FOR AUTHORS
Vol. 69 No. s3 (2025): Proceedings of the 35th National Conference of the Italian Group for the Study of Neuromorphology
Published:
12 December 2025
35th National Conference of the Italian Group for the Study of Neuromorphology, November 28-29, 2025
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EX VIVO MAPPING OF NIGRO-THALAMIC DOPAMINERGIC TERMINALS REVEALS REGIONAL SPECIALIZATION AND SYNAPTIC MARKERS IN THE HUMAN THALAMUS Cirillo G1, Montella M2, La Mantia E2, Tedesco I2, De Luca C1, Virtuoso A1, De Angelis F1, Riccio L1, Esposito F3, Cirillo M3, Franco R2 and Papa M1 | 1Division of Human Anatomy, Neuronal Networks Morphology & Systems Biology Lab, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 2Division of Pathology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli, Naples, Italy; 3Department of Advanced Medical and Surgical Sciences, Advanced MRI Research Center, University of Campania Luigi Vanvitelli, Naples, Italy
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NEUROPROTECTIVE POTENTIAL OF ADIPOSE MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES ON DAMAGED MOTONEURONS Caprioli M1, Sganzerla D1, Scambi I1, Virla F1, Grazioli N2, Greco N2, Turano E1 and Mariotti R1 | 1Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 2Department of Engineering for Innovation Medicine, University of Verona, Italy
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ACTIVITY-DEPENDENT NEUROPROTECTIVE PROTEIN EXPRESSION IS REGIONALLY UPREGULATED BY MODERATE AEROBIC EXERCISE IN THE RAT BRAIN Palmeri N1, D’Amico AG2, Pricoco E3, D’Agata V2 and Maugeri G1 | 1Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 2Department of Drug and Health Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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KAEMPFEROL TARGETS LIPID BALANCE, ENDOCANNABINOID PATHWAYS, AND PPAR-α IN THE RAT CEREBRAL CORTEX AFTER TRANSIENT BILATERAL COMMON CAROTID ARTERY OCCLUSION AND REPERFUSION Serra MP#, Carta G#, Murru E, Boi M, Manca C, Lai Y, Cabboi M, Carta A, Banni S* and Quartu M* | Department of Biomedical Sciences, University of Cagliari, Italy #equal contribution; *co-seniorship
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MODULATION OF EXTRACELLULAR SIGNAL-RELATED KINASE, CYCLIN D1, GLIAL FIBRILLARY ACIDIC PROTEIN, AND VIMENTIN EXPRESSION IN ESTRADIOL-PRETREATED ASTROCYTE CULTURES TREATED WITH COMPETENCE AND PROGRESSION GROWTH FACTORS Barbagallo A1, Barbagallo F1, Rapisarda G1 and Avola R1 | 1Department of Biometec (Biochemistry Section), University of Catania, Italy
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UNRAVELING GLIAL REMODELING IN SPACE AND TIME DURING GLIOBLASTOMA EVOLUTION Riccio L1, De Luca C1, Rega C1, Papa M1 and Virtuoso A1 | 1Laboratory of Neuronal Networks Morphology and System Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
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PURKINJE CELL INTEGRITY IS PRESERVED BY EXERCISE IN PARANEOPLASTIC CEREBELLAR DEGENERATION: EVIDENCE FROM A CANCER CACHEXIA MOUSE MODEL Zummo FP1, Saqagandomabadi V1, Barone R1, Macaluso F1, D’Amico D1, Sausa M1, Carini F1, Di Felice V1 and David S1 | 1Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Italy
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GENERATION AND CHARACTERIZATION OF A KNOCK-IN MOUSE MODEL FOR FLVCR1-RELATED SENSORY NEUROPATHY Abalai RE1, Marvaldi L2, Ferrini F3, Riganti C1, Zanin Venturini DI1, Metani L1, Tolosano E1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (TO), Italy; 3Dipartimento di Morfofisiologia Veterinaria and Rita Levi Montalcini Center for Brain Repair, Grugliasco (TO), Italy
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HIGH RESOLUTION MAGNETIC RESONANCE IMAGING TO ASSESS AXONAL DAMAGE IN NEUROPATHY MODELS Bontempi P1, Mastropietro A2, Rizzo G2, Taccogna M2, Napolitano A3, Gerevini S4, Kraus MF5,6, Di Girolamo S5,7, Cavaletti G5,7, Tamburin S8 and Alberti P5,7 | 1Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy; 2Institute for Biomedical Technologies, National Research Council (ITB-CNR), Segrate, Italy; 3Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy; 4Department of Neuroradiology, ASST Papa Giovanni XXIII, Bergamo, Italy; 5Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy 6S.C. Neuroscienze, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle D’Aosta, Torino, Italy; 7NeuroMI (Milan Center for Neuroscience), Milan, Italy; 8Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy
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MYELIN MAINTENANCE AND CELL VIABILITY: INVESTIGATING BECLIN 1 IN VIVO AND IN VITRO Bertone F1, Russo L2, Jorkesh A2, Khodaparast S1, Gambarotta G1, Ronchi G1 and Cescon M2 | 1Department of Clinical and Biological Sciences, University of Torino, Torino, Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy
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SHORT-TERM EXPOSURE TO PARTICULATE MATTER TRIGGERS SELECTIVE MOLECULAR AND BEHAVIORAL ALTERATIONS IN A MOUSE MODEL OF MULTIPLE SCLEROSIS Bonato M1,2, Montarolo F1,2, Cerrato V1,2, Parolisi R1,2, Abbadessa G3, Caudana M3, Di Cintio N1,2, De Francia S3, Bertolotto A2,4, Buffo A1,2, and Boda E1,2 | 1Dept. of Neuroscience Rita Levi Montalcini, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Orbassano (Turin), Italy; 3Department of Clinical and Biological Sciences, University of Turin, Orbassano (Turin), Italy; 4Koelliker Hospital, Turin, Italy
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THE DUAL EFFECT OF CADMIUM IN ASTROCYTE PHYSIOLOGY: FROM ADAPTIVE ACTIVATION TO POTENTIAL NEUROTOXICITY Branca JJV, Guarnieri G, Mencarelli F, Gulisano M, Morelli A and Pacini A | Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Firenze, Firenze, Italy
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MULTI SCAFFOLD 3D-BIOPRINTED MODEL OF SPINAL CORD ARCHITECTURE IN VITRO Chasseur S1, Traldi C2,3,4, Chiappini V1, Tonda-Turo C2,3,4 and Boido M1 | 1Department of Neuroscience «Rita Levi Montalcini», Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Turin, Italy; 2Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; 3POLITO BIOMedLAB, Politecnico di Torino, Turin, Italy; 4Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy
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A NOVEL DRUG TARGETTING THE INFLAMMASOME AMELYORATES AD PATHOLOGY IN THE MURINE MODEL 5xFAD Chicote J1, Rosano V1, Mezzanotte M1, Bertinaria M2, Marini E2, Vercelli A1 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Drug Science and Technology, University of Turin, Italy
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THE NEUROPROTECTIVE PEPTIDES PACAP AND ADNP RESCUE CEREBELLAR GRANULE CELLS FROM APOPTOSIS D’Amico AG1, La Cognata V3, Maugeri G2, Morello G3, Cavallaro S3 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Institute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), Catania, Italy
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CRAFTING THE MICROVASCULAR CANVAS: BIOENGINEERED MATERIALS OR NATIVE EXTRACELLULAR MATRIX FOR THE CENTRAL NERVOUS SYSTEM De Luca C1, Virtuoso A1, Cirillo G1, De Angelis F1, Guedán A2, Maduna T3, Morin A4, Sepulveda Diaz J4, Vlachos A3,5,6, Panetsos F7, Pérez-Rigueiro J8 and Papa M1,9 | 1Laboratory of Morphology of Neuronal Networks and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Bioactive Surfaces S.L., Madrid, Spain; 3Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg, Germany; 4Microfluidics Innovation Center, Paris, France; 5Center for Basics in Neuromodulation (NeuroModulBasics), Faculty of Medicine. University of Freiburg, Freiburg, Germany 6Center BrainLinks-BrainTools, University of Freiburg, Freiburg, Germany; 7Universidad Complutense de Madrid, Madrid, Spain 8Universidad Politécnica de Madrid, Spain; 9SYSBIO Centre of Systems Biology ISBE-IT, Milan, Italy
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MICROBIAL INFLUENCE ON PERIPHERAL NERVOUS SYSTEM: INSIGHTS FROM GERM-FREE AND RECOLONIZED MICE Farzin S1, Pellegrino D1, Cicconetti C2, Bertone F1, Oliviero S2, Basic M3, Bolsega S3, Haastert-Talini K4, Cescon M5, Gambarotta G1 and Ronchi G1 | 1Department of Clinical and Biological Sciences (DSCB), University of Torino, Orbassano, (Torino), Italy; 2Department of Life Sciences and System Biology, University of Torino, Torino, Italy; 3Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Lower- Saxony, Germany; 4Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Lower-Saxony, Germany; 5Department of Molecular Medicine, University of Padova, Padova, Italy
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HUMAN INDUCED PLURIPOTENT STEM CELLS-DERIVED CEREBRAL ORGANOIDS AS A MODEL FOR C9ORF72-LINKED FRONTO-TEMPORAL DEMENTIA: INSIGHTS INTO NEURONAL AND GLIAL DIFFERENTIATION DYNAMICS Ferrero C1,2,3, Pacca P1,2, Vercelli A1,2 and Boido M1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi, Italy 3University School for Advanced Studies IUSS Pavia, Pavia, Italy
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OVEREXPRESSION OF ANOSMIN-1 ALTERS THE MYELINATION PATTERN AND THE MORPHOLOGY OF AXONAL COMPONENTS IN CEREBELLAR PURKINJE CELLS Fieromonte A1, Lorenzati M1, Staffa A2, Bribian A2, Barderas MG3, Aguilar J4, De Castro F2 and Buffo A1 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Department of Neuroscience ita Levi, Montalcini, Turin, Italy; 2Instituto Cajal-CSIC, Grupo de Neurobiologia del Desarrollo-GNDe, Madrid, Spain; 3Servicio de Salud de Castilla- La Mancha-SESCAM, Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, Toledo, Spain; 4Servicio de Salud de Castilla-La Mancha-SESCAM, Experimental Neurophysiology Group, Hospital Nacional de Paraplejicos, Toledo, Spain
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CALRETININ IMMUNOREACTIVITY IN NERVE CELLS OF THE HUMAN MIDBRAIN AND THEIR POTENTIAL ROLE IN NEURODEGENERATIVE DISORDERS Flace P1, Caporusso C2, Galletta D3, Stolfa M2, Cacciola A4,5, Scarcella VS2, Branca JJV6, Gulisano M6, Milardi D7, Gradini R8, Livrea P9 and Marzullo A2 | 1Medical School, University of Bari Aldo Moro, Bari, Italy; 2Department of Precision and Regenerative Medicine and Ionian Area, Pathology Unit, University of Bari Aldo Moro, Bari, Italy; 3Specialization School Neuropsychology, University of Campania Luigi Vanvitelli, Caserta, Italy; 4IRCCS Humanitas Research Hospital, Milan, Italy; 5Department of Biomedical Sciences, Humanotas University, Milan, Italy; 6Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; 7Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy; 8Department of Experimental Medicine, Sapienza University, Roma, Italy; 9University of Bari Aldo Moro, Bari, Italy
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MORPHOLOGICAL AND TRANSCRIPTOMIC ANALYSES HIGHLIGHT DIFFERENTIAL REGENERATION KINETICS IN IMMEDIATE VERSUS DELAYED NERVE REPAIR García-Bejarano M1,2,3, Zen F1,2, El Soury M1,2, Camandona A1, M. de la Fuente J3, Perroteau I1, Ronchi G1,2, Ferrero G1 and Gambarotta G1,2 | 1Department of Clinical and Biological Sciences (DSCB), University of Torino, Orbassano (Torino), Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Orbassano (Torino), Italy; 3Institute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza & CIBER-BBN, Zaragoza, Spain
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CHEMOTHERAPY-INDUCED REMODELING OF CORTICAL PYRAMIDAL NEURONS: MORPHOLOGICAL EFFECTS OF OXALIPLATIN AND PACLITAXEL Iezzi G1,2, Marmiroli P3,4, Vercelli A1,2 and Cavaletti G3,4 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi,Turin, Italy; 3University of Milano-Bicocca, Italy; 4Experimental Neurology Unit, Monza, Italy
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THERAPEUTIC VERSUS PREVENTIVE ADMINISTRATION OF NEUROACTIVE STEROIDS TO TREAT BORTEZOMIB-INDUCED PAINFUL NEUROPATHY Iseppon F1, Tonelli E1,2, Fabbro V1, Chiorazzi A1, Canta A1, Alberti P1, Carozzi VA1, Pozzi E1, Cherchi L1,2, Fermi S1,2, Segmani I1,2, Fantoni L1, Rodriguez-Menendez V1, Ballarini E1, Cavaletti G1 and Meregalli C1 | 1University of Milano-Bicocca, Department of Medicine and Surgery, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy
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BEYOND THE SPINAL CORD: MORPHOLOGICAL ALTERATIONS OF CORTICAL PROJECTION NEURON IN SPINAL MUSCULAR ATROPHY La Rocca F1,2, Schellino R1,2, Iezzi G1,2, Caretto A1,2, Boido B1,2 and Vercelli A1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri, Ottolenghi, University of Turin, Turin, Italy
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EXPERIMENTAL PARKINSONISM RECRUITS CHOLINERGIC MEDIAL SEPTAL NEURONS Lenzi P1, Lazzeri G1, Ferrucci M1, Scotto M1, Giambelluca MA1, Binda P1 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy; 2IRCCS, Neuromed, Pozzili, Italy
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GAIT CHARACTERIZATION IN A MOUSE MODEL OF CHRONIC MILD STRESS- AND 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROINFLAMMATION Serinelli FC1, Kashyrina M2, De Nuccio F2, Panaro MA3, Cianciulli A3, Ruggiero M3, Porro C4, Ichas F5, Nicolardi N1 and Lofrumento DD1 | 1Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy; 2Department of Experimental Medicine, University of Salento, Lecce, Italy; 3Department of Biosciences, Biotechnologies and Environment, University of Bari, Italy; 4Department of Clinical and Experimental Medicine, University of Foggia, Italy; 5Institut des Maladies Neurodégénératives, CNRS, Université de Bordeaux, France
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THE LINK BETWEEN NEURONAL BRANCHING AND PAIN Dotta S1, Muraglia L1, Musso G1, Rother F2,3, Pritz. C1, Luzzati F1, Bader M2,3,4, Buffo A1, Vercelli A1 and Marvaldi L1 | 1Department of Neuroscience Rita Levi Montalcini, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Orbassano (TO), Italy; 2Max Delbrück Center for Molecular Medicine, Berlin, Germany; 3Center for Structural and Cellular Biology in Medicine, Institute of Biology, University of Lübeck, Germany; 4Charité, Universitätsmedizin, Berlin, Germany
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MORPHOLOGICAL AND SYNAPTIC CHANGES OF THE CORTICAL GABAERGIC INHIBITORY SYSTEM IN SPINAL MUSCULAR ATROPHY Menduti G1,2, Ferrini F3,4, Caretto A1,2, Hassan A5,6, di Vito R6,7, Beltrando G1,2, Marnetto D2, Usiello A6,7, Di Cunto F1,2, Boido M1,2, and Vercelli A1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; 2Department of Neuroscience «Rita Levi Montalcini», University of Turin, Italy; 3Department of Veterinary Sciences, University of Turin, Grugliasco, Turin, Italy; 4Department of Psychiatry and Neuroscience, Université Laval, Québec, Canada; 5European School of Molecular medicine, University of Milan, Italy; 6Laboratory of Translational Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy; 7Department of Environmental, Biological and Pharmaceutical Science and Technologies, Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy
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INVESTIGATION OF STRUCTURAL PRESERVATION OF PERIPHERAL NERVE EXTRACELLULAR MATRIX FOLLOWING EX VIVO LIMB PERFUSION Metafune M1,2, Haastert-Talini K3, Muratori L1,2 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Turin, Italy; 2Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Lower-Saxony, Germany
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FLVCR1a REGULATES CORTICAL INTERNEURON DEVELOPMENT AND MIGRATION IN THE EMBRYONIC CORTEX Metani L1, Zanin Venturini DI1, Abalai RE1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “Guido Tarone”, University of Torino, Torino, Italy
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5XFAD MOUSE MODEL: INVESTIGATING BRAIN IRON IMBALANCE AND MITOCHONDRIAL FEATURES’ ALTERATION Mezzanotte M1, Chicote J1, Scimia N1, Riganti C2, Porporato PE3 and Stanga S1 | 1Neuroscience Institute Cavalieri Ottolenghi, Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; 2Department of Oncology, Oncological Pharmacology Lab, University of Turin, Italy; 3Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin, Italy
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REDUCING PACLITAXEL-INDUCED PERIPHERAL NEUROTOXICITY VIA LIPOSOMAL DRUG TARGETING Molteni L1, Persico A2, Kravicz M3, Antoniou A4, Peqini K4, Mantecca P2, Nicolini G1, Pellegrino S4, Re F3 and Bragato C2 | 1Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 2POLARIS Research Center, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, Italy; 3School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 4Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
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EXPLORING NEURON–GLIOMA SIGNALING THROUGH IN VITRO CO-CULTURES Nicorvo E¹, Ferraro A¹, Pacca P¹, Boido M¹, Di Cunto F¹ and Vercelli A¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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EFFECTS OF MATERNAL LOW-PROTEIN AND PHYTOESTROGEN-ENRICHED DIETS ON THE CORRELATION BETWEEN EATING BEHAVIORS AND ANXIETY IN OFFSPRING Ricci E1,2, Ontiveros N1, Bellantoni MT3, Lafaenza S1,4, Gotti S1,2 and Marraudino M1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy; 2Department of Neuroscience Rita Levi Montalcini, University of Torino, Torino, Italy; 3Department of Medicine and Surgery, Neuroscience Unit, University of Parma; 4Department of Science and Technological Innovation, DISIT, University of Eastern Piedmont
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SCHWANN CELLS BEHAVIOR ON SMART ELECTROCONDUCTIVE BIOMATERIALS FOR PERIPHERAL NERVE REGENERATION Paravizzini G1,2, Sandu E1, Fregnan F1,2, Shirosaki Y3 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy; 2Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, Orbassano, Turin, Italy; 3Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi, Fukuoka, Japan
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DISTRIBUTION, DENSITY, AND PHYLOGENETIC VARIATION OF CORTICAL IMMATURE NEURONS IN MACAQUES (RHESUS MONKEY) Pattaro A1,2, Sherwood CC3 and Bonfanti L1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano (TO), Italy; 2Department of Veterinary Sciences, University of Turin, Grugliasco (TO), Italy; 3Department of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington DC, USA
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THE EFFECT OF ANTIBIOTIC-INDUCED DYSBIOSIS ON PERIPHERAL NERVE REPAIR Pellegrino D1, El Soury M1, Farzin S1, Elmelgy AA1, Muratori L1, Calabrò S2, Ferrocino I3, Ferrero G1, Camandona A1, Haastert- Talini K4, Cescon M2, Gambarotta G1 and Ronchi G1 | 1Department of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Orbassano, (Torino), Italy; 2Department of Molecular Medicine, University of Padova, Padova, Italy; 3Department of Scienze Agrarie, Forestali e Alimentari, DISAFA, University of Torino, Grugliasco, (Torino), Italy; 4Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Carl-Neuberg-Str.1, Hannover, Lower-Saxony, Germany
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THE ESTABLISHMENT OF A HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED IN VITRO MODEL TO STUDY DIABETIC PERIPHERAL NEUROPATHY Rando S1,2, Muratori L1,2, Contato A2,3, Lorenzati M2,3, Dotta S2,3, Marvaldi L2,3, Buffo A2,3 and Raimondo S1,2 | 1Department of Clinical and Biological Sciences, University of Turin, Turin, Italy; 2Neuroscience Institute Cavalieri Ottolenghi (NICO), Turin, Italy; 3Department of Neuroscience “Rita Levi Montalcini” University of Turin, Turin, Italy
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MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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ENDOCRINE DISRUPTOR EXPOSURE ACROSS GESTATION AND LACTATION MODIFIES MATERNAL AND ANXIETY-RELATED BEHAVIORAL PATTERNS Ricci E1,2, Guarini E1, Marraudino M1,2 and Gotti S1,2 | 1Neuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, Orbassano, Torino, Italy; 2Department of Neuroscience ‘Rita Levi Montalcini’, University of Torino, Torino, Italy
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MITOCHONDRIAL DYSFUNCTION AS A KEY FACTOR OF MOTOR NEURON DEGENERATION: INSIGHTS FROM AMYOTROPHIC LATERAL SCLEROSIS CELLULAR MODELS Scimia N¹, Carletti RM², Rasà MD¹, Ferrari D3, Boido M¹ and Stanga S¹ | ¹Neuroscience Institute Cavalieri Ottolenghi, Orbassano (TO), Department of Neuroscience Rita Levi Montalcini, University of Turin, Italy; ²Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 3Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy
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A PILOT STUDY TO INVESTIGATE THE ANTIAGING EFFECTS OF THE OLIVE POMACE BY-PRODUCT ON THE BRAIN OF DROSOPHILA MELANOGASTER Makladissi S1†, Tomassoni D2†*, Nardin T3, Bellitto V2, Cappelli A2, Di Cara F1‡ and Beghelli D2‡ | 1Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; 2School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, MC, Italy ; 3Chemical Unit Oenological Vines Agri-food - Technology Transfer Centre Foundation Edmund Mach, TN, Italy †These authors equally contributed. ‡These authors share the authorship
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CHANGE IN AQUAPORIN-4 EXPRESSION AND LOCALIZATION DURING AMYOTROPHIC LATERAL SCLEROSIS AND SPINAL MUSCULAR ATROPHY PROGRESSION Tuninetti A1, Boido M1, Vercelli A1 and Pacca P1 | 1Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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ALPHA SYNUCLEIN REGULATION IN BRAIN AND BONE MARROW IS RELETED TO THE DIFFERENTIAL EXPRESSION OF GATA1 TRANSCRIPTION FACTOR Velardi V1, Arciprete F1, Caturano C1, Rana RA1, Mancinelli R2, Zingariello M1 and Vivacqua G1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Department of Anatomic, Histologic, Forensic Medicine and Locomotor Apparatus Science, Sapienza University of Rome, Italy
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GENETIC AND MORPHOLOGICAL FACTORS IN CORTICAL FOLDING: STUDIES ON THE ROLANDIC FISSURE Martinet S¹, Pizzagalli F¹ and Vercelli A¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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CONNEXIN 43 HEMICHANNELS CAN DRIVE THE GLIOBLASTOMA SPREADING Virtuoso A1, De Luca C1, Altieri R2, Milior G3, Moulard J3, Huberfeld J3, Cirillo G1, Barbarisi M2, Rouach N3 and Papa M1 | 1Laboratory of Neural Network Morphology and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy; 2Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy; 3Interdisciplinary Research Center in Biology, College de France, CNRS, INSERM, Labex Memolife, Université PSL, Paris, France
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AN INDUCED PLURIPOTENT STEM CELL MODEL OF FLVCR1-RELATED NEUROPATHY UNCOVERS MITOCHONDRIAL AND MEMBRANE DISORGANIZATION IN SENSORY NEURONS Zanin Venturini DI1, Kopecka J2, Zhao B3, Yu TW3, Abalai RE1, Metani L1, Salio C4, Riganti C2, Tolosano E1 and Chiabrando D1 | 1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) “Guido Tarone”, University of Torino, Turin, Italy; 2Department of Oncology, Molecular Biotechnology Center, University of Turin, Italy; 3Division of Genetics and Genomics, Boston Children’s Hospital, Boston, MA, Harvard Medical School, USA; 4Department of Veterinary Sciences, University of Torino, Turin, Italy
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MODULATION OF IMMATURE NEURONS IN THE NEOCORTICAL LAYER II OF SHEEP KEPT IN DIFFERENT ENVIRONMENTAL CONDITIONS Zanone A1, Pattaro A1,2, Chincarini M3, Ghibaudi M1,2,#, Minero M4, Cozzi B5 and Bonfanti L1,2 | 1Neuroscience Institute Cavalieri Ottolenghi, Orbassano, Italy; 2Department of Veterinary Sciences, University of Turin, Italy; 3Department of Veterinary Medicine, University of Teramo, Italy 4Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy; 5Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy; #Present address: Department of Neuroscience, University of Pittsburgh, PA, USA
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HOW DO THE CYTOSKELETON AND ITS BINDING PARTNERS CONTRIBUTE TO THE ESTABLISHMENT OF THE BRAIN MORPHOLOGY AND ITS FUNCTION? Sato M1,2,3 | 1Department of Anatomy and Neuroscience, Graduate School of Medicine, The University of Osaka, Japan; 2Molecular Brain Sciences, Department of Child Development, United Graduate School of Child Development-Osaka University, Kanazawa University, Hamamatsu University of Medicine, Chiba University and University of Fukui (UGSCD), The University of Osaka, Japan; 3Department of Neurosciences Rita Levi Montalcini, University of Turin, Italy
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PRENATAL N-ACETYL-CYSTEINE PREVENTS NEURONAL, EMOTIONAL AND METABOLIC IMPAIRMENTS IN AN ANIMAL MODEL OF ADVERSE EXPERIENCES Cirulli F | Center for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy
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VGF AS BIOMARKER OF PRE-SYMPTOMATIC PHASE OF PARKINSON’S DISEASE Manai AL1, Modi A2, Noli B1, Choudhary SM2, Ruda-Kucerova J3, Dražanová E3,4, Khairnar A2,5, Cocco C1 | 1Department of Biomedical Sciences, University of Cagliari, Monserrato, Italy; 2International Clinical Research Center, St. Anne’s University Hospital Brno, Czech Republic; 3Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 4Institute of Scientific Instruments of the CAS, v. v. i., Brno, Czech Republic; 5Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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STRESS GRANULES AND α-SYNUCLEIN: INTERPLAY BETWEEN CELLULAR STRESS AND PROTEIN AGGREGATION IN PARKINSON’S DISEASE Zanchi G1, Novello C1, Calogero AM2, Mazzetti S2, Bonaldo B1, Gomez MCL1, Rolando C1, Calandrella D2,3, Pezzoli G2 and Cappelletti G1 | 1Department of Biosciences, University of Milan, Milan, Italy 2Fondazione Pezzoli per la Malattia di Parkinson, Milan, Italy 3Parkinson Institute, ASST G. Pini-CTO, Milan, Milan, Italy
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THE ROLE OF RETINAL mTOR IN RETINAL DEGENERATION Lazzeri G1, Lenzi P1, Ferrucci M1, Biagioni F2, Busceti CL2, Giambelluca M1, Puglisi-Allegra S2 and Fornai F1,2 | 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa; 2IRCCS, Neuromed, Pozzilli, Italy
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NEUROBIOLOGY OF SUICIDE: MORPHOLOGICAL ASSESSMENT OF MICROGLIAL NETWORK IN HUMAN POST-MORTEM PREFRONTAL CORTEX Tambuzzi S1, Bertolotto N2, Massari S2, Madaschi L3, Alini M2, Brandolese D2, Ubezio MC1, Cattaneo C1 and Amadeo A2 | 1Institute of Forensic Medicine, Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy; 2Department of Biosciences, Università degli Studi di Milano, Milan, Italy; 3UNITECH NOLIMITS, Università degli Studi di Milano, Milan, Italy
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GLIAL INFLAMMASOME ACTIVATION AND BLOOD-BRAIN BARRIER BREAKDOWN IN AGE-RELATED NEURODEGENERATION Errede M1, Girolamo F1, d’Amati A1,2, de Giorgis M1, Lorusso L1, Pierucci C3, Bernardini N3, Pellegrini C3, Virgintino D1 and Annese T2 | 1University of Bari, Department of Translational Biomedicine and Neuroscience – Human Anatomy and Histology Unit, Bari, Italy; 2Libera Università del Mediterraneo (LUM) Giuseppe Degennaro University, Department of Medicine and Surgery, Bari, Italy; 3University of Pisa, Department of Clinical and Experimental Medicine - Unit of Histology and Medical Embryology, Pisa, Italy
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STANDARDIZING LIGHT SHEET IMAGING AND 3D IMAGE ANALYSIS FOR WHOLE BRAIN VASCULAR NET QUANTIFICATION Zanella L1, Moretti M1, Quadalti C2, Giardino L1,3,4, Calzà L2,3,4, Baldassarro VA1,4 and Lorenzini L1,4 | 1Department of Veterinary Medical Science, University of Bologna, Ozzano dell’Emilia, Bologna, Italy; 2Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; 3IRET Foundation, Ozzano dell’Emilia, Bologna, Italy; 4Interdepartmental Centre for Industrial Research in Health Sciences and Technology ICIR-HST, University of Bologna, Ozzano dell’Emilia, Bologna, Italy
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WHOLE-BRAIN CATECHOLAMINERGIC CONNECTOMICS IN ALZHEIMER’S DISEASE Bellomi FE1, Loffredo G2, Petrocchi F1, Ullman NS1, Caturano C1, Cauzzi E2, Cognini F3, Mittoni F4, LaBarbera L2, Soda P5, D’Amelio M2 and Vivacqua G1 | 1Microscopic and Ultrastructural Anatomy Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 2Molecular Neuroscience Laboratory, Campus Bio-medico University of Rome, Rome, Italy; 3Carl Zeiss S.p.A., Milan, Italy; 4Interconsulting services, RINA Services S.p.A., Rome, Italy; 5Department of Bio-engineering, Campus Bio-medico University of Rome, Rome, Italy
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CONNECTOME-BASED BRAIN FINGERPRINTS PREDICT ART THERAPY RESPONSE IN PARKINSON’S DISEASE Ielo A1,§, Genovese D2,3,§, Falcó-Roget J4, Amico E5,6, Norcini M7, Quartarone A1, Ghilardi MF8 and Cacciola A9,10 | 1IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy; 2Institute of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; 3Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; 4Computational Neuroscience Group, Sano Centre for Computational Medicine, Kraków, Poland; 5School of Mathematics, University of Birmingham, Birmingham, UK; 6Centre for Human Brain Health, University of Birmingham, Birmingham, UK; 7NYU Langone Health, Department of Neurology, New York, USA; 8Department of Molecular, Cellular & Biomedical Sciences, School of Medicine, City University of New York, New York, USA; 9Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; 10IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. §Shared co-first authorship
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A PRECLINICAL STUDY ON THE MODULATION OF THE MICROBIOTA–GUT–BRAIN AXIS BY A FUNCTIONAL SNACK PROMOTING HEALTHY AGING Bellitto V1, Grasselli F1, Martinelli I2, Nittari G2, Vittadini E1, Eleuteri AM1, Tayebati SK2, Bonfili L1 and Tomassoni D1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Italy
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SENSORY NEURON TOXICITY TRIGGERED BY ANTICANCER DRUGS IS COUNTERACTED BY EXTRACELLULAR VESICLES DERIVED FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS D’Aprile C1, Naghshbandieh A1,3, Fabbro V1, Turano E2, Scambi I2, Virla F2, Caprioli M2, Mariotti R2, Scuteri A1 and Meregalli C1 | 1Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Italy; 2Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Italy; 3PhD Program in Neuroscience, University of Milano- Bicocca, Italy
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LOCUS COERULEUS STRUCTURAL INTEGRITY IS ASSOCIATED WITH CIRCULATING SOLUBLE AXL IN ALZHEIMER’S DISEASE Galgani A1, Scotto M2, Mary A3, Lombardo F4, Martini N4, Siciliano G5, Ceravolo R5, Heneka MT3,6 and Giorgi FS1,7 | 1Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Italy; 2Laboratory of Medical Science, Institute of Life Sciences, Scuola Superiore Sant’Anna, Pisa, Italy; 3Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; 4Department of Radiology, Fondazione Toscana “G. Monasterio”, Pisa, Italy; 5Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; 6Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; 7I.R.C.C.S. Stella Maris, Calambrone, Pisa, Italy
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SODIUM-CALCIUM EXCHANGER PIVOTAL ROLE IN OXALIPLATIN-INDUCED ALTERATIONS LEADING TO PERIPHERAL NEUROTOXICITY, AXONAL DAMAGE AND NECROPTOSIS Di Girolamo S1, Invernizzi C1, Kraus MF3, Ballarini E1 and Alberti P1,2 | 1Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy; 2Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; 3S.C. Neuroscienze, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle D’Aosta, Torino, Italy
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CONTRIBUTION OF MAGNETIC RESONANCE IMAGING ASSOCIATED WITH MACHINE LEARNING TO AN EARLY ASSESSMENT OF THE CONVERSION OF MILD COGNITIVE IMPAIRMENT IN OVERT DEMENTIA Amenta F, Battineni G, Chintalapudi N and Traini E | Clinical Research Centre, School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
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INSIGHTS INTO THE EVOLUTION OF DOPAMINERGIC CONTROL OF REPRODUCTION: THE BRAIN-PITUITARY-GONADAL AXIS OF THE SMALL-SPOTTED CATSHARK SCYLIORHINUS CANICULA Porceddu R1,2, Mulas G1, Porcu C1 and Follesa MC1,2 | 1Sezione di Biologia Animale ed Ecologia, Dipartimento di Scienze della Vita e dell’Ambiente, Università degli Studi di Cagliari, Cagliari, Italy; 2CoNISMa Consorzio Nazionale Interuniversitario per le Scienze Mare, Rome, Italy
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NEUROACTIVE STEROIDS PROTECT FROM BORTEZOMIB-INDUCED TOXICITY: EVIDENCE FROM IN VITRO MODELS Fabbro V1, Tonelli E1,2, Scuteri A1,3, D’Aprile C1, Naghshbandieh A1,2, Lim D4, Distasi C4, Giatti S5 and Meregalli C1 | 1School of Medicine and Surgery, Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano- Bicocca, Monza, Italy; 2University of Milano-Bicocca, PhD Program in Neuroscience, Monza, Italy; 3Milan Center for Neuroscience (NeuroMI); 4University of Piemonte Orientale, Department of Pharmaceutical Sciences, Novara, Italy; 5University of Milan, Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, Milan, Italy
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