARACTERISTICS OF NORMAL AND CANCEROUS BLADDER TISSUE AS AN ALTERNATIVE METHOD IN PRECLINICAL STUDIES M.E. Kreft1, L. Tratnjek1, A. Janev1, N. Resnik1, U. Cerkvenik1, U. D. Jerman1, G. Markovič1, T.Ž. Ramuta1, T. Višnjar1, Ž. Sardoč1, A.Punčuh1, S. Kralj2, M. Čemažar3, P. Veranič1 |1Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 2Department for Materials Synthesis, Jožef Stefan Institute, Ljubljana, Slovenia; 3Institute of Oncology Ljubljana, Ljubljana, Slovenia
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Elastofibroma dorsi: a histochemical and immunohistochemical study
2736PDF: 906HTML: 1099 -
5XFAD MOUSE MODEL: INVESTIGATING BRAIN IRON IMBALANCE AND MITOCHONDRIAL FEATURES’ ALTERATION Mezzanotte M1, Chicote J1, Scimia N1, Riganti C2, Porporato PE3 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Oncology, Oncological Pharmacology Lab, University of Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Italy
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The penetration of methanol into bovine cardiac and hepatic tissues is faster than ethanol and formalin
2028PDF: 836Supplementary: 207HTML: 53 -
AN INDUCED PLURIPOTENT STEM CELL MODEL OF FLVCR1-RELATED NEUROPATHY UNCOVERS MITOCHONDRIAL AND MEMBRANE DISORGANIZATION IN SENSORY NEURONS Zanin Venturini DI1, Kopecka J2, Zhao B3, Yu TW3, Abalai RE1, Metani L1, Salio C4, Riganti C2, Tolosano E1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) “Guido Tarone”, University of Torino, Turin, Italy; 2Department of Oncology, Molecular Biotechnology Center, University of Turin, Italy; 3Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, Harvard Medical School, USA; 4Department of Veterinary Sciences, University of Torino, Turin, Italy
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P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo1, S. Boccia2, E. Del Genio1, R. Pastore1, M. De Falco3, I. Belviso4 | 1Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 2Dept. of Biology, University of Naples Federico II, Naples, Italy; 3Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; 4Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy
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P19 | IDENTIFICATION OF MIR-129-5P AS A COMMON REGULATOR OF E3 UBIQUITIN LIGASES WITH A POTENTIAL ROLE IN GLIOBLASTOMA PROGRESSION N. Martella1, A.B. Díaz Méndez2, G. Regazzo2, G.F. Bufalieri3, A. Frati4, A. Arcella4, L. Di Marcotullio3, M.G. Rizzo2, S. Di Bartolomeo1 | 1Dept. of Biosciences and Territory, University of Molise, Italy; 2Dept. of Research, Advanced Diagnostics and Technological Innovation, Translational Oncology Research Unit, IRCCS -Regina Elena National Cancer Institute, Rome, Italy; 3Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 4IRCCS Neuromed, Pozzilli (IS), Italy
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FROM CLOUD TO BEDSIDE C. Tacchetti1,2 | 1Medical School & S.RACE (San-Raffaele Artificial Intelligence Center);Vita-Salute University San Raffaele, Milan, Italy; 2Experimental Imaging Center, IRCCS Hospital San Raffaele, Milan, Italy
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Expression of the endocannabinoid receptors in human fascial tissue
3484PDF: 1802HTML: 2364
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