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Varying effects of EGF, HGF and TGFβ on formation of invadopodia and invasiveness of melanoma cell lines of different origin
2223PDF: 909Supplementary: 276HTML: 415 -
Knockdown of miR-411-3p induces M2 macrophage polarization and promotes colorectal cancer progression by regulation of MMP7
792PDF: 348Supplementary: 37HTML: 42 -
P82 | PROINFLAMMATORY BONE MARROW NICHES AND NEUTROPHIL ACTIVATION ARE ASSOCIATED WITH TIGIT EXPRESSION IN MULTIPLE MYELOMA V. Velardi1, F. Arciprete1, V. Tomarchio2, G. Vivacqua1, M.A. Tafuri2, M. Di Cecca2, L. Rigacci2, A. Crescenzi3, R. Rana1, O. Annibali2, M. Zingariello1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Unit of Hematology, Stem Cell Transplantation, University Hospital Campus Bio-Medico Rome, Italy; 3Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, Italy
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P51 | DECELLULARIZATION OF HUMAN LUNG SCAFFOLD FOR TUMOR MICROENVIRONMENT MODELLING STUDY A. Mileo1, S. Boccia2, E. Del Genio1, R. Pastore1, M. De Falco3, I. Belviso4 | 1Dept. of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 2Dept. of Biology, University of Naples Federico II, Naples, Italy; 3Dept. of Biology, University of Naples Federico II, Naples, Italy; National Institute of Biostructures and Biosystems (INBB), Rome, Italy; 4Dept. of Wellness, Nutrition and Sport, Telematic University Pegaso, Naples, Italy
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Syndecan expressions in the human amnion and chorionic plate
1754PDF: 641HTML: 654 -
P16 | A 3D IN VITRO MODEL TO STUDY CAF PLASTICITY AND TUMOR-STROMA INTERACTIONS IN OVARIAN CANCER P. Chiodelli1, J. Romoli1, P. Bonassi Signoroni2, E. Vertua2, C. Ferrari3, E. Giuzzi2, A. Paini2, E. Scalvini2, A. Papait1, F.R. Stefani2, A. R. Silini2, O. Parolini1 | 1Department of Life Science and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; 2Centro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy; 3Research and Clinical Trials Unit, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy
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Forever particles: histochemistry in the plasticene age
847PDF: 437HTML: 42 -
MICROFLUIDIC PLATFORM TO UNRAVEL GLIOMASECRETOME INTERACTION D’Amico AG1, Rasà DM1, Maugeri G2, Pricoco E3, Gulisano M1 and D’Agata V2 | 1Department of Drug and Health Sciences, University of Catania, Italy; 2Department of Biomedical and Biotechnological Sciences, University of Catania, Italy; 3Anatomic Pathology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy
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P21 | EARLY BIOLOGICAL EFFECTS ON CELL PROLIFERATION AND DIFFERENTIATION INDUCED BY EXTRACELLULAR MICROVESICLES (EVS) DERIVED FROM HUMAN KERATINOCYTES IN PSORIATIC MICROENVIRONMENT D. Daluiso1, B. Barco1, C. Porro2, E. Donetti3, F. Riva1 | 1Department of Publich Health, Experimental and Forensic Medicine, Histology and Embryology Unit, University of Pavia, Pavia, Italy; 2Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy; 3Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
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UNRAVELING GLIAL REMODELING IN SPACE AND TIME DURING GLIOBLASTOMA EVOLUTION Riccio L1, De Luca C1, Rega C1, Papa M1 and Virtuoso A1 | 1Laboratory of Neuronal Networks Morphology and System Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy
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P64 | EX VIVO EXTRACTION OF GLIOMA SECRETOME: A NOVEL MICROENVIRONMENT-BASED PROTOCOL FOR METABOLIC AND MOLECULAR PROFILING I. Neri1, M.V. Marvi1, V. Righi2, V. Papa3, E. Boschetti1, S. Blando1, E. Franceschi4, M. Zoli4, D. Mazzatenta4, N. Neri4, A. Vignaroli4, L. Cocco1, L. Manzoli1, S. Ratti1 | 1Cellular Signalling Laboratory, Anatomy Center, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; 2Department of Life Quality Sciences, University of Bologna, Bologna, Italy; 3IRCCS St. Orsola, Bologna, Italy; 4IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
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Reliable hexokinase 3 protein detection in human cell lines and primary tissue
1638PDF: 410Supplementary: 50Uncropped Western blots: 45HTML: 10 -
EXPLORING NEURON–GLIOMA SIGNALING THROUGH IN VITRO CO-CULTURES Nicorvo E¹, Ferraro A¹, Pacca P¹, Boido M¹, Di Cunto F¹ and Vercelli A¹ | ¹Department of Neuroscience “Rita Levi Montalcini”, Neuroscience Institute Cavalieri Ottolenghi, University of Turin, Italy
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P05 | ENTERIC NERVOUS SYSTEM NEUROPLASTICITY IN COLON OF ANIMAL MODELS OF OBESITY V. Bellitto1, I. Martinelli2, G. Nittari2, S.K. Tayebati2, D. Tomassoni1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Camerino, Italy
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UNRAVELING THE RELATIONSHIPS BETWEEN TUMOR CELLS AND THEIR MICROENVIRONMENT USING HIGH-RESOLUTION SPATIAL TRANSCRIPTOMICS M. Cordenonsi |Department of Molecular Medicine, University of Padova, Padova, Italy
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ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION C. Giampietri1, E. Pizzichini1, F. Somma1, S. Petrungaro1, A. Facchiano2, A. Filippini1, C. Fabrizi1, E. Gaudio1 | 1Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy; 2Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Rome, Italy
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P86 | THE EFFECTS OF NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITION ON THE EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR IN THE OLFACTORY BULB ORGANOTYPIC SLICE CULTURES I. Atasoy1, S. Yilmazer2, D. Gezen Ak3, E. Dursun3 | 1Medical Biology Department, İstabul University-Cerrahpasa Faculty of Medicine Istanbul, Türkiye; 2Department of Medical Biology Halic University, Faculty of Medicine, Istanbul, Türkiye; 3Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Türkiye
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Long noncoding RNA H19 accelerates tenogenic differentiation by modulating miR-140-5p/VEGFA signaling
1723PDF: 915Supplementary: 156HTML: 23 -
HACAT CELLS AS A 2D EXPERIMENTAL DIFFERENTIATING MODEL TO ANALYZE THE EARLY BIOLOGICAL EFFECTS INDUCED BY A PSORIATIC PROINFLAMMATORY MICROENVIRONMENT: CELL PROLIFERATION, DIFFERENTIATION AND FERROPTOSIS F. Riva1, S. Recalcati2, E. Gammella2, D. Daluiso1, F. Prignano3, E. Donetti2 | 1Dept. Public Health, Experimental and Forensic Medicine; Histology and Embryology Unit, University of Pavia, Pavia, Italy; 2Dept. Biomedical Sciences for Health, University of Milan, Milan, Italy; 3Dept. Health Sciences, Section of Dermatology, University of Florence, Florence, Italy
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P48 | NEW STRATEGIES TO IMPROVE THE RESPONSE OF AML CELLS TO TARGETED THERAPIES BY OVERCOMING THE PROTECTIVE EFFECT OF THE BONE MARROW MESENCHYMAL STEM CELLS G. Mazzanti1, F. Liccardo2, L. Pace1, M. Marcotulli3, L. Lafrate3, G. Cidonio3, T. Ottone4, S. Travaglini4, M.T. Voso4, V. Fulci5, M. Sampaolesi1, F. Fazi1, S. Masciarelli1 | 1Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences and Medical Embryology, Section of Histology Sapienza University of Rome, Rome, Italy; 2Centre de Recherches en Cancérologie de Toulouse, Inserm/ U1037, Université de Toulouse, Toulouse, France; 3Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, Rome, Italy; 4Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy; 5Department of Molecular Medicine, Sapienza, University of Rome, Rome, Italy
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A PRECLINICAL STUDY ON THE MODULATION OF THE MICROBIOTA–GUT–BRAIN AXIS BY A FUNCTIONAL SNACK PROMOTING HEALTHY AGING Bellitto V1, Grasselli F1, Martinelli I2, Nittari G2, Vittadini E1, Eleuteri AM1, Tayebati SK2, Bonfili L1 and Tomassoni D1 | 1School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy; 2School of Medicinal and Health Products Sciences, University of Camerino, Italy
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BIOLOGICAL RESPONSE OF TREATMENT WITH SAFFRON PETAL EXTRACT ON CYTOKYNE-INDUCED OXIDATIVE STRESS AND INFLAMMATION IN THE CACO-2/THP1 COCOLTURE MODEL V. Panella1, F. De Cecco2, S. Franceschelli1, M. A. Maggi3, S. Bisti4, A. Bravo Nuevo5, D. D’Ardes1, F. Cipollone1, L. Speranza1 | 1Department of Medicine and Aging Sciences, University «G. D’Annunzio», Chieti; 2Italian Institute of Technology, Genoa, Italy; 3Hortus Novus, L’Aquila, Italy; 4National Institute of Biostructure and Biosystem, Rome, Italy; 5Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine (PCOM), Philadelphia, USA
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P02 | THE C-C CHEMOKINE-RECEPTOR 2 (CCR2)/CCL2 AXIS PARTICIPATE IN PLATELET FUNCTION IN MYELOFIBROSIS F. Arciprete1, V. Velardi1, G. Pozzi2, C. Carubbi3, S. Cortellazzi3, A.M. Vannucchi4, M. Vitale5, R.A. Rana1, G. Vivacqua1, E. Masselli3, M. Zingariello1 | 1Unit of Microscopic and Ultrastructural Anatomy, University Campus Bio-Medico, Rome, Italy; 2Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; 3Anatomy Unit, Department of Medicine and Surgery (DiMeC), University of Parma, Parma, Italy; 4Center Research and Innovation of Myeloproliferative Neoplasm, University Hospital Careggi, University of Florence, Florence, Italy; 5San Raffaele University, Milano, Italy
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REDUCING PACLITAXEL-INDUCED PERIPHERAL NEUROTOXICITY VIA LIPOSOMAL DRUG TARGETING Molteni L1, Persico A2, Kravicz M3, Antoniou A4, Peqini K4, Mantecca P2, Nicolini G1, Pellegrino S4, Re F3 and Bragato C2 | 1Experimental Neurology Unit, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 2POLARIS Research Center, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Milan, Italy; 3School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; 4Department of Pharmaceutical Sciences, University of Milan, Milan, Italy
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Galunisertib enhances chimeric antigen receptor-modified T cell function
1986PDF: 1038Supplementary: 153HTML: 17 -
P03 | THE ROLE OF FILAMIN A IN REGULATING BREAST CANCER CELL BEHAVIOR AND TUMOR MICROENVIRONMENT INTERACTIONS W. Arendt1, P. Zawadka1, M. Hałas-Wiśniewska1, M. Gagat2, M. Izdebska1 | 1 Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń, Poland; 2Department of Histology and Embryology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Płock, Poland
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ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS M. Barroso | Department of Molecular and Cellular Physiology Albany Medical College, Albany NY 12208, USA
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P66 | FROM INNERVATION TO STEROIDOGENIC DEFECT: IMPLICATIONS OF CGRP IN THE PATHOPHYSIOLOGY OF POLYCYSTIC OVARY SYNDROME L. Sallicandro1, R. Gentile2, B. Filová3, S. Polakovičová3, A. Biagini1, F. Ballarino4, D. Del Bianco4, I. Varga5, A. Malvasi6, B. Fioretti2 | 1Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 3Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 4Department of Chemistry, Biology and Biotechnologies, University of Perugia, Italy; 5Department of Histology and Embriology, Comenius University, Bratislava, Slovakia; 6Department of Biomedical Sciences and Human Oncology, Obstetrics and Gynecology Unit, University of Bari Aldo Moro, Bari, Italy
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